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Urinary Dickkopf-3 and the evaluation of chronic kidney disease progression
Danilo Fliser
doi : 10.1093/ndt/gfab246
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2161–2163
Call for emergency action to limit global temperature increases, restore biodiversity and protect health: Wealthy nations must do much more, much faster*
Lukoye Atwoli, Abdullah H Baqui, Thomas Benfield, Raffaella Bosurgi, Fiona Godlee, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Carlos Augusto Monteiro, Ian Norman, Kirsten Patrick, Nigel Praities, Marcel G M Olde Rikkert, Eric J Rubin, Peush Sahni, Richard Smith, Nick Talley, Sue Turale, Damián Vázquez
doi : 10.1093/ndt/gfab236
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2164–2166
Global warming applied to dialysis: facts and figures
Michel Burnier, Denis Fouque
doi : 10.1093/ndt/gfab260
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2167–2169
Dialysis dose and mortality: where is the limit?
Francesco Locatelli, Lucia Del Vecchio
doi : 10.1093/ndt/gfab265
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2170–2172
Strategies designed to increase the motivation for and adherence to dietary recommendations in patients with chronic kidney disease
Raíssa Antunes Pereira, Marle S Alvarenga, Carla Maria Avesani, Lilian Cuppari
doi : 10.1093/ndt/gfaa177
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2173–2181
Chronic kidney disease (CKD) often requires several dietary adjustments to control the disease-related disturbances. This is challenging for both patients and healthcare providers, and particularly for dietitians, who deal closely with the poor adherence to dietary recommendations. Factors associated with poor adherence within the CKD scenario and the need for a shift in the paradigm have already been indicated in several studies; however, rarely are any different and/or potential strategies actually formulated in order to change this paradigm. In this review, we aimed to explore the concepts and factors surrounding adherence to dietary recommendations in CKD and further describe certain potential strategies for a nutritional counseling approach. Such strategies, while poorly explored within CKD, have shown positive results in other chronic disease scenarios. It is timely, therefore, for healthcare providers to acquire these new counseling skills; nevertheless, this would require a rethinking of the traditional attitudes and approaches in order to build a partnership, based on a nonjudgmental and compassionate style in order to guide behavior change. The reflections presented in this review may contribute towards enhancing motivation and the adherence to dietary recommendations in CKD patients.
Volume overload in hemodialysis: diagnosis, cardiovascular consequences, and management
Charalampos Loutradis, Pantelis A Sarafidis, Charles J Ferro, Carmine Zoccali
doi : 10.1093/ndt/gfaa182
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2182–2193
Volume overload in haemodialysis (HD) patients associates with hypertension and cardiac dysfunction and is a major risk factor for all-cause and cardiovascular mortality in this population. The diagnosis of volume excess and estimation of dry weight is based largely on clinical criteria and has a notoriously poor diagnostic accuracy. The search for accurate and objective methods to evaluate dry weight and to diagnose subclinical volume overload has been intensively pursued over the last 3 decades. Most methods have not been tested in appropriate clinical trials and their usefulness in clinical practice remains uncertain, except for bioimpedance spectroscopy and lung ultrasound (US). Bioimpedance spectroscopy is possibly the most widely used method to subjectively quantify fluid distributions over body compartments and produces reliable and reproducible results. Lung US provides reliable estimates of extravascular water in the lung, a critical parameter of the central circulation that in large part reflects the left ventricular end-diastolic pressure. To maximize cardiovascular tolerance, fluid removal in volume-expanded HD patients should be gradual and distributed over a sufficiently long time window. This review summarizes current knowledge about the diagnosis, prognosis and treatment of volume overload in HD patients.
Hypertension management in chronic kidney disease
Francesca Mallamaci, Anna Pisano, Giovanni Tripepi
doi : 10.1093/ndt/gfz279
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2194–2195
Vitamin K: should we supplement to protect the kidneys and the heart?
Markus Ketteler, Moritz Schanz, Severin Schricker
doi : 10.1093/ndt/gfz291
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2196–2198
Urinary Dickkopf-3: a new biomarker for CKD progression and mortality
Beatriz Sánchez-Álamo, Francisco José García-Iñigo, Amir Shabaka, Juan Manuel Acedo, Clara Cases-Corona, Patricia Domínguez-Torres, Yunayka Diaz-Enamorado, Eugenia Landaluce, Juan F Navarro-González, José Luis Gorriz, Alberto Martínez-Castelao, Gema Fernández-Juárez
doi : 10.1093/ndt/gfab198
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2199–2207
Kidney fibrosis has been reported to be a prognostic factor in chronic kidney disease (CKD) progression. Previous studies have shown that the assessment of urinary Dickkopf-3 (uDKK3), a stress-induced tubular epithelial-derived profibrotic glycoprotein, might be a potential tubulointerstitial fibrosis biomarker and might identify patients at short-term risk of glomerular filtration rate loss. We aim to evaluate uDKK3 as a potential biomarker for progression of CKD in a cohort with various aetiologies of CKD and subsequently in an overt diabetic nephropathy cohort.
