دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Metabolic signature might be an option to identify patients with early CP
Bálint Er?ss, Andrea Szentesi, Peter Hegyi
doi : 10.1136/gutjnl-2021-324206
Gut 2021;70:2023-2024.
Uniting the global gastroenterology community to meet the challenge of climate change and non-recyclable waste
Desmond Leddin, M Bishr Omary, Andrew Veitch, Geoffrey Metz, Naima Amrani, Lars Aabakken, Raja Affendi Raja Ali, Mario Reis Alvares-Da-Silva, David Armstrong, Sedat Boyacioglu, Ye Chen, Reda Elwakil, Kwong-Ming Fock, Saeed S Hamid, Govind Makharia, Finlay Macrae, Reza Malekzadeh, Chris J Mulder, Alejandro Piscoya, Mai ling Perman, Anahita Sadeghi, Roque Saenz, Jean-Christophe Saurin, Amna Subhan Butt, Kaichun Wu, Yeong Yeh Lee
doi : 10.1136/gutjnl-2021-325789
Gut 2021;70:2025-2029.
British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults
Jonathon Snook, Neeraj Bhala, Ian L P Beales, David Cannings, Chris Kightley, Robert PH Logan, D Mark Pritchard, Reena Sidhu, Sue Surgenor, Wayne Thomas, Ajay M Verma, Andrew F Goddard
doi : 10.1136/gutjnl-2021-325210
Gut 2021;70:2030-2051.
Iron deficiency anaemia (IDA) is a major cause of morbidity and burden of disease worldwide. It can generally be diagnosed by blood testing and remedied by iron replacement therapy (IRT) using the oral or intravenous route. The many causes of iron deficiency include poor dietary intake and malabsorption of dietary iron, as well as a number of significant gastrointestinal (GI) pathologies. Because blood is iron-rich it can result from chronic blood loss, and this is a common mechanism underlying the development of IDA—for example, as a consequence of menstrual or GI blood loss.
Endoscopic transmural route for dissection of gastric submucosal tumors with extraluminal growth: experience in two cases
Xinyang Liu, Tianyin Chen, Jing Cheng, Pingting Gao, Quanlin Li, Weifeng Chen, Yiqun Zhang, Pinghong Zhou, Jianwei Hu
doi : 10.1136/gutjnl-2021-324027
Gut 2021;70:2052-2054.
Integrated genomic profiling and modelling for risk stratification in patients with advanced oesophagogastric adenocarcinoma
Dapeng Hao, Siyuan He, Kazuto Harada, Melissa Pool Pizzi, Yang Lu, Pujun Guan, Lu Chen, Ruiping Wang, Shaojun Zhang, Matheus Sewastjanow-Silva, Ahmed Abdelhakeem, Namita Shanbhag, Manoop Bhutani, Guangchun Han, Jeffrey H Lee, Shuangtao Zhao, Brian Weston, Mariela Blum Murphy, Rebecca Waters, Jeannelyn Santiano Estrella, Sinchita Roy-Chowdhuri, Qiong Gan, Ju-Seog Lee, Guang Peng, Samir M Hanash, George Adrian Calin, Xingzhi Song, Jianhua Zhang, Shumei Song, Linghua Wang, Jaffer A Ajani
doi : 10.1136/gutjnl-2020-322707
Gut 2021;70:2055-2065.
Prognosis of patients with advanced oesophagogastric adenocarcinoma (mEGAC) is poor and molecular determinants of shorter or longer overall survivors are lacking. Our objective was to identify molecular features and develop a prognostic model by profiling the genomic features of patients with mEGAC with widely varying outcomes.
Association between proton pump inhibitor use and gastric cancer: a population-based cohort study using two different types of nationwide databases in Korea
Seung In Seo, Chan Hyuk Park, Seng Chan You, Jae Young Kim, Kyung Joo Lee, Jinseob Kim, Yerim Kim, Jong Jin Yoo, Won-Woo Seo, Hyung Seok Lee, Woon Geon Shin
doi : 10.1136/gutjnl-2020-323845
Gut 2021;70:2066-2075.
The association between proton pump inhibitor (PPI) use and gastric cancer related to Helicobacter pylori eradication has not been fully investigated in geographical regions with high risk of gastric cancer. We aimed to evaluate the association between PPIs and gastric cancer in Korea.
