American Journal of Respiratory and Critical Care Medicine




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سفارش

 Ending on a Crescendo: Reflections on Seven Years of a Successful Journal

Jadwiga A. Wedzicha 1*, Laurent Brochard 2*, Gavin C. Donaldson 1*, Fernando D. Martinez 3*, and Fernando J. Martinez 4*

doi : 10.1164/rccm.202111-2478ed

Volume 204, Issue 12, pp: 1351–1352

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 The Upper Airway Microbiome and Lung Injury in COVID-19

John E. McGinniss and Ronald G. Collman

doi : 10.1164/rccm.202109-2226ed

Volume 204, Issue 12, pp: 1353–1355

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 Reducing Ventilator-associated Brain Injury by Diaphragm Neurostimulation: Racking the Diaphragm to Protect the Brain?

Martin Dres 1,2 and Gianluigi Li Bassi 3,4,5,6

doi : 10.1164/rccm.202110-2312ed

Volume 204, Issue 12, pp: 1355–1357

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 T–Follicular Helper–like Cells in Sarcoidosis: Lending a Helping Hand

Shaikh M. Atif 1 and Andrew P. Fontenot 2,3

doi : 10.1164/rccm.202109-2139ed

Volume 204, Issue 12, pp: 1357–1359

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 Cell Therapy with the Cell or without the Cell for Premature Infants?: Time Will Tell

Bernard Thébaud 1,2,3 and Michael A. Matthay 4

doi : 10.1164/rccm.202109-2070ed

Volume 204, Issue 12, pp: 1359–1361

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 Matrix Metalloproteinase-8 in Pulmonary Hypertension: The Sheep in the Wolf’s Skin?

Elena A. Goncharova 1, Tatiana V. Kudryashova 1, Giovanni Maroli 2, and Soni S. Pullamsetti 2

doi : 10.1164/rccm.202109-2144ed

Volume 204, Issue 12, pp: 1361–1363

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 New Insights into the Limitations of Host Transcriptional Biomarkers of Tuberculosis

Mahdad Noursadeghi 1 and Rishi K. Gupta 2

doi : 10.1164/rccm.202109-2146ed

Volume 204, Issue 12, pp: 1363–1365

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 Double Trouble: Airflow and Pulmonary Vascular Obstruction

Michael H. Lee 1,2, Brian B. Graham 1,2, and Todd M. Bull 3

doi : 10.1164/rccm.202109-2153ed

Volume 204, Issue 12, pp: 1365–1367

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 Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline

A. Ioana Cristea , Clement L. Ren , Reshma Amin , Laurie C. Eldredge , Jonathan C. Levin , Parevi P. Majmudar , Anne E. May , Rebecca S. Rose , Michael C. Tracy , Karen F. Watters , Julian Allen , Eric D. Austin , Mary E. Cataletto , Joseph M. Collaco , Robert J. Fleck , Andrew Gelfand , Don Hayes Jr., Marcus H. Jones , Sheila S. Kun , Erica W. Mandell , Sharon A. McGrath-Morrow , Howard B. Panitch , Rizwana Popatia , Lawrence M. Rhein , Alejandro Teper , Jason C. Woods , Narayan Iyer , and Christopher D. Baker ; on behalf of the American Thoracic Society Assembly on Pediatrics

doi : 10.1164/rccm.202110-2269st

Volume 204, Issue 12, pp: e115–e133

Premature birth affects millions of neonates each year, placing them at risk for respiratory disease due to prematurity. Bronchopulmonary dysplasia is the most common chronic lung disease of infancy, but recent data suggest that even premature infants who do not meet the strict definition of bronchopulmonary dysplasia can develop adverse pulmonary outcomes later in life. This post-prematurity respiratory disease (PPRD) manifests as chronic respiratory symptoms, including cough, recurrent wheezing, exercise limitation, and reduced pulmonary function. This document provides an evidence-based clinical practice guideline on the outpatient management of infants, children, and adolescents with PPRD.

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 Dynamics of the Upper Respiratory Tract Microbiota and Its Association with Mortality in COVID-19

Lili Ren 1,2*, Yeming Wang 3,4*, Jiaxin Zhong 5,6*, Xia Li 7, Yan Xiao 1,2, Jie Li 8, Jing Yang 5,6, Guohui Fan 9, Li Guo 1,2, Zijie Shen 5,6, Lu Kang 5,6, Leisheng Shi 5,6, Qiong Li 8, Jizhou Li 8, Lin Di 10, Haibo Li 3,11, Conghui Wang 1, Ying Wang 1, Xinming Wang 1, Xiaohui Zou 3,11, Jian Rao 1,2, Li Zhang 5,6, Jianbin Wang 8, Yanyi Huang 10,12, Bin Cao 3,4,11,13‡, Jianwei Wang 1,2‡, and Mingkun Li 5,6,14‡

doi : 10.1164/rccm.202103-0814oc

Volume 204, Issue 12, pp: 1379–1390

Alteration of human respiratory microbiota had been observed in coronavirus disease (COVID-19). How the microbiota is associated with the prognosis in COVID-19 is unclear.

