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Remembering Dennis Ahnen
Robert S. Bresalier
doi : 10.1007/s10620-021-07285-8
Digestive Diseases and Sciences volume 66, page4069 (2021)
Frailty, Thy Diagnosis Is Uncertain: Impact on IBD Readmission and Mortality
Simon J. Hong & Seymour Katz
doi : 10.1007/s10620-021-06926-2
Digestive Diseases and Sciences volume 66, pages4070–4071 (2021)
Palliative Care for Patients with End-Stage Liver Disease on the Liver Transplant Waiting List: An International Systematic Review
Shan Shan Vijeratnam, Bridget Candy, Rachel Craig, Aileen Marshall, Patrick Stone & Joseph T. S. Low
doi : 10.1007/s10620-020-06779-1
Digestive Diseases and Sciences volume 66, pages4072–4089 (2021)
People with end-stage liver disease on the liver transplant waiting list have high symptom burden, which can successfully be addressed by specialist palliative care. Potential tensions with the perceived curative nature of liver transplant make delivering specialist palliative care challenging. This systematic review seeks to establish what is known on the impact of specialist palliative care for patients on liver transplant waiting lists, healthcare professionals’ perspectives of providing specialist palliative care for this population, and uptake of advance care planning (ACP). Medline, Embase, and CINAHL were searched to May 5, 2020. Qualitative and quantitative findings were grouped together according to main relevant themes. Eight studies of mixed quality and mainly quantitative, were identified. Findings suggest early palliative care intervention improve patients’ symptoms and prompt ACP conversations, but patients on the waiting list receive limited palliative care input. Liver physicians’ lack of clarity on referral criteria and liver transplant patients’ concerns of being abandoned, were reasons for reluctance to refer to specialist palliative care. They felt referral to specialist palliative care is appropriate only for patients receiving hospice or end of life care. Uptake and understanding of ACP and goals of care designation by patients is poor. This review found evidence of benefit of specialist palliative care for patients on liver transplant waiting lists, but found in a limited understanding of their role. Evidence is limited to studies from North America. Future research is needed to understand better how palliative care could be provided into this clinical environment.
Liver Biopsy in Pregnancy: Two Case Reports and Review of the Literature
Kemmian D. Johnson, Abhilash Perisetti, Hemant Goyal, Ragesh Thandassery, Mahesh Gajendran, Mohammad Aziz, Benjamin Tharian & Sumant Inamdar
doi : 10.1007/s10620-020-06786-2
Digestive Diseases and Sciences volume 66, pages4090–4098 (2021)
The etiology of most cases of liver diseases in pregnancy can be diagnosed with a thorough history, physical examination, laboratory values, serology, and noninvasive imaging. However, atypical clinical and laboratory presentations of liver diseases/chemistries require a liver biopsy to render an accurate diagnosis in cases where the biopsy results affect the timing of delivery or impact choice of medical therapy. According to the American College of Gastroenterology, liver biopsy can be effectively and safely conducted in pregnant women. Conventional routes of performing a liver biopsy include the percutaneous, transjugular route, and surgical methods. Endoscopic ultrasound-guided liver biopsy is a recent technique that has not yet gained widespread adoption but can potentially serve as an alternative route for obtaining the liver sample. Adverse events associated with liver biopsy include abdominal pain and hemorrhage. Maternal and fetal outcomes are limited to increased risk of preterm birth and small for gestational age neonate. However, very few studies have formally evaluated the safety of liver biopsy in pregnant women. In this review, we present two successful cases of liver biopsy performed during pregnancy and summarize the most recent evidence regarding the safety and outcomes of the procedure in pregnancy to assist clinicians in their decision to perform a liver biopsy during pregnancy or postpone it until after delivery.
Eosinophilic Esophagitis and IgG4: Is There a Relationship?
Amanda H. Lim, Stephanie Wong & Nam Q. Nguyen
doi : 10.1007/s10620-020-06788-0
Digestive Diseases and Sciences volume 66, pages4099–4108 (2021)
Our knowledge of the pathophysiology of eosinophilic esophagitis is constantly evolving. There is significant association between eosinophilic esophagitis and atopy; however, multiple studies have refuted the role of IgE in its pathogenesis. Instead, new data have demonstrated an elevated IgG4 level in patients with eosinophilic esophagitis. We review the current understanding of eosinophilic esophagitis pathogenesis and highlight the increasing evidence for the role of IgG4.