The influence of proton pump inhibitor therapy on the outcome of infliximab therapy in inflammatory bowel disease: a patient-level meta-analysis of randomised controlled studies
Thomas X Lu, Matthew Dapas, Erika Lin, Trevor Peters, Atsushi Sakuraba
doi : 10.1136/gutjnl-2020-321609
Gut 2021;70:2076-2084.
In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD.
Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial
Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Hila Zelicha, Alon Kaplan, Philip Rosen, Ilan Shelef, Ilan Youngster, Aryeh Shalev, Matthias Blüher, Uta Ceglarek, Michael Stumvoll, Kieran Tuohy, Camilla Diotallevi, Urska Vrhovsek, Frank Hu, Meir Stampfer, Iris Shai
doi : 10.1136/gutjnl-2020-323106
Gut 2021;70:2085-2095.
To examine the effectiveness of green-Mediterranean (MED) diet, further restricted in red/processed meat, and enriched with green plants and polyphenols on non-alcoholic fatty liver disease (NAFLD), reflected by intrahepatic fat (IHF) loss.
Diet quality and risk and severity of COVID-19: a prospective cohort study
Jordi Merino, Amit D Joshi, Long H Nguyen, Emily R Leeming, Mohsen Mazidi, David A Drew, Rachel Gibson, Mark S Graham, Chun-Han Lo, Joan Capdevila, Benjamin Murray, Christina Hu, Somesh Selvachandran, Alexander Hammers, Shilpa N Bhupathiraju, Shreela V Sharma, Carole Sudre, Christina M Astley, Jorge E Chavarro, Sohee Kwon, Wenjie Ma, Cristina Menni, Walter C Willett, Sebastien Ourselin, Claire J Steves, Jonathan Wolf, Paul W Franks, Timothy D Spector, Sarah Berry, Andrew T Chan
doi : 10.1136/gutjnl-2021-325353
Gut 2021;70:2096-2104.
Poor metabolic health and unhealthy lifestyle factors have been associated with risk and severity of COVID-19, but data for diet are lacking. We aimed to investigate the association of diet quality with risk and severity of COVID-19 and its interaction with socioeconomic deprivation.
Human and preclinical studies of the host–gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health
François Brial, Julien Chilloux, Trine Nielsen, Sara Vieira-Silva, Gwen Falony, Petros Andrikopoulos, Michael Olanipekun, Lesley Hoyles, Fatima Djouadi, Ana L Neves, Andrea Rodriguez-Martinez, Ghiwa Ishac Mouawad, Nicolas Pons, Sofia Forslund, Emmanuelle Le-chatelier, Aurélie Le Lay, Jeremy Nicholson, Torben Hansen, Tuulia Hyötyläinen, Karine Clément, Matej Oresic, Peer Bork, Stanislav Dusko Ehrlich, Jeroen Raes, Oluf Borbye Pedersen, Dominique Gauguier, Marc-Emmanuel Dumas
doi : 10.1136/gutjnl-2020-323314
Gut 2021;70:2105-2114.
Gut microbial products are involved in regulation of host metabolism. In human and experimental studies, we explored the potential role of hippurate, a hepatic phase 2 conjugation product of microbial benzoate, as a marker and mediator of metabolic health.
Multicentre, prospective, randomised study comparing the diagnostic yield of colon capsule endoscopy versus CT colonography in a screening population (the TOPAZ study)
Brooks D Cash, Mark R Fleisher, Steven Fern, Elizabeth Rajan, Robyn Haithcock, David M Kastenberg, David Pound, Neofytos P Papageorgiou, Ignacio Fernández-Urién, Ira J Schmelkin, Douglas K Rex
doi : 10.1136/gutjnl-2020-322578
Gut 2021;70:2115-2122.
Colon capsule endoscopy (CCE) has shown promise for colorectal neoplasia detection compared with optical colonoscopy (OC), but has not been compared with other screening tests in average risk screening patients.
F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer
Jie Hong, Fangfang Guo, Shi-Yuan Lu, Chaoqin Shen, Dan Ma, Xinyu Zhang, Yile Xie, Tingting Yan, TaChung Yu, Tiantian Sun, Yun Qian, Ming Zhong, Jinxian Chen, Yanshen Peng, Cheng Wang, Xiang Zhou, Jianjun Liu, Qiang Liu, Xiong Ma, Ying-Xuan Chen, Haoyan Chen, Jing-Yuan Fang
doi : 10.1136/gutjnl-2020-322780
Gut 2021;70:2123-2137.
Microbiota disorder promotes chronic inflammation and carcinogenesis. High glycolysis is associated with poor prognosis in patients with colorectal cancer (CRC). However, the potential correlation between the gut microbiota and glucose metabolism is unknown in CRC.