Subsequent urinary stone events are predicted by the magnitude of urinary oxalate excretion in enteric hyperoxaluria
Matthew R D’Costa, Annamaria T Kausz, Kevin J Carroll, Jóhann P Ingimarsson, Felicity T Enders, Kristin C Mara, Ramila A Mehta, John C Lieske
doi : 10.1093/ndt/gfaa281
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2208–2215
Data directly demonstrating the relationship between urinary oxalate (UOx) excretion and stone events in those with enteric hyperoxaluria (EH) are limited. Therefore, we assessed the relationship between UOx excretion and risk of kidney stone events in a retrospective population-based EH cohort. In all, 297 patients from Olmsted County, Minnesota were identified with EH based upon having a 24-h UOx ?40?mg/24?h preceded by a diagnosis or procedure associated with malabsorption. Diagnostic codes and urologic procedures consistent with kidney stones during follow-up after baseline UOx were considered a new stone event. Logistic regression and accelerated failure time modeling were performed as a function of UOx excretion to predict the probability of new stone event and the annual rate of stone events, respectively, with adjustment for urine calcium and citrate. Mean?±?standard deviation age was 51.4?±?11.4?years and 68% were female. Median (interquartile range) UOx was 55.4 (46.6–73.0) mg/24?h and 81 patients had one or more stone event during a median follow-up time of 4.9 (2.8–7.8) years. Higher UOx was associated with a higher probability of developing a stone event (P?<?0.01) and predicted an increased annual risk of kidney stones (P?=?0.001). Estimates derived from these analyses suggest that a 20% decrease in UOx is associated with 25% reduction in the annual odds of a future stone event. Thus, these data demonstrate an association between baseline UOx and stone events in EH patients and highlight the potential benefit of strategies to reduce UOx in this patient group.
Seropositive PLA2R-associated membranous nephropathy but biopsy-negative PLA2R staining
Jiao Luo, Wang Zhang, Cailing Su, Zhanmei Zhou, Guobao Wang
doi : 10.1093/ndt/gfaa239
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2216–2223
Serum phospholipase A2 receptor (PLA2R) antibody (SAb) and glomerular deposits of PLA2R antigen (GAg) have been tested widely in idiopathic membranous nephropathy (MN). Recently, we noticed a special form of PLA2R-associated MN with positive circulating PLA2R antibody but negative PLA2R deposits in the glomeruli by immunofluorescence on frozen tissue (IF-F). The significance of this form of PLA2R-associated MN is yet to be elucidated. This study aimed to explore the clinicopathological features of these PLA2R-associated MN patients.
Change in ankle–brachial index and mortality among individuals with chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort Study
Kirsten S Dorans, Hua He, Jing Chen, Mirela Dobre, Alan S Go, L Lee Hamm, Bernard G Jaar, Rupal C Mehta, Mahboob Rahman, Ana C Ricardo, Sylvia E Rosas, Anand Srivastava, Jiang He, the CRIC Study Investigators
doi : 10.1093/ndt/gfaa246
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2224–2231
Patients with chronic kidney disease (CKD) have an increased risk of peripheral arterial disease (PAD). The ankle–brachial index (ABI), a noninvasive measure of PAD, is a predictor of adverse events among individuals with CKD. In general populations, changes in ABI have been associated with mortality, but this association is not well understood among patients with CKD.
Predictive effect of salt intake on patient and kidney survival in non-dialysis CKD: competing risk analysis in older versus younger patients under nephrology care
Carlo Garofalo, Michele Provenzano, Michele Andreucci, Antonio Pisani, Luca De Nicola, Giuseppe Conte, Silvio Borrelli
doi : 10.1093/ndt/gfaa252
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2232–2240
The optimal level of salt intake remains ill-defined in non-dialysis chronic kidney disease (CKD) patients under regular nephrology care. This unanswered question becomes critical in older patients who are exposed to higher risk of worsening of cardiorenal disease due to volemic changes.
