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Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting
Osita Ezenwosu, Barth Chukwu, Ifeyinwa Ezenwosu, Ndubuisi Uwaezuoke, Christopher Eke, Maria Udorah, Chinedu Idoko, Anthony Ikefuna & Ifeoma Emodi
doi : 10.1186/s12887-021-03015-1
BMC Pediatrics volume 21, Article number: 533 (2021)
Sickle cell anaemia (SCA) is the commonest monogenic haematologic disorder resulting from the inheritance of homozygous mutant haemoglobin genes from both parents. Some factors have been identified as important in explaining the variability in depression in sickle cell anaemia (SCA). Information on this is limited in a resource-limited setting like Nigeria. This study aims to determine factors which influence depression in children and adolescents with sickle cell anaemia in a resource-limited setting.
Tackling equitable coverage and quality of care for neonates in hospitals: a pre-post assessment on asphyxia interventions in Mesoamerica
Aruna M. Kamath, Maximilian G. Thom, Casey K. Johanns, Katie Panhorst Harris, Karla Schwarzbauer, José C. Ochoa, Paola Zuniga-Brenes, Diego Rios-Zertuche, Ali H. Mokdad & Bernardo Hernandez
doi : 10.1186/s12887-021-02999-0
BMC Pediatrics volume 21, Article number: 534 (2021)
Intrapartum-related hypoxic events, or birth asphyxia, causes one-fourth of neonatal deaths globally and in Mesoamerica. Multidimensional care for asphyxia must be implemented to ensure timely and effective care of newborns. Salud Mesoamérica Initiative (SMI) is a performance-based program seeking to improve maternal and child health for low-income areas of Central America. Our objective was to assess the impact of SMI on neonatal asphyxia care in health centers and hospitals in the region.
BMI status relative to international and national growth references among Pakistani school-age girls
Rizwan Qaisar & Asima Karim
doi : 10.1186/s12887-021-03017-z
BMC Pediatrics volume 21, Article number: 535 (2021)
A sizable proportion of school-going children from developing countries has abnormal growth parameters, often not standardized with international reference values. We aimed to assess the prevalence of underweight, overweight, and obesity in the schoolgirls of Punjab according to international and local references.
Effect of gut microbiota from Henoch-Schönlein Purpura patients on acid-sensitive ion channel 3 expression and intestinal motility in germ-free rats
Jin-kun Wang, Bo Yan, Jun-mei Zhao & Li-ping Yuan
doi : 10.1186/s12887-021-03013-3
BMC Pediatrics volume 21, Article number: 536 (2021)
It has been proven that gut microbiota alterations are involved in the development of Henoch-Schönlein Purpura (HSP). However, the pathogenesis of HSP hasn’t been eluciated. This study was to investigate the impact of gut microbiota from HSP on ASIC3 expression and interactions between microbiota and ASIC3 expression in the development of HSP.
Developing practical clinical tools for predicting neonatal mortality at a neonatal intensive care unit in Tanzania
Dory Kovacs, Delfina R. Msanga, Stephen E. Mshana, Muhammad Bilal, Katarina Oravcova & Louise Matthews
doi : 10.1186/s12887-021-03012-4
BMC Pediatrics volume 21, Article number: 537 (2021)
Neonatal mortality remains high in Tanzania at approximately 20 deaths per 1000 live births. Low birthweight, prematurity, and asphyxia are associated with neonatal mortality; however, no studies have assessed the value of combining underlying conditions and vital signs to provide clinicians with early warning of infants at risk of mortality. The aim of this study was to identify risk factors (including vital signs) associated with neonatal mortality in the neonatal intensive care unit (NICU) in Bugando Medical Centre (BMC), Mwanza, Tanzania; to identify the most accurate generalised linear model (GLM) or decision tree for predicting mortality; and to provide a tool that provides clinically relevant cut-offs for predicting mortality that is easily used by clinicians in a low-resource setting.
Nutritional status and associated factors among children with congenital heart disease in selected governmental hospitals and cardiac center,Addis Ababa Ethiopia
Rediet Woldesenbet, Rajalakshmi Murugan, Feven Mulugeta & Tamirat Moges
doi : 10.1186/s12887-021-03023-1
BMC Pediatrics volume 21, Article number: 538 (2021)
Children with congenital heart disease are at risk for poor growth and under-nutrition compared with healthy children. The aim of this study was to assess the nutritional status of children with congenital heart disease and associated factors in selected governmental hospitals and cardiac center Addis Ababa, Ethiopia.
25-Hydroxyvitamin D levels among 2-year-old children: findings from the Japan environment and Children’s study (JECS)
Limin Yang, Miori Sato, Mayako Saito-Abe, Makoto Irahara, Minaho Nishizato, Hatoko Sasaki, Mizuho Konishi, Kazue Ishitsuka, Hidetoshi Mezawa, Kiwako Yamamoto-Hanada & Yukihiro Ohya for the Japan Environment and Children’s Study (JECS) Group)
doi : 10.1186/s12887-021-03005-3
BMC Pediatrics volume 21, Article number: 539 (2021)
The study aim was to obtain epidemiological data on vitamin D levels for the pediatric population in Japan. We assessed the prevalence of vitamin D deficiency and insufficiency in 2-year-old Japanese children using data from a large ongoing birth cohort study.
Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?
Ajay Anvekar, Sam Athikarisamy, Shripada Rao, Andy Gill, Elizabeth Nathan, Dorota Doherty & Geoffrey Lam
doi : 10.1186/s12887-021-03027-x
BMC Pediatrics volume 21, Article number: 540 (2021)
Poor weight gain in the first few weeks of life has been studied as a predictor of retinopathy of prematurity (ROP). Our aim was to assess whether time taken to regain birthweight (BW) be used as an additional marker to identify infants with type 1 ROP.
Fluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study
Rana Ismail, Prashanth Murthy, Ayman Abou Mehrem, Zhiying Liang & Amelie Stritzke
doi : 10.1186/s12887-021-03025-z
BMC Pediatrics volume 21, Article number: 541 (2021)
Cardiovascular and renal adaptation in neonates with Respiratory Distress Syndrome (RDS) and Transient Tachypnea of the Newborn (TTN) may be different.
Prevalence of anemia and its associated factors among under-five age children in Shanan gibe hospital, Southwest Ethiopia
Destaw Kebede, Fantahun Getaneh, Kirubel Endalamaw, Tariku Belay & Abebe Fenta
doi : 10.1186/s12887-021-03011-5
BMC Pediatrics volume 21, Article number: 542 (2021)
Anemia is a major health problem in the worldwide. Because of health and socioeconomic problems, the prevalence of anemia is higher in developing countries. However, there was a limited finding in our study area. Therefore, the aim of this study was to determine the prevalence of anemia and its associated factors among under-five age children in Shanan Gibe Hospital (SGH), Southwest Ethiopia.
Retrospective analysis of pneumothorax after repair of esophageal atresia/tracheoesophageal fistula
Jiawei Zhao, Shen Yang, Siqi Li, Peize Wang, Yanan Zhang, Yong Zhao, Kaiyun Hua, Yichao Gu, Junmin Liao, Shuangshuang Li, Yongwei Chen & Jinshi Huang
doi : 10.1186/s12887-021-02948-x
BMC Pediatrics volume 21, Article number: 543 (2021)
To analyze the possible causes, treatment and outcomes of postoperative pneumothorax in patients with Gross type C esophageal atresia/tracheoesophageal fistula (EA/TEF).
Cerebral palsy in children: subtypes, motor function and associated impairments in Addis Ababa, Ethiopia
Selamenesh Tsige, Ayalew Moges, Amha Mekasha, Workeabeba Abebe & Hans Forssberg
doi : 10.1186/s12887-021-03026-y
BMC Pediatrics volume 21, Article number: 544 (2021)
Although, there is no population-level data in Ethiopia, a previous retrospective hospital-based study identified CP as the most common developmental disability in children. The overall aim of this study is to describe the clinical spectrum of CP in Tikur Anbessa Specialized Hospital in Addis Ababa, including CP subtype, gross and fine motor function, presence and pattern of associated impairments, and possible risk factors in children aged 2 to 18?years.
The value of lymphocyte-to-monocyte ratio and neutrophil-to-lymphocyte ratio in differentiating pneumonia from upper respiratory tract infection (URTI) in children: a cross-sectional study
Jinghua Wu, Xu Wang, Mingqi Zhou, Guo-Bo Chen, Jing Du, Ying Wang & Chengyin Ye
doi : 10.1186/s12887-021-03018-y
BMC Pediatrics volume 21, Article number: 545 (2021)
Early and accurate diagnosis of pediatric pneumonia in primary health care can reduce the chance of long-term respiratory diseases, related hospitalizations and mortality while lowering medical costs. The aim of this study was to assess the value of blood biomarkers, clinical symptoms and their combination in assisting discrimination of pneumonia from upper respiratory tract infection (URTI) in children.
Truncating mutation in TANC2 in a Chinese boy associated with Lennox-Gastaut syndrome: a case report
Yang Tian, Zhen Shi, Chi Hou, Wenjuan Li, Xiuying Wang, Haixia Zhu, Xiaojing Li & Wen-Xiong Chen
doi : 10.1186/s12887-021-03021-3
BMC Pediatrics volume 21, Article number: 546 (2021)
Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy that can be caused by brain malformations or genetic mutations. Recently, genome-wide association studies have led to the identification of novel mutations associated with LGS. The TANC2 gene, encodes a synaptic scaffolding protein that interacts with other proteins at the postsynaptic density to regulate dendritic spines and excitatory synapse formation. The TANC2 gene mutations were reported in neurodevelopmental disorders and epilepsy but not in LGS ever.
