دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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The Association of Illness Uncertainty and Hope With Depression and Anxiety Symptoms in Women With Systemic Lupus Erythematosus: A Cross-sectional Study of Psychological Distress in Systemic Lupus Erythematosus Women
Cui, Chunying MS; Li, Yifei MS; Wang, Lie MD
doi : 10.1097/RHU.0000000000001280
December 2021 - Volume 27 - Issue 8 - p 299-305
Depression and anxiety are commonly observed psychological symptoms in patients diagnosed with systemic lupus erythematosus (SLE). This study aimed to explore the possible factors that influence depression and anxiety symptoms development in SLE women.
Fas and microRNAs Variations as a Possible Risk for Behçet Disease
Yenmis, Guven PhD?; Soydas, Tugba MSc†; Ekmekci, Cumhur Gokhan PhD?,‡; Yazici Guvercin, Ayse Canan PhD§; Kucuk, Ozlem Su MD?; Sultuybek, Gonul Kanigur PhD†
doi : 10.1097/RHU.0000000000001254
December 2021 - Volume 27 - Issue 8 - p 306-310
Behçet disease (BD) belongs to a disease family that has a transparent borderline between autoinflammatory and autoimmune disorders. Fas and some miRNAs have revealed to display remarkable roles in both autoimmune and autoinflammatory processes, and they can play important roles in defective apoptosis in BD. We investigated the association of the susceptibility of BD with Fas, miRNA variations, and their both single and combined presence in a Turkish population as a case-control study.
Medicaid Payer Status, Higher Comorbidity, and Low Income Are Associated With Poorer Outcomes After Total Elbow Arthroplasty
Singh, Jasvinder A. MBBS, MPH?,†,‡; Cleveland, John D. MS†
doi : 10.1097/RHU.0000000000001246
December 2021 - Volume 27 - Issue 8 - p 311-316
To assess whether insurance payer, comorbidity, and income are associated with total elbow arthroplasty (TEA) outcomes.
Galectin-1 and Galectin-3 Expression in Lesional Skin of Patients With Systemic Sclerosis—Association With Disease Severity
Mora, Gabriela Fernanda MD, PhD?; Zubieta, Mariana Rodríguez MD, PhD†
doi : 10.1097/RHU.0000000000001367
December 2021 - Volume 27 - Issue 8 - p 317-323
Galectin-1 (Gal-1) and galectin-3 (Gal-3) are carbohydrate-binding proteins involved in normal processes, autoimmunity, and cancer. Increased serum Gal-3 levels in scleroderma were associated with active disease, vasculopathy, and mortality.
Interstitial Lung Disease in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Patients
Kwon, Minkyung MD?; Lee, Augustine S. MD?; Mira-Avendano, Isabel MD?; Rojas, Carlos A. MD†; Grage, Rolf MD†; Abril, Andy MD‡
doi : 10.1097/RHU.0000000000001357
December 2021 - Volume 27 - Issue 8 - p 324-330
Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) may involve the kidney, respiratory tract, skin, or central and peripheral nervous system. Reports of interstitial lung disease (ILD) in AAV (AAV-ILD) have been increasing.
Diffuse Alveolar Hemorrhage in Primary Versus Secondary Antiphospholipid Syndrome
Sangli, Swathi S. MBBS; Ryu, Jay H. MD; Baqir, Misbah MD
doi : 10.1097/RHU.0000000000001358
December 2021 - Volume 27 - Issue 8 - p e297-e301
Diffuse alveolar hemorrhage (DAH) occurs in patients with both primary and secondary antiphospholipid antibody syndrome (APS). We sought to determine the differences in clinical presentation, management, and outcomes of DAH in these patients.
Myositis-Specific Antibodies and Myositis-Associated Antibodies in Patients With Idiopathic Inflammatory Myopathies From the PANLAR Myositis Study Group
González-Bello, Yelitza MD?,†; Garcia-Valladares, Ignacio MD?; Reyes-Pérez, Itzel Viridiana PhD‡; García-Cerda, Daniel MD†; Medrano-Ramírez, Gabriel MD§; Navarro-Zarza, José E. MD?; Andrade-Ortega, Lilia MD¶; Maradiaga-Ceceña, Marco MD#; Cardenas-Anaya, Alicia QFB†; Nava-Zavala, Arnulfo H. MD†,??; Orozco-Barocio, Gerardo MD†; Vázquez-Del Mercado, Mónica MD††; Rojo-Mejia, Armando MD‡‡; Loyo, Esthela MD§§; Gottschalk, Paola MD§§; Iglesias-Gamarra, Antonio MD??; Vega, Kelly MD??; Rojas, Cilia MD??; Mantilla, Rubén MD¶¶; Gómez, Graciela MD##; García-Kutzbach, Abraham MD???,†††; Fritzler, Marvin J. MD†††; García-De La Torre, Ignacio MD?,†
doi : 10.1097/RHU.0000000000001350
December 2021 - Volume 27 - Issue 8 - p e302-e306
Dermatomyositis (DM) and polymyositis (PM) are forms of idiopathic inflammatory myopathies (IIMs), which are associated with the production of autoantibodies that are useful in the diagnosis and prognosis of the disease.