Prevalence and Impact of Post-traumatic Stress Disorder in Gastrointestinal Conditions: A Systematic Review
Heidi Glynn, Stephan P. Möller, Helen Wilding, Pragalathan Apputhurai, Gregory Moore & Simon R. Knowles
doi : 10.1007/s10620-020-06798-y
Digestive Diseases and Sciences volume 66, pages4109–4119 (2021)
Psychological distress is often observed in patients with gastrointestinal illness. To date, there has been limited research conducted to assess the prevalence and impact of post-traumatic stress disorder (PTSD) in gastrointestinal cohorts. The aim of this systematic review is to review the evidence for the prevalence of PTSD in gastrointestinal cohorts versus comparator groups (healthy controls and chronic illness groups), predictive factors associated with the development and management of PTSD and the impact on patient outcomes. Adult studies were identified through systematic searches of eight databases (MEDLINE, Embase, Emcare, PsycINFO, Ovid Nursing, CINAHL, Informit Health Collection, and Cochrane Library) in February 2020. The overall pooled prevalence rate of PTSD in GI cohorts was 36%; however, the prevalence rate in non-veteran-specific gastrointestinal cohorts of 18% across all GI classification groups is likely to be the more representative rate. The non-gastrointestinal chronic illness cohort PTSD prevalence rate was 11%. Predictors identified in the development of post-traumatic stress in gastrointestinal cohorts include: female gender, poor social support, life adversity, subjective pain, and dietary choices. Post-traumatic stress was found to exacerbate gastrointestinal symptoms in a Crohn’s Disease sample, whereby disease exacerbation was four times in those who met the criteria for probable PTSD. Post-traumatic stress symptoms affect around one in five individuals (non-veteran status) with a gastrointestinal condition. Further research is needed to understand the psychological and biological mechanisms by which PTSD increases the risk of developing and exacerbating gastrointestinal symptoms.
Use of Pharmacogenomics to Guide Proton Pump Inhibitor Therapy in Clinical Practice
Dana M. Harris, Fernando F. Stancampiano, M. Caroline Burton, Ann M. Moyer, Michael J. Schuh, Jose R. Valery & Yan Bi
doi : 10.1007/s10620-020-06814-1
Digestive Diseases and Sciences volume 66, pages4120–4127 (2021)
Prescribing the right medication, at the right dose, to the right patient is the goal of every physician. Pharmacogenomic information is an emerging tool that can be used to deliver precision medicine. In this review, we discuss the pharmacogenomics of available PPIs, racial differences of CYP2C19 and how PPI pharmacogenomics affects the treatment of common gastrointestinal diseases. We also provide practical guidance on when to order pharmacogenomic testing, which test to order, and how to modify treatment based on published guidelines.
Antibiotic Therapy of 3 Days May Be Sufficient After Biliary Drainage for Acute Cholangitis: A Systematic Review
Sylke Haal, Mattheus C. B. Wielenga, Paul Fockens, Charlotte A. Leseman, Cyriel Y. Ponsioen, Ellert J. van Soest, Roy L. J. van Wanrooij, Elske Sieswerda & Rogier P. Voermans
doi : 10.1007/s10620-020-06820-3
Digestive Diseases and Sciences volume 66, pages4128–4139 (2021)
The optimal antibiotic therapy duration for cholangitis is unclear. Guideline recommendations vary between 4 and 14 days after biliary drainage. Clinical observations and some evidence however suggest that shorter antibiotic therapy may be sufficient.
Price Is Right: Exploring Prescription Drug Coverage Barriers for Irritable Bowel Syndrome Using Threshold Pricing Analysis
Eric D. Shah, Lin Chang, Anthony Lembo, Kyle Staller, Michael A. Curley & William D. Chey
doi : 10.1007/s10620-020-06806-1
Digestive Diseases and Sciences volume 66, pages4140–4148 (2021)
Prescription drug costs exert profound effects on commercial insurance coverage and access to effective therapy.
Rehospitalization, Treatment, and Resource Use After Inpatient Admission for Achalasia in the USA
Kamesh Gupta, Ahmad Khan, Jean Chalhoub, Kevin Groudan & David Desilets
doi : 10.1007/s10620-020-06775-5
Digestive Diseases and Sciences volume 66, pages4149–4158 (2021)
Readmission for achalasia treatment is associated with significant morbidity and cost. Factors predictive of readmission would be useful in identifying patients at risk.
Utility of Endoscopy in Hospitalized Patients with Gastrointestinal Hemorrhage and Pulmonary Hypertension
Amandeep Singh, Mohamed Tausif Siddiqui, Wael Al-Yaman, Rajat Garg, Sanguk Jang, Prabhleen Chahal & John Vargo
doi : 10.1007/s10620-020-06803-4
Digestive Diseases and Sciences volume 66, pages4159–4168 (2021)
Gastrointestinal hemorrhage (GIH) has been reported as one of the most common GI complications in patients with pulmonary hypertension (PH). There is paucity of data on the national burden of GIH in patients with PH. We aimed to assess the prevalence, trends and outcomes of endoscopic interventions in patients with PH who were admitted with GIH.
Inflammatory Bowel Disease Does Not Impact Mortality but Increases Length of Hospitalization in Patients with Acute Myocardial Infarction
Preetika Sinh, James H. Tabibian, Prachi S. Biyani, Kathan Mehta, Emad Mansoor, Edward V. Loftus Jr. & Maneesh Dave
doi : 10.1007/s10620-020-06818-x
Digestive Diseases and Sciences volume 66, pages4169–4177 (2021)
Inflammatory bowel diseases (IBD) have been associated with increased risk of cardiovascular events. We aimed to investigate the outcomes of myocardial infarction (MI) in patients with IBD.
