American Journal of Gastroenterology

Laube, Robyn BMed, MD, MPH, FRACP1,2; Tran, Yvonne BSc PhD3; Paramsothy, Sudarshan BSc, MBBS, MRCP, FRACP, PhD1,2,4; Leong, Rupert W. MBBS, FRACP, MD, AGAF1,2,4,5

doi : 10.14309/ajg.0000000000001537

December 2021 - Volume 116 - Issue 12 - p 2334-2344

خرید پکیج و مشاهده آنلاین مقاله

Diagnostic Evaluation of Gastric Motor and Sensory Disorders

Lacy, Brian E. PhD, MD, FACG1; Crowell, Michael D. PhD, FACG2; Cangemi, David J. MD1; Lunsford, Tisha N. MD2; Simren, Magnus MD, PhD3,4; Tack, Jan MD5

doi : 10.14309/ajg.0000000000001562

December 2021 - Volume 116 - Issue 12 - p 2345-2356

Disorders of gastric motor and sensory function affect 10%-20% of the world’s population and adversely impact nutrition, quality of life, work productivity, and health care costs. Classifying these disorders can be challenging given the heterogeneity of symptom presentation, the presence of symptoms unexplained by endoscopic, radiographic and/or laboratory evaluation, and overlap with other luminal gastrointestinal disorders. Accurately diagnosing these highly prevalent disorders relies upon an understanding of epidemiology and risk factors, the ability to take a careful clinical history focused on symptoms, and the presence of predisposing medical, surgical, and psychological conditions. A variety of diagnostic studies are now available to assess gastric motor function and identify maladaptive relaxation, accommodation, and abnormal sensation. FDA-approved treatment options are limited and thus many patients undergo a series of empirical treatment trials that target individual symptoms, often without much benefit. This article provides updated recommendations for identifying and classifying the most common gastric motor and sensory disorders using currently accepted diagnostic tests, and provides a brief supplemental overview on treatment options. “Things sweet to taste prove in digestion sour.” –Shakespeare, Richard II, 1595.

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Classifying Esophageal Motility by FLIP Panometry: A Study of 722 Subjects With Manometry

Carlson, Dustin A. MD, MS1; Gyawali, C. Prakash MD, MRCP2; Khan, Abraham MD3; Yadlapati, Rena MD, MS4; Chen, Joan MD, MS5; Chokshi, Reena V. MD6; Clarke, John O. MD7; Garza, Jose M. MD8; Jain, Anand S. MD9; Katz, Philip MD10; Konda, Vani MD11; Lynch, Kristle MD12; Schnoll-Sussman, Felice H. MD10; Spechler, Stuart J. MD11,13; Vela, Marcelo F. MD, MS14; Prescott, Jacqueline E. BS1; Baumann, Alexandra J. DO1; Donnan, Erica N. MD1; Kou, Wenjun PhD1; Kahrilas, Peter J. MD1; Pandolfino, John E. MD, MS1

doi : 10.14309/ajg.0000000000001532

December 2021 - Volume 116 - Issue 12 - p 2357-2366

Functional luminal imaging probe (FLIP) panometry can evaluate esophageal motility in response to sustained esophageal distension at the time of sedated endoscopy. This study aimed to describe a classification of esophageal motility using FLIP panometry and evaluate it against high-resolution manometry (HRM) and Chicago Classification v4.0 (CCv4.0).

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Comparative Safety of Endoscopic vs Radiological Gastrostomy Tube Placement: Outcomes From a Large, Nationwide Veterans Affairs Database

Kohli, Divyanshoo R. MD1; Kennedy, Kevin F. MS2; Desai, Madhav MD1; Sharma, Prateek MD1

doi : 10.14309/ajg.0000000000001504

December 2021 - Volume 116 - Issue 12 - p 2367-2373

A gastrostomy is generally performed in patients who are unable to maintain volitional intake of food. We compared outcomes of percutaneous endoscopic gastrostomy (PEG) and interventional radiologist–guided gastrostomy (IRG) using an integrated nationwide database.

