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Transcatheter Replacement of Transcatheter Versus Surgically Implanted Aortic Valve Bioprostheses
Uri Landes, Janarthanan Sathananthan, Guy Witberg, Ole De Backer, ... John G. Webb
doi : 10.1016/j.jacc.2020.10.053
Volume 77, Issue 1, 5–12 January 2021, Pages 1-14
Surgical aortic valve replacement and transcatheter aortic valve replacement (TAVR) are now both used to treat aortic stenosis in patients in whom life expectancy may exceed valve durability. The choice of initial bioprosthesis should therefore consider the relative safety and efficacy of potential subsequent interventions.
As Patients Live Longer, Are We on the Cusp of a New Valve Epidemic?
Anthony A. Bavry, Dharam J. Kumbhani
doi : 10.1016/j.jacc.2020.11.024
Volume 77, Issue 1, 5–12 January 2021, Pages 15-17
Association of Age With 10-Year Outcomes After Coronary Surgery in the Arterial Revascularization Trial
Mario Gaudino, Antonino Di Franco, Marcus Flather, Stephen Gerry, ... David P. Taggart
doi : 10.1016/j.jacc.2020.10.047
Volume 77, Issue 1, 5–12 January 2021, Pages 18-26
The association of age with the outcomes of bilateral internal thoracic arteries (BITAs) versus single internal thoracic arteries (SITAs) for coronary bypass grafting (CABG) remains to be determined.
Why Not Give All Patients the Opportunity to Have the Benefits of BITA Grafting??
Jennifer S. Lawton
doi : 10.1016/j.jacc.2020.11.015
Volume 77, Issue 1, 5–12 January 2021, Pages 27-28
Myocardial Fibrosis as a Predictor of Sudden Death in Patients With Coronary Artery Disease
Abbasin Zegard, Osita Okafor, Joseph de Bono, Manish Kalla, ... Francisco Leyva
doi : 10.1016/j.jacc.2020.10.046
Volume 77, Issue 1, 5–12 January 2021, Pages 29-41
The “gray zone” of myocardial fibrosis (GZF) on cardiovascular magnetic resonance may be a substrate for ventricular arrhythmias (VAs).
Risk Stratification for Sudden Death and Arrhythmias: A Role for Gadolinium-Enhanced CMR
Andrew E. Arai, Andrew J. Bradley, Arlene Sirajuddin
doi : 10.1016/j.jacc.2020.11.014
Volume 77, Issue 1, 5–12 January 2021, Pages 42-44
Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study
Jiao Luo, Saskia le Cessie, Diana van Heemst, Raymond Noordam
doi : 10.1016/j.jacc.2020.10.048
Volume 77, Issue 1, 5–12 January 2021, Pages 45-54
Previously, observational studies have identified associations between higher levels of dietary-derived antioxidants and lower risk of coronary heart disease (CHD), whereas randomized clinical trials showed no reduction in CHD risk following antioxidant supplementation.
Application of Mendelian Randomization to the Oxidative Modification Hypothesis
Gordon S. Huggins, Eli Simsolo
doi : 10.1016/j.jacc.2020.11.016
Volume 77, Issue 1, 5–12 January 2021, Pages 55-56
Calcium-Induced Autonomic Denervation in Patients With Post-Operative Atrial Fibrillation
Huishan Wang, Yuji Zhang, Fangran Xin, Hui Jiang, ... Sunny S. Po
doi : 10.1016/j.jacc.2020.10.049
Volume 77, Issue 1, 5–12 January 2021, Pages 57-67
Post-operative atrial fibrillation (POAF) is associated with worse long-term cardiovascular outcomes.