Hyponatremia and other electrolyte abnormalities in patients receiving immune checkpoint inhibitors
Harish Seethapathy, Nifasha Rusibamayila, Donald F Chute, Meghan Lee, Ian Strohbehn, Leyre Zubiri, Alexander T Faje, Kerry L Reynolds, Kenar D Jhaveri, Meghan E Sise
doi : 10.1093/ndt/gfaa272
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2241–2247
Hyponatremia due to endocrinopathies such as adrenal insufficiency and hypothyroidism has been reported in patients receiving immune checkpoint inhibitors (ICIs). We determined the risk and predictors of hyponatremia and other electrolyte abnormalities in a ‘real-world’ sample of patients receiving ICIs to treat advanced malignancies.
Serum bicarbonate is associated with kidney outcomes in autosomal dominant polycystic kidney disease
Charles J Blijdorp, David Severs, Usha M Musterd-Bhaggoe, Ronald T Gansevoort, Robert Zietse, Ewout J Hoorn, DIPAK Consortium
doi : 10.1093/ndt/gfaa283
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2248–2255
Metabolic acidosis accelerates progression of chronic kidney disease, but whether this is also true for autosomal dominant polycystic kidney disease (ADPKD) is unknown.
CD62L on blood basophils: a first pre-treatment predictor of remission in severe lupus nephritis
Matthieu Halfon, Delphine Bachelet, Guillaume Hanouna, Barbara Dema, Christophe Pellefigues, Pauline Manchon, Cedric Laouenan, Nicolas Charles, Eric Daugas
doi : 10.1093/ndt/gfaa263
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2256–2262
Basophils were recently shown to contribute to lupus nephritis (LN). This study assessed blood basophil activation markers (BAMs) for the diagnosis of LN severity and as pre-treatment prognostic markers of the response to treatment in patients with severe LN.
Effects of the chymase inhibitor fulacimstat in diabetic kidney disease—results from the CADA DIA trial
Peter Rossing, Jorma Strand, Angelo Avogaro, Michael Becka, Friederike Kanefendt, Christiane Otto on behalf of the investigators of the CADA DIA trial
doi : 10.1093/ndt/gfaa299
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2263–2273
The protease chymase generates multiple factors involved in tissue remodelling including angiotensin II (Ang II) and has been implicated in the pathophysiology of diabetic kidney disease (DKD). This study investigated the effects of the chymase inhibitor fulacimstat on albuminuria in patients with Type II diabetes mellitus and a clinical diagnosis of DKD.
Frailty and the risk of kidney function decline in the elderly population: the Rugao Longevity and Ageing Study
Mengjing Wang, Xuehui Sun, Weichen Zhang, Qian Zhang, Jing Qian, Weisheng Chen, Shun Yao, Li Jin, Kamyar Kalantar-Zadeh, Xiaofeng Wang, Jing Chen
doi : 10.1093/ndt/gfaa323
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2274–2281
The diverse risk factors for kidney impairments suggest that kidney function decline is more likely to occur in individuals with a broadly constituted health deficit. Here we conducted a longitudinal cohort study to evaluate the association of baseline frailty status with the risk of estimated glomerular filtration rate (eGFR) decline.
Association of circulating cardiac biomarkers with electrocardiographic abnormalities in chronic kidney disease
Alexander J Kula, Ronit Katz, Leila R Zelnick, Elsayed Soliman, Alan Go, Michael Shlipak, Rajat Deo, Bonnie Ky, Ian DeBoer, Amanda Anderson, Rob Christenson, Stephen L Seliger, Chris Defilippi, Harold I Feldman, Myles Wolf, John Kusek, Tariq Shafi, Jiang He, Nisha Bansal
doi : 10.1093/ndt/gfaa296
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2282–2289
Among patients with chronic kidney disease (CKD), the circulating cardiac biomarkers soluble ST2 (SST2), galectin-3, growth differentiation factor-15 (GDF-15), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin-T (hsTnT) possibly reflect pathophysiologic processes and are associated with clinical cardiovascular disease. Whether these biomarkers are associated with electrocardiographic findings is not known. The aim of this study was to test the association between serum cardiac biomarkers and the presence of electrocardiographic changes potentially indicative of subclinical myocardial disease in patients with CKD.
Functional vitamin K status and risk of incident chronic kidney disease and microalbuminuria: a prospective general population-based cohort study
Dion Groothof, Adrian Post, Camilo G Sotomayor, Charlotte A Keyzer, Jose L Flores-Guerero, Eelko Hak, Jens H J Bos, Leon J Schurgers, Gerjan J Navis, Reinold O B Gans, Coby Eelderink, Martin H de Borst, Stephan J L Bakker, Ineke J Riphagen
doi : 10.1093/ndt/gfaa304
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2290–2299
Circulating desphospho-uncarboxylated matrix ?-carboxyglutamate (Gla) protein (dp-ucMGP), a marker of vitamin K status, is associated with renal function and may serve as a potentially modifiable risk factor for incident chronic kidney disease (CKD). We aimed to assess the association between circulating dp-ucMGP and incident CKD.