Increasing Prevalence of Frailty and Its Association with Readmission and Mortality Among Hospitalized Patients with IBD
Adam S. Faye, Timothy Wen, Ali Soroush, Ashwin N. Ananthakrishnan, Ryan Ungaro, Garrett Lawlor, Frank J. Attenello, William J. Mack, Jean-Frederic Colombel & Benjamin Lebwohl
doi : 10.1007/s10620-020-06746-w
Digestive Diseases and Sciences volume 66, pages4178–4190 (2021)
Although age is often used as a clinical risk stratification tool, recent data have suggested that adverse outcomes are driven by frailty rather than chronological age.
Treatment Adherence and Clinical Outcomes of Patients with Inflammatory Bowel Disease on Biological Agents During the SARS-CoV-2 Pandemic
Ignacio Iborra, Maria Puig, Laura Marín, Margalida Calafat, Fiorella Cañete, Carles Quiñones, Laura González-González, Glòria Cardona, Míriam Mañosa & Eugeni Domènech
doi : 10.1007/s10620-020-06807-0
Digestive Diseases and Sciences volume 66, pages4191–4196 (2021)
The outbreak of COVID19 evolved rapidly into a global pandemic, forcing hospitals, including inflammatory bowel disease (IBD) referral units, to change their practices to ensure quality of care.
Perception of Illness and Its Association with Treatment Willingness in Patients with Newly Diagnosed Nonalcoholic Fatty Liver Disease
Harpal S. Dhaliwal, Ripudaman Singh, Abin M. Abraham, Rajan Sharma, N. K. Goyal, Rajat Soloman, Pankaj Bansal & Amandeep Goyal
doi : 10.1007/s10620-020-06794-2
Digestive Diseases and Sciences volume 66, pages4197–4207 (2021)
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease of immense public health relevance. Understanding illness perceptions in the NAFLD population will provide sound scientific evidence for planning high-quality patient-centered care and implementing effective interventions. The Brief Illness Perception Questionnaire (BIPQ) is a robust psychometric tool to systematically assess the dimensions of illness perceptions in various chronic ailments.
Colorectal Cancer Screening Guidelines Are Primarily Based on Low–Moderate-Quality Evidence
Simcha Weissman, Alexander Goldowsky, Muhammad Aziz, Tej I. Mehta, Sachit Sharma, Megan Lipcsey, Trent Walradt, Umair Iqbal, Sameh Elias & Joseph D. Feuerstein
doi : 10.1007/s10620-020-06755-9
Digestive Diseases and Sciences volume 66, pages4208–4219 (2021)
Owning to colorectal cancer’s (CRC) high mortality, multiple societies developed screening guidelines.
Endoscopy Is Cost-Effective for Gastric Cancer Screening After Successful Helicobacter pylori Eradication
Akiko Kowada
doi : 10.1007/s10620-020-06813-2
Digestive Diseases and Sciences volume 66, pages4220–4226 (2021)
After successful Helicobacter pylori eradication, patients with gastric mucosal atrophy are at high risk of gastric cancer. Endoscopy can detect early gastric cancer with high sensitivity.
Thirty-Day Readmission Among Patients with Alcoholic Acute Pancreatitis
Pedro Palacios Argueta, Miguel Salazar, Ishaan Vohra, Juan E. Corral, Frank J. Lukens, John J. Vargo, Prabhleen Chahal & C. Roberto Simons-Linares
doi : 10.1007/s10620-020-06765-7
Digestive Diseases and Sciences volume 66, pages4227–4236 (2021)
Alcoholic acute pancreatitis (AAP) comprises the second most common cause of acute pancreatitis in the USA, and there is lack of data regarding 30-day specific readmission causes and predictors. We aim to identify 30-day readmission rate, causes, and predictors of readmission.
DRG1 Maintains Intestinal Epithelial Cell Junctions and Barrier Function by Regulating RAC1 Activity in Necrotizing Enterocolitis
Li Lu, Weijue Xu, Jiangbin Liu, Liping Chen, Shaohua Hu, Qingfeng Sheng, Minghua Zhang & Zhibao Lv
doi : 10.1007/s10620-020-06812-3
Digestive Diseases and Sciences volume 66, pages4237–4250 (2021)
An immature intestine is a high-risk factor for necrotizing enterocolitis (NEC), which is a serious intestinal disease in newborns. The regulation of developmentally regulated GTP-binding protein 1 (DRG1) during organ development suggests a potential role of DRG1 in the maturation process of the intestine.
