Epigenetic Age and the Risk of Incident Atrial Fibrillation

Jason D. Roberts, Eric Vittinghoff, Ake T. Lu, Alvaro Alonso, Biqi Wang, Colleen M. Sitlani, Pedrum Mohammadi-Shemirani, Myriam Fornage, Jelena Kornej, Jennifer A. Brody, Dan E. Arking, Honghuang Lin, Susan R. Heckbert, Ivana Prokic, Mohsen Ghanbari, Allan C. Skanes, Traci M. Bartz, Marco V. Perez, Kent D. Taylor, Steven A. Lubitz, Patrick T. Ellinor, Kathryn L. Lunetta, James S. Pankow, Guillaume Paré, Nona Sotoodehnia, Emelia J. Benjamin, Steve Horvath, and Gregory M. Marcus

doi : 10.1161/CIRCULATIONAHA.121.056456

Circulation. 2021;144:1899–1911

The most prominent risk factor for atrial fibrillation (AF) is chronological age; however, underlying mechanisms are unexplained. Algorithms using epigenetic modifications to the human genome effectively predict chronological age. Chronological and epigenetic predicted ages may diverge in a phenomenon referred to as epigenetic age acceleration (EAA), which may reflect accelerated biological aging. We sought to evaluate for associations between epigenetic age measures and incident AF.

خرید پکیج و مشاهده آنلاین مقاله

Accelerated Epigenetic Aging and Incident Atrial Fibrillation: New Outlook on an Immutable Risk Factor?

Cavin K. Ward-Caviness

doi : 10.1161/CIRCULATIONAHA.121.057533

Circulation. 2021;144:1912–1914

خرید پکیج و مشاهده آنلاین مقاله

Inequalities in Income and Education Are Associated With Survival Differences After Out-of-Hospital Cardiac Arrest: Nationwide Observational Study

Martin Jonsson, Juho Härkönen, Petter Ljungman, Per Nordberg, Mattias Ringh, Geir Hirlekar, Araz Rawshani, Johan Herlitz, Rickard Ljung, and Jacob Hollenberg

doi : 10.1161/CIRCULATIONAHA.121.056012

Circulation. 2021;144:1915–1925

Despite the acknowledged importance of socioeconomic factors as regards cardiovascular disease onset and survival, the relationship between individual-level socioeconomic factors and survival after out-of-hospital cardiac arrest is not established. Our aim was to investigate whether socioeconomic variables are associated with 30-day survival after out-of-hospital cardiac arrest.

خرید پکیج و مشاهده آنلاین مقاله

CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases

Nikolaus Berndt, Johannes Eckstein, Iwona Wallach, Sarah Nordmeyer, Marcus Kelm, Marieluise Kirchner, Leonid Goubergrits, Marie Schafstedde, Anja Hennemuth, Milena Kraus, Tilman Grune, Philipp Mertins, Titus Kuehne, and Hermann-Georg Holzhütter

doi : 10.1161/CIRCULATIONAHA.121.055646

Circulation. 2021;144:1926–1939

Many heart diseases can result in reduced pumping capacity of the heart muscle. A mismatch between ATP demand and ATP production of cardiomyocytes is one of the possible causes. Assessment of the relation between myocardial ATP production (MVATP) and cardiac workload is important for better understanding disease development and choice of nutritional or pharmacologic treatment strategies. Because there is no method for measuring MVATP in vivo, the use of physiology-based metabolic models in conjunction with protein abundance data is an attractive approach.

خرید پکیج و مشاهده آنلاین مقاله

Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency

Huijuan Dou, Andriana Kotini, Wenli Liu, Trevor Fidler, Kaori Endo-Umeda, Xiaoli Sun, Malgorzata Olszewska, Tong Xiao, Sandra Abramowicz, Mustafa Yalcinkaya, Brian Hardaway, Sotirios Tsimikas, Xuchu Que, Alexander Bick, Conor Emdin, Pradeep Natarajan, Eirini P. Papapetrou, Joseph L. Witztum, Nan Wang, and Alan R. Tall

doi : 10.1161/CIRCULATIONAHA.121.056414

Circulation. 2021;144:1940–1954

LNK/SH2B3 inhibits Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling by hematopoietic cytokine receptors. Genome-wide association studies have shown association of a common single nucleotide polymorphism in LNK (R262W, T allele) with neutrophilia, thrombocytosis, and coronary artery disease. We have shown that LNK(TT) reduces LNK function and that LNK-deficient mice display prominent platelet–neutrophil aggregates, accelerated atherosclerosis, and thrombosis. Platelet–neutrophil interactions can promote neutrophil extracellular trap (NET) formation. The goals of this study were to assess the role of NETs in atherosclerosis and thrombosis in mice with hematopoietic Lnk deficiency.