Dialysis dose and mortality in haemodialysis: is higher better?
Lisa Béguin, Thierry Krummel, Nathalie Longlune, Roula Galland, Cécile Couchoud, Thierry Hannedouche on behalf of the REIN registry
doi : 10.1093/ndt/gfab202
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2300–2307
The effect of dialysis dose on mortality remains unsettled. Current guidelines recommend targeting a single-pool Kt/V (spKt/V) at 1.20–1.40 per thrice-weekly dialysis session. However, the optimal dialysis dose remains mostly disputed.
Clinical triage of patients on kidney replacement therapy presenting with COVID-19: an ERACODA registry analysis
Sandip Mitra, Anuradha Jayanti, Priya Vart, Armando Coca, Maurizio Gallieni, Marius Altern Øvrehus, Karsten Midtvedt, Samar Abd ElHafeez, Iliaria Gandolfini, Stefan Büttner, Casper F M Franssen, Marc H Hemmelder, ERACODA Collaborators
doi : 10.1093/ndt/gfab196
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2308–2320
Patients on kidney replacement therapy (KRT) are at very high risk of coronavirus disease 2019 (COVID-19). The triage pathway for KRT patients presenting to hospitals with varying severity of COVID-19 illness remains ill-defined. We studied the clinical characteristics of patients at initial and subsequent hospital presentations and the impact on patient outcomes.
Can the assessment of ultrasound lung water in haemodialysis patients be simplified?
Claudia Torino, Rocco Tripepi, Charalampos Loutradis, Pantelis Sarafidis, Giovanni Tripepi, Francesca Mallamaci, Carmine Zoccali
doi : 10.1093/ndt/gfaa285
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2321–2326
Lung ultrasound (US) reliably estimates lung water and it is increasingly applied in clinical practice in dialysis patients. A semi-quantitative US score summing up the US-B lines (an equivalent of B lines in the standard chest X-ray) at 28 sites in the intercostal spaces (Jambrik et al. Usefulness of ultrasound lung comets as a non-radiologic sign of extravascular lung water. Am J Cardiol 2004; 93: 1265–1270) is the most used score.
Mapping health-related quality of life after kidney transplantation by group comparisons: a systematic review
Yiman Wang, Marc H Hemmelder, Willem Jan W Bos, Jaapjan D Snoep, Aiko P J de Vries, Friedo W Dekker, Yvette Meuleman
doi : 10.1093/ndt/gfab232
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2327–2339
Health-related quality of life (HRQOL) is becoming an increasingly important outcome in kidney transplantation (KT). To describe HRQOL in kidney transplant recipients (KTRs), this systematic review summarizes literature that compared HRQOL among KTRs and other relevant populations [i.e. patients receiving dialysis, patients on the waiting list (WL) for KT, patients with chronic kidney disease (CKD) not receiving renal replacement therapy (RRT), the general population (GP) and healthy controls (HCs)] and themselves before KT.
Antibody maintenance 3 months after complete messenger RNA COVID-19 vaccination in haemodialysis patients
José Jesús Broseta, Diana Rodríguez-Espinosa, José Luis Bedini, Néstor Rodríguez, Francisco Maduell
doi : 10.1093/ndt/gfab272
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2340–2341
Iron deficiency, with and without anaemia, across strata of kidney function in kidney transplant recipients
Gizem Ayerdem, Gaston van Hassel, Joanna Sophia J Vinke, Daan J Kremer, Carlo A J M Gaillard, Martin H de Borst, Stephan J L Bakker, Michele F Eisenga
doi : 10.1093/ndt/gfab173
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2342–2344
Genetic determinant of thymopoiesis and clinical outcomes in renal transplantation
Mathieu Legendre, Elise Marechal, Jean-Michel Rebibou, Emilie Gaiffe, Cecile Courivaud, Jamal Bamoulid, Thomas Crepin, Didier Ducloux
doi : 10.1093/ndt/gfab180
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2345–2347
Prevalence of hepatitis C virus infection in non-dialysis CKD patients: a multicentre study in renal clinics
Roberto Minutolo, Maura Ravera, Adamasco Cupisti, Felice Nappi, Marcora Mandreoli, Giorgio Soragna, Pietro Manuel Ferraro, Luca De Nicola on behalf of the Collaborative Study Group on the Conservative Treatment of CKD of the Italian Society of Nephrology
doi : 10.1093/ndt/gfab190
Nephrology Dialysis Transplantation, Volume 36, Issue 12, December 2021, Pages 2348–2350
