Cardiovascular Outcomes Trials for Weight Loss Interventions: Another Tool for Cardiovascular Prevention?

Ian J. Neeland, Darren K. McGuire, Naveed Sattar

doi : 10.1161/CIRCULATIONAHA.121.056742

Circulation. 2021;144:1359–1361

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Health Impact and Cost-Effectiveness of Achieving the National Salt and Sugar Reduction Initiative Voluntary Sugar Reduction Targets in the United States: A Microsimulation Study

Siyi Shangguan, Dariush Mozaffarian, Stephen Sy, Yujin Lee, Junxiu Liu, Parke E. Wilde, Andrea L. Sharkey, Erin A. Dowling, Matti Marklund, Shafika Abrahams-Gessel, Thomas A. Gaziano, Renata Micha

doi : 10.1161/CIRCULATIONAHA.121.053678

Circulation. 2021;144:1362–1376

High intake of added sugar is linked to weight gain and cardiometabolic risk. In 2018, the US National Salt and Sugar Reduction Initiative proposed government-supported voluntary national sugar reduction targets. This intervention’s potential effects and cost-effectiveness are unclear.

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Microsimulation Model for Health Economic Evaluation of Public Health Policies: An Imperfect but Useful Tool

Olivia Wu

doi : 10.1161/CIRCULATIONAHA.121.056502

Circulation. 2021;144:1377–1379

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Outcomes of Participants With Diabetes in the ISCHEMIA Trials

Jonathan D. Newman, Rebecca Anthopolos, G.B. John Mancini, Sripal Bangalore, Harmony R. Reynolds, Dennis F. Kunichoff, Roxy Senior, Jesus Peteiro, Balram Bhargava, Pallav Garg, Jorge Escobedo, Rolf Doerr, Tomasz Mazurek, Jose Gonzalez-Juanatey, Grzegorz Gajos, Carlo Briguori, Hong Cheng, Andras Vertes, Sandeep Mahajan, Luis A. Guzman, Matyas Keltai, Aldo P. Maggioni, Gregg W. Stone, Jeffrey S. Berger, Yves D. Rosenberg, William E. Boden, Bernard R. Chaitman, Jerome L. Fleg, Judith S. Hochman, David J. Maron

doi : 10.1161/CIRCULATIONAHA.121.054439

Circulation. 2021;144:1380–1395

Among patients with diabetes and chronic coronary disease, it is unclear if invasive management improves outcomes when added to medical therapy.

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Native Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients With Transcatheter Aortic Valve Implantation

Jacek Kwiecinski, Evangelos Tzolos, Timothy R.G. Cartlidge, Alexander Fletcher, Mhairi K. Doris, Rong Bing, Jason M. Tarkin, Michael A. Seidman, Gaurav S. Gulsin, Nicholas L. Cruden, Anna K. Barton, Neal G. Uren, Michelle C. Williams, Edwin J.R. van Beek, Jonathon Leipsic, Damini Dey, Raj R. Makkar, Piotr J. Slomka, James H.F. Rudd, David E. Newby, Stephanie L. Sellers, Daniel S. Berman, Marc R. Dweck

doi : 10.1161/CIRCULATIONAHA.121.056891

Circulation. 2021;144:1396–1408

Major uncertainties remain regarding disease activity within the retained native aortic valve, and regarding bioprosthetic valve durability, after transcatheter aortic valve implantation (TAVI). We aimed to assess native aortic valve disease activity and bioprosthetic valve durability in patients with TAVI in comparison with subjects with bioprosthetic surgical aortic valve replacement (SAVR).

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Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome

Markus Krane, Martina Dreßen, Gianluca Santamaria, Ilaria My, Christine M. Schneider, Tatjana Dorn, Svenja Laue, Elisa Mastantuono, Riccardo Berutti, Hilansi Rawat, Ralf Gilsbach, Pedro Schneider, Harald Lahm, Sascha Schwarz, Stefanie A. Doppler, Sharon Paige, Nazan Puluca, Sophia Doll, Irina Neb, Thomas Brade, Zhong Zhang, Claudia Abou-Ajram, Bernd Northoff, Lesca M. Holdt, Stefanie Sudhop, Makoto Sahara, Alexander Goedel, Andreas Dendorfer, Fleur V.Y. Tjong, Maria E. Rijlaarsdam, Julie Cleuziou, Nora Lang, Christian Kupatt, Connie Bezzina, Rüdiger Lange, Neil E. Bowles, Matthias Mann, Bruce D. Gelb, Lia Crotti, Lutz Hein, Thomas Meitinger, Sean Wu, Daniel Sinnecker, Peter J. Gruber, Karl-Ludwig Laugwitz, Alessandra Moretti

