دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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January 2022 Stroke Highlights
José Rafael Romero
doi : 10.1161/STROKEAHA.121.037778
Stroke. 2022;53:4
Stroke Rehabilitation Performance Measures: A Road Map to Quality Improvement
Terrie Black
doi : 10.1161/STROKEAHA.121.037020
Stroke. 2022;53:5–6
Effect of Occlusion Site on the Safety and Efficacy of Intravenous Alteplase Before Endovascular Thrombectomy: A Prespecified Subgroup Analysis of DIRECT-MT
Yu Zhou, Pengfei Xing, Zifu Li, Xiaoxi Zhang, Lei Zhang, Yongxin Zhang, Yongwei Zhang, Bo Hong, Yi Xu, Qinghai Huang, Qiang Li, Kaijun Zhao, Chao Zou, Ying Yu, Qiao Zuo, Shen Liu, Liyong Zhang, Charles B.L.M. Majoie, Yvo B.W.E.M. Roos, K.M. Treurniet, Xiaofei Ye, Ya Peng, Pengfei Yang, Jianmin Liu, and on behalf of DIRECT-MT Investigators
doi : 10.1161/STROKEAHA.121.035267
Stroke. 2022;53:7–16
Recent trials showed thrombectomy alone was comparable to bridging therapy in patients with anterior circulation large vessel occlusion eligible for both intravenous alteplase and endovascular thrombectomy. We performed this study to examine whether occlusion site modifies the effect of intravenous alteplase before thrombectomy.
Treatment Effect of Intravenous Thrombolysis Bridging to Mechanical Thrombectomy on Vessel Occlusion Site
Thanh N. Nguyen and Urs Fischer
doi : 10.1161/STROKEAHA.121.037603
Stroke. 2022;53:17–19
Efficacy of Intravenous Mesenchymal Stem Cells for Motor Recovery After Ischemic Stroke: A Neuroimaging Study
Jungsoo Lee, Won Hyuk Chang, Jong-Won Chung, Suk Jae Kim, Soo-Kyoung Kim, Jin Soo Lee, Sung-Il Sohn, Yun-Hee Kim, and Oh Young Bang
doi : 10.1161/STROKEAHA.121.034505
Stroke. 2022;53:20–28
Stem cell–based therapy is a promising approach to repair brain damage after stroke. This study was conducted to investigate changes in neuroimaging measures using stem cell–based therapy in patients with ischemic stroke.
Effects of Cilostazol and Isosorbide Mononitrate on Cerebral Hemodynamics in the LACI-1 Randomized Controlled Trial
Gordon W. Blair, Esther Janssen, Michael S. Stringer, Michael J. Thrippleton, Francesca Chappell, Yulu Shi, Iona Hamilton, Katie Flaherty, Jason P. Appleton, Fergus N. Doubal, Philip M. Bath, and Joanna M. Wardlaw
doi : 10.1161/STROKEAHA.121.034866
Stroke. 2022;53:29–33
Cerebral small vessel disease—a major cause of stroke and dementia—is associated with cerebrovascular dysfunction. We investigated whether short-term isosorbide mononitrate (ISMN) and cilostazol, alone or in combination, improved magnetic resonance imaging–measured cerebrovascular function in patients with lacunar ischemic stroke.
Endovascular Thrombectomy in Young Patients With Stroke: A MR CLEAN Registry Study
Josje Brouwer, Johanna A. Smaal, Bart J. Emmer, Inger R. de Ridder, Ido R. van den Wijngaard, Frank-Erik de Leeuw, Jeannette Hofmeijer, Wim H. van Zwam, Jasper M. Martens, Yvo B.W.E.M. Roos, Charles B. Majoie, Robert J. van Oostenbrugge, Jonathan M. Coutinho, and on behalf of the MR CLEAN Registry Investigators†
doi : 10.1161/STROKEAHA.120.034033
Stroke. 2022;53:34–42
Acute ischemic stroke due to large vessel occlusion is uncommon in young adults. We assessed stroke cause in young patients and compared their outcomes after endovascular thrombectomy with older patients.