Retraction Note to: Vitamin A deficiency and sleep disturbances related to autism symptoms in children with autism spectrum disorder: a cross-sectional study
Jing Wen, Ting Yang, Jiang Zhu, Min Guo, Xi Lai, Ting Tang, Li Chen, Jie Chen, Ming Xue & Tingyu Li
doi : 10.1186/s12887-021-03000-8
BMC Pediatrics volume 21, Article number: 547 (2021)
Clinical features and outcomes of bowel perforation in primary pediatric gastrointestinal lymphoma
Jiayu Yan, Yanlong Duan, Tingting Liu, Jianlin Guo, Chunhui Peng, Wenbo Pang, Dan Zhang, Yun Peng & Yajun Chen
doi : 10.1186/s12887-021-02944-1
BMC Pediatrics volume 21, Article number: 548 (2021)
Whether surgery can improve the prognosis of patients with primary pediatric gastrointestinal lymphoma (PPGL) who experienced bowel perforation remains controversial. This study aimed to evaluate the prognosis of such patients.
Socioeconomic disparities and infancy growth trajectory: a population-based and longitudinal study
Zi-yu Shao, Peng Wang, Pei Li, Yu Sun, Pei-pei Li & Peng Zhu
doi : 10.1186/s12887-021-02995-4
BMC Pediatrics volume 21, Article number: 549 (2021)
The association of low socioeconomic status (SES) with childhood and adolescent obesity has been reported. It is unknown whether low SES affects body mass index (BMI) growth trajectory in the first 12 mo of life. Moreover, accelerated growth as a compensatory mechanism for low birth weight (LBW) during infancy, is an important predictor of later obesity. The aim of the present study was to examine the association of low SES with infancy BMI growth rate and trajectory for LBW and normal birth weight (NBW) infants.
Hordeum murinum aspiration revealed by a pneumopleurocutaneous fistula in a 15-month-old infant
Nicolas Richard, Audrey Paygambar, Hubert Ducou Le Pointe, Sarah Biaz & Harriet Corvol
doi : 10.1186/s12887-021-03016-0
BMC Pediatrics volume 21, Article number: 550 (2021)
Hordeum murinum is a specie of grass rarely reported among the aspirated foreign body. It has high tissue penetration power and may cause lung damages.
Factors associated with stunting among children aged 6–59?months in Bensa District, Sidama Region, South Ethiopia: unmatched case-control study
Temesgen Tafesse, Amanuel Yoseph, Kaleb Mayiso & Taye Gari
doi : 10.1186/s12887-021-03029-9
BMC Pediatrics volume 21, Article number: 551 (2021)
Stunting remains one of the most common malnutrition problems among children in Ethiopia. Identifying the risk factors of stunting assists health planners to prioritize prevention strategies, and is a fundamental step for intervention. Therefore, this study aimed to assess factors associated with stunting among children aged 6–59?months in Bensa district, Sidama Region, South Ethiopia, 2018.
Characteristics of inhomogeneous lower extremity growth and development in early childhood: a cross-sectional study
Sudarat Apibantaweesakul, Shiho Omura, Weihuang Qi, Hiroto Shiotani, Pavlos E. Evangelidis, Natsuki Sado, Fumiko Tanaka & Yasuo Kawakami
doi : 10.1186/s12887-021-02998-1
BMC Pediatrics volume 21, Article number: 552 (2021)
Early childhood is a transferring stage between the two accelerated growth periods (infant and adolescent). Body dimensions are related to physical growth and development. The purpose of this study was to investigate physical growth in terms of anthropometry, muscle growth of the lower extremity, and functional development over early childhood.
Demographic, clinical, and socioeconomic factors associated with delayed diagnosis and management of pediatric testicular torsion in West China: a retrospective study of 301 cases in a single tertiary children’s hospital
Chengjun Yu, Jie Zhao, Jiandong Lu, Yi Wei, Li Jiang, Tianxin Zhao, Tao Lin, Dawei He, Sheng Wen, Shengde Wu & Guanghui Wei
doi : 10.1186/s12887-021-03001-7
BMC Pediatrics volume 21, Article number: 553 (2021)
To investigate the association between geographic, clinical, socioeconomic factors and delayed management of pediatric testicular torsion (TT) in West China.
Evaluation of parental knowledge, attitudes and practices regarding antibiotic use in acute upper respiratory tract infections in children under 18?years of age: a cross-sectional study in Turkey
Asl?nur Albayrak, Nazmi Mutlu Karaka? & Bensu Karahalil
doi : 10.1186/s12887-021-03020-4
BMC Pediatrics volume 21, Article number: 554 (2021)
Upper respiratory tract infections (URTIs) are common in children. Antibiotics still continue to be prescribed although most URTIs are of viral origin. This is inappropriate use and this unnecessary administration contributes or may cause antibiotic resistance. The problem of unnecessary antibiotic use among children is a concern for antibiotic resistance in low- and middle-income developing countries. This study aims to evaluate the knowledge and attitudes of parents of children with upper respiratory tract infections regarding antibiotic use and their antibiotic administration practices in a tertiary care hospital in Turkey.