doi : 10.1161/CIRCULATIONAHA.121.056198

Circulation. 2021;144:1409–1428

Complex molecular programs in specific cell lineages govern human heart development. Hypoplastic left heart syndrome (HLHS) is the most common and severe manifestation within the spectrum of left ventricular outflow tract obstruction defects occurring in association with ventricular hypoplasia. The pathogenesis of HLHS is unknown, but hemodynamic disturbances are assumed to play a prominent role.

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Breath of Life: Heart Disease Link to Developmental Hypoxia

Dino A. Giussani

doi : 10.1161/CIRCULATIONAHA.121.054689

Circulation. 2021;144:1429–1443

Heart disease remains one of the greatest killers. In addition to genetics and traditional lifestyle risk factors, we now understand that adverse conditions during pregnancy can also increase susceptibility to cardiovascular disease in the offspring. Therefore, the mechanisms by which this occurs and possible preventative therapies are of significant contemporary interest to the cardiovascular community. A common suboptimal pregnancy condition is a sustained reduction in fetal oxygenation. Chronic fetal hypoxia results from any pregnancy with increased placental vascular resistance, such as in preeclampsia, placental infection, or maternal obesity. Chronic fetal hypoxia may also arise during pregnancy at high altitude or because of maternal respiratory disease. This article reviews the short- and long-term effects of hypoxia on the fetal cardiovascular system, and the importance of chronic fetal hypoxia in triggering a developmental origin of future heart disease in the adult progeny. The work summarizes evidence derived from human studies as well as from rodent, avian, and ovine models. There is a focus on the discovery of the molecular link between prenatal hypoxia, oxidative stress, and increased cardiovascular risk in adult offspring. Discussion of mitochondria-targeted antioxidant therapy offers potential targets for clinical intervention in human pregnancy complicated by chronic fetal hypoxia.

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Left Bundle-Branch Block Tachycardia After Transcatheter Aortic Valve Replacement

Bernard Belhassen, Ayelet Shauer, Yitschak Biton

doi : 10.1161/CIRCULATIONAHA.121.056237

Circulation. 2021;144:1444–1448

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Clinical Outcomes of Rivaroxaban Monotherapy in Heart Failure Patients With Atrial Fibrillation and Stable Coronary Disease: Insights From the AFIRE Trial

Yoshiyuki Yazaki, Masato Nakamura, Raisuke Iijima, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa, and on behalf of the AFIRE Investigators

doi : 10.1161/CIRCULATIONAHA.121.055374

Circulation. 2021;144:1449–1451

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Three-Dimensional Visualization of Hypoxia-Induced Pulmonary Vascular Remodeling in Mice

Takayuki Fujiwara, Norifumi Takeda, Hironori Hara, Satoshi Ishii, Genri Numata, Hiroyuki Tokiwa, Sonoko Maemura, Takaaki Suzuki, Hiroshi Takiguchi, Yoshiaki Kubota, Kinya Seo, Asuka Sakata, Seitaro Nomura, Masaru Hatano, Kazutaka Ueda, Mutsuo Harada, Haruhiro Toko, Eiki Takimoto, Hiroshi Akazawa, Satoshi Nishimura, Issei Komuro

doi : 10.1161/CIRCULATIONAHA.121.056219

Circulation. 2021;144:1452–1455

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Letter by Braillon Regarding Article, “Very High Coronary Artery Calcium (?1000) and Association With Cardiovascular Disease Events, Non–Cardiovascular Disease Outcomes, and Mortality: Results From MESA”

Alain Braillon

doi : 10.1161/CIRCULATIONAHA.121.055717

Circulation. 2021;144:e274

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Response by Peng et al to Letter Regarding Article, “Very High Coronary Artery Calcium (?1000) and Association With Cardiovascular Disease Events, Non–Cardiovascular Disease Outcomes, and Mortality: Results From MESA”

Allison W. Peng, Zeina A. Dardari, Michael J. Blaha

doi : 10.1161/CIRCULATIONAHA.121.056534

Circulation. 2021;144:e275–e276

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