European Heart Journal

Xin Jiang, Yong-Jian Zhu, Yu-Ping Zhou, Fu-Hua Peng, Lan Wang, Wei Ma, Yun-Shan Cao, Xin Pan, Gang-Cheng Zhang, Feng Zhang, Fen-Ling Fan, Bing-Xiang Wu, Wei Huang, Zhen-Wen Yang, Cheng Hong, Meng-Tao Li, Yi-Ning Wang, Xi-Qi Xu, Duo-Lao Wang, Shu-Yang Zhang, Zhi-Cheng Jing

doi : 10.1093/eurheartj/ehab599

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4298–4305

This study aimed to assess the clinical characteristics and long-term survival outcome in patients with Takayasu’s arteritis-associated pulmonary hypertension (TA-PH).

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Takayasu arteritis-associated pulmonary hypertension

Yoshihiro Fukumoto

doi : 10.1093/eurheartj/ehab688

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4306–4308

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Impact of cholesterol on proinflammatory monocyte production by the bone marrow

Lotte C A Stiekema, Lisa Willemsen, Yannick Kaiser, Koen H M Prange, Nicholas J Wareham, S Matthijs Boekholdt, Carlijn Kuijk, Menno P J de Winther, Carlijn Voermans, Matthias Nahrendorf, Erik S G Stroes, Jeffrey Kroon

doi : 10.1093/eurheartj/ehab465

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4309–4320

Preclinical work indicates that low-density lipoprotein cholesterol (LDL-C) not only drives atherosclerosis by directing the innate immune response at plaque level but also augments proinflammatory monocyte production in the bone marrow (BM) compartment. In this study, we aim to unravel the impact of LDL-C on monocyte production in the BM compartment in human subjects.

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LDL-cholesterol drives reversible myelomonocytic skewing in human bone marrow

Laurent Yvan-Charvet, Marit Westerterp

doi : 10.1093/eurheartj/ehab630

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4321–4323

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Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study

Renato Quispe, Seth Shay Martin, Erin Donelly Michos, Isha Lamba, Roger Scott Blumenthal, Anum Saeed, Joao Lima, Rishi Puri, Sarah Nomura, Michael Tsai, John Wilkins, Christie Mitchell Ballantyne, Stephen Nicholls, Steven Richard Jones, Mohamed Badreldin Elshazly

doi : 10.1093/eurheartj/ehab432

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4324–4332

Emerging evidence suggests that remnant cholesterol (RC) promotes atherosclerotic cardiovascular disease (ASCVD). We aimed to estimate RC-related risk beyond low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB) in patients without known ASCVD.

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Keeping remnants in perspective

Jan Borén, Chris J Packard

doi : 10.1093/eurheartj/ehab531

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4333–4335

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STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases

Phuong Tran Pham, Daiju Fukuda, Sachiko Nishimoto, Joo-Ri Kim-Kaneyama, Xiao-Feng Lei, Yutaka Takahashi, Tomohito Sato, Kimie Tanaka, Kumiko Suto, Yutaka Kawabata, Koji Yamaguchi, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi, Michio Shimabukuro, Mitsutoshi Setou, Glen N Barber, Masataka Sata

doi : 10.1093/eurheartj/ehab249

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4336–4348

Lifestyle-related diseases promote atherosclerosis, a chronic inflammatory disease; however, the molecular mechanism remains largely unknown. Endogenous DNA fragments released under over-nutrient condition provoke sterile inflammation through the recognition by DNA sensors. Here, we investigated the role of stimulator of interferon genes (STING), a cytosolic DNA sensor, in atherogenesis.