Helping babies breathe: assessing the effectiveness of simulation-based high-frequency recurring training in a community-based setting of Pakistan
Kiran Mubeen, Marina Baig, Sadia Abbas, Farzana Adnan, Arusa Lakhani, Shireen Shehzad Bhamani, Bushra Rehman, Shahnaz Shahid & Rafat Jan
doi : 10.1186/s12887-021-03014-2
BMC Pediatrics volume 21, Article number: 555 (2021)
Birth asphyxia is one of the significant causes of neonatal deaths in Pakistan. Poor newborn resuscitation skills of birth attendants are a major cause of neonatal mortality in low resource settings across the globe. This study aimed to evaluate the effectiveness of the Simulation-Based High-Frequency training of the Helping Babies Breathe for Community Midwives (CMW), in district Gujrat, Pakistan.
Clinical features of respiratory syncytial virus bronchiolitis in an infant: rapid and fatal brain involvement
Paolo Bottino, Rebecca Miglino, Lisa Pastrone, Anna Maria Barbui, Giovanni Botta, Elisa Zanotto, Francesca Sidoti, Cristina Costa & Rossana Cavallo
doi : 10.1186/s12887-021-03045-9
BMC Pediatrics volume 21, Article number: 556 (2021)
Respiratory Syncytial Virus (RSV) infection is a significant cause of bronchiolitis and pneumonia, mostly responsible for hospitalization and infant death worldwide. However, in recent years the importance of extrapulmonary RSV manifestations, especially at neurological level, have become evident. Seizures, lethargy, ataxia and status epilepticus are suggestive of brain involvement, but also in their absence a direct neurological damage RSV-related need to be evaluated.
Case report : a novel ASXL3 gene variant in a Sudanese boy
Ke Wu & Yan Cong
doi : 10.1186/s12887-021-03038-8
BMC Pediatrics volume 21, Article number: 557 (2021)
Bainbridge-Ropers syndrome (BRPS) [OMIM#615485] is a neurodevelopmental disorder, characterized by delayed psychomotor development with generalized hypotonia, moderate to severe intellectual disability, poor or absent speech, feeding difficulties, growth failure, dysmorphic craniofacial features and minor skeletal features. The aim of this study was to investigate the genetic etiology of a Sudanese boy with severe developmental delay, intellectual disability, and craniofacial phenotype using trio-based whole-exome sequencing. To our knowledge, no patients with ASXL3 gene variant c.3043C>T have been reported detailedly in literature.
Parents’ pandemic NICU experience in the United States: a qualitative study
Ashlee J. Vance, Kathryn J. Malin, Jacquelyn Miller, Clayton J. Shuman, Tiffany A. Moore & Annella Benjamin
doi : 10.1186/s12887-021-03028-w
BMC Pediatrics volume 21, Article number: 558 (2021)
Prior to the COVID-19 pandemic, parents of infants in the Neonatal Intensive Care Unit (NICU) frequently reported high levels of stress, uncertainty, and decreased parenting confidence. Early research has demonstrated that parents have had less access to their infants in the hospital due to restrictions on parental presence secondary to the pandemic. It is unknown how parents have perceived their experiences in the NICU since the beginning of the COVID-19 pandemic. The purpose of this study was to describe the lived experience of parents who had an infant in the NICU in the context of the COVID-19 pandemic to inform healthcare providers and policy makers for future development of policies and care planning.
Brain and renal oxygenation measured by NIRS related to patent ductus arteriosus in preterm infants: a prospective observational study
Jurate Navikiene, Ernestas Virsilas, Ramune Vankeviciene, Arunas Liubsys & Augustina Jankauskiene
doi : 10.1186/s12887-021-03036-w
BMC Pediatrics volume 21, Article number: 559 (2021)
Patent ductus arteriosus (PDA) is common among preterm neonates. Haemodynamically significant ductus arteriosus (hsPDA) can cause ductal steal and contribute to poor outcomes. Our aim was to evaluate ductus arteriosus patency and significance using two-site near-infrared spectroscopy (NIRS) measurements in preterm infants older than 72?h as a supplemental tool to echocardiography.
The clinical effects of high-frequency oscillatory ventilation in the treatment of neonatal severe meconium aspiration syndrome complicated with severe acute respiratory distress syndrome
Guang Yang, Yunxia Qiao, Xinxin Sun, Tiandan Yang, Aiying Lv & Min Deng
doi : 10.1186/s12887-021-03042-y
BMC Pediatrics volume 21, Article number: 560 (2021)
To explore the efficacy and safety of high-frequency oscillatory ventilation (HFOV) in the treatment of severe meconium aspiration syndrome (MAS) complicated with severe acute respiratory distress syndrome (ARDS).