7,8-Dihydroxyflavone Enhanced Colonic Cholinergic Contraction and Relieved Loperamide-Induced Constipation in Rats
Li Ma, Zhiqiang Qu, Luo Xu, Lei Han, Qingfang Han, Juan He, Xiao Luan, Bingxiang Wang, Yongye Sun & Baoguo He
doi : 10.1007/s10620-020-06817-y
Digestive Diseases and Sciences volume 66, pages4251–4262 (2021)
Whether 7,8-dihydroxyflavone (7,8-DHF), a tyrosine kinase receptor B (TrkB) agonist, modulates colonic smooth muscle motility and/or alleviates constipation has not yet been studied.
P63 Deficiency and CDX2 Overexpression Lead to Barrett’s-Like Metaplasia in Mouse Esophageal Epithelium
Yu Fang, Wenbo Li & Xiaoxin Chen
doi : 10.1007/s10620-020-06756-8
Digestive Diseases and Sciences volume 66, pages4263–4273 (2021)
The cellular origin and molecular mechanisms of Barrett’s esophagus (BE) are still controversial. Trans-differentiation is a mechanism characterized by activation of the intestinal differentiation program and inactivation of the squamous differentiation program.
Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric Cancer via miR-409-3p/MAP7 Axis
Li Yu, Jie Xie, Xiaoming Liu, Yan Yu & Siping Wang
doi : 10.1007/s10620-020-06816-z
Digestive Diseases and Sciences volume 66, pages4274–4289 (2021)
Exosome-mediated transfer of circular RNAs (circRNAs) is related to gastric cancer (GC) development. CircRNA NIMA-related kinase 9 (circNEK9; hsa_circ_0032683) was reported to be up-regulated in GC.
Circ_0004104 Accelerates the Progression of Gastric Cancer by Regulating the miR-539-3p/RNF2 Axis
Furong Yue, Keyu Peng, Li Zhang & Jun Zhang
doi : 10.1007/s10620-020-06802-5
Digestive Diseases and Sciences volume 66, pages4290–4301 (2021)
Circular RNA (circRNA) has been shown to be closely associated with cancer progression, including gastric cancer (GC). However, the function of circ_0004104 in GC progression has not been clarified.
Circ_PGPEP1 Serves as a Sponge of miR-1297 to Promote Gastric Cancer Progression via Regulating E2F3
Yingxin Wang, Xia Liu, Liwei Wang, Zhenduo Zhang, Zhong Li & Ming Li
doi : 10.1007/s10620-020-06783-5
Digestive Diseases and Sciences volume 66, pages4302–4313 (2021)
Circular RNA (circRNA) is a special kind of noncoding RNA that plays a vital function in the progression of gastric cancer (GC). However, the role of a new circRNA, circ_PGPEP1, in GC is unclear.
HIF1A-AS2 Promotes the Proliferation and Metastasis of Gastric Cancer Cells Through miR-429/PD-L1 Axis
Linsong Mu, Yeli Wang, Hailong Su, Yang Lin, Wu Sui, Xiang Yu & Zhongchuan Lv
doi : 10.1007/s10620-020-06819-w
Digestive Diseases and Sciences volume 66, pages4314–4325 (2021)
Gastric cancer (GC) is a common leading cause of cancer-related mortality of all malignancies. LncRNA hypoxia-inducible factor-1 alpha antisense RNA-2 (HIF1A-AS2) has been identified to involve in the development of GC. Therefore, we further explored the detailed molecular mechanism of HIF1A-AS2 in GC progression.
Curcumin Chemoprevention Reduces the Incidence of Braf Mutant Colorectal Cancer in a Preclinical Study
Alexandra M. Kane, Cheng Liu, Dewan T. Akhter, Diane M. McKeone, Craig A. Bell, Kristofer J. Thurecht, Barbara A. Leggett & Vicki L. J. Whitehall
doi : 10.1007/s10620-020-06752-y
Digestive Diseases and Sciences volume 66, pages4326–4332 (2021)
Colorectal cancer is a leading cause of cancer-related death worldwide and approximately 20% of cases can be attributed to a mutation in the BRAF oncogene. Curcumin is a promising chemopreventive agent with various anti-cancer benefits. Although curcumin has been reported to have poor bioavailability, this limitation has been overcome by the formulation of nano-carriers. In this preclinical study, we investigated the ability of an improved formulation of curcumin to reduce the incidence of Braf mutant carcinoma.
Protective Effect of miR-193a-5p and miR-320-5p on Caerulein-Induced Injury in AR42J Cells
Wenchao Yu, Min Zhang, Xin Li, Ning Pan, Xia Bian & Wei Wu
doi : 10.1007/s10620-020-06800-7
Digestive Diseases and Sciences volume 66, pages4333–4343 (2021)
Acute pancreatitis is a common inflammatory disease. MicroRNAs have been implicated in the pathogenesis of acute pancreatitis.