Measuring Choroid Thickness as a Marker of Systemic Inflammation in Patients With Ankylosing Spondylitis
Steiner, Martina MD?,†; del Mar Esteban-Ortega, Maria PhD†,‡; Thuissard-Vasallo, Israel MSc§; García-Lozano, Isabel PhD‡; Moriche-Carretero, Manuel PhD†,‡; García-González, Alejandro Javier MD?; Pérez-Blázquez, Eugenio PhD¶; Sambricio, Javier MD¶; García-Aparicio, Ángel MD#; Casco-Silva, Bruno Francisco MD??; Sanz-Sanz, Jesús PhD††; Valdés-Sanz, Nuria MD‡‡; Fernández-Espartero, Cruz PhD§§; Díaz-Valle, Teresa MD??; Gurrea-Almela, María MD??; Fernández-Melón, Julia PhD¶¶; Gómez-Resa, María PhD##; Pato-Cour, Esperanza PhD???; Díaz-Valle, David PhD†††; Méndez-Fernández, Rosalía MD†††; Navío Marco, Teresa PhD‡‡‡; Almodóvar, Raquel PhD§§§; García-Saenz, María Carmen MD???; del-Prado-Sánchez, Cristina MD???; Muñoz-Fernández, Santiago PhD?,†; on behalf of the Choroidal Thickness in Spondylitis (COnTEST) Study Group
doi : 10.1097/RHU.0000000000001348
December 2021 - Volume 27 - Issue 8 - p e307-e311
Ankylosing spondylitis (AS) is an inflammatory disease, and choroidal thickness (CT) has been proposed and evaluated as a potential marker of systemic inflammation associated with AS and other inflammatory diseases. This study compared CT measurements taken from patients with severe AS disease activity without eye inflammation with those taken from healthy subjects.
Evaluation of Dental Status and Temporomandibular Joint in Children With Generalized Joint Hypermobility
Demir, Ferhat MD?; Tüzüner, Tamer MD†; Bayg?n, Özgül MD†; Kalyoncu, Mukaddes MD?
doi : 10.1097/RHU.0000000000001356
December 2021 - Volume 27 - Issue 8 - p e312-e316
The aim of this study was to evaluate the dental status and temporomandibular diseases (TMDs)–related symptoms in children with generalized joint hypermobility (GJH) and compare them with healthy controls (HCs).
Checkpoint Inhibitor–Associated Arthritis
Ghosh, Nilasha MD?,†; Tiongson, Michael D. BA‡; Stewart, Carolyn BA†; Chan, Karmela K. MD?,†; Jivanelli, Bridget MLIS?; Cappelli, Laura MD§; Bass, Anne R. MD?,†
doi : 10.1097/RHU.0000000000001370
December 2021 - Volume 27 - Issue 8 - p e317-e322
We performed a systematic literature review to identify all reports of immune checkpoint inhibitor–associated inflammatory arthritis to describe it phenotypically and serologically.
The Thai Translation of the Pediatric Gait, Arms, Legs, Spine Tool is Useful for Pediatric Residents in Detecting Musculoskeletal Abnormalities in Children
Sukharomana, Maynart MD; Charuvanij, Sirirat MD
doi : 10.1097/RHU.0000000000001372
December 2021 - Volume 27 - Issue 8 - p e323-e329
The pediatric Gait, Arms, Legs, Spine (pGALS) tool is used to screen musculoskeletal (MSK) abnormalities in children. This study aimed to evaluate the application of the Thai translation of pGALS tool in outpatient clinical settings.
Prevalence of Osteopenia in Drug-Naive Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Yoo, Byung-Woo MD?; Jung, Seung Min MD?; Song, Jason Jungsik MD, PhD?,†; Park, Yong-Beom MD, PhD?,†; Lee, Sang-Won MD, PhD?,†
doi : 10.1097/RHU.0000000000001413
December 2021 - Volume 27 - Issue 8 - p e330-e335
To examine the bone mineral density and prevalence of osteoporosis and osteopenia in glucocorticoid- and immunosuppressive drug–naive patients younger than 55 years with antineutrophil cytoplasmic antibody–associated vasculitis (AAV).
Role of Serum MRP8/14 in Predicting Response to Methotrexate in Children With Juvenile Idiopathic Arthritis
Bagri, Narendra Kumar MD?; Karmakar, Subhradip PhD†; Haldar, Partha MD‡; Lodha, Rakesh MD?; Kabra, S. K. MD?
doi : 10.1097/RHU.0000000000001406
December 2021 - Volume 27 - Issue 8 - p e336-e341
Nearly 40% of children with juvenile idiopathic arthritis (JIA) might not respond to first-line disease-modifying antirheumatic drugs (DMARDs) including methotrexate (MTX). Hence, there is a need for a biomarker that can predict MTX response and help in tailoring initial therapy. Our objective was to study the role of serum myeloid-related protein (MRP) 8/14, and other inflammatory cytokines, as predictors of response to MTX among children with JIA.
The Possible Relationship Between Familial Mediterranean Fever and Chronic Nonbacterial Osteomyelitis
Çiçek, Sümeyra Özdemir MD?; ?ahin, Nihal MD?; Karaman, Zehra Filiz MD†; Ta?k?n, Sema Nur MD?; K?saarslan, Ay?enur Paç MD?; Gündüz, Zübeyde MD‡; Poyrazo?lu, Muammer Hakan MD?; Dü?ünsel, Ruhan MD?
doi : 10.1097/RHU.0000000000001431
December 2021 - Volume 27 - Issue 8 - p e342-e348
Chronic nonbacterial osteomyelitis (CNO) is an inflammatory disease characterized by recurrent attacks and remissions due to sterile bone inflammation. The CNO may be accompanied by various inflammatory diseases. The aims of our study were to determine the clinical, laboratory, and radiological characteristics of children with CNO, and to investigate the possible effect of concomitant diseases on the course of CNO.
