Toward CRISPR Therapies for Cardiomyopathies

Takahiko Nishiyama, Rhonda Bassel-Duby, and Eric N. Olson

doi : 10.1161/CIRCULATIONAHA.121.057203

Circulation. 2021;144:1525–1527

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Combined Associations of Changes in Noncombustible Nicotine or Tobacco Product and Combustible Cigarette Use Habits With Subsequent Short-Term Cardiovascular Disease Risk Among South Korean Men: A Nationwide Cohort Study

Seulggie Choi, Kiheon Lee, and Sang Min Park

doi : 10.1161/CIRCULATIONAHA.121.054967

Circulation. 2021;144:1528–1538

The associations of changes in noncombustible nicotine or tobacco product (NNTP) and combustible cigarette (CC) use habits with subsequent cardiovascular disease (CVD) risk are still unclear.

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Heating Tobacco Sticks Instead of Combusting Conventional Cigarettes and Future Heart Attacks: Still Smoke, and Risk

Reto Auer, Pascal Diethelm, and Aurélie Berthet

doi : 10.1161/CIRCULATIONAHA.121.056959

Circulation. 2021;144:1539–1542

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Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial

Dhanunjaya Lakkireddy, David Thaler, Christopher R. Ellis, Vijendra Swarup, Lars Sondergaard, John Carroll, Michael R. Gold, James Hermiller, Hans-Christoph Diener, Boris Schmidt, Lee MacDonald, Moussa Mansour, Brijeshwar Maini, Laura O’Brien, Stephan Windecker, on behalf of the Amulet IDE Investigators

doi : 10.1161/CIRCULATIONAHA.121.057063

Circulation. 2021;144:1543–1552

Percutaneous closure of the left atrial appendage (LAA) is an alternative to chronic oral anticoagulation to reduce stroke risk in patients with nonvalvular atrial fibrillation. The Amulet IDE trial (Amplatzer Amulet Left Atrial Appendage Occluder IDE Trial) was designed to evaluate the safety and effectiveness of the dual-seal mechanism of the Amulet LAA occluder compared with the Watchman device.

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Incidence and Predictors of Progression to Chagas Cardiomyopathy: Long-Term Follow-Up of Trypanosoma cruzi–Seropositive Individuals

Maria Carmo P. Nunes, Lewis F. Buss, Jose Luiz P. Silva, Larissa Natany A. Martins, Claudia Di Lorenzo Oliveira, Clareci Silva Cardoso, Bruno Oliveira de Figueiredo Brito, Ariela Mota Ferreira, Lea Campos Oliveira, Ana Luiza Bierrenbach, Fabio Fernandes, Michael P. Busch, Viviane Tiemi Hotta, Luiz Mario Baptista Martinelli, Maria Carolina F. Almeida Soeiro, Adriana Brentegani, Vera M.C. Salemi, Marcia M. Menezes, Antonio Luiz P. Ribeiro, and Ester Cerdeira Sabino

doi : 10.1161/CIRCULATIONAHA.121.055112

Circulation. 2021;144:1553–1566

There are few contemporary cohorts of Trypanosoma cruzi–seropositive individuals, and the basic clinical epidemiology of Chagas disease is poorly understood. Herein, we report the incidence of cardiomyopathy and death associated with T. cruzi seropositivity.

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Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization

Francesca Fasolo, Hong Jin, Greg Winski, Ekaterina Chernogubova, Jessica Pauli, Hanna Winter, Daniel Y. Li, Nadiya Glukha, Sabine Bauer, Susanne Metschl, Zhiyuan Wu, Marlys L. Koschinsky, Muredach Reilly, Jaroslav Pelisek, Wolfgang Kempf, Hans-Henning Eckstein, Oliver Soehnlein, Ljubica Matic, Ulf Hedin, Alexandra Bäcklund, Claes Bergmark, Valentina Paloschi, and Lars Maegdefessel

doi : 10.1161/CIRCULATIONAHA.120.052023

Circulation. 2021;144:1567–1583

Long noncoding RNAs (lncRNAs) are important regulators of biological processes involved in vascular tissue homeostasis and disease development. The present study assessed the functional contribution of the lncRNA myocardial infarction-associated transcript (MIAT) to atherosclerosis and carotid artery disease.