Mesenteric Lymph Duct Ligation Alleviates Acute Lung Injury Caused by Severe Acute Pancreatitis Through Inhibition of High Mobility Group Box 1-Induced Inflammation in Rats
Yishuang Tang, Jing Kong, Bingduo Zhou, Xiaosu Wang, Xiaowen Liu, Yi Wang & Shengliang Zhu
doi : 10.1007/s10620-020-06801-6
Digestive Diseases and Sciences volume 66, pages4344–4353 (2021)
Acute lung injury (ALI) is the most common complication and one of the leading causes of mortality of severe acute pancreatitis (SAP). Nevertheless, no effective therapeutic schemes are presently available.
Hepatic Vein Contrast-Enhanced Ultrasound Subharmonic Imaging Signal as a Screening Test for Portal Hypertension
Priscilla Machado, Ipshita Gupta, Sriharsha Gummadi, Maria Stanczak, Corinne E. Wessner, Jonathan M. Fenkel, Colette M. Shaw, Susan Shamini-Noori, Susan Schultz, Michael C. Soulen, Chandra M. Sehgal, Kirk Wallace, John R. Eisenbrey & Flemming Forsberg
doi : 10.1007/s10620-020-06790-6
Digestive Diseases and Sciences volume 66, pages4354–4360 (2021)
Portal hypertension is the underlying cause of most complications associated with cirrhosis, with the hepatic venous pressure gradient (HVPG) used for diagnosis and disease progression. Subharmonic imaging (SHI) is a contrast-specific imaging technique receiving at half the transmit frequency resulting in better tissue suppression.
Circular RNA circZFR Promotes Hepatocellular Carcinoma Progression by Regulating miR-375/HMGA2 Axis
Rui Xu, Shiwu Yin, Meng Zheng, Xiaohong Pei & Xuebing Ji
doi : 10.1007/s10620-020-06805-2
Digestive Diseases and Sciences volume 66, pages4361–4373 (2021)
Mounting evidence indicates that circular RNAs (circRNAs) have vital roles in human diseases, especially in cancers.
CircZKSCAN1 Suppresses Hepatocellular Carcinoma Tumorigenesis by Regulating miR-873-5p/Downregulation of Deleted in Liver Cancer 1
Jing Li, Siyang Bao, Linqi Wang & Ronglong Wang
doi : 10.1007/s10620-020-06789-z
Digestive Diseases and Sciences volume 66, pages4374–4383 (2021)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality worldwide. CircZKSCAN1 (hsa_circ_0001727) was reported to be related to HCC development. The present study aims to elucidate the potential role and molecular mechanism of circZKSCAN1 in the regulation of HCC progression.
Lidocaine Inhibits Hepatocellular Carcinoma Development by Modulating circ_ITCH/miR-421/CPEB3 Axis
LiLi Zhao, Ning Ma, Gaihong Liu, Ni Mao, Fei Chen & Jiao Li
doi : 10.1007/s10620-020-06787-1
Digestive Diseases and Sciences volume 66, pages4384–4397 (2021)
Lidocaine plays an anticancer role in hepatocellular carcinoma. Nevertheless, the mechanism of lidocaine in hepatocellular carcinoma remains largely unclear.
Prevalence of Clostridioides difficile and Other Gastrointestinal Pathogens in Patients with COVID-19
Monika Laszkowska, Judith Kim, Adam S. Faye, Andrew M. Joelson, Myles Ingram, Han Truong, Elisabeth R. Silver, Benjamin May, William G. Greendyke, Jason Zucker, Benjamin Lebwohl, Chin Hur & Daniel E. Freedberg
doi : 10.1007/s10620-020-06760-y
Digestive Diseases and Sciences volume 66, pages4398–4405 (2021)
Gastrointestinal symptoms are common in patients with COVID-19, but prevalence of co-infection with enteric pathogens is unknown.
Regional Gastrointestinal Transit and Contractility Patterns Vary in Postural Orthostatic Tachycardia Syndrome (POTS)
Wendy Zhou, Thomas A. Zikos, John O. Clarke, Linda A. Nguyen, George Triadafilopoulos & Leila Neshatian
doi : 10.1007/s10620-020-06808-z
Digestive Diseases and Sciences volume 66, pages4406–4413 (2021)
Postural orthostatic tachycardia syndrome (POTS) is an autonomic disorder that affects multiple organs, including the gastrointestinal system. These patients often have multiple GI complaints with a severe impact on their quality of life. GI dysmotility patterns in POTS remains poorly understood and difficult to manage.
Long-Term Dietary Changes in Subjects with Glucose Galactose Malabsorption Secondary to Biallelic Mutations of SLC5A1
Alvin P. Chan, Shweta S. Namjoshi, Patricia M. Jardack, Lisa Maloney, Atrin Ardjmand, Nicholas N. Jackson & Martin G. Martin
doi : 10.1007/s10620-020-06792-4
Digestive Diseases and Sciences volume 66, pages4414–4422 (2021)
Glucose galactose malabsorption (GGM) is a congenital diarrheal disorder of intestinal Na+/glucose cotransport (SGLT1/SLC5A1). The required glucose and galactose-restricted diet has been well described in infancy, but long-term nutrition follow-up is limited.