Metabolic Syndrome, Disease Activity, and Adipokines in Patients With Newly Diagnosed Inflammatory Joint Diseases
Kononoff, Aulikki MD?; Vuolteenaho, Katriina MD, PhD†; Hämäläinen, Mari PhD†; Kautiainen, Hannu MSc‡,§; Elfving, Pia MD, PhD?; Savolainen, Elina MD?; Arstila, Leena MD?,?; Niinisalo, Helena MD¶,#; Rutanen, Jarno MD, PhD?; Marjoniemi, Olga MD?; Moilanen, Eeva MD, PhD†; Kaipiainen-Seppänen, Oili MD, PhD?
doi : 10.1097/RHU.0000000000001412
December 2021 - Volume 27 - Issue 8 - p e349-e356
To investigate metabolic syndrome (MetS), disease activity, and adipokine levels among patients with rheumatoid arthritis (RA), spondyloarthritis (SpA), and undifferentiated arthritis (UA) at the time of diagnosis and after 1 year of follow-up.
Association of Arthritis and Antihypertensive Medication Use Among Individuals With Hypertension
Liew, Jean W. MD?,†; Cannon, Chase A. MD†,‡; Ji, Yuekai BM†; Littman, Alyson J. PhD†; Hawes, Stephen E. PhD†
doi : 10.1097/RHU.0000000000001426
December 2021 - Volume 27 - Issue 8 - p e357-e361
The aim of this study was to assess whether arthritis is associated with lower antihypertensive medication (AHM) use among those with hypertension and whether this relationship differs by age or cardiovascular (CV) comorbidity.
Serum Urate Levels of Hemodialyzed Renal Patients Revisited
Arenas, María-Dolores MD, PhD?; Soriano, Raquel MD†; Andrés, Mariano MD, PhD†,‡; Pascual, Eliseo MD, PhD†,‡
doi : 10.1097/RHU.0000000000001438
December 2021 - Volume 27 - Issue 8 - p e362-e366
The need of maintaining serum urate (SU)–lowering agents in hemodialysis (HD) patients is an understudied area that requires a review, as it is a common practice. The aims were to assess the SU reduction achieved under HD and to analyze the kinetics of SU in a week of intermittent HD.
Ultrasonography Reliability in the Detection of Inflammatory and Structural Abnormalities
Brites, Luisa MD?; Santiago, Mariana MD?,†; Rovisco, João MD?,†; Freitas, João MD?; A.P. Silva, José PhD?,†,‡; Silva, Inês MD§; Teixeira, Filipa MD?; Faria, Daniela S. MD?; Silva, Cândida G. PhD¶,#,??; Falcão, Sandra PhD§,††
doi : 10.1097/RHU.0000000000001440
December 2021 - Volume 27 - Issue 8 - p e367-e370
Ultrasonography is an image technique that allows rheumatologists to visualize structural and inflammatory changes within a joint. The objective of this study was to assess the interobserver and intraobserver reliability of musculoskeletal ultrasound (US) in the detection of inflammatory and destructive joint changes in patients with polyarthritis.
Predictors of Long-term Outcomes in Patients With Connective Tissue Disease Associated With Pulmonary Arterial Hypertension
Nakayama, Kazuhiko MD, PhD?; Nakajima, Yasuo MSc†; Tanaka, Rika PhD†; Hirata, Ken-ichi MD, PhD?; Emoto, Noriaki MD, PhD?,‡
doi : 10.1097/RHU.0000000000001447
December 2021 - Volume 27 - Issue 8 - p e371-e377
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by increased pulmonary arterial pressure and pulmonary vascular resistance that can lead to right-sided heart failure. Connective tissue disease–associated PAH (CTD-PAH) often has poorer outcomes than idiopathic or hereditary PAH, suggesting the presence of non-PAH factors that could affect the prognoses. This cohort study aimed to identify prognostic factors for CTD-PAH management.
Thai Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Outcomes and Risk Factors for Mortality
Intapiboon, Porntip MD; Siripaitoon, Boonjing MD, MSc
doi : 10.1097/RHU.0000000000001456
December 2021 - Volume 27 - Issue 8 - p e378-e384
Patients with antineutrophil cytoplasmic antibody–associated vasculitis (AAV) have an increased risk of premature death. Different subtypes, predictors, and ethnicities may affect the overall survival. However, the overall survival of Thai AAV patients has not been reported. We examined the mortality and prognosis of these patients.
Scientific Productivity in Rheumatoid Arthritis
Zhong, Mingliang MD; Xu, Canhua MD; Wu, Yaohong MD; Chen, Qin MD; Chen, Rongchun MD
doi : 10.1097/RHU.0000000000001475
December 2021 - Volume 27 - Issue 8 - p e385-e390
Assessment of scientific productivity provides a macroscopic view of research activity in a specific field. However, no analyses of rheumatoid arthritis (RA) have been published to date. Thus, this study aimed to investigate the characteristics of studies published on RA worldwide.
Rheumatic Diseases Associated With Posterior Reversible Encephalopathy Syndrome
Manadan, Augustine MD?,†; Kambhatla, Soumyasri MD?,‡; Gauto-Mariotti, Estefania MD‡; Okoli, Chimuanya MD?; Block, Joel A. MD?
doi : 10.1097/RHU.0000000000001470
December 2021 - Volume 27 - Issue 8 - p e391-e394
Posterior reversible encephalopathy syndrome (PRES) is an acute neurological syndrome. There are many reports of PRES occurring in the setting of rheumatic diseases. However, it remains uncertain whether rheumatic diseases are truly a risk factor for PRES, as the literature consists of case reports and small clinical series. Here, we evaluated the relationship between PRES and the rheumatic diseases, using a large population-based data set as the reference.
Screening for Hydroxychloroquine Retinal Toxicity in Indian Patients
Dadhaniya, Nikunjkumar V. MD?; Sood, Isha MD?; Patil, Abhishek MD?; Mallaiah, Uma FRCS†; Upadhyaya, Sundeep DM?; Handa, Rohini MD?; Gupta, Sirinder J. FRCP?
doi : 10.1097/RHU.0000000000001479
December 2021 - Volume 27 - Issue 8 - p e395-e398
Several studies have reported hydroxychloroquine (HCQ) retinal toxicity in East Asian patients. However, at present, there are limited data from Indian patients. The aim of this study was to investigate the prevalence and pattern of HCQ retinal toxicity in Indian population and to see if screening protocol for retinal toxicity in Indian patients should be any different to others.