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DNA damage and extranuclear DNA sensors: a dangerous duo in atherosclerosis

Donato Santovito, Sabine Steffens

doi : 10.1093/eurheartj/ehab300

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4349–4351

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Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice

Anahita Mojiri, Brandon K Walther, Chongming Jiang, Gianfranco Matrone, Rhonda Holgate, Qiu Xu, Elisa Morales, Guangyu Wang, Jianhua Gu, Rongfu Wang, John P Cooke

doi : 10.1093/eurheartj/ehab547

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4352–4369

Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated ageing syndrome associated with premature vascular disease and death due to heart attack and stroke. In HGPS a mutation in lamin A (progerin) alters nuclear morphology and gene expression. Current therapy increases the lifespan of these children only modestly. Thus, greater understanding of the underlying mechanisms of HGPS is required to improve therapy. Endothelial cells (ECs) differentiated from induced pluripotent stem cells (iPSCs) derived from these patients exhibit hallmarks of senescence including replication arrest, increased expression of inflammatory markers, DNA damage, and telomere erosion. We hypothesized that correction of shortened telomeres may reverse these measures of vascular ageing.

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Vascular rejuvenation: a new therapeutic target?

Rosalinda Madonna

doi : 10.1093/eurheartj/ehab587

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4370–4372

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Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection

Hongtu Cui, Yanghui Chen, Ke Li, Rui Zhan, Mingming Zhao, Yangkai Xu, Zhiyong Lin, Yi Fu, Qihua He, Paul C Tang, Ienglam Lei, Jifeng Zhang, Chenze Li, Yang Sun, Xinhua Zhang, Tiffany Horng, Hong S Lu, Y Eugene Chen, Alan Daugherty, Daowen Wang, Lemin Zheng

doi : 10.1093/eurheartj/ehab605

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4373–4385

Aortic aneurysm and dissection (AAD) are high-risk cardiovascular diseases with no effective cure. Macrophages play an important role in the development of AAD. As succinate triggers inflammatory changes in macrophages, we investigated the significance of succinate in the pathogenesis of AAD and its clinical relevance.

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Breaking the cycle: Succinate in aortic diseases

Rohan Bhandari, Scott J Cameron

doi : 10.1093/eurheartj/ehab514

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4386–4388

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The JAK–STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms

Chiara Baldini, Francesca Romana Moriconi, Sara Galimberti, Peter Libby, Raffaele De Caterina

doi : 10.1093/eurheartj/ehab447

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4389–4400

Inflammation contributes centrally to cardiovascular diseases, and anti-inflammatory treatments can reduce cardiovascular events. The JAK–STAT pathway is an emerging target in inflammation, mainly in rheumatoid arthritis (RA) and chronic myeloproliferative neoplasms (MPNs), disorders that heighten cardiovascular risk. The aim of this study was to review the international literature on the relationship between dysregulation of the JAK–STAT pathway in RA/MPNs and cardiovascular risk and on the potential cardiovascular effects of JAK–STAT inhibitors. The JAK–STAT pathway sustains inflammatory and thrombotic events in autoimmune disorders such as RA and MPNs. Here, an imbalance exists between pro- and anti-inflammatory cytokines [increased levels of interleukin (IL)-6, IL-1-?, tumour necrosis factor-?, decreased levels of IL-10] and the over-expression of some prothrombotic proteins, such as protein kinase C?, on the surface of activated platelets. This pathway also operates in atherosclerotic cardiovascular disease. JAK–STAT inhibitors may reduce cardiovascular events and related deaths in such conditions, but the potential of these agents requires more studies, especially with regard to cardiovascular safety, and particularly for potential prothrombotic effects. JAK–STAT inhibitors merit consideration to curb heightened cardiovascular risk in patients with RA and MPNs, with rigorous assessment of the potential benefits and risks.

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Coronary artery stenosis prediction does not mean coronary artery stenosis obstruction

Francois Derimay, Gerard Finet, Gilles Rioufol

doi : 10.1093/eurheartj/ehab332

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Page 4401

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Selecting the right cohorts and endpoints for the validation of pre-test probability models for obstructive coronary artery disease

Simon Winther, Samuel Emil Schmidt, Juhani Knuuti, Morten Bøttcher

doi : 10.1093/eurheartj/ehab336

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Pages 4402–4403

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Spontaneous true lumen expansion in chronic type B aortic dissection

Masashi Kawamura, Osamu Monta

doi : 10.1093/eurheartj/ehab436

European Heart Journal, Volume 42, Issue 42, 7 November 2021, Page 4403

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