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 Follicular Helper–like T Cells in the Lung Highlight a Novel Role of B Cells in Sarcoidosis

Laura Bauer 1,2*, Lisa Jasmin Müller 2*, Sarah M. Volkers 3, Frederik Heinrich 4, Mir-Farzin Mashreghi 4, Clemens Ruppert 5,6, Leif E. Sander 3,6, and Andreas Hutloff 1,2,7

doi : 10.1164/rccm.202012-4423oc

Volume 204, Issue 12, pp: 1403–1417

Pulmonary sarcoidosis is generally presumed to be a T-helper cell type 1– and macrophage-driven disease. However, mouse models have recently revealed that chronically inflamed lung tissue can also comprise T follicular helper (Tfh)-like cells and represents a site of active T-cell/B-cell cooperation.

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Extracellular Vesicles Protect the Neonatal Lung from Hyperoxic Injury through the Epigenetic and Transcriptomic Reprogramming of Myeloid Cells

Gareth R. Willis 1,2, Monica Reis 1,2, Ali Hashemi Gheinani 3,4,5, Angeles Fernandez-Gonzalez 1,2, Elizabeth S. Taglauer 1,2, Vincent Yeung 1,2, Xianlan Liu 1, Maria Ericsson 6, Eric Haas 7, S. Alex Mitsialis 1,2*, and Stella Kourembanas 1,2*

doi : 10.1164/rccm.202102-0329oc

Volume 204, Issue 12, pp: 1418–1432

Mesenchymal stem/stromal cell (MSC)–small extracellular vesicle (MEx) treatment has shown promise in experimental models of neonatal lung injury. The molecular mechanisms by which MEx afford beneficial effects remain incompletely understood.

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A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature

Paul B. Dieffenbach 1*, Christina Mallarino Haeger 1*, Rakhshinda Rehman 1*, Alexis M. Corcoran 1, Anna Maria F. Coronata 1, Shamsudheen K. Vellarikkal 2, Izabela Chrobak 3, Aaron B. Waxman 1, Sally H. Vitali 4, Lynette M. Sholl 5, Robert F. Padera 5, David Lagares 6, Francesca Polverino 1‡, Caroline A. Owen 1§, and Laura E. Fredenburgh 1

doi : 10.1164/rccm.202108-1863oc

Volume 204, Issue 12, pp: 1433–1451

Mechanical signaling through cell–matrix interactions plays a major role in progressive vascular remodeling in pulmonary arterial hypertension (PAH). MMP-8 (matrix metalloproteinase-8) is an interstitial collagenase involved in regulating inflammation and fibrosis of the lung and systemic vasculature, but its role in PAH pathogenesis remains unexplored.

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 Endotyping Sleep Apnea One Breath at a Time: An Automated Approach for Separating Obstructive from Central Sleep-disordered Breathing

Ankit Parekh 1, Thomas M. Tolbert 1, Anne M. Mooney 1, Jaime Ramos-Cejudo 2, Ricardo S. Osorio 2, Marcel Treml 3, Simon-Dominik Herkenrath 3, Winfried J. Randerath 3, Indu Ayappa 1, and David M. Rapoport 1

doi : 10.1164/rccm.202011-4055oc

Volume 204, Issue 12, pp: 1452–1462

Determining whether an individual has obstructive or central sleep apnea is fundamental to selecting the appropriate treatment.

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 Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis

Humphrey Mulenga 1*, Munyaradzi Musvosvi 1*, Simon C. Mendelsohn 1*, Adam Penn-Nicholson 1, Stanley Kimbung Mbandi 1, Andrew Fiore-Gartland 2, Michèle Tameris 1, Simbarashe Mabwe 1, Hadn Africa 1, Nicole Bilek 1, Fazlin Kafaar 1, Shabaana A. Khader 3, Balie Carstens 1, Katie Hadley 1, Chris Hikuam 1, Mzwandile Erasmus 1, Lungisa Jaxa 1, Rodney Raphela 1, Onke Nombida 1, Masooda Kaskar 1, Mark P. Nicol 4,5, Slindile Mbhele 4, Judi Van Heerden 4, Craig Innes 6, William Brumskine 6, Andriëtte Hiemstra 7, Stephanus T. Malherbe 7, Razia Hassan-Moosa 8,9, Gerhard Walzl 7, Kogieleum Naidoo 8,9, Gavin Churchyard 6,10, Mark Hatherill 1, Thomas J. Scriba 1, and the CORTIS Study Team

doi : 10.1164/rccm.202103-0548oc

Volume 204, Issue 12, pp: 1463–1472

Performance of blood transcriptomic tuberculosis (TB) signatures in longitudinal studies and effects of TB-preventive therapy and coinfection with HIV or respiratory organisms on transcriptomic signatures has not been systematically studied.