The American College of Rheumatology Fibromyalgia Criteria Are Useful in the Evaluation of Fibromyalgia Symptoms in Patients With Ankylosing Spondylitis
Magrey, Marina N. MD?; Thomas, Charles BS?,†; Khan, Muhammad Asim MD?
doi : 10.1097/RHU.0000000000001490
December 2021 - Volume 27 - Issue 8 - p e399-e403
Fibromyalgia (FM) is common among patients with ankylosing spondylitis (AS), and its coexistence is believed to interfere with the measurement of patient-reported outcomes of disease activity and function in AS because of overlapping symptoms between the 2 diseases. This can confound clinical assessment and treatment decisions.
Well-Being, Burnout, and Resiliency Among Early-Career Rheumatologists
Kumar, Bharat MD, MME, FACP, RhMSUS?; Swee, Melissa L. MD, MME†; Suneja, Manish MD‡; Iyer, Priyanka MD, MPH?
doi : 10.1097/RHU.0000000000001485
December 2021 - Volume 27 - Issue 8 - p e404-e411
Physician well-being is being increasingly recognized for its important role in high-quality patient care, integrity of the healthcare system, and vitality of the workforce. However, little is known about well-being, resiliency, and burnout among rheumatologists, particularly early-career rheumatologists. In this qualitative study, the investigators explore these concepts among early-career rheumatologists.
Anti–Cyclic Citrullinated Peptide Antibodies Correlate to Ultrasound Synovitis in Rheumatoid Arthritis Better Than C-Reactive Protein
Lu, Cheng-Hsun MD?,†; Chen, Lung-Fang MD‡; Huang, Yi-Min MD§; Cheng, Chiao-Feng MD§; Hsieh, Song-Chou PhD?; Li, Ko-Jen MD, PhD?
doi : 10.1097/RHU.0000000000001499
December 2021 - Volume 27 - Issue 8 - p e412-e417
The aim of this study was to compare ultrasound (US) grading and laboratory measures in patients with rheumatoid arthritis.
Progression of Large Vessel Disease in Patients With Giant Cell Arteritis–Associated Ischemic Stroke: The Role of Vascular Imaging
Guisado-Alonso, Daniel MD?; Edo, M. Carmen MD?; Estrada Alarcón, Paula Valentina MD†; García-Sánchez, Sonia María MD?; Font, Maria Àngels MD?; Mena Romo, Luis MD?; Marrero-González, Paula MD?; Mengual, Juan José MD?; Castrillo, Laura MD‡; Montull, Caterina MD, PhD‡; Corominas, Hector MD, PhD†; Gómez-Choco, Manuel MD, PhD?
doi : 10.1097/RHU.0000000000001498
December 2021 - Volume 27 - Issue 8 - p e418-e424
Giant cell arteritis (GCA) can cause ischemic stroke (IS) due to the involvement of the internal carotid and vertebral arteries. The aim of our study is to describe the pattern of stroke recurrence in patients with GCA-related IS and the role of vascular imaging in the follow-up of these patients.
Temperament and Character Profiles of Ankylosing Spondylitis Patients Compared With Major Depression Patients and Healthy Controls
Tönük, ?ükrü Burak MD?; Ar?soy, Özden MD†; Öztürk, Erhan Arif MD‡; Bozta?, Mehmet Hamid MD†; Çifci Kaygusuz, Çi?dem MD†,§; Erdem Sultano?lu, Tuba MD?
doi : 10.1097/RHU.0000000000001510
December 2021 - Volume 27 - Issue 8 - p e425-e431
Depressive disorder is common in patients with ankylosing spondylitis (AS), who exhibit specific brain imaging abnormalities resembling those in major depression (MD). We compared temperament and character profiles between patients with AS and MD.
Going Further: Comprehensive Disease Control of Rheumatoid Arthritis, Targeting Cytokines and Chemokines
Chavarria-Avila, Efrain PhD?,†,‡; Vazquez-Del Mercado, Monica MD, PhD†,‡,§,?; Pizano-Martínez, Oscar PhD†,¶; Roman-Lugo, German MD†; Arrona-Rios, Karla MD‡; Perez-Vazquez, Felipe MD, PhD?,†,‡,#; De-La-Cruz, Jeniffer P. MD‡; Calderon-Espinoza, Ivette MD‡; Aguilar-Vazquez, Andrea BSc†,??; Esesarte-Rodriguez, Marisol MD†; Rubio-Arrellano, Edy D. MD, PhD#; Duran-Barragan, Sergio MD†,§,¶,††
doi : 10.1097/RHU.0000000000001515
December 2021 - Volume 27 - Issue 8 - p e432-e439
Mechanism of action of biological and synthetic disease-modifying antirheumatic drugs (DMARDs) includes the inhibition of specific proinflammatory cytokines. This study aimed to elucidate the cytokines and chemokines inhibited by different treatments (conventional synthetic DMARD [csDMARD], biological and targeted synthetic DMARD) in rheumatoid arthritis (RA).
Sleep Disturbance Trajectories in Osteoarthritis
Song, Jing MS?; Lee, Jungwha PhD, MPH†; Lee, Yvonne C. MD, MMSc?,†; Chang, Alison H. PT, DPT, MS‡; Semanik, Pamela A. PhD, APN§; Chang, Rowland W. MD, MPH?,†,?; Ehrlich-Jones, Linda RN, PhD¶; Dunlop, Dorothy D. PhD?,†,#
doi : 10.1097/RHU.0000000000001512
December 2021 - Volume 27 - Issue 8 - p e440-e445
Sleep disturbance is common among adults with osteoarthritis (OA), but little is known about patterns over time. In this cohort study, we identified restless sleep trajectories and associated factors in adults with or at high risk for knee OA.