Large Vessel Stroke in the Young: A Tale Untold
Laura Stein and Johanna T. Fifi
doi : 10.1161/STROKEAHA.121.036480
Stroke. 2022;53:43–44
Frequency and Patterns of Brain Infarction in Patients With Embolic Stroke of Undetermined Source: NAVIGATE ESUS Trial
Mukul Sharma, Eric E. Smith, Lesly A. Pearce, Ashkan Shoamanesh, Kanjana S. Perera, Shelagh B. Coutts, Dorte Damgaard, Sebastian F. Ameriso, Joung-Ho Rha, Boris Modrau, Byung-Woo Yoon, Marina Romano, Steven R. Messé, Jessica Barlinn, Johann Lambeck, Feryal Saad, Scott D. Berkowitz, Hardi Mundl, Stuart J. Connolly, and Robert G. Hart
doi : 10.1161/STROKEAHA.120.032976
Stroke. 2022;53:45–52
The spectrum of brain infarction in patients with embolic stroke of undetermined source (ESUS) has not been well characterized. Our objective was to define the frequency and pattern of brain infarcts detected by magnetic resonance imaging (MRI) among patients with recent ESUS participating in a clinical trial.
Temporal Profile of Pneumonia After Stroke
Jeroen C. de Jonge, Diederik van de Beek, Patrick Lyden, Marian C. Brady, Philip M. Bath, and H. Bart van der Worp
doi : 10.1161/STROKEAHA.120.032787
Stroke. 2022;53:53–60
The occurrence of pneumonia after stroke is associated with a higher risk of poor outcome or death. We assessed the temporal profile of pneumonia after stroke and its association with poor outcome at several time points to identify the most optimal period for testing pneumonia prevention strategies.
Added Value of a Blinded Outcome Adjudication Committee in an Open-Label Randomized Stroke Trial
Nadinda A.M. van der Ende, Bob Roozenbeek, Olvert A. Berkhemer, Peter J. Koudstaal, Jelis Boiten, Ewoud J. van Dijk, Yvo B.W.E.M. Roos, Robert J. van Oostenbrugge, Charles B.L.M. Majoie, Wim van Zwam, Hester F. Lingsma, Aad van der Lugt, and Diederik W.J. Dippel
doi : 10.1161/STROKEAHA.121.035301
Stroke. 2022;53:61–69
Blinded outcome assessment in trials with prospective randomized open blinded end point design is challenging. Unblinding can result in misclassified outcomes and biased treatment effect estimates. An outcome adjudication committee assures blinded outcome assessment, but the added value for trials with prospective randomized open blinded end point design and subjective outcomes is unknown. We aimed to assess the degree of misclassification of modified Rankin Scale (mRS) scores by a central assessor and its impact on treatment effect estimates in a stroke trial with prospective randomized open blinded end point design.
Day-by-Day Blood Pressure Variability in the Subacute Stage of Ischemic Stroke and Long-Term Recurrence
Kenji Fukuda, Ryu Matsuo, Masahiro Kamouchi, Fumi Kiyuna, Noriko Sato, Kuniyuki Nakamura, Jun Hata, Yoshinobu Wakisaka, Tetsuro Ago, Tsutomu Imaizumi, Hisashi Kai, and Takanari Kitazono
doi : 10.1161/STROKEAHA.120.033751
Stroke. 2022;53:70–78
This study aimed to determine whether variability of day-by-day blood pressure (BP) during the subacute stage of acute ischemic stroke is predictive of long-term stroke recurrence.
Atherogenic Dyslipidemia and Residual Vascular Risk After Stroke or Transient Ischemic Attack
Takao Hoshino, Kentaro Ishizuka, Sono Toi, Takafumi Mizuno, Ayako Nishimura, Shuntaro Takahashi, Sho Wako, and Kazuo Kitagawa
doi : 10.1161/STROKEAHA.121.034593
Stroke. 2022;53:79–86
Notwithstanding the current guideline-based management, patients with stroke retain a substantial risk of further vascular events. We aimed to assess the contribution of atherogenic dyslipidemia (AD) to this residual risk.
