Spotlight on the January 4 Issue

José G. Merino

doi : 10.1212/WNL.0000000000013039

vol. 98 no. 1 1-2

خرید پکیج و مشاهده آنلاین مقاله

Message From the Editors to Our Reviewers

José G. Merino, Olga Ciccarelli, Bradford B. Worrall, Anthony A. Amato, Rebecca Burch, Stacey L. Clardy, Peter Hedera, Linda A. Hershey, Barbara C. Jobst, Renée A. Shellhaas, Elizabeth Silbermann, Roy E. Strowd, Rawan Tarawneh

doi : 10.1212/WNL.0000000000013044

vol. 98 no. 1 3-11

خرید پکیج و مشاهده آنلاین مقاله

Multiple Sclerosis Diagnostic Criteria

Gary R. Cutter, Marcus W. Koch

doi : 10.1212/WNL.0000000000013014

vol. 98 no. 1 12-13

خرید پکیج و مشاهده آنلاین مقاله

Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome

Massimo Filippi, Paolo Preziosa, Alessandro Meani, Gloria Dalla Costa, Sarlota Mesaros, Jelena Drulovic, Jovana Ivanovic, Alex Rovira, Mar Tintorè, Xavier Montalban, Olga Ciccarelli, Wallace Brownlee, Katherine Miszkiel, Christian Enzinger, Michael Khalil, Frederik Barkhof, Eva M.M. Strijbis, Jette L. Frederiksen, Stig P. Cramer, Enrico Fainardi, Maria Pia Amato, Claudio Gasperini, Serena Ruggieri, Vittorio Martinelli, Giancarlo Comi, Maria A. Rocca, on behalf of the MAGNIMS Study Group

doi : 10.1212/WNL.0000000000013016

vol. 98 no. 1 e1-e14

To compare the performance of the 2017 revisions to the McDonald criteria with the 2010 McDonald criteria in establishing multiple sclerosis (MS) diagnosis and predicting prognosis in patients with clinically isolated syndrome (CIS) suggestive of MS.

خرید پکیج و مشاهده آنلاین مقاله

Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population

Milou J. Angevaare, Jet M.J. Vonk, Laiss Bertola, Laura Zahodne, Caitlin Wei-Ming Watson, Amelia Boehme, Nicole Schupf, Richard Mayeux, Mirjam I. Geerlings, Jennifer J. Manly

doi : 10.1212/WNL.0000000000013017

vol. 98 no. 1 e15-e26

To investigate sociodemographic and medical predictors of incident mild cognitive impairment (MCI) and subsequent course of MCI at follow-up, including sustained MCI diagnosis, classification as cognitively normal, and progression to dementia.

خرید پکیج و مشاهده آنلاین مقاله

Association Between Antemortem FLAIR White Matter Hyperintensities and Neuropathology in Brain Donors Exposed to Repetitive Head Impacts

Madeline Uretsky, Sylvain Bouix, Ronald J. Killiany, Yorghos Tripodis, Brett Martin, Joseph Palmisano, Asim Z. Mian, Karen Buch, Chad Farris, Daniel H. Daneshvar, Brigid Dwyer, Lee Goldstein, Douglas Katz, Christopher Nowinski, Robert Cantu, Neil Kowall, Bertrand Russell Huber, Robert A. Stern, Victor E. Alvarez, Thor D. Stein, Ann McKee, Jesse Mez, Michael L. Alosco

doi : 10.1212/WNL.0000000000013012

vol. 98 no. 1 e27-e39

Late neuropathologies of repetitive head impacts from contact sports can include chronic traumatic encephalopathy (CTE) and white matter degeneration. White matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) MRI scans are often viewed as microvascular disease from vascular risk, but might have unique underlying pathologies and risk factors in the setting of repetitive head impacts. We investigated the neuropathologic correlates of antemortem WMH in brain donors exposed to repetitive head impacts. The association between WMH and repetitive head impact exposure and informant-reported cognitive and daily function were tested.