Clinical Course of Terminal Ileal Ulcers Observed Incidentally During Colonoscopy
Jae Hyun Kim, Jong Yoon Lee, Yong Eun Park, Jong Hoon Lee, Jongha Park, Tae Oh Kim, Won Moon, Seun Ja Park & Busan Ulsan Gyeongnam Intestinal Study Group Society (BIGS)
doi : 10.1007/s10620-020-06781-7
Digestive Diseases and Sciences volume 66, pages4423–4428 (2021)
Cecal intubation is essential during colonoscopy, and observation of the terminal ileum is performed in most clinical practices. However, data on terminal ileal (TI) ulcers observed incidentally during colonoscopy are rare.
Low Levels of Fecal Calprotectin 3 Months After Surgery Predict Subsequent Endoscopic Postoperative Remission in Crohn’s Disease
Florian Veyre, Gilles Boschetti, Camille Meunier, Charlotte Cuerq, Claire Gay, Anne-Laure Charlois, Remi Duclaux-Loras, Pauline Danion, Eddy Cotte, Vahan Kepenekian, Anne Mialon, Mathias Faure, Xavier Roblin, Bernard Flourie & Stéphane Nancey
doi : 10.1007/s10620-020-06751-z
Digestive Diseases and Sciences volume 66, pages4429–4435 (2021)
In Crohn’s disease (CD) few data are available on the usefulness of monitoring fecal calprotectin (FC) in the early postoperative setting. We assessed prospectively the accuracy of FC measured 3 months after surgery to predict the risk of endoscopic postoperative recurrence (POR) within 1 year after resection.
A More Severe Non-melanoma Skin Cancer Phenotype Is Seen in Patients with Inflammatory Bowel Disease on Tumor Necrosis Factor-? Antagonists
Cassandra M. Townsend, Reena Khanna & Aze Suzanne Wilson
doi : 10.1007/s10620-020-06773-7
Digestive Diseases and Sciences volume 66, pages4436–4440 (2021)
Limited data suggest that non-melanoma skin cancer (NMSC) risk is higher in patients with inflammatory bowel disease (IBD) particularly in those on a tumor necrosis factor-? antagonist (TNF antagonist). It remains unknown whether TNF antagonist exposure alters the clinical course of NMSC in patients with IBD or if this therapy should be discontinued.
Recurrence of Clostridium Difficile and Cytomegalovirus Infections in Patients with Ulcerative Colitis Who Undergo Ileal Pouch-Anal Anastomosis
Jonathan Pastrana Del Valle, Grace C. Lee, Jose Cataneo Serrato, Joseph D. Feuerstein, Liliana Grigorievna Bordeianou, Richard Hodin, Hiroko Kunitake & Vitaliy Poylin
doi : 10.1007/s10620-020-06772-8
Digestive Diseases and Sciences volume 66, pages4441–4447 (2021)
Patients with ulcerative colitis (UC) are at increased risk for infections such as Clostridium difficile and cytomegalovirus (CMV) colitis due to chronic immunosuppression. These patients often undergo multiple surgeries putting them at risk for recurrence of the infection. However, rates of recurrence in this setting and outcomes are not well understood.
Small-Dose Endoscopic Tattooing Using a Novel Needle for Localization Prior to Laparoscopic Surgery of Colorectal Cancer
Kenichiro Imai, Kinichi Hotta, Sayo Ito, Yuichiro Yamaguchi, Yoshihiro Kishida, Yusuke Yamaoka, Shoichi Manabe, Hitoshi Hino, Hiroyasu Kagawa, Tomohiro Yamaguchi, Akio Shiomi, Yusuke Kinugasa, Keita Mori & Hiroyuki Ono
doi : 10.1007/s10620-020-06757-7
Digestive Diseases and Sciences volume 66, pages4448–4456 (2021)
Endoscopic tattooing failure by deep mural injection or tattoo leakage-induced massive staining causes localization errors or decreased laparoscopic visualization. To overcome these, we developed a novel tattoo needle with comparatively shorter needle (length, 2.5 mm) and minimal-caliber catheter (volume, 0.3 mL).
Increased Use of Prophylactic Measures in Preventing Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Christina J. Sperna Weiland, Megan M. L. Engels, Alexander C. Poen, Abha Bhalla, Niels G. Venneman, Jeanin E. van Hooft, Marco J. Bruno, Robert C. Verdonk, Paul Fockens, Joost P. H. Drenth & Erwin J. M. van Geenen for the Dutch Pancreatitis Study Group
doi : 10.1007/s10620-020-06796-0
Digestive Diseases and Sciences volume 66, pages4457–4466 (2021)
Nonsteroidal anti-inflammatory drugs (NSAIDs), pancreatic duct stenting, and intensive intravenous hydration have been proven to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Trial participation and guideline changes demanded an assessment of the clinical practice of post-ERCP pancreatitis prophylaxis.