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Mucocutaneous Manifestations in Autoimmune Gastritis: A Prospective Case-Control Study

Gonzalez, Agustin MD1; Latorre, Gonzalo MD2; Paredes, Loreto MD1; Montoya, Lorena MD1; Maquilon, Sara MD2; Shah, Shailja C. MD, MPH3,4; Espino, Alberto MD2; Sabatini, Natalia MD1; Torres, Javiera MD5; Roa, Juan Carlos MD5; Riquelme, Arnoldo MD, MMedEd2,6; Kolbach, Marianne MD1

doi : 10.14309/ajg.0000000000001501

December 2021 - Volume 116 - Issue 12 - p 2374-2384

Autoimmune gastritis (AIG) is associated with nutritional deficiencies, autoimmune diseases, and gastric malignancies. The aims of the study were to test the hypothesis that mucocutaneous (MC) manifestations occur more often in patients with vs without AIG and to delineate patterns of MC manifestations in AIG.

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Liver-Unrelated Comorbid Conditions Do Not Affect Cognitive Performance or Hepatic Encephalopathy Progression in Cirrhosis

Acharya, Chathur MD1; Nadhem, Omar MD1; Shaw, Jawaid MD1; Hassouneh, Ramzi MD1; Fagan, Andrew BS1; McGeorge, Sara BS1; Sterling, Richard K. MD1; Puri, Puneet MD1; Fuchs, Michael MD1; Luketic, Velimir MD1; Sanyal, Arun J. MD1; Wade, James B. PhD2; Gilles, HoChong S. FNP3; Heuman, Douglas M. MD1; Tinsley, Felicia RN1; Matherly, Scott MD1; Lee, Hannah MD1; Siddiqui, Mohammad S. MD1; Thacker, Leroy R. PhD3; Bajaj, Jasmohan S. MD1

doi : 10.14309/ajg.0000000000001346

December 2021 - Volume 116 - Issue 12 - p 2385-2389

We aimed to determine the effect of comorbidities on covert hepatic encephalopathy (CHE) diagnosis and overt hepatic encephalopathy (OHE) development.

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Impact of Alcohol Abstinence on the Risk of Hepatocellular Carcinoma in Patients With Alcohol-Related Liver Cirrhosis

Rodríguez, Manuel MD1,2; González-Diéguez, María Luisa MD1; Varela, María MD1,2,3; Cadahía, Valle MD1; Andrés-Vizán, Sara María PhD4; Mesa, Alicia MD5; Castaño, Andrés MD1; Alvarez-Navascués, Carmen MD1

doi : 10.14309/ajg.0000000000001399

December 2021 - Volume 116 - Issue 12 - p 2390-2398

Although alcohol cessation is the only effective treatment for alcohol-related liver disease, few data exist concerning its influence on the risk of hepatocellular carcinoma (HCC). We aimed to evaluate the effect of alcohol abstinence on the incidence of HCC in patients with alcohol-related cirrhosis.

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Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease

Harrison, Stephen A. MD1; Baum, Seth J. MD2; Gunn, Nadege T. MD3; Younes, Ziad H. MD4; Kohli, Anita MD5; Patil, Rashmee MD6; Koziel, Margaret J. MD7; Chera, Harinder BS7; Zhao, Jeff PhD7; Chakravarthy, Manu V. MD, PhD7

doi : 10.14309/ajg.0000000000001375

December 2021 - Volume 116 - Issue 12 - p 2399-2409

AXA1125 and AXA1957 are novel, orally administered endogenous metabolic modulator compositions, specifically designed to simultaneously support multiple metabolic and fibroinflammatory pathways associated with nonalcoholic fatty liver disease (NAFLD). This study assessed safety, tolerability, and biologic activity of AXA1125 and AXA1957 in NAFLD.

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Quality of Care Program Reduces Unplanned Health Care Utilization in Patients With Inflammatory Bowel Disease

Melmed, Gil Y. MD, MS1; Oliver, Brant PhD, MS, MPH, FNP2; Hou, Jason K. MD3; Lum, Donald MD4; Singh, Siddharth MD5; Crate, Damara RN6; Almario, Christopher MD, MSHPM1,7; Bray, Harry MD4; Bresee, Catherine MS8; Gerich, Mark MD9; Gerner, Donna RN10; Heagy, Erica FNP-C4; Holthoff, Megan MSHS2; Hudesman, David MD11; McCutcheon Adams, Kelly LICSW12; Mattar, Mark C. MD13; Metwally, Mark MD10; Nelson, Eugene DSc, MPH2; Ostrov, Arthur MD10; Rubin, David T. MD14; Scott, Frank MD, MSCE9; Samir, Shah MD15; van Deen, Welmoed PhD, MD7; Younes, Ziad MD16; Oberai, Ridhima BS17; Weaver, Alandra MPH17; Siegel, Corey A. MD, MS6, on behalf of IBD Qorus

doi : 10.14309/ajg.0000000000001547

December 2021 - Volume 116 - Issue 12 - p 2410-2418

There is significant variation in processes and outcomes of care for patients with inflammatory bowel disease (IBD), suggesting opportunities to improve quality of care. We aimed to determine whether a structured quality of care program can improve IBD outcomes, including the need for unplanned health care utilization.