خرید پکیج و مشاهده آنلاین مقاله

Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease

Chadwick W. Christine, R. Mark Richardson, Amber D. Van Laar, Marin E. Thompson, Elisabeth M. Fine, Omar S. Khwaja, Chunming Li, Grace S. Liang, Andreas Meier, Eiry W. Roberts, Madeline L. Pfau, Josh R. Rodman, Krystof S. Bankiewicz, Paul S. Larson

doi : 10.1212/WNL.0000000000012952

vol. 98 no. 1 e40-e50

To report final, 36-month safety and clinical outcomes from the PD-1101 trial of NBIb-1817 (VY-AADC01) in participants with moderately advanced Parkinson disease (PD) and motor fluctuations.

خرید پکیج و مشاهده آنلاین مقاله

Hemiplegic Migraine Associated With PRRT2 Variations

Florence Riant, Caroline Roos, Agathe Roubertie, Cécile Barbance, Jessica Hadjadj, Stéphane Auvin, Guillaume Baille, Marion Beltramone, Cécile Boulanger, Alice Cahn, Florina Cata, Emmanuel Cheuret, Jean-Christophe Cuvellier, Antoine Defo, Genevieve Demarquay, Anne Donnet, Nicolas Gaillard, Evelyne Massardier, Nathalie Guy, Sylvie Lamoureux, Laurence Le Moigno, Christian Lucas, Diana Ratiu, Sylvain Redon, Caroline Rey, Christel Thauvin, François Viallet, Elisabeth Tournier-Lasserve, Anne Ducros

doi : 10.1212/WNL.0000000000012947

vol. 98 no. 1 e51-e61

PRRT2 variants have been reported in a few cases of patients with hemiplegic migraine. To clarify the role of PRRT2 in familial hemiplegic migraine, we studied this gene in a large cohort of affected probands.

خرید پکیج و مشاهده آنلاین مقاله

Serum Neuron-Specific Enolase Thresholds for Predicting Postcardiac Arrest Outcome

Kartavya Sharma, Merin John, Song Zhang, Gary Gronseth

doi : 10.1212/WNL.0000000000012967

vol. 98 no. 1 e62-e72

To determine thresholds of serum neuron-specific enolase (NSE) for prediction of poor outcome after cardiac arrest with >95% specificity using a unique method of multiple thresholds meta-analysis.

خرید پکیج و مشاهده آنلاین مقاله

Fatigue in Patients With Multiple System Atrophy

Lingyu Zhang, Bei Cao, Yanbing Hou, Xiaojing Gu, Qian-Qian Wei, Ruwei Ou, Bi Zhao, Wei Song, Huifang Shang

doi : 10.1212/WNL.0000000000012968

vol. 98 no. 1 e73-e82

Nonmotor symptoms are common in patients with multiple system atrophy (MSA), but there is limited knowledge regarding fatigue in MSA. This study aimed to investigate the frequency and evolution of fatigue and the factors related to fatigue and its progression in patients with MSA at an early stage.

خرید پکیج و مشاهده آنلاین مقاله

Synaptic Damage and Its Clinical Correlates in People With Early Huntington Disease

Aline Delva, Laura Michiels, Michel Koole, Koen Van Laere, Wim Vandenberghe

doi : 10.1212/WNL.0000000000012969

vol. 98 no. 1 e83-e94

Synaptic damage has been proposed to play a major role in the pathophysiology of Huntington disease (HD), but in vivo evidence in humans is lacking. We performed a PET imaging study to assess synaptic damage and its clinical correlates in early HD in vivo.

خرید پکیج و مشاهده آنلاین مقاله

Polyneuropathy Quality Measurement Set

Brian C. Callaghan, Carmel Armon, Vera Bril, Lindsay Colbert, William S. David, David R. Del Toro, Kenneth Fink, Lyell K. Jones, Robert Kleemeier, Leslie C. MacGregor, Amy Bennett, Anant Shenoy

doi : 10.1212/WNL.0000000000013037

vol. 98 no. 1 22-30

خرید پکیج و مشاهده آنلاین مقاله

Oral and Topical Treatment of Painful Diabetic Polyneuropathy: Practice Guideline Update Summary

Raymond Price, Don Smith, Gary Franklin, Gary Gronseth, Michael Pignone, William S. David, Carmel Armon, Bruce A. Perkins, Vera Bril, Alexander Rae-Grant, John Halperin, Nicole Licking, Mary Dolan O'Brien, Scott R. Wessels, Leslie C. MacGregor, Kenneth Fink, Lawrence B. Harkless, Lindsay Colbert, Brian C. Callaghan

doi : 10.1212/WNL.0000000000013038

vol. 98 no. 1 31-43

To update the 2011 American Academy of Neurology (AAN) guideline on the treatment of painful diabetic neuropathy (PDN) with a focus on topical and oral medications and medical class effects.