Long-term effectiveness of behavioural intervention in preschool children with attention deficit hyperactivity disorder in Southeast China – a randomized controlled trial
Xin-xin Huang, Ping Ou, Qin-fang Qian & Yan Huang
doi : 10.1186/s12887-021-03046-8
BMC Pediatrics volume 21, Article number: 561 (2021)
Attention-deficit hyperactivity disorder (ADHD) is the most common behavioral disorder. Behavioural intervention in preschool children with ADHD is considered effective. This study discussed the long-term effectiveness of behavioural intervention in the context of nondrug therapy.
Predictors for time to recovery from sever acute malnutrition among under-five children admitted to therapeutic feeding unit at Dubti referral hospital, Afar region, Ethiopia
Awoke Seyoum Tegegne & Denekew Bitew Belay
doi : 10.1186/s12887-021-03043-x
BMC Pediatrics volume 21, Article number: 562 (2021)
Currently, about 165 million children are categorized under malnutrition and 51.5 million suffering from acute malnutrition in world wide. Hence, the objective of current study was to assess the recovery time and its predictors of children under five from severe acute malnutrition admitted to Therapeutic Feeding Unit at Dubti Referral Hospital, Afar region, Eastern Ethiopia.
Red flags of poor prognosis in pediatric cases of COVID-19: the first 6610 hospitalized children in Iran
Sedigheh Madani, Sarvenaz Shahin, Moein Yoosefi, Naser Ahmadi, Erfan Ghasemi, Sogol Koolaji, Esmaeil Mohammadi, Sahar Mohammadi Fateh, Amirali Hajebi, Ameneh Kazemi, Erfan Pakatchian, Negar Rezaei, Hamidreza Jamshidi, Bagher Larijani & Farshad Farzadfar
doi : 10.1186/s12887-021-03030-2
BMC Pediatrics volume 21, Article number: 563 (2021)
COVID-19 clinical course, effective therapeutic regimen, and poor prognosis risk factors in pediatric cases are still under investigation and no approved vaccinehas been introduced for them.
Co-inheritance of G6PD deficiency and 211?G to a variation of UGT1A1 in neonates with hyperbilirubinemia in eastern Guangdong
Jia-Xin Xu, Fen Lin, Zi-Kai Chen, Zhao-Yun Luo, Xiao-Fen Zhan, Jiao-Ren Wu, Yu-Bin Ma, Jian-Dong Li & Li-Ye Yang
doi : 10.1186/s12887-021-03010-6
BMC Pediatrics volume 21, Article number: 564 (2021)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, which may manifest as neonatal hyperbilirubinemia, is the most prevalent erythrocytic enzyme-related disease in the world.
Dietary diversity and associated factors among children aged 6 to 23?months in Chelia District, Ethiopia
Shambel Keno, Haile Bikila, Tesfaye Shibiru & Werku Etafa
doi : 10.1186/s12887-021-03040-0
BMC Pediatrics volume 21, Article number: 565 (2021)
Although minimum dietary diversity (MDD) is one of the core indicators of a high-quality diet for infants and young children, meeting this dietary diversity standard remains a challenge in Ethiopia. Therefore, adequate information on the status and factors affecting minimum dietary diversity is essential to identify potential strategic interventions. This study to study is to assess DD and associated factors among children aged 6 to 23?months in Chelia District, Ethiopia.
CASP5 and CR1 as potential biomarkers for Kawasaki disease: an Integrated Bioinformatics-Experimental Study
Yazdan Rahmati, Hasan Mollanoori, Sajad Najafi, Sajjad Esmaeili & Mohammad Reza Alivand
doi : 10.1186/s12887-021-03003-5
BMC Pediatrics volume 21, Article number: 566 (2021)
Kawasaki disease (KD) is a pediatric inflammatory disorder causes coronary artery complications. The disease overlapping manifestations with a set of symptomatically like diseases such as bacterial and viral infections, juvenile idiopathic arthritis, Henoch-Schönlein purpura, infection of unknown etiology, group-A streptococcal and adenoviral infections, and incomplete KD could lead to misdiagnosis of the disease.
An outbreak of RSV infections in a neonatology clinic during the RSV-season
Liliya Vakrilova, Stanislava Hitrova Nikolova, Sergei Slavov, Petya Radulova & Boryana Slancheva
doi : 10.1186/s12887-021-03053-9
BMC Pediatrics volume 21, Article number: 567 (2021)
Respiratory syncytial virus (RSV) is the predominant cause of lower respiratory tract infections (LRTI) in infancy. Preterm infants with bronchopulmonary dysplasia (BPD) are at the highest risk of severe RSV-LRTI. This is a retrospective study that analyses a nosocomial outbreak of RSV infections in the Neonatology clinic of the University Hospital of Obstetrics and Gynecology, Sofia, 2019.