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Options to Minimize the Use of Central Lines: Midodrine, Peripheral Venous Lines, and Midline Catheters

Rania Farhat , Jennifer Minoff , Shannon Burke , and Setu Patolia

doi : 10.1164/rccm.202103-0685rr

Volume 204, Issue 12, pp: 1473–1475

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Endobronchial Clear-Cell Sugar Tumor

Chang-Hui Xiao 1, Xian-Zheng Tan 1, Gong-Xun Xie 2, Peng Liu 1, and Jian-Bin Liu 1

doi : 10.1164/rccm.202102-0332im

Volume 204, Issue 12, pp: 1476–1477

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Autoimmune Pulmonary Alveolar Proteinosis: Evidence of the Pathogenicity of GM-CSF Antibodies

Aurélie Le Gal 1, Alexandre Chabrol 1, Anne-Laure Brun 2, Séverine Fraboulet 1, Louis-Jean Couderc 1,3,4, and Hélène Salvator 1,3,4

doi : 10.1164/rccm.202101-0073im

Volume 204, Issue 12, pp: e134–e135

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Evolution of Obstructive Lung Function in Advanced Pulmonary Arterial Hypertension

Farbod N. Rahaghi 1, Megan Trieu 2, Faisal Shaikh 2, Fereidoun Abtin 2, Alejandro A. Diaz 1, Lloyd L. Liang 2, Igor Barjaktarevic 2, Richard N. Channick 2, Raúl San José Estépar 1, George R. Washko 1, and Rajan Saggar 2*

doi : 10.1164/rccm.202105-1169le

Volume 204, Issue 12, pp: 1478–1481

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 Evaluating Approaches to Improve Equity in Critical Care Resource Allocation in the COVID-19 Pandemic

Katherine Ross-Driscoll 1, Gregory Esper 1, Kathy Kinlaw 1, Yi-Ting Hana Lee 1, Alanna A. Morris 1, David J. Murphy 1, Rebecca D. Pentz 1, Chad Robichaux 1, Gerard Vong 1, Kevin Wack 2, and Neal W. Dickert 1*

doi : 10.1164/rccm.202106-1462le

Volume 204, Issue 12, pp: 1481–1484

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An Association between Positive Airway Pressure Device Manufacturer and Incident Cancer? A Secondary Data Analysis

Tetyana Kendzerska 1,2,3*, Richard S. Leung 4,5, Mark I. Boulos 4,6, Daniel I. McIsaac 1,2,3, Brian J. Murray 4,6, Gregory L. Bryson 1,3, Robert Talarico 2,3, Atul Malhotra 7, Andrea S. Gershon 2,4,6, Constance Mackenzie 8,9, and Marcus Povitz 10

doi : 10.1164/rccm.202107-1734le

Volume 204, Issue 12, pp: 1484–1488

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 The Mystery of Futility of Appropriate Antibiotics for Coinfection in COVID-19

Daisuke Kasugai *, Naruhiro Jingushi , Norihiro Omote , Yuichiro Shindo , and Yukari Goto

doi : 10.1164/rccm.202107-1656le

Volume 204, Issue 12, pp: 1489

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 Reply to Kasugai et al.: The Mystery of Futility of Appropriate Antibiotics for Coinfection in COVID-19

Anahita Rouzé 1,2, Julien Labreuche 1,2, and Saad Nseir 1,2*; on behalf of all the authors

doi : 10.1164/rccm.202108-1846le

Volume 204, Issue 12, pp: 1489–1491

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 Initial Triple Combination Therapy for Intermediate-and High-Risk Pulmonary Arterial Hypertension: Standard of Care or Still Too Soon to Tell?

Qi Jin *, Lihua Guan *, Wenzhi Pan , and Daxin Zhou ‡

doi : 10.1164/rccm.202107-1622le

Volume 204, Issue 12, pp: 1491–1492

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 Treatment of Pulmonary Hypertension: Is Triple Therapy Necessarily Better than Monotherapy?

Xishi Sun 1,2*, Riken Chen 3,6,7*, Xiaoyun Yao 4*, Zhenzhen Zheng 2*, Manxia Wang 2*, Chaoyu Wang 5*, and Junfen Cheng 2‡

doi : 10.1164/rccm.202108-1965le

Volume 204, Issue 12, pp: 1492–1493

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 Reply to Jin et al. and to Sun et al.

Athénaïs Boucly 1,2,3*, Jason Weatherald 4*, Laurent Savale 1,2,3, Xavier Jaïs 1,2,3, David Montani 1,2,3, Marc Humbert 1,2,3, and Olivier Sitbon 1,2,3‡

doi : 10.1164/rccm.202107-1725le

Volume 204, Issue 12, pp: 1494–1495

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 Lung Cancer

Suzanne Lareau , Christopher Slatore , and Robert Smyth

doi : 10.1164/rccm.20411p21

Volume 204, Issue 12, pp: P21–P22

NO ABSTRACT

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