خرید پکیج و مشاهده آنلاین مقاله

Exercise-Induced Cardiac Troponin Elevations: From Underlying Mechanisms to Clinical Relevance

Vincent L. Aengevaeren, Aaron L. Baggish, Eugene H. Chung, Keith George, Øyunn Kleiven, Alma M.A. Mingels, Stein Ørn, Rob E. Shave, Paul D. Thompson, and Thijs M.H. Eijsvogels

doi : 10.1161/CIRCULATIONAHA.121.056208

Circulation. 2021;144:1955–1972

Serological assessment of cardiac troponins (cTn) is the gold standard to assess myocardial injury in clinical practice. A greater magnitude of acutely or chronically elevated cTn concentrations is associated with lower event-free survival in patients and the general population. Exercise training is known to improve cardiovascular function and promote longevity, but exercise can produce an acute rise in cTn concentrations, which may exceed the upper reference limit in a substantial number of individuals. Whether exercise-induced cTn elevations are attributable to a physiological or pathological response and if they are clinically relevant has been debated for decades. Thus far, exercise-induced cTn elevations have been viewed as the only benign form of cTn elevations. However, recent studies report intriguing findings that shed new light on the underlying mechanisms and clinical relevance of exercise-induced cTn elevations. We will review the biochemical characteristics of cTn assays, key factors determining the magnitude of postexercise cTn concentrations, the release kinetics, underlying mechanisms causing and contributing to exercise-induced cTn release, and the clinical relevance of exercise-induced cTn elevations. We will also explain the association with cardiac function, correlates with (subclinical) cardiovascular diseases and exercise-induced cTn elevations predictive value for future cardiovascular events. Last, we will provide recommendations for interpretation of these findings and provide direction for future research in this field.

خرید پکیج و مشاهده آنلاین مقاله

Nano-miR-133a Replacement Therapy Blunts Pressure Overload–Induced Heart Failure

Jessica Modica, Vittoria Di Mauro, Maria Barandalla-Sobrados, Samuel Elias Pineda Chavez, Pierluigi Carullo, Simona Nemska, Achille Anselmo, Gianluigi Condorelli, Michele Iafisco, Michele Miragoli, and Daniele Catalucci

doi : 10.1161/CIRCULATIONAHA.121.055866

Circulation. 2021;144:1973–1976

خرید پکیج و مشاهده آنلاین مقاله

Letter by Zheng et al Regarding Article, “Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials”

Feng Zheng, Niklas von Spreckelsen, and Weipeng Hu

doi : 10.1161/CIRCULATIONAHA.121.056054

Circulation. 2021;144:e491–e492

خرید پکیج و مشاهده آنلاین مقاله

Response by Trifan et al to Letter Regarding Article, “Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials”

Gabriela Trifan, Philip B. Gorelick, and Fernando D. Testai

doi : 10.1161/CIRCULATIONAHA.121.057471

Circulation. 2021;144:e493–e494

خرید پکیج و مشاهده آنلاین مقاله

Strategies for Promotion of a Healthy Lifestyle in Clinical Settings: Pillars of Ideal Cardiovascular Health: A Science Advisory From the American Heart Association

Penny M. Kris-Etherton, Kristina S. Petersen, Jean-Pierre Després, Cheryl A.M. Anderson, Prakash Deedwania, Karen L. Furie, Scott Lear, Alice H. Lichtenstein, Felipe Lobelo, Pamela B. Morris, Frank M. Sacks, Jun Ma, on behalf of the American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; Stroke Council; Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Hypertension

doi : 10.1161/CIR.0000000000001018

Circulation. 2021;144:e495–e514

Engagement in healthy lifestyle behaviors is suboptimal. The vast majority of the US population does not meet current recommendations. A healthy lifestyle is defined by consuming a healthy dietary pattern, engaging in regular physical activity, avoiding exposure to tobacco products, habitually attaining adequate amounts of sleep, and managing stress levels. For all these health behaviors there are well-established guidelines; however, promotion in clinical settings can be challenging. It is critical to overcome these challenges because greater promotion of heathy lifestyle practices in clinical settings effectively motivates and initiates patient behavior change. The 5A Model (assess, advise, agree, assist, and arrange) was developed to provide a framework for clinical counseling with requisite attention to the demands of clinical settings. In this science advisory, we present strategies, based on the 5A Model, that clinicians and other health care professionals can use for efficient lifestyle-related behavior change counseling in patients at all levels of cardiovascular disease risk at every visit. In addition, we discuss the underlying role of psychological health and well-being in lifestyle-related behavior change counseling, and how clinicians can leverage health technologies when providing brief patient-centered counseling. Greater attention to healthy lifestyle behaviors during routine clinician visits will contribute to promoting cardiovascular health.