External Validation of Risk Prediction Models to Improve Selection of Patients for Carotid Endarterectomy
Michiel H.F. Poorthuis, Reinier A.R. Herings, Kirsten Dansey, Johanna A.A. Damen, Jacoba P. Greving, Marc L. Schermerhorn, and Gert J. de Borst
doi : 10.1161/STROKEAHA.120.032527
Stroke. 2022;53:87–99
The net benefit of carotid endarterectomy (CEA) is determined partly by the risk of procedural stroke or death. Current guidelines recommend CEA if 30-day risks are <6% for symptomatic stenosis and <3% for asymptomatic stenosis. We aimed to identify prediction models for procedural stroke or death after CEA and to externally validate these models in a large registry of patients from the United States.
In-Hospital Outcomes of Urgent, Early, or Late Revascularization for Symptomatic Carotid Artery Stenosis
Christina L. Cui, Hanaa Dakour-Aridi, Jinny J. Lu, Kevin S. Yei, Marc L. Schermerhorn, and Mahmoud B. Malas
doi : 10.1161/STROKEAHA.120.032410
Stroke. 2022;53:100–107
Advancements in carotid revascularization have produced promising outcomes in patients with symptomatic carotid artery stenosis. However, the optimal timing of revascularization procedures after symptomatic presentation remains unclear. The purpose of this study is to compare in-hospital outcomes of transcarotid artery revascularization (TCAR), transfemoral carotid stenting (TFCAS), or carotid endarterectomy (CEA) performed within different time intervals after most recent symptoms.
Transcarotid Artery Stenting: Hype or Hope?
Gert J. de Borst
doi : 10.1161/STROKEAHA.121.036464
Stroke. 2022;53:108–110
Prevalence and Prognostic Significance of Malnutrition Risk in Patients With Acute Ischemic Stroke: Results From the Third China National Stroke Registry
Guitao Zhang, Yuesong Pan, Runhua Zhang, Mengxing Wang, Xia Meng, Zixiao Li, Hao Li, Yilong Wang, Xingquan Zhao, Gaifen Liu, and Yongjun Wang
doi : 10.1161/STROKEAHA.121.034366
Stroke. 2022;53:111–119
To investigate the prevalence of malnutrition risk in patients with acute ischemic stroke (AIS) at admission, the association between malnutrition risk and long-term outcomes, and whether the predictive ability would be improved after adding to previous prognostic models for poor outcomes.
Multiple Chronic Conditions Explain Ethnic Differences in Functional Outcome Among Patients With Ischemic Stroke
Xiaqing Jiang, Lewis B. Morgenstern, Christine T. Cigolle, Lu Wang, Edward S. Claflin, and Lynda D. Lisabeth
doi : 10.1161/STROKEAHA.120.032595
Stroke. 2022;53:120–127
Mexican Americans (MAs) have worse stroke outcomes and a different profile of multiple chronic conditions (MCC) compared with non-Hispanic White people. MCC has implications for stroke treatment, complications, and poststroke care, which impact poststroke functional outcome (FO). We sought to assess the contribution of MCC to the ethnic difference in FO at 90 days between MAs and non-Hispanic White people.
No Racial Disparity in Outcome Measures After Endovascular Treatment for Stroke in the Elderly
Mahmoud H. Mohammaden, Diogo C. Haussen, Leonardo Pisani, Alhamza R. Al-Bayati, Nicolas Bianchi, Bernardo Liberato, Nirav Bhatt, Michael R. Frankel, and Raul G. Nogueira
doi : 10.1161/STROKEAHA.120.033537
Stroke. 2022;53:128–133
Despite the lower rates of good outcomes and higher mortality in elderly patients, age does not modify the treatment effect of mechanical thrombectomy for large vessel occlusion strokes. We aimed to study whether racial background influences the outcome after mechanical thrombectomy in the elderly population.