Osteomyelitis in Immunocompromised children and neonates, a case series
Bryan Foong, Kenneth Pak Leung Wong, Carolin Joseph Jeyanthi, Jiahui Li, Kevin Boon Leong Lim & Natalie Woon Hui Tan
doi : 10.1186/s12887-021-03031-1
BMC Pediatrics volume 21, Article number: 568 (2021)
Osteomyelitis in immunocompromised children can present differently from immunocompetent children and can cause devastating sequelae if treated inadequately. We aim to review the aetiology, clinical profile, treatment and outcomes of immunocompromised children with osteomyelitis.
Mortality by opioid poisoning in children and teenagers and opioid prescriptions
Elise Cranfield, Elizabeth Ashcroft & Patrice Forget
doi : 10.1186/s12887-021-03061-9
BMC Pediatrics volume 21, Article number: 569 (2021)
No comparisons between mortality from opioids in children and teenagers and opioid prescription patterns have been made in England.
When first line treatment of neonatal infection is not enough: blood culture and resistance patterns in neonates requiring second line antibiotic therapy in Bangui, Central African Republic
Andrea Nebbioso, Oluwakemi F. Ogundipe, Ernestina Carla Repetto, Calorine Mekiedje, Hugues Sanke-Waigana, Gilles Ngaya, Brecht Ingelbeen & Julita Gil-Cuesta
doi : 10.1186/s12887-021-02911-w
BMC Pediatrics volume 21, Article number: 570 (2021)
Infectious diseases account for the third most common cause of neonatal deaths. Globally, antibiotic resistance (ABR) has been increasingly challenging neonatal sepsis treatment, with 26 to 84% of gram-negative bacteria resistant to third-generation cephalosporins. In sub-Saharan Africa, limited evidence is available regarding the neonatal microbiology and ABR. To our knowledge, no studies have assessed neonatal bacterial infections and ABR in Central-African Republic (CAR). Therefore, this study aimed to describe the pathogens isolated and their specific ABR among patients with suspected antibiotic-resistant neonatal infection admitted in a CAR neonatal unit.
Effect of COVID-19 on Kawasaki Disease: Decrease Age of Onset and Increase Skin Manifestation
Hossein Esmaeilzadeh, Negar Mortazavi, Alireza Salehi, Hossein Fatemian, Seyed Mohsen Dehghani, Mohebat Vali & Hossein Molavi Vardanjani
doi : 10.1186/s12887-021-03060-w
BMC Pediatrics volume 21, Article number: 571 (2021)
Kawasaki Disease (KD) is the most common childhood vasculitis and cause of acquired heart disease for no apparent reason. There is some evidence indicating infectious agents as possible triggers for KD. During the COVID-19 pandemic, vasculitis has been a presentation of COVID-19 in children. We performed this study to assess the association between KD and COVID-19.
The association between living environmental factors and adolescents’ body weight: a cross-sectional study
Siyi Huang, Sha Sha, Wei Du, Hanwen Zhang, Xinyi Wu, Chongmin Jiang, Yan Zhao & Jie Yang
doi : 10.1186/s12887-021-03054-8
BMC Pediatrics volume 21, Article number: 572 (2021)
The effect of the living environment on public health has received increasingly scholarly attention. This study aims to explore the relationship between adolescents’ body weight and their living environmental factors.
Acute malnutrition and its determinants of preschool children in Bangladesh: gender differentiation
Md. Reazul Karim, Abu Sayed Md. Al Mamun, Md. Masud Rana, Rashidul Alam Mahumud, Nurun Naher Shoma, Dhiman Dutt, Premananda Bharati & Md. Golam Hossain
doi : 10.1186/s12887-021-03033-z
BMC Pediatrics volume 21, Article number: 573 (2021)
Children acute malnutrition (AM) is a global public health concern, especially in low and middle income countries. AM is associated with multiple physiological vulnerabilities, including immune dysfunction, enteric barrier disruption, gut microbiome dysbiosis, and essential nutrient deficits. This study aimed to determine the prevalence of AM and its associated factors among preschool children in Rajshahi district, Bangladesh.
A study of students’ use of restraint systems in school transportation services in primary and secondary schools in northern Iran: an observational study
Shahrokh Yousefzade-Chabok, Samira Azari, Leila Kouchakinejad-Eramsadati, Enayatollah Homaie Rad, Marjan Hosseinnia & Naema Khodadadi-Hassankiadeh
doi : 10.1186/s12887-021-03048-6
BMC Pediatrics volume 21, Article number: 574 (2021)
Traffic accidents are one of the leading causes of death and severe injury among child occupants of vehicles in most countries. This has led to the consideration of how to use restraint systems for students in school buses. The purpose of the present study was to determine the percentage of students’ use of restraint systems in school transportation services in 2020.
A rare case of fetus in fetu in the sacrococcygeal region: CT and MRI findings
Tao Lu, Junmei Ma & Xudan Yang
doi : 10.1186/s12887-021-03063-7
BMC Pediatrics volume 21, Article number: 575 (2021)
Fetus in fetu is a rare condition in which a malformed fetus is found in the body of a living twin. The retroperitoneum is the most common location of this condition. However, the sacrococcygeal region is a rare site of the disease. The presence of vertebral bodies and limbs differentiates FIF from teratoma. Imaging modalities are important for diagnosing FIF.