Pain and Fatigue in Patients With Ankylosing Spondylitis Treated With Tumor Necrosis Factor Inhibitors
Strand, Vibeke MD?; Deodhar, Atul MD†; Alten, Rieke MD, PhD‡; Sullivan, Emma BSc§; Blackburn, Stuart BSc§; Tian, Haijun PhD?; Gandhi, Kunal K. MD, MPH?; Jugl, Steffen M. MA¶; Conaghan, Philip G. MBBS, PhD#
doi : 10.1097/RHU.0000000000001544
December 2021 - Volume 27 - Issue 8 - p e446-e455
Patients with ankylosing spondylitis (AS) experience symptoms and comorbidities that impact their health-related quality of life (HRQoL) and ability to work. This real-world, global survey was conducted among AS patients receiving tumor necrosis factor inhibitors (TNFis) to evaluate both the frequency and severity of persistent symptoms, and the impact of pain and fatigue on HRQoL, employment status, and work activity.
Pneumococcal Vaccination Among Lupus Patients
Arora, Shilpa MD; Nika, Ailda MD; Sequeira, Winston MD; Block, Joel A. MD; Jolly, Meenakshi MD, MS
doi : 10.1097/RHU.0000000000001536
December 2021 - Volume 27 - Issue 8 - p e456-e461
Pneumococcal vaccination (PV) is indicated for the elderly (age ?65 years) and those with chronic disease or who are immunosuppressed. We aimed to study the rate and predictors of recommendation/receipt of 23 valent pneumococcal polysaccharide vaccine (PPSV23) in immunosuppressed systemic lupus erythematosus (SLE) patients.
The Effects of Hyperbaric Oxygen on Rheumatoid Arthritis
Sit, Michelle T. MD?; Schmidt, Thomas W. MD†; Edmonds, Lance D. MD?; Kelly, Jason A. MD‡; Sky, Karen M. MD§; Thornton, Jennifer A. PhD‡; McNeary-Garvin, Antoinette M. MSN‡; Thom, Stephen R. MD, PhD?; Slade, John B. MD‡
doi : 10.1097/RHU.0000000000001540
December 2021 - Volume 27 - Issue 8 - p e462-e468
This case series pilot study assessed the effects of hyperbaric oxygen therapy (HBO2) for treating rheumatoid arthritis (RA).
Urinary Cellular Profile as a Biomarker for Lupus Nephritis
Abdelati, Abeer Ali MD?; Eshak, Nouran Y. MS?; Donia, Hanaa M. MD†; El-Girby, Amira H. MD?
doi : 10.1097/RHU.0000000000001553
December 2021 - Volume 27 - Issue 8 - p e469-e476
A search for the ideal biomarker for lupus nephritis (LN) is still underway, one that can be used for early detection and correlate with the class and activity of LN. Urine is normally devoid of leukocytes; however, it has been observed that macrophages and T lymphocytes are routinely present in the urine of LN patients and those with other proliferative renal diseases. This provides the idea for their potential use as biomarkers for proliferative LN. Here, we measured the urinary CD4+, CD8+ T lymphocytes, and CD14+ monocytes in patients with systemic lupus erythematosus (SLE) as potential biomarkers for LN.
Systemic Sclerosis Is Associated With Increased Inpatient Mortality in Patients Admitted for Atrial Fibrillation
Edigin, Ehizogie MD?; Ojemolon, Pius Ehiremen MD†; Eseaton, Precious Obehi MD‡; Shaka, Hafeez MD?; Akuna, Emmanuel MD?; Asemota, Iriagbonse Rotimi MD?; Manadan, Augustine MD§
doi : 10.1097/RHU.0000000000001543
December 2021 - Volume 27 - Issue 8 - p e477-e481
The aim of this study was to compare the outcomes of patients primarily admitted for atrial fibrillation (AFib) with and without a secondary diagnosis of systemic sclerosis (SSc). The primary outcome was inpatient mortality. Hospital length of stay (LOS), total hospital charges, odds of undergoing ablation, and electrical cardioversion were secondary outcomes of interest.
Incidence Rates of Interstitial Lung Disease Events in Tofacitinib-Treated Rheumatoid Arthritis Patients
Citera, Gustavo MD?; Mysler, Eduardo MD†; Madariaga, Hugo MD‡; Cardiel, Mario H. MD, MSc§; Castañeda, Oswaldo MD?; Fischer, Aryeh MD¶; Richette, Pascal MD, PhD#; Chartrand, Sandra MD, FRCPC??; Park, Jin Kyun MD††; Strengholt, Sander MD‡‡; Rivas, Jose L. MD§§; Thorat, Amit V. MD??; Girard, Tanya PhD¶¶; Kwok, Kenneth MSc##; Wang, Lisy MD???; Ponce de Leon, Dario MD†††
doi : 10.1097/RHU.0000000000001552
December 2021 - Volume 27 - Issue 8 - p e482-e490
Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Interstitial lung disease (ILD) is an extra-articular manifestation of RA. We investigated incidence rates of ILD in patients with RA, receiving tofacitinib 5 or 10 mg twice daily, and identified potential risk factors for ILD.
Determinants of Diagnostic Delay in Complex Regional Pain Syndrome Type 1
Varenna, Massimo MD, PhD?; Crotti, Chiara MD?; Ughi, Nicola MD?; Zucchi, Francesca MD?; Caporali, Roberto MD?,†
doi : 10.1097/RHU.0000000000001558
December 2021 - Volume 27 - Issue 8 - p e491-e495
Complex regional pain syndrome type 1 (CRPS-1) is a disabling painful disease, with variable outcomes in terms of chronic pain and disability. A long time between onset and diagnosis seems predictive for late recovery and progression toward a chronic disease. This study aims to investigate demographic and clinical variables associated with delayed CRPS-1 diagnosis.