Evaluating the utility of tumour mutational signatures for identifying hereditary colorectal cancer and polyposis syndrome carriers
Peter Georgeson, Bernard J Pope, Christophe Rosty, Mark Clendenning, Khalid Mahmood, Jihoon E Joo, Romy Walker, Ryan A Hutchinson, Susan Preston, Julia Como, Sharelle Joseland, Aung Ko Win, Finlay A Macrae, John L Hopper, Dmitri Mouradov, Peter Gibbs, Oliver M Sieber, Dylan E O'Sullivan, Darren R Brenner, Steve Gallinger, Mark A Jenkins, Ingrid M Winship, Daniel D Buchanan
doi : 10.1136/gutjnl-2019-320462
Gut 2021;70:2138-2149.
Germline pathogenic variants (PVs) in the DNA mismatch repair (MMR) genes and in the base excision repair gene MUTYH underlie hereditary colorectal cancer (CRC) and polyposis syndromes. We evaluated the robustness and discriminatory potential of tumour mutational signatures in CRCs for identifying germline PV carriers.
Identification and validation of a multivariable prediction model based on blood plasma and serum metabolomics for the distinction of chronic pancreatitis subjects from non-pancreas disease control subjects
M Gordian Adam, Georg Beyer, Nicole Christiansen, Beate Kamlage, Christian Pilarsky, Marius Distler, Tim Fahlbusch, Ansgar Chromik, Fritz Klein, Marcus Bahra, Waldemar Uhl, Robert Grützmann, Ujjwal M Mahajan, Frank U Weiss, Julia Mayerle, Markus M Lerch
doi : 10.1136/gutjnl-2020-320723
Gut 2021;70:2150-2158.
Chronic pancreatitis (CP) is a fibroinflammatory syndrome leading to organ dysfunction, chronic pain, an increased risk for pancreatic cancer and considerable morbidity. Due to a lack of specific biomarkers, diagnosis is based on symptoms and specific but insensitive imaging features, preventing an early diagnosis and appropriate management.
Reticulon 3-mediated Chk2/p53 activation suppresses hepatocellular carcinogenesis and is blocked by hepatitis B virus
Shushu Song, Yinghong Shi, Weicheng Wu, Hao Wu, Lei Chang, Peike Peng, Lei Zhang, Jia Fan, Jianxin Gu, Yuanyuan Ruan
doi : 10.1136/gutjnl-2020-321386
Gut 2021;70:2159-2171.
Dysfunction of endoplasmic reticulum (ER) proteins is closely related to homeostasis disturbance and malignant transformation of hepatocellular carcinoma (HCC). Reticulons (RTN) are a family of ER-resident proteins critical for maintaining ER function. Nevertheless, the precise roles of RTN in HCC remain largely unclear. The aim of the study is to examine the effect of reticulon family member RTN3 on HCC development and explore the underlying mechanisms.
Cost-effectiveness of antiviral treatment in adult patients with immune-tolerant phase chronic hepatitis B
Hye-Lin Kim, Gi-Ae Kim, Jae-A Park, Hye-Rim Kang, Eui-Kyung Lee, Young-Suk Lim
doi : 10.1136/gutjnl-2020-321309
Gut 2021;70:2172-2182.
The cost-effectiveness of antiviral treatment in adult immune-tolerant (IT) phase chronic hepatitis B (CHB) patients is uncertain.
Hepatic Krüppel-like factor 16 (KLF16) targets PPAR? to improve steatohepatitis and insulin resistance
Nannan Sun, Chuangpeng Shen, Lei Zhang, Xiaojie Wu, Yuanyuan Yu, Xiaoying Yang, Chen Yang, Chong Zhong, Zhao Gao, Wei Miao, Zehong Yang, Weihang Gao, Ling Hu, Kevin Williams, Changhui Liu, Yongsheng Chang, Yong Gao
doi : 10.1136/gutjnl-2020-321774
Gut 2021;70:2183-2195.
Impaired hepatic fatty acids oxidation results in lipid accumulation and redox imbalance, promoting the development of fatty liver diseases and insulin resistance. However, the underlying pathogenic mechanism is poorly understood. Krüppel-like factor 16 (KLF16) is a transcription factor that abounds in liver. We explored whether and by what mechanisms KLF16 affects hepatic lipid catabolism to improve hepatosteatosis and insulin resistance.