Analysis of Risk Factors in Endoscopic Retrograde Cholangiopancreatography-Related Immediate and Delayed Hemorrhage
Xiaoling Ye, Yu Zhang, Xinyue Wan & Tao Deng
doi : 10.1007/s10620-020-06815-0
Digestive Diseases and Sciences volume 66, pages4467–4474 (2021)
Hemorrhage is a serious complication of endoscopic retrograde cholangiopancreatography (ERCP). However, there is a lack of comparative studies on immediate and delayed hemorrhage. The present study aims to explore the relevant risk factors of immediate and delayed hemorrhage of ERCP and compare the similarities and differences.
Nafamostat Mesylate is Not Effective in Preventing Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Takaaki Matsumoto, Kosuke Okuwaki, Hiroshi Imaizumi, Mitsuhiro Kida, Tomohisa Iwai, Hiroshi Yamauchi, Toru Kaneko, Rikiya Hasegawa, Hironori Masutani, Masayoshi Tadehara, Kai Adachi, Masafumi Watanabe, Takahiro Kurosu, Akihiro Tamaki, Hidehiko Kikuchi, Takashi Ohno & Wasaburo Koizumi
doi : 10.1007/s10620-020-06782-6
Digestive Diseases and Sciences volume 66, pages4475–4484 (2021)
Endoscopic retrograde cholangiopancreatography (ERCP) is associated with complications such as post-ERCP pancreatitis (PEP). Protease inhibitors, including nafamostat mesylate (NM), have been evaluated for prophylaxis against PEP.
Necrotizing Pancreatitis from Hypertriglyceridemia: More Severe Disease?
T. K. Maatman, J. A. Westfall-Snyder, E. P. Ceppa, M. G. House, A. Nakeeb, T. K. Nguyen, C. M. Schmidt & N. J. Zyromski
doi : 10.1007/s10620-020-06766-6
Digestive Diseases and Sciences volume 66, pages4485–4491 (2021)
Necrotizing pancreatitis (NP) is caused by hypertriglyceridemia (HTG) in up to 10% of patients. Clinical experience suggests that HTG-NP is associated with increased clinical severity; objective evidence is limited and has not been specifically studied in NP.
Advanced Liver Fibrosis Is Associated with Necroinflammatory Grade but Not Hepatic Steatosis in Chronic Hepatitis B Patients
Yi-Cheng Chen, Chao-Wei Hsu, Wen-Juei Jeng & Chun-Yen Lin
doi : 10.1007/s10620-020-06761-x
Digestive Diseases and Sciences volume 66, pages4492–4500 (2021)
Patients with chronic hepatitis B (CHB) are at an increased risk of disease progression. The influence of hepatic steatosis (HS) to liver fibrosis was controversial. We aim to investigate the association between HS and liver fibrosis and explore the predicting factors for advanced fibrosis.
Hepamet Fibrosis Score in Nonalcoholic Fatty Liver Disease Patients in Mexico: Lower than Expected Positive Predictive Value
Fátima Higuera-de-la-Tijera, Jacqueline Córdova-Gallardo, Elizabeth Buganza-Torio, Beatriz Barranco-Fragoso, Aldo Torre, Sara Parraguirre-Martínez, Martin Edgardo Rojano-Rodríguez, Gabriel Quintero-Bustos, Graciela Castro-Narro & Carlos Moctezuma-Velazquez
doi : 10.1007/s10620-020-06821-2
Digestive Diseases and Sciences volume 66, pages4501–4507 (2021)
Nonalcoholic fatty liver disease (NAFLD) has been associated with different negative outcomes in the presence of advanced fibrosis. The Hepamet Fibrosis Score (HFS), a recently described noninvasive score, has shown excellent performance for the detection of advanced fibrosis. The aim of this study was to assess its performance in a Mexican population with NAFLD.
Comparison of Seven Noninvasive Models for Predicting Decompensation and Hospitalization in Patients with Cirrhosis
Chia-Yang Hsu, Neehar D. Parikh, Teh-Ia Huo & Elliot B. Tapper
doi : 10.1007/s10620-020-06763-9
Digestive Diseases and Sciences volume 66, pages4508–4517 (2021)
Patients with cirrhosis have poor outcomes once decompensation occurs; however, we lack adequate predictors of decompensation. To use a national claim database to compare the predictive accuracy of seven models for decompensation and hospitalization in patients with compensated cirrhosis.
Development and Validation of an Easy-to-Use Risk Scoring System for Screening High-Risk Varices in Patients with HBV-Related Compensated Advanced Chronic Liver Disease
Yuling Yan, Xian Xing, Xiaoze Wang, Ruoting Men, Xuefeng Luo & Li Yang
doi : 10.1007/s10620-020-06764-8
Digestive Diseases and Sciences volume 66, pages4518–4524 (2021)
A large portion of patients with compensated advanced chronic liver disease (cACLD) do not have varices or only have low risk varices.