Intensive Multicomponent Fibromyalgia Treatment
Bruce, Barbara K. PhD?; Allman, Madeleine E. MPH†; Rivera, Fernando A. MD‡; Wang, Benjamin MD§; Berianu, Florentina MD§; Butendieck, Ronald R. MD§; Calamia, Kenneth T. MD§; Hines, Stephanie L. MD‡; Rummans, Teresa A. MD?; Niazi, Shehzad K. MD?,?; Abril, Andy MD§
doi : 10.1097/RHU.0000000000001555
December 2021 - Volume 27 - Issue 8 - p e496-e500
The current study was designed to evaluate the translation of clinical trial outcomes and clinical guidelines for the treatment of fibromyalgia (FM) into an intensive multicomponent clinical program embedded in routine care delivery. The study aimed to assess the adaptation of these recommended strategies into routine clinical care while evaluating their effectiveness and durability in improving functional status and level of distress in a large clinical sample of FM patients.
Elevated Serum IgG4 Was Found in Eosinophilic Granulomatosis With Polyangiitis
Wu, Ziyan MD?; Zhang, Shulan MM?; Li, Ping MM?; Song, Ning MS?; Zhang, Fengchun MS?; Li, Yongzhe MS†
doi : 10.1097/RHU.0000000000001606
December 2021 - Volume 27 - Issue 8 - p e501-e504
The aim was to determine the levels and clinical impact of immunoglobulin G4 (IgG4) and other IgG subclasses in a Chinese population with eosinophilic granulomatosis with polyangiitis (EGPA).
Paraneoplastic Arthritides
Parperis, Konstantinos MD, FACR?; Constantinidou, Anastasia MD, PhD†; Panos, George MD, PhD‡
doi : 10.1097/RHU.0000000000001202
December 2021 - Volume 27 - Issue 8 - p e505-e509
Paraneoplastic arthritides are a group of inflammatory rheumatic syndromes induced by an occult and manifest malignancy, characterized by a wide range of musculoskeletal signs and symptoms that masquerade other rheumatic diseases such as rheumatoid arthritis. Although the pathogenesis of paraneoplastic arthritides is unknown, immune-mediated mechanisms can induce a paraneoplastic syndrome, with a dominant feature the polyarthritis. Common entities of paraneoplastic arthritides include paraneoplastic polyarthritis, hypertrophic osteoarthropathy, remitting seronegative symmetrical synovitis with pitting edema, palmar fasciitis and polyarthritis, and polyarthritis and panniculitis associated with pancreatic carcinoma. The electronic databases PubMed and Scopus were scrutinized using the following terms: paraneoplastic arthritis, paraneoplastic polyarthritis, or paraneoplastic rheumatic diseases. Abstracts, full articles, and selected references were reviewed. The aim of the present narrative review article was to describe the clinical characteristics, diagnostic evaluation, and management of paraneoplastic arthritides, and highlight the challenges that health care providers may encounter, distinguishing those conditions from other autoimmune rheumatic disorders. Future studies are needed to give insight into the mechanisms associated with paraneoplastic arthritides, leading to the development of novel diagnostic biomarkers.
Can We Expect Any Effect of Rituximab on Fatigue in Primary Sjögren Syndrome?
Hermans, An-Marie MD?; Vulsteke, Jean-Baptiste MD?,†; Lenaerts, Jan MD?; De Langhe, Ellen MD, PhD?,†
doi : 10.1097/RHU.0000000000001217
December 2021 - Volume 27 - Issue 8 - p e510-e515
Fatigue is a major determinant of impaired quality of life in primary Sjögren syndrome (pSS) patients. Effective therapeutic strategies are lacking.
Role of Interleukin 6 Inhibitors in the Management of Rheumatoid Arthritis
Yip, Ronald Man Lung FRCP (Edin), FHKCP?; Yim, Cheuk Wan FRCP, FHKCP†
doi : 10.1097/RHU.0000000000001293
December 2021 - Volume 27 - Issue 8 - p e516-e524
Rheumatoid arthritis (RA) is a multisystem disease that affects the joints and various organs, resulting in compromised quality of life and increased mortality. A wide spectrum of treatment options is available for RA. Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) are the first-line of treatment for RA, whereas tumor necrosis factor ? inhibitors are commonly used as a second-line biological disease-modifying antirheumatic drug following inadequate response to csDMARDs. However, remission remains difficult to achieve. No single agent is effective for all patients. It is important to consider patients' comorbidities, perspectives, and preferences when selecting treatment.
A Meta-analysis and Systematic Review of Valvular Heart Disease in Systemic Lupus Erythematosus and Its Association With Antiphospholipid Antibodies
Hussain, Kifah MD?; Gauto-Mariotti, Estefania MD?; Cattoni, Hugo Macchi MD†; Arif, Abdul Wahab MD?; Richardson, Carrie MD‡; Manadan, Augustine MD?; Yadav, Neha MD?
doi : 10.1097/RHU.0000000000001464
December 2021 - Volume 27 - Issue 8 - p e525-e532
Valvular heart disease (VHD) is a known cardiac manifestation of systematic lupus erythematosus (SLE). This systematic review aims to pool data from studies to estimate the frequency of valvular lesions in SLE patients. It also aims to demonstrate the association between VHD in SLE and antiphospholipid antibodies positivity.