خرید پکیج و مشاهده آنلاین مقاله

Training in Neurology: Resident Perception of the Utility and Applicability of Global Neurology Morning Reports

Andrew M. Agostini, Michael R. Halstead, Arun Venkatesan, Deanna R. Saylor

doi : 10.1212/WNL.0000000000012950

vol. 98 no. 1 44-47

Interest in global health is increasing among neurology residents. However, funding, time, and, recently, COVID-19 travel restrictions remain barriers to widespread participation. To meet this need, we instituted virtual global neurology morning reports with the objectives of (1) improving knowledge about neurologic diseases common in sub-Saharan Africa and (2) developing clinical reasoning skills through consideration of diagnostic and therapeutic limitations in resource-limited settings. Interactive case-based sessions were presented from Zambia via videoconference by a Johns Hopkins faculty member or Zambian neurology trainee. An anonymous cross-sectional survey was conducted among Johns Hopkins neurology residents. Of eligible participants, 69% (n = 30) completed the survey, 66% of whom were female, and 33% reported prior in-person global health experience. Although most participants did not anticipate a career in global health, the majority (85%) reported that exposure to global health was important. All but 1 participant (96%) reported satisfaction with the global neurology morning reports, with 100% reporting that they were useful to their clinical knowledge and 86% reporting that they were useful to their clinical practice. All respondents felt that morning reports should continue, and 69% ranked the educational value of the experience in the top quartile of the residency curriculum. Resident satisfaction with and perceived utility of global neurology morning reports were high, although the majority did not plan to pursue global neurology opportunities as part of their career. Remote learning opportunities may increase interest in global health among neurology residents.

خرید پکیج و مشاهده آنلاین مقاله

Clinical Reasoning: A 56-Year-Old Man With Unusual Presentation of Subacute Encephalopathy and Seizure

Tian Wang, Amy Li Safadi, Earn Chun Christabel Lee, Nathan Bicher, Brian Barry, Bilaal Sirdar, Gholam K. Motamedi, Benjamin Osborne

doi : 10.1212/WNL.0000000000012951

vol. 98 no. 1 e95-e102

خرید پکیج و مشاهده آنلاین مقاله

Teaching NeuroImage: Bilateral Nucleus Tractus Solitarius Lesions in Neurogenic Respiratory Failure

Bindu Parayil Sankaran, Saskia B. Wortman, Michel A. Willemsen, Shanti Balasubramaniam

doi : 10.1212/WNL.0000000000012614

vol. 98 no. 1 e103-e104

خرید پکیج و مشاهده آنلاین مقاله

Teaching NeuroImage: Bilateral Middle Cerebellar Peduncle Stroke in Giant Cell Arteritis

Yasmin Aghajan, Richard N. Mitchell, Shamik Bhattacharyya, Tiffany Y.-T. Hsu, Joshua P. Klein

doi : 10.1212/WNL.0000000000012953

vol. 98 no. 1 e105-e106

خرید پکیج و مشاهده آنلاین مقاله

Editors' Note: Risk of Hospitalization and Death Associated With Pimavanserin Use in Older Adults With Parkinson Disease

Aravind Ganesh, Steven Galetta

doi : 10.1212/WNL.0000000000013041

vol. 98 no. 1 48

خرید پکیج و مشاهده آنلاین مقاله

Reader Response: Risk of Hospitalization and Death Associated With Pimavanserin Use in Older Adults With Parkinson Disease

Ponni Subbiah, Dilesh Doshi, Mary Ellen Turner

doi : 10.1212/WNL.0000000000013042

vol. 98 no. 1 49

خرید پکیج و مشاهده آنلاین مقاله

Author Response: Risk of Hospitalization and Death Associated With Pimavanserin Use in Older Adults With Parkinson Disease

Y. Joseph Hwang, G. Caleb Alexander, Thomas J. Moore, Hemalkumar B. Mehta

doi : 10.1212/WNL.0000000000013043

vol. 98 no. 1 49-50

خرید پکیج و مشاهده آنلاین مقاله