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Colchicine in Patients With Acute Coronary Syndrome: Two-Year Follow-Up of the Australian COPS Randomized Clinical Trial

David C. Tong, Jason E. Bloom, Stephen Quinn, Arthur Nasis, Chin Hiew, Philip Roberts-Thomson, Heath Adams, Rumes Sriamareswaran, Nay M. Htun, William Wilson, Dion Stub, William van Gaal, Laurie Howes, Allysha Yeap, Brian Yip, Sam Wu, Padeepa Perera, Nicholas Collins, Andy Yong, Ravinay Bhindi, Robert Whitbourn, Astin Lee, Manuja Premaratne, Kaleab Asrress, Melanie Freeman, John Amerena, and Jamie Layland

doi : 10.1161/CIRCULATIONAHA.121.054610

Circulation. 2021;144:1584–1586

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Letter by Schaefer et al Regarding Article, “Diagnostic Performance of High-Sensitivity Cardiac Troponin T Strategies and Clinical Variables in a Multisite US Cohort”

Ibrahim Schaefer, Pedro Lopez-Ayala, and Christian Mueller

doi : 10.1161/CIRCULATIONAHA.121.055719

Circulation. 2021;144:e283–e284

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Response by Allen et al to Letter Regarding Article, “Diagnostic Performance of High-Sensitivity Cardiac Troponin T Strategies and Clinical Variables in a Multisite US Cohort”

Brandon R. Allen, Robert H. Christenson, Scott A. Cohen, Michael T. Weaver, Kai Yang, and Simon A. Mahler

doi : 10.1161/CIRCULATIONAHA.121.056533

Circulation. 2021;144:e285–e286

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Diagnosis and Management of Patients With Myocardial Injury After Noncardiac Surgery: A Scientific Statement From the American Heart Association

Kurt Ruetzler, Nathaniel R. Smilowitz, Jeffrey S. Berger, P.J. Devereaux, Bradley A. Maron, L. Kristin Newby, Vinicio de Jesus Perez, Daniel I. Sessler, Duminda N. Wijeysundera, on behalf of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Clinical Cardiology; and Council on Cardiovascular Surgery and Anesthesia

doi : 10.1161/CIR.0000000000001024

Circulation. 2021;144:e287–e305

Myocardial injury after noncardiac surgery is defined by elevated postoperative cardiac troponin concentrations that exceed the 99th percentile of the upper reference limit of the assay and are attributable to a presumed ischemic mechanism, with or without concomitant symptoms or signs. Myocardial injury after noncardiac surgery occurs in ?20% of patients who have major inpatient surgery, and most are asymptomatic. Myocardial injury after noncardiac surgery is independently and strongly associated with both short-term and long-term mortality, even in the absence of clinical symptoms, electrocardiographic changes, or imaging evidence of myocardial ischemia consistent with myocardial infarction. Consequently, surveillance of myocardial injury after noncardiac surgery is warranted in patients at high risk for perioperative cardiovascular complications. This scientific statement provides diagnostic criteria and reviews the epidemiology, pathophysiology, and prognosis of myocardial injury after noncardiac surgery. This scientific statement also presents surveillance strategies and treatment approaches.

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Correction to: Combined Associations of Changes in Noncombustible Nicotine or Tobacco Product and Combustible Cigarette Use Habits With Subsequent Short-Term Cardiovascular Disease Risk Among South Korean Men: A Nationwide Cohort Study

doi : 10.1161/CIR.0000000000001034

Circulation. 2021;144:e306

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