Pharmacological Management of Osteoarthritis With a Focus on Symptomatic Slow-Acting Drugs
Alexander, Lila A. M. MD?; LN, Denisov MD?,†; EG, Zotkin MD?; IS, Dydykina PhD?; AY, Kochish MD‡; SS, Rodionova MD§; EA, Trofimov PhD?; SP, Yakupova MD¶; EZ, Yakupov MD#; L, Gallelli MD, PhD??
doi : 10.1097/RHU.0000000000001507
December 2021 - Volume 27 - Issue 8 - p e533-e539
This article describes an updated stepwise algorithm for the pharmacological management of osteoarthritis (OA) to establish a treatment method for patients with OA.
Stages of Lyme Arthritis
Miller, John B. MD; Aucott, John N. MD
doi : 10.1097/RHU.0000000000001513
December 2021 - Volume 27 - Issue 8 - p e540-e546
Lyme arthritis was described in 1977, after an apparent outbreak of juvenile idiopathic arthritis in Lyme, Connecticut. The evolution of the disease has been meticulously described with presentation dependent on disease duration and previous therapy.
Clinical Manifestations and Diagnosis of Axial Spondyloarthritis
Walsh, Jessica A. MD?; Magrey, Marina MD†
doi : 10.1097/RHU.0000000000001575
December 2021 - Volume 27 - Issue 8 - p e547-e560
Axial spondyloarthritis (axSpA) is a chronic, rheumatic disease characterized by inflammation of the sacroiliac joint, spine, and entheses. Axial spondyloarthritis affects up to 1.4% of adults in the United States and is associated with decreased quality of life, increased mortality, and substantial health care–related costs, imposing a high burden on patients, their caregivers, and society.
Atypical Large Vessel Vasculitis Presenting With Cholestatic Liver Abnormalities
Sangha, Sameet MD?; Lenert, Aleksander MD, MS?; Dawoud, Salma MD?; Kaur, Aneet MD?; Yazan, Hasan MD†; Voigt, Michael D. MD†; Lenert, Petar MD, PhD?
doi : 10.1097/RHU.0000000000001596
December 2021 - Volume 27 - Issue 8 - p e561-e567
Clinicians usually easily recognize cranial manifestations of giant cell arteritis (GCA) such as new-onset headache, jaw claudication, scalp tenderness, and abrupt changes in visual acuity or blindness; however, when presented with an aberrant clinical course, the diagnosis becomes more elusive. In addition to temporal arteries and other extracranial branches of the carotid arteries, large vessel vasculitis (LVV) can also affect other blood vessels including coronary arteries, aorta with its major branches, intracranial blood vessels, and hepatic arteries.
Masquerades of Giant Cell Arteritis Evident on Temporal Artery Biopsy
Micieli, Jonathan A. MD, CM?,†; Grossniklaus, Hans E. MD, MBA‡,§; Peragallo, Jason H. MD‡,?
doi : 10.1097/RHU.0000000000001072
December 2021 - Volume 27 - Issue 8 - p e568-e574
Procalcitonin Serum Level Is a Specific Marker to Distinguish Septic Arthritis of the Knee in Patients With a Previous Diagnosis of Gout
Guillén-Astete, Carlos Antonio MD, PhD; García-García, Verónica MD; Vazquez-Díaz, Monica MD
doi : 10.1097/RHU.0000000000001215
December 2021 - Volume 27 - Issue 8 - p e575-e579
The Association of MTHFR C677T and MTR A2756G Gene Polymorphisms With the Risk of Systemic Lupus Erythematosus
Huang, Yu-Chen MD?,†,‡; Lai, I-Wen MD§; Chang, Hua-Ching MD, MS?
doi : 10.1097/RHU.0000000000001240
December 2021 - Volume 27 - Issue 8 - p e580-e582
A Family With A20 Haploinsufficiency Presenting With Novel Clinical Manifestations and Challenges for Treatment
Hautala, Timo MD, PhD?,†; Vähäsalo, Paula MD, PhD‡; Kuismin, Outi MD, PhD§; Keskitalo, Salla PhD?; Rajamäki, Kristiina PhD¶; Väänänen, Antti MD#; Simojoki, Marja MD??; Säily, Marjaana MD, PhD?; Pelkonen, Ilpo MD††; Tokola, Heikki MD, PhD‡‡; Mäkinen, Markus MD, PhD‡‡; Kaarteenaho, Riitta MD, PhD§§; Jartti, Airi MD, PhD??; Hautala, Nina MD, PhD¶¶; Kantola, Saara MD##; Jackson, Päivi MD???; Glumoff, Virpi PhD†; Saarela, Janna MD, PhD†††; Varjosalo, Markku PhD?,‡‡‡; Eklund, Kari K. MD, PhD§§§; Seppänen, Mikko R. J. MD, PhD¶,???
doi : 10.1097/RHU.0000000000001268
December 2021 - Volume 27 - Issue 8 - p e583-e587
Tumor necrosis factor ?–induced protein 3 gene (TNFAIP3, also called A20) haploinsufficiency (HA20) leads to autoinflammation and autoimmunity. We have recently shown that a p.(Lys91*) mutation in A20 disrupts nuclear factor ?B signaling, impairs protein-protein interactions of A20, and leads to inflammasome activation.
A National Survey Across Primary Care Pediatricians Regarding Immunization Views and Practices in Children With Rheumatic Diseases
Papailiou, Stayroula MD; Markade, Aikaterini MD; Eleftheriou, Irene MD; Tsolia, Maria N. MD, PhD; Garoufi, Anastasia MD, PhD; Maritsi, Despoina N. MD, PhD
doi : 10.1097/RHU.0000000000001251
December 2021 - Volume 27 - Issue 8 - p e588-e590
The aims of this study were to describe the knowledge, attitude, and current practice of general pediatricians working in primary care regarding vaccination in children with rheumatic diseases (RDs) and to identify barriers and facilitators that could be used to promote uptake.