Risk Factor Characterization of Ischemic Stroke Subtypes Among West Africans
Fred S. Sarfo, Bruce Ovbiagele, Onoja Akpa, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Godwin Ogbole, Benedict Calys-Tagoe, Adekunle Fakunle, Taofeek Sanni, Gebregziabher Mulugeta, Salaam Abdul, Adeseye A. Akintunde, Samuel Olowookere, Ezinne O. Uvere, Philip Ibinaiye, Joshua Akinyemi, Kelechukwu Uwanuruochi, Balogun Olayemi, Olufemi A. Odunlami, Esther Abunimye, Oyedunni Arulogun, Suleiman Y. Isah, Sani A. Abubakar, Adebayo Oladimeji, Philip Adebayo, Vincent Shidali, Innocent I. Chukwuonye, Josephine Akpalu, Moyinoluwalogo M. Tito-Ilori, Osahon J. Asowata, Emmanuel O. Sanya, Ganiyu Amusa, Ugochukwu Onyeonoro, James A. Ogunmodede, Abdullateef G. Sule, Cynthia Akisanya, Yaw Mensah, Olalekan I. Oyinloye, Lambert Appiah, Atinuke M. Agunloye, Godwin O. Osaigbovo, Eunice Olabinri, Philip M. Kolo, Obiora Okeke, Abiodun M. Adeoye, Olabamiji Ajose, Carolyn Jenkins, Daniel T. Lackland, Adedeji A. Egberongbe, Olaleye Adeniji, Osimhiarherhuo Ohifemen Adeleye, Hemant K. Tiwari, Donna Arnett, Ruth Y. Laryea, Taiwo Olunuga, Kazeem S. Akinwande, Lucius Imoh, Okechukwu S. Ogah, Ezinne S. Melikam, Adeyemo Adebolaji, Wisdom Oguike, Olumayowa Ogunronbi, Wasiu Adeniyi, Obiabo Y. Olugbo, Abiodun H. Bello, Kenneth A. Ohagwu, Luqman Ogunjimi, Francis Agyekum, Henry Iheonye, Julius Adesina, Samuel Diala, Hamisu A. Dambatta, Joyce Ikubor, Arti Singh, Sheila Adamu, Vida Obese, Nathaniel Adusei, Dorcas Owusu, Michael Ampofo, Raelle Tagge, Richard Efidi, Bimbo Fawale, Joseph Yaria, Rufus Akinyemi, Mayowa Owolabi, and on behalf of SIREN See fewer authors
doi : 10.1161/STROKEAHA.120.032072
Stroke. 2022;53:134–144
To identify the qualitative and quantitative contributions of conventional risk factors for occurrence of ischemic stroke and its key pathophysiologic subtypes among West Africans.
Protective Role of Caregiver Preparedness on the Relationship Between Depression and Quality of Life in Stroke Dyads
Gianluca Pucciarelli, Karen S. Lyons, Antonello Petrizzo, Rossella Ambrosca, Silvio Simeone, Rosaria Alvaro, Christopher S. Lee, and Ercole Vellone
doi : 10.1161/STROKEAHA.120.034029
Stroke. 2022;53:145–153
Depression and quality of life (QOL) have an interdependent and transactional nature in stroke survivor-caregiver dyads. While the strong relationship between depression and physical and emotional QOL in stroke survivor-caregiver dyads is well known, it is less clear if this relationship is moderated by caregiver preparedness, which could easily be targeted with interventions. In this study, we examined the moderating role of caregiver preparedness on the association between depression and QOL in stroke survivor-caregiver dyads.
Adherence to the EAT-Lancet Diet and Risk of Stroke and Stroke Subtypes: A Cohort Study
Daniel B. Ibsen, Anne H. Christiansen, Anja Olsen, Anne Tjønneland, Kim Overvad, Alicja Wolk, Janne K. Mortensen, and Christina C. Dahm
doi : 10.1161/STROKEAHA.121.036738
Stroke. 2022;53:154–163
We investigated the association between adherence to the EAT-Lancet diet, a sustainable and mostly plant-based diet, and risk of stroke and subtypes of stroke in a Danish population. For comparison, we also investigated the Alternate Healthy Eating Index-2010 (AHEI).
Can Dietary Patterns That Support Planetary Health Benefit Population Health?