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Volumetric Rectal Perception Testing: Is It Clinically Relevant? Results From a Large Patient Cohort

Mazor, Yoav MD, PhD1,2; Trieu, Rose Qizhengyan MD3,4; Prott, Gillian CNS3; Jones, Michael PhD5; Ejova, Anastasia PhD5,6; Kellow, John MD3,4; Malcolm, Allison MD3,4

doi : 10.14309/ajg.0000000000001526

December 2021 - Volume 116 - Issue 12 - p 2419-2429

Rectal perception testing is a recommended component of anorectal physiology testing. Although recent consensus (London) guidelines suggested criteria for categorizing hyporectal and hyper-rectal sensitivity, these were based on scant evidence. Moreover, data regarding diagnostic capabilities and clinical utility of rectal perception testing are lacking. The aims of this study were to determine the association between rectal perception testing and both clinical and physiological variables to enhance the analysis and interpretation of real-life test results.

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Age-Specific Rates and Time-Courses of Gastrointestinal and Nongastrointestinal Complications Associated With Screening/Surveillance Colonoscopy

Ladabaum, Uri MD, MS1; Mannalithara, Ajitha PhD1; Desai, Manisha PhD2; Sehgal, Maanek3; Singh, Gurkirpal MD1,4

doi : 10.14309/ajg.0000000000001531

December 2021 - Volume 116 - Issue 12 - p 2430-2445

The rates of serious cardiac, neurologic, and pulmonary events attributable to colonoscopy are poorly characterized, and background event rates are usually not accounted for.

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Cystic Fibrosis Transmembrane Conductance Regulator Modulator Use Is Associated With Reduced Pancreatitis Hospitalizations in Patients With Cystic Fibrosis

Ramsey, Mitchell L. MD1; Gokun, Yevgeniya MS2; Sobotka, Lindsay A. DO1; Wellner, Michael R. MD1; Porter, Kyle MAS2; Kirkby, Stephen E. MD3; Li, Susan S. MD4; Papachristou, Georgios I. MD, PhD1; Krishna, Somashekar G. MD, MPH1; Stanich, Peter P. MD1; Hart, Phil A. MD1; Conwell, Darwin L. MD, MSc1; Lara, Luis F. MD1

doi : 10.14309/ajg.0000000000001527

December 2021 - Volume 116 - Issue 12 - p 2446-2454

Acute pancreatitis (AP) occurs among patients with pancreas-sufficient cystic fibrosis (PS-CF) but is reportedly less common among patients with pancreas-insufficient cystic fibrosis (PI-CF). The incidence of AP may be influenced by cystic fibrosis transmembrane conductance regulator (CFTR) modulator use. We hypothesized that CFTR modulators would reduce AP hospitalizations, with the greatest benefit in PS-CF.

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Association of Terry Nails With Liver Cirrhosis

Sack, Jordan S. MD, MPH1; Liu, Anne F. MD1; Gray, Meagan MD2; Roat, James MD3; Zucker, Stephen D. MD1,3

doi : 10.14309/ajg.0000000000001492

December 2021 - Volume 116 - Issue 12 - p 2455-2458

We looked at the association between Terry nails and liver cirrhosis in an ambulatory population from hepatology and gastroenterology clinics.

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Health Economic Impact of a Multicenter Quality-of-Care Initiative for Reducing Unplanned Healthcare Utilization Among Patients With Inflammatory Bowel Disease

Almario, Christopher V. MD, MSHPM1,2; Kogan, Lawrence MD3; van Deen, Welmoed K. PhD, MD4; Scott, Frank I. MD, MSCE5; Singh, Siddharth MD6; Hou, Jason K. MD, MS7; Lum, Donald MD8; Aguilar, Humberto MD9; Betteridge, John MD10; Flynn, Ann MD11; Gerich, Mark MD5; Kaufman, Lia MD12; Mattar, Mark C. MD13; Mize, Carrie LPN14; Ostrov, Arthur MD15; Shah, Samir A. MD16; Younes, Ziad MD14; Weaver, S. Alandra MPH17; Heller, Caren MD17; Siegel, Corey A. MD, MS18; Melmed, Gil Y. MD, MS1,19

doi : 10.14309/ajg.0000000000001540

December 2021 - Volume 116 - Issue 12 - p 2459-2464

A multicenter adult inflammatory bowel disease learning health system (IBD Qorus) implemented clinical care process changes for reducing unplanned emergency department visits and hospitalizations using a Breakthrough Series Collaborative approach.