Socio-demographic and environmental risk factors associated with multiple under-five child loss among mothers in Bangladesh
Rasel Kabir, Marwa Farag, Hyun Ja Lim, Nigatu Geda & Cindy Feng
doi : 10.1186/s12887-021-03034-y
BMC Pediatrics volume 21, Article number: 576 (2021)
Despite the substantial decline in child mortality globally over the last decade, reducing neonatal and under-five mortality in Bangladesh remains a challenge. Mothers who experienced multiple child losses could have substantial adverse personal and public health consequences. Hence, prevention of child loss would be extremely desirable during women’s reproductive years. The main objective of this study was to determine the risk factors associated with multiple under-five child loss from the same mother in Bangladesh.
A promising new predictive factor for detecting bowel resection in childhood intussusception: the lymphocyte-C-reactive protein ratio
Bailin Chen, Jian Cao, Chengwei Yan, Chao Zheng, Jingyu Chen & Chunbao Guo
doi : 10.1186/s12887-021-03068-2
BMC Pediatrics volume 21, Article number: 577 (2021)
The most critical concern for the management of childhood intussusception is bowel resection due to intestinal ischemia and necrosis. The early prediction of this problem is of great importance. We investigated the value of various combinations of inflammatory factors to predict intestinal necrosis and resection.
Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report
Katarína Brennerová, Martina Škopková, Mária Ostrožlíková, Jana Šaligová, Juraj Staník, Vladimír Bzdúch & Daniela Gašperíková
doi : 10.1186/s12887-021-03067-3
BMC Pediatrics volume 21, Article number: 578 (2021)
Isolated methylmalonic aciduria can be caused by pathogenic mutations in the gene for methylmalonyl-CoA mutase or in the genes encoding enzymes involved in the intracellular metabolism of cobalamin. Some of these mutations may be cobalamin responsive. The type of methylmalonic aciduria cannot always be assumed from clinical manifestation and the responsiveness to cobalamin has to be assessed for appropriate cobalamin administration, or to avoid unnecessary treatment. The cases presented herein highlight the importance of genetic testing in methylmalonic aciduria cases and the need for standardisation of the in vivo cobalamin-responsiveness assessment.
Factors affecting rehabilitation of infants with Central Coordination Disorders during a three-month-long observation
Malgorzata Andrzejewska, Katarzyna Hap, Karolina Biernat, Edyta Sutkowska, Iwona Demczyszak, Dominik Marciniak & Natalia Kuciel
doi : 10.1186/s12887-021-03066-4
BMC Pediatrics volume 21, Article number: 579 (2021)
Central coordination disorders (CCD) encompass various abnormalities observed in infants but early therapy may have an impact on their condition. The aim was to seek factors that may affect the early results of therapy of infants with CCD.
Sex differences in children's health status as measured by the Pediatric Quality of Life Inventory (PedsQL)™: cross-sectional findings from a large school-based sample in the Netherlands
Annelieke Hijkoop, Chantal A. ten Kate, Marlous J. Madderom, Hanneke IJsselstijn, Julie A. Reuser, Hendrik Koopman, Joost van Rosmalen & André B. Rietman
doi : 10.1186/s12887-021-03059-3
BMC Pediatrics volume 21, Article number: 580 (2021)
Previous research has shown that female adolescents and adults report lower health status than their male peers. Possibly, this discrepancy already develops during childhood. We collected sex-specific data with the Pediatric Quality of Life Inventory (PedsQL) in a large school-based sample.
Urate-lowering therapy for gout and asymptomatic hyperuricemia in the pediatric population: a cross-sectional study of a Japanese health insurance database
Masataka Honda, Hideki Horiuchi, Tomoko Torii, Akihiro Nakajima, Takeshi Iijima, Hiroshi Murano, Hisashi Yamanaka & Shuichi Ito
doi : 10.1186/s12887-021-03051-x
BMC Pediatrics volume 21, Article number: 581 (2021)
Our previous research showed that uric acid lowering therapy (ULT) for gout and hyperuricemia is being prescribed for pediatric patients even though these drugs have not been approved for use in children. However, the actual clinical situation has not been clearly elucidated. In this paper, we provide an in-depth look at the details of actual clinical practice.
Early aEEG can predict neurodevelopmental outcomes at 12 to 18?month of age in VLBWI with necrotizing enterocolitis: a cohort study
Si Chen, Xiuman Xiao, Su Lin, Jianghu Zhu, Lidan Liang, Minli Zhu, Zuqin Yang, Shangqin Chen, Zhenlang Lin & Yanli Liu
doi : 10.1186/s12887-021-03056-6
BMC Pediatrics volume 21, Article number: 582 (2021)
Studies have shown that neurological damage is common in necrotizing enterocolitis (NEC) survivors. The purpose of the study was to investigate the predictive value of amplitude-integrated electroencephalogram (aEEG) for neurodevelopmental outcomes in preterm infants with NEC.