Cheryl Carcel and Cheryl Bushnell
doi : 10.1161/STROKEAHA.121.037314
Stroke. 2022;53:164–166
A Robust Deep Learning Segmentation Method for Hematoma Volumetric Detection in Intracerebral Hemorrhage
Nannan Yu, He Yu, Haonan Li, Nannan Ma, Chunai Hu, and Jia Wang
doi : 10.1161/STROKEAHA.120.032243
Stroke. 2022;53:167–176
Hematoma volume (HV) is a significant diagnosis for determining the clinical stage and therapeutic approach for intracerebral hemorrhage (ICH). The aim of this study is to develop a robust deep learning segmentation method for the fast and accurate HV analysis using computed tomography.
Treatment-Relevant Findings in Transesophageal Echocardiography After Stroke: A Prospective Multicenter Cohort Study
Götz Thomalla, Mira Upneja, Stephan Camen, Märit Jensen, Julian Schröder, Ewgenia Barow, Stefan Boskamp, Birgit Ostermeier, Sandra Kissling, Elke Leinisch, Claudia Tiburtius, Henning Clausen, Bastian Cheng, Stefan Blankenberg, Max Nedelmann, Andreas Steinbrecher, Frank Andres, Michael Rosenkranz, Christoph Sinning, Renate B. Schnabel, and Christian Gerloff
doi : 10.1161/STROKEAHA.121.034868
Stroke. 2022;53:177–184
Cardiac ultrasound to identify sources of cardioembolism is part of the diagnostic workup of acute ischemic stroke. Recommendations on whether transesophageal echocardiography (TEE) should be performed in addition to transthoracic echocardiography (TTE) are controversial. We aimed to determine the incremental diagnostic yield of TEE in addition to TTE in patients with acute ischemic stroke with undetermined cause.
Arterial Spin Labeling for the Etiological Workup of Intracerebral Hemorrhage in Children
Jean François Hak, Grégoire Boulouis, Basile Kerleroux, Sandro Benichi, Sarah Stricker, Florent Gariel, Lorenzo Garzelli, Philippe Meyer, Manoelle Kossorotoff, Nathalie Boddaert, Vincent Vidal, Nadine Girard, Volodia Dangouloff Ros, Francis Brunelle, Thomas Blauwblomme, and Olivier Naggara
doi : 10.1161/STROKEAHA.120.032690
Stroke. 2022;53:185–193
Pediatric nontraumatic intracerebral hemorrhage accounts for half of stroke in children. Early diagnostic of the causative underlying lesion is the first step toward prevention of hemorrhagic recurrence. We aimed to investigate the performance of arterial spin labeling sequence (ASL) in the acute phase etiological workup for the detection of an arteriovenous shunt (AVS: including malformation and fistula), the most frequent cause of pediatric nontraumatic intracerebral hemorrhage.
Detection of Advanced Lesions of Atherosclerosis in Carotid Arteries Using 3-Dimensional Motion-Sensitized Driven-Equilibrium Prepared Rapid Gradient Echo (3D-MERGE) Magnetic Resonance Imaging as a Screening Tool
Duygu Baylam Geleri, Hiroko Watase, Baocheng Chu, Li Chen, Huilin Zhao, Xihai Zhao, Thomas S Hatsukami, Chun Yuan, and on behalf of the CARE-II Study Collaborators
doi : 10.1161/STROKEAHA.120.032505
Stroke. 2022;53:194–200
Two-dimensional high-resolution multicontrast magnetic resonance imaging (2D-MC MRI) is currently the most reliable and reproducible noninvasive carotid vessel wall imaging technique. However, the long scan time required for 2D-MC MRI restricts its practical clinical application. Alternatively, 3-dimensional motion-sensitized driven-equilibrium prepared rapid gradient echo (3D-MERGE) vessel wall MRI can provide high isotropic resolution with extensive coverage in two minutes. In this study, we sought to prove that 3D-MERGE alone can serve as a screening tool to identify advanced carotid lesions.
Quantitative Lesion Water Uptake as Stroke Imaging Biomarker: A Tool for Treatment Selection in the Extended Time Window?