Arthroscopic Treatment of Synovial Lipomatosis of the Hip, With Concurrent Femoroacetabular Impingement
Nishimura, Haruki MD?; Suzuki, Hitoshi MD, PhD†; Ohnishi, Yasuo MD, PhD†; Ayeni, Olufemi R. MD, PhD‡; Sakai, Akinori MD, PhD?; Uchida, Soshi MD, PhD†
doi : 10.1097/RHU.0000000000001259
December 2021 - Volume 27 - Issue 8 - p e591-e595
Parental Smoking Influence in Disease Activity in a Low-Income Juvenile Idiopathic Arthritis Cohort
Vasques Dantas Landim, Joaquim Ivo MD?; da Rocha, Leila Nascimento MD?; Silva, Mateus Francelino MD?; dos Santos Brasil, Lucas Teixeira MD?; Lima Rocha, Hermano Alexandre MD, PhD†; Junior, Carlos Nobre Rabelo MD, PhD‡; Rocha, Francisco Airton Castro MD, PhD?
doi : 10.1097/RHU.0000000000001299
December 2021 - Volume 27 - Issue 8 - p e596-e598
Effects of Bosentan in the Treatment of Digital Ulcers in Korean Patients With Systemic Sclerosis
Lee, Kyung-Ann MD, PhD?; Park, Suyeon MS†; Kim, Bo Young MD‡; Kim, Yun Sung MD, PhD§; Ju, Ji Hyeon MD, PhD?; Son, Chang-Nam MD, PhD¶; Kim, Sang-Hyon MD, PhD¶; Kim, Hyun-Sook MD, PhD?
doi : 10.1097/RHU.0000000000001461
December 2021 - Volume 27 - Issue 8 - p e599-e601
Carotid Plaque Is Not Associated With Increased Levels of Interleukin 1, Interleukin 6, and Tumor Necrosis Factor ? in Rheumatoid Arthritis
Arvizu-Rivera, Rosa I. MD?; Azpiri-Lopez, Jose R. PhD†; Colunga-Pedraza, Iris J. MSc‡; Cardenas-de la Garza, Jesus A. MD‡; Vera-Pineda, Raymundo MD?; Garcia-Arellano, Gisela MD?; Martinez-Moreno, Adrian MD†; Abundis-Marquez, Estefania E. MD?; Galarza-Delgado, Dionicio A. PhD‡
doi : 10.1097/RHU.0000000000001503
December 2021 - Volume 27 - Issue 8 - p e602-e605
Correlation Between Corneal Nerve Density and Symptoms of Small Fiber Neuropathy in Patients With Fibromyalgia: The Confounding Role of Severe Anxiety or Depression
Ramírez, Manuel MD?; Guerra-Juárez, Arturo MD?; Miyake, Daniel-Yoshiro MD?; Sebastian-Arellano, Christian MD?; Estrada-Mata, Aranza-Guadalupe MD?; González-Moyotl, Nadia-Janet MD?; Rodríguez-Aguayo, Allan-Miguel MD?; Martínez-Lavin, Manuel MD†; Martínez-Martínez, Laura-Aline Msc†
doi : 10.1097/RHU.0000000000001592
December 2021 - Volume 27 - Issue 8 - p e606-e608
A consistent line of investigation proposes fibromyalgia as a dysautonomia-associated neuropathic pain syndrome. Comorbid anxiety or depression amplifies fibromyalgia symptoms. The recent recognition of small fiber neuropathy in fibromyalgia patients supports the neuropathic nature of the illness. Corneal confocal microscopy accurately identifies small nerve fiber pathology. The newly developed Small-Fiber Symptom Survey captures the spectrum of small fiber neuropathy symptoms. We aimed to correlate corneal nerve density with different fibromyalgia disease severity questionnaires including the Small-Fiber Symptom Survey. We defined the possible confounding role of comorbid anxiety or depression severity in the clinical-pathological association.
Adenosine Deaminase Gene Polymorphism and Baseline Serum Level of Adenosine Deaminase as a Biomarker of Response to Methotrexate in Rheumatoid Arthritis
Gangadharan, Harikrishnan MD; Singh, Ankita PhD; Majumder, Sanjukta PhD; Aggarwal, Amita MD, DM
doi : 10.1097/RHU.0000000000001594
December 2021 - Volume 27 - Issue 8 - p e609-e611
Methotrexate (MTX) is the first-line therapy for rheumatoid arthritis (RA), but nearly 30% of RA patients do not respond to it. Methotrexate acts by enhancing the level of adenosine, which gets converted to inosine by the enzyme adenosine deaminase (ADA). We studied whether ADA gene polymorphism and serum levels of total ADA are associated with responsiveness to MTX.
An Initiative to Improve Timely Glucocorticoid Tapering in Vasculitis
Mendel, Arielle MD, MSc?; Ennis, Daniel MD†; Lake, Shirley MD, MSc‡; Carette, Simon MD, MPhil§; Pagnoux, Christian MD, MSc, MPH§
doi : 10.1097/RHU.0000000000001744
December 2021 - Volume 27 - Issue 8 - p e612-e615
High-dose glucocorticoids (GCs) are required in the initial treatment of systemic vasculitis. However, slow or delayed tapering can lead to unnecessary GC exposure and toxicity. In this quality improvement initiative, we aimed to increase appropriate GC tapering among newly referred patients awaiting specialty consultation at a tertiary vasculitis clinic.
Intravenous Immunoglobulin for Inflammatory Myositis
Ohad, Maayan BMedSc?; Shemer, Asaf MD?,†; Lavie, Inbar BMedSc?; Ozeri, David MD†,‡; Shoenfeld, Yehuda MD?,†,§,?; Kivity, Shaye MD?,†,‡,¶,#
doi : 10.1097/RHU.0000000000001418
December 2021 - Volume 27 - Issue 8 - p e616-e621