CLIF-C AD Score Predicts Development of Acute Decompensations and Survival in Hospitalized Cirrhotic Patients
Caroline Baldin, Juliana Piedade, Lívia Guimarães, Lívia Victor, Joana Duarte, Zulane Veiga, Camila Alcântara, Flávia Fernandes, João Luiz Pereira & Gustavo Pereira
doi : 10.1007/s10620-020-06791-5
Digestive Diseases and Sciences volume 66, pages4525–4535 (2021)
Patients with decompensated cirrhosis are at increased risk of mortality, even in absence of ACLF. The CLIF-C AD score (CLIF-C ADs) was proposed as a prognostic score but lacks sufficient validation. Our aim was to describe clinical characteristics and hospital evolution according to score groups and evaluate prognostic capability of CLIF-C ADs alone or in combination with other scores.
Computed Tomography-Measured Liver Volume Predicts the Risk of Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients
Namkyu Kang, Jung Wha Chung, Eun Sun Jang, Sook-Hyang Jeong & Jin-Wook Kim
doi : 10.1007/s10620-020-06762-w
Digestive Diseases and Sciences volume 66, pages4536–4544 (2021)
In this retrospective cohort study, we evaluated the significance of liver volume in the prediction of hepatocellular carcinoma (HCC) in 277 chronic hepatitis C (CHC) patients who received dynamic computed tomography (CT) during surveillance.
Clinical Significance of Alpha-Fetoprotein in Alpha-Fetoprotein Negative Hepatocellular Carcinoma Underwent Curative Resection
Kongying Lin, Qizhen Huang, Jianxing Zeng, Zongren Ding, Lei Wang, Zhenwei Chen, Pengfei Guo, Yongyi Zeng, Weiping Zhou & Jingfeng Liu
doi : 10.1007/s10620-020-06797-z
Digestive Diseases and Sciences volume 66, pages4545–4556 (2021)
The clinical value of alpha-fetoprotein (AFP) in patients with AFP-negative (<?20 ng/ml) hepatocellular carcinoma (HCC) who underwent curative resection remained controversial.
Novel Case Report: A Previously Reported, but Pathophysiologically Unexplained, Association Between Collagenous Colitis and Protein-Losing Enteropathy May Be Explained by an Undetected Link with Collagenous Duodenitis
Inayat Gill, Aciel Ahmed Shaheen, Ahmed Iqbal Edhi, Mitual Amin, Ketan Rana & Mitchell S. Cappell
doi : 10.1007/s10620-020-06804-3
Digestive Diseases and Sciences volume 66, pages4557–4564 (2021)
Collagenous colitis (CC) is associated with non-bloody, watery diarrhea, which is pathophysiologically reasonable because normal colonic absorption (or excretion) of water and electrolytes can be blocked by the abnormally thick collagen layer in CC. However, CC has also been associated with six previous cases of protein-losing enteropathy (PLE), with no pathophysiologic explanation. The colon does not normally absorb (or excrete) amino acids/proteins, which is primarily the function of the small bowel. Collagenous duodenitis (CD) has not been associated with PLE. This work reports a novel case of CD (and CC) associated with PLE; a pathophysiologically reasonable mechanism for CD causing PLE (by the thick collagen layer of CD blocking normal intestinal amino acid absorption); and a novel association of PLE with severe COVID-19 infection (attributed to relative immunosuppression from hypoproteinemia, hypoalbuminemia, hypogammaglobulinemia, and malnutrition from PLE).
Transjugular Intrahepatic Portosystemic Shunt: A Single-Centre Mid-term Experience Using the Viatorr Controlled-Expansion Stent
Roberto Miraglia, Luigi Maruzzelli & Angelo Luca
doi : 10.1007/s10620-021-06867-w
Digestive Diseases and Sciences volume 66, pages4565–4567 (2021)
Risk Factors for Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt: Beyond Stent Diameter
Xiaoze Wang, Xuefeng Luo & Li Yang
doi : 10.1007/s10620-021-06868-9
Digestive Diseases and Sciences volume 66, pages4568–4569 (2021)
Microarray Analysis of the Chemoprophylaxis Effect of Zinc Gluconate: Inspiring but Caution Required
Yuqing Wang, Wei Liu, Xinxin Xu & Lei Yan
doi : 10.1007/s10620-021-07238-1
Digestive Diseases and Sciences volume 66, pages4570–4571 (2021)
Correction to: A New Intraepithelial ?? T-Lymphocyte Marker for Celiac Disease Classification in Formalin-Fixed Paraffin-Embedded (FFPE) Duodenal Biopsies
Alina Popp, Juha Taavela, Paolo Graziano, Paola Parente, Claudia Covelli, Carmela Lamacchia, Angelo Andriulli, Markku Mäki & Jorma Isola
doi : 10.1007/s10620-020-06731-3
Digestive Diseases and Sciences volume 66, page4572 (2021)