خرید پکیج و مشاهده آنلاین مقاله

Special Considerations for Healthy Lifestyle Promotion Across the Life Span in Clinical Settings: A Science Advisory From the American Heart Association

Penny M. Kris-Etherton, Kristina S. Petersen, Jean-Pierre Després, Lynne Braun, Sarah D. de Ferranti, Karen L. Furie, Scott A. Lear, Felipe Lobelo, Pamela B. Morris, Frank M. Sacks, … See all authors

doi : 10.1161/CIR.0000000000001014

Circulation. 2021;144:e515–e532

At a population level, engagement in healthy lifestyle behaviors is suboptimal in the United States. Moreover, marked disparities exist in healthy lifestyle behaviors and cardiovascular risk factors as a result of social determinants of health. In addition, there are specific challenges to engaging in healthy lifestyle behaviors related to age, developmental stage, or major life circumstances. Key components of a healthy lifestyle are consuming a healthy dietary pattern, engaging in regular physical activity, avoiding use of tobacco products, habitually attaining adequate sleep, and managing stress. For these health behaviors, there are guidelines and recommendations; however, promotion in clinical settings can be challenging, particularly in certain population groups. These challenges must be overcome to facilitate greater promotion of healthy lifestyle practices in clinical settings. The 5A Model (assess, advise, agree, assist, and arrange) was developed to provide a framework for clinical counseling with consideration for the demands of clinical settings. In this science advisory, we summarize specific considerations for lifestyle-related behavior change counseling using the 5A Model for patients across the life span. In all life stages, social determinants of health and unmet social-related health needs, as well as overweight and obesity, are associated with increased risk of cardiovascular disease, and there is the potential to modify this risk with lifestyle-related behavior changes. In addition, specific considerations for lifestyle-related behavior change counseling in life stages in which lifestyle behaviors significantly affect cardiovascular disease risk are outlined. Greater attention to healthy lifestyle behaviors during every clinician visit will contribute to improved cardiovascular health.

خرید پکیج و مشاهده آنلاین مقاله

Health Behavior Change Programs in Primary Care and Community Practices for Cardiovascular Disease Prevention and Risk Factor Management Among Midlife and Older Adults: A Scientific Statement From the American Heart Association

Deepika Laddu, Jun Ma, Jill Kaar, Cemal Ozemek, Raegan W. Durant, Tavis Campbell, Jean Welsh, Stephanie Turrise, on behalf of the American Heart Association Behavioral Change for Improving Health Factors Committee of the Council on Epidemiology and Prevention and the Council on Lifestyle and Cardiometabolic Health; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Hypertension; and Stroke Council

doi : 10.1161/CIR.0000000000001026

Circulation. 2021;144:e533–e549

Cardiovascular disease predominates as the leading health burden among middle-aged and older American adults, but progress in improving cardiovascular health remains slow. Comprehensive, evidenced-based behavioral counseling interventions in primary care are a recommended first-line approach for promoting healthy behaviors and preventing poor cardiovascular disease outcomes in adults with cardiovascular risk factors. Assisting patients to adopt and achieve their health promotion goals and arranging follow-up support are critical tenets of the 5A Model for behavior counseling in primary care. These 2 steps in behavior counseling are considered essential to effectively promote meaningful and lasting behavior change for primary cardiovascular disease prevention. However, adoption and implementation of behavioral counseling interventions in clinical settings can be challenging. The purpose of this scientific statement from the American Heart Association is to guide primary health care professional efforts to offer or refer patients for behavioral counseling, beyond what can be done during brief and infrequent office visits. This scientific statement presents evidence of effective behavioral intervention programs that are feasible for adoption in primary care settings for cardiovascular disease prevention and risk management in middle-aged and older adults. Furthermore, examples are provided of resources available to facilitate the widespread adoption and implementation of behavioral intervention programs in primary care or community-based settings and practical approaches to appropriately engage and refer patients to these programs. In addition, current national models that influence translation of evidence-based behavioral counseling in primary care and community settings are described. Finally, this scientific statement highlights opportunities to enhance the delivery of equitable and preventive care that prioritizes effective behavioral counseling of patients with varying levels of cardiovascular disease risk.

خرید پکیج و مشاهده آنلاین مقاله

Correction to: Heating Tobacco Sticks Instead of Combusting Conventional Cigarettes and Future Heart Attacks: Still Smoke, and Risk

doi : 10.1161/CIR.0000000000001049

Circulation. 2021;144:e550

خرید پکیج و مشاهده آنلاین مقاله