Preventing Atrial Fibrillation After Cardiac Surgery: What Matters Most
John H. Alexander
doi : 10.1016/j.jacc.2020.10.050
Volume 77, Issue 1, 5–12 January 2021, Pages 68-70
Semilunar Valve Interventions for Congenital Heart Disease: JACC State-of-the-Art Review
Brian H. Morray, Doff B. McElhinney
doi : 10.1016/j.jacc.2020.10.052
Volume 77, Issue 1, 5–12 January 2021, Pages 71-79
Transcatheter balloon valvuloplasty for the treatment of aortic and pulmonary valve stenosis was first described nearly 40 years ago. Since that time, the technique has been refined in an effort to optimize acute outcomes while reducing the long-term need for reintervention and valve replacement. Balloon pulmonary valvuloplasty is considered first-line therapy for pulmonary valve stenosis and generally results in successful relief of valvar obstruction. Larger balloon to annulus (BAR) diameter ratios can increase the risk for significant valvar regurgitation. However, the development of regurgitation resulting in right ventricular dilation and dysfunction necessitating pulmonary valve replacement is uncommon in long-term follow-up. Balloon aortic valvuloplasty has generally been the first-line therapy for aortic valve stenosis, although some contemporary studies have documented improved outcomes following surgical valvuloplasty in a subset of patients who achieve tri-leaflet valve morphology following surgical repair. Over time, progressive aortic regurgitation is common and frequently results in the need for aortic valve replacement. Neonates with critical aortic valve stenosis remain a particularly high-risk group. More contemporary data suggest that acutely achieving an aortic valve gradient <35 mm Hg with mild aortic regurgitation may improve long-term valve performance and reduce the need for valve replacement. Continued study will help to further improve outcomes and reduce the need for future reinterventions.
Transcatheter Intervention for Congenital Defects Involving the Great Vessels: JACC Review Topic of the Week
Bryan H. Goldstein, Jacqueline Kreutzer
doi : 10.1016/j.jacc.2020.11.019
Volume 77, Issue 1, 5–12 January 2021, Pages 80-96
Since the development of balloon angioplasty and balloon-expandable endovascular stent technology in the 1970s and 1980s, percutaneous transcatheter intervention has emerged as a mainstay of therapy for congenital heart disease (CHD) lesions throughout the systemic and pulmonary vascular beds. Congenital lesions of the great vessels, including the aorta, pulmonary arteries, and patent ductus arteriosus, are each amenable to transcatheter intervention throughout the lifespan, from neonate to adult. In many cases, on-label devices now exist to facilitate these therapies. In this review, we seek to describe the contemporary approach to and outcomes from transcatheter management of major CHD lesions of the great vessels, with a focus on coarctation of the aorta, single- or multiple-branch pulmonary artery stenoses, and persistent patent ductus arteriosus. We further comment on the future of transcatheter therapies for these CHD lesions.
Left-Handed Cardiology Trainees
Prashant Patel, Mandira Patel
doi : 10.1016/j.jacc.2020.11.042
Volume 77, Issue 1, 5–12 January 2021, Pages 97-101
RESPONSE: Left-Handedness as an Example of Progress
Simon Kendall
doi : 10.1016/j.jacc.2020.11.053
Volume 77, Issue 1, 5–12 January 2021, Pages 100-101
Association of Mitral Annular Disjunction With Premature Cardiac Mortality in a Large Series of Autopsies
Nan Zhou, Qianhao Zhao, Xiaofeng Zeng, Da Zheng, ... Jianding Cheng
doi : 10.1016/j.jacc.2020.10.051
Volume 77, Issue 1, 5–12 January 2021, Pages 102-104
Pitfalls of Unfractionated Heparin Use During ST-Segment Elevation Myocardial Infarction in Patients With COVID-19 Infection
Fizzah A. Choudry, Krishnaraj S. Rathod, Andreas Baumbach, Anthony Mathur, Daniel A. Jones
doi : 10.1016/j.jacc.2020.08.090
Volume 77, Issue 1, 5–12 January 2021, Page 104
Reply: Pitfalls of Unfractionated Heparin Use During ST-Segment Elevation Myocardial Infarction in Patients With COVID-19 Infection
Fizzah A. Choudry, Krishnaraj S. Rathod, Andreas Baumbach, Anthony Mathur, Daniel A. Jones
doi : 10.1016/j.jacc.2020.11.004
Volume 77, Issue 1, 5–12 January 2021, Pages 105-106