خرید پکیج و مشاهده آنلاین مقاله

Changes in National Google Trends and Local Healthcare Utilization After High-Impact Gastroenterology Publications

Kamboj, Amrit K. MD1; Agarwal, Siddharth MBBS1; Chedid, Victor G. MD1; Iyer, Prasad G. MD, MS1; Bailey, Kent R. PhD2; Harmsen, William S. MS2; Katzka, David A. MD1

doi : 10.14309/ajg.0000000000001516

December 2021 - Volume 116 - Issue 12 - p 2465-2469

We examined national Google Trends and local healthcare utilization after 3 high-impact gastroenterology publications.

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Question on Databases Used to Examine the Association Between Gastric Cancer and Heavy Alcohol Use

Wang, Yanfei MD1; Jiang, Yiqian MD1; Zhu, Zhongxin PhD2

doi : 10.14309/ajg.0000000000001392

December 2021 - Volume 116 - Issue 12 - p 2470

خرید پکیج و مشاهده آنلاین مقاله

The Association Between Heavy Alcohol Use and Gastric Cancer

Wu, Hua BS1; Chen, Hong-Lin MD2

doi : 10.14309/ajg.0000000000001325

December 2021 - Volume 116 - Issue 12 - p 2470-2471

خرید پکیج و مشاهده آنلاین مقاله

Responses to Wu et al. and Wang et al.

Laszkowska, Monika MD, MS1; Rodriguez, Steven MD2; Kim, Judith MD, MS3; Hur, Chin MD, MPH2,3,4

doi : 10.14309/ajg.0000000000001523

December 2021 - Volume 116 - Issue 12 - p 2472-2474

خرید پکیج و مشاهده آنلاین مقاله

Response to “Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy”

Cheng, Yung-Yin MD1,2; Tsai, Ming-Che MD, MPH, PhD3,4,5; Wei, James Cheng-Chung MD, PhD5,6,7

doi : 10.14309/ajg.0000000000001495

December 2021 - Volume 116 - Issue 12 - p 2474

خرید پکیج و مشاهده آنلاین مقاله

Response to Cheng et al.

Liu, Julia J. MD1; Owings, Anna H. DO2; Claggett, Brian PhD3; Robinson, Tanya PhD2; Glover, Sarah C. DO2

doi : 10.14309/ajg.0000000000001513

December 2021 - Volume 116 - Issue 12 - p 2474-2475

خرید پکیج و مشاهده آنلاین مقاله

Acute Liver Failure due to Manufactured Alkaline Water: A Case Series of “Real Water”-Induced Liver Injury

Berk, Corrie DNP1; Ammar, Tarek MD2; Lee, Brian T. MD3

doi : 10.14309/ajg.0000000000001353

December 2021 - Volume 116 - Issue 12 - p 2476-2477

خرید پکیج و مشاهده آنلاین مقاله

COVID-19 Vaccine for Chronic Gastroenterology and Hepatology Patients: A Need for Better Evidence

Fu, Xue-Lei MM1; Chen, Hong-Lin MD2

doi : 10.14309/ajg.0000000000001405

December 2021 - Volume 116 - Issue 12 - p 2478

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Immunotherapy as a Downstaging Tool for Liver Transplantation in Hepatocellular Carcinoma

Lizaola-Mayo, Blanca C. MD1,2; Mathur, Amit K. MD2,3; Borad, Mitesh-J. MD4; Jadlowiec, Caroline C. MD2,3; Lam-Himlin, Dora M. MD5; Corey, Rebecca L. BCPS2,6; Iqbal, Sara MD1,2; Okubo, Keita MD, PhD2,3; Byrne, Thomas J. MD1,2; Moss, Adyr A. MD2,3; Aqel, Bashar A. MD1,2; Chascsa, David M. MD1,2

doi : 10.14309/ajg.0000000000001391

December 2021 - Volume 116 - Issue 12 - p 2478-2480

خرید پکیج و مشاهده آنلاین مقاله