Alternative treatments for type 2 diabetes and associated metabolic diseases: medical therapy or endoscopic duodenal mucosal remodelling?
Annieke C G van Baar, Suzanne Meiring, Frits Holleman, David Hopkins, Geltrude Mingrone, Jacques Devière, Max Nieuwdorp, Jacques J G H M Bergman
doi : 10.1136/gutjnl-2020-323931
Gut 2021;70:2196-2204.
GI highlights from the literature
Philip J Smith
doi : 10.1136/gutjnl-2021-326159
Gut 2021;70:2205-2206.
There is still a place for optimised thiopurine therapy in IBD
Femke Crouwel, Hans J C Buiter, Nanne K H de Boer
doi : 10.1136/gutjnl-2020-323481
Gut 2021;70:2207.
Does water immersion WASH in bowel scope?
Sauid Ishaq, Keith Siau, Sergio Cadoni
doi : 10.1136/gutjnl-2020-323393
Gut 2021;70:2208.
Association between duodenal bile salts and gastric emptying in patients with functional dyspepsia
Lucas Wauters, Matthias Ceulemans, Maarten Lambaerts, Alison Accarie, Joran Toth, Raf Mols, Patrick Augustijns, Jan Tack, Tim Vanuytsel
doi : 10.1136/gutjnl-2020-323598
Gut 2021;70:2208-2210.
Response to faecal microbiota transplantation in ulcerative colitis is not sustained long term following induction therapy
Craig Haifer, Aiasha Saikal, Ramesh Paramsothy, Nadeem O Kaakoush, Rupert W Leong, Thomas J Borody, Michael A Kamm, Sudarshan Paramsothy
doi : 10.1136/gutjnl-2020-323581
Gut 2021;70:2210-2211.
Lack of relationship of AT1001 to zonulin and prehaptoglobin-2: clinical implications
Ludvig M Sollid, Frits Koning
doi : 10.1136/gutjnl-2020-323829
Gut 2021;70:2211-2212.
Risk stratification for proton pump inhibitor-associated type 2 diabetes: a population-based cohort study
Qiangsheng He, Man Yang, Xiwen Qin, Die Fan, Jinqiu Yuan, Yihang Pan
doi : 10.1136/gutjnl-2020-323816
Gut 2021;70:2215-2216.
Rescue of male fertility following faecal microbiota transplantation from alginate oligosaccharide-dosed mice
Cong Zhang, Bohui Xiong, Liang Chen, Wei Ge, Shen Yin, Yanni Feng, Zhongyi Sun, Qingyuan Sun, Yong Zhao, Wei Shen, Hongfu Zhang
doi : 10.1136/gutjnl-2020-323593
Gut 2021;70:2213-2215.
Colorectal cancer and absolute risks
Blake J Lawrence, Elise Alexander, Hayley Grant, Moira O'Connor
doi : 10.1136/gutjnl-2020-323505
Gut 2021;70:2215-2216.
Where should ascitic drains be placed? Revisiting anatomical landmarks for paracentesis
Keith Siau, Naomi Robson, Steven Bollipo
doi : 10.1136/gutjnl-2020-323731
Gut 2021;70:2216-2217.
Guts UK 50 years old: onwards and upwards
Julie Harrington, John McLaughlin, Jonathan M Rhodes
doi : 10.1136/gutjnl-2021-325324
Gut 2021;70:2217-2218.
SARS-CoV-2 transmission via endoscopy in the COVID-19 era
Theodor Alexandru Voiosu, Claudia Irina Puscasu, Andrei Voiosu
doi : 10.1136/gutjnl-2021-324276
Gut 2021;70:2218-2219.
Enhanced donor screening for faecal microbial transplantation during COVID-19
Seema Nair Parvathy, John G Lenehan, Ricardo Fernandes, Susan M Poutanen, Susy Hota, Saman Maleki Vareki, Michael Silverman
doi : 10.1136/gutjnl-2021-324593
Gut 2021;70:2219-2220.
Focal pancreatic lesions in autoimmune pancreatitis and weight loss
Ali Aghdassi, Quang Trung Tran, Thomas Bulla, Robin Bülow, Silvia Ribback, Markus M Lerch, Tilman Pickartz
doi : 10.1136/gutjnl-2020-321987
Gut 2021;70:2065-2195.
Correction: Risk factors for SARS-CoV-2 infection and course of COVID-19 disease in patients with IBD in the Veterans Affair Healthcare System
doi : 10.1136/gutjnl-2021-324356corr1
Gut 2021;70:e8.