Complementary feeding practice and associated factors among internally displaced mothers of children aged 6–23?months in Amhara region, Northwest Ethiopia: a cross-sectional study
Alex Yeshaneh, Meron Zebene, Molla Gashu, Haimanot Abebe & Habtemariam Abate
doi : 10.1186/s12887-021-03050-y
BMC Pediatrics volume 21, Article number: 583 (2021)
Internally displaced populations are susceptible to food deprivation. Specifically, children aged 6–23 are commonly vulnerable to poor complementary feeding. Proper complementary feeding is of paramount importance to the healthy growth and survival of a children. Therefore, this study aimed to assess the level of appropriate complementary feeding practices and associated factors among internally displaced children aged 6–23?months in northwest Ethiopia, 2020.
Fatal accidental lipid overdose with intravenous composite lipid emulsion in a premature newborn: a case report
Maliha Badr, Marion Goulard, Bénédicte Theret, Agathe Roubertie, Stéphanie Badiou, Roselyne Pifre, Virginie Bres & Gilles Cambonie
doi : 10.1186/s12887-021-03064-6
BMC Pediatrics volume 21, Article number: 584 (2021)
Tenfold or more overdose of a drug or preparation is a dreadful adverse event in neonatology, often due to an error in programming the infusion pump flow rate. Lipid overdose is exceptional in this context and has never been reported during the administration of a composite intravenous lipid emulsion (ILE).
The effect of acetate Ringer’s solution versus lactate Ringer’s solution on acid base physiology in infants with biliary atresia
Xiang Liu, Hongyan Cao, Xiaona Tan, Jing Shi, Li Qiao, Qi Zhang & Lei Shi
doi : 10.1186/s12887-021-03074-4
BMC Pediatrics volume 21, Article number: 585 (2021)
The choice of the perioperative crystalloid is a key component of the fluid management and must take into account the liver function and the appearing metabolic disorders to avoid increase the liver extra metabolism. The aim of this study is to analyze the effect of acetate Ringer’s solution or lactate Ringer’s solution in biliary atresia patients.
IgG4-related chronic sclerosing sialadenitis in a child with recurrent parotitis: a case report
Fabio Timeus, Mario Michele Calvo, Anna Maria Caci, Giorgio Oliviero Gallone & Federico Vittone
doi : 10.1186/s12887-021-03004-4
BMC Pediatrics volume 21, Article number: 586 (2021)
IgG4-related disease (IgG4-RD) includes a group of immune-mediated diseases histologically characterized by lymphoplasmacytic infiltrate with a prevalence of IgG4-positive plasma cells, storiform fibrosis and obliterative phlebitis. Autoimmune pancreatitis, sialadenitis, dacryoadenitis and retroperitoneal fibrosis are the most frequent manifestations. IgG4-related sialadenitis usually affects submandibular glands and is very rare in children.
Intussusception in preterm neonates: A systematic review of a rare condition
Mostafa Kotb, Mostafa Abdelatty, Hayssam Rashwan, Yasmine AbdelMeguid & Ahmed Elrouby
doi : 10.1186/s12887-021-03065-5
BMC Pediatrics volume 21, Article number: 587 (2021)
While necrotizing enterocolitis (NEC) is a prevalent condition in preterm neonates admitted to neonatal intensive care unit (NICU), intussusception is exceedingly uncommon and often overlooked. This is due to the fact that they share many clinical characteristics. The initial misdiagnosis of intussusception in preterm neonates (IPN) especially has led to a delay in their management, which increases the risk of developing compromised bowel. Additionally, it is difficult to reach a diagnosis as neonatal intussusception does not have any classical radiological signs even when contrast enema is used. This systematic review is based on the published literature including case reports and case series to review the clinical features of IPN and how to differentiate it from NEC in order to shed the light on this rare disease and how having a high index of suspicion would help practitioners to make an early and accurate diagnosis
Case Report : Li-Fraumeni Syndrome with Central Nervous System Tumors in Two Siblings
Zishi Fang, Yan Su, Hailang Sun, Ming Ge, Zhan Qi, Chanjuan Hao, Suyun Qian & Xiaoli Ma
doi : 10.1186/s12887-021-03070-8
BMC Pediatrics volume 21, Article number: 588 (2021)
Li-Fraumeni syndrome (LFS) is a rare autosomal dominant cancer predisposition syndrome caused by germline TP53 gene mutations. It is characterized by high risk of early-onset cancer, and has been confirmed as associated with multiple tumors clinically. So pediatricians should be more alert to LFS in children with tumors. Choroid plexus carcinoma (CPC) is a rare, malignant tumor which account for less than 1% of all central nervous system (CNS) tumors. However, when such tumorigenesis occurs, it is important to be vigilant for the presence of LFS.