Gabriel Broocks, Andre Kemmling, Svenja Teßarek, Rosalie McDonough, Lukas Meyer, Tobias D. Faizy, Helge Kniep, Gerhard Schön, Marie Teresa Nawka, Sarah Elsayed, Noel van Horn, Bastian Cheng, Götz Thomalla, Jens Fiehler, and Uta Hanning
doi : 10.1161/STROKEAHA.120.033025
Stroke. 2022;53:201–209
Patients presenting in the extended time window may benefit from mechanical thrombectomy. However, selection for mechanical thrombectomy in this patient group has only been performed using specialized image processing platforms, which are not widely available. We hypothesized that quantitative lesion water uptake calculated in acute stroke computed tomography (CT) may serve as imaging biomarker to estimate ischemic lesion progression and predict clinical outcome in patients undergoing mechanical thrombectomy in the extended time window.
Angiographic and Hemodynamic Features in Asymptomatic Hemispheres of Patients With Moyamoya Disease
Haogeng Sun, Wanjiang Li, Chao Xia, Yutao Ren, Lu Ma, Anqi Xiao, Chao You, Yi Liu, and Rui Tian
doi : 10.1161/STROKEAHA.121.035296
Stroke. 2022;53:210–217
There is also a risk of stroke in the asymptomatic hemispheres of moyamoya disease (MMD), but it does not draw enough attention. The study investigated the differences between the three types of asymptomatic hemispheres in MMD and their associations with the two types of symptomatic hemispheres, respectively.
Complex Profiles of Cerebrovascular Disease Pathologies in the Aging Brain and Their Relationship With Cognitive Decline
Melissa Lamar, Sue Leurgans, Alifiya Kapasi, Lisa L. Barnes, Patricia A. Boyle, David A. Bennett, Konstantinos Arfanakis, and Julie A. Schneider
doi : 10.1161/STROKEAHA.121.034814
Stroke. 2022;53:218–227
Cerebrovascular disease (CVD) pathologies including vessel disease (atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy) and tissue injury (macroinfarcts and microinfarcts) each contribute to Alzheimer and other forms of dementia. CVD is often a complex mix of neuropathologies, with little known about the frequencies of differing combinations or their associations with cognition.
Long-Term Evolution of Functional Limitations in Stroke Survivors Compared With Stroke-Free Controls: Findings From 15 Years of Follow-Up Across 3 International Surveys of Aging
Andres Gil-Salcedo, Aline Dugravot, Aurore Fayosse, Louis Jacob, Mikaela Bloomberg, Séverine Sabia, and Alexis Schnitzler
doi : 10.1161/STROKEAHA.121.034534
Stroke. 2022;53:228–237
In the chronic phase 2 to 5 years poststroke, limitations in activities of daily living (ADL) and instrumental ADL (IADL) initially plateau before steady increasing. However, the impact of age and differences in initial levels of disability on the evolution of these limitations remains unclear. As such, this study aims to evaluate differences in long-term evolution of ADL/IADL limitations between stroke survivors and stroke-free population, and how limitations differ by initial level of disability for stroke survivors.
Adenosine A1R/A3R (Adenosine A1 and A3 Receptor) Agonist AST-004 Reduces Brain Infarction in a Nonhuman Primate Model of Stroke
Theodore E. Liston, Aldric Hama, Johannes Boltze, Russell B. Poe, Takahiro Natsume, Ikuo Hayashi, Hiroyuki Takamatsu, William S. Korinek, and James D. Lechleiter
doi : 10.1161/STROKEAHA.121.036396
Stroke. 2022;53:238–248
Treatment with A1R/A3R (adenosine A1 and A3 receptor) agonists in rodent models of acute ischemic stroke results in significantly reduced lesion volume, indicating activation of adenosine A1R or A3R is cerebroprotective. However, dosing and timing required for cerebroprotection has yet to be established, and whether adenosine A1R/A3R activation will lead to cerebroprotection in a gyrencephalic species has yet to be determined.
Circadian Rhythmicity in Cerebral Microvascular Tone Influences Subarachnoid Hemorrhage–Induced Injury
Darcy Lidington, Hoyee Wan, Danny D. Dinh, Chloe Ng, and Steffen-Sebastian Bolz
doi : 10.1161/STROKEAHA.121.036950
Stroke. 2022;53:249–259
Circadian rhythms influence the extent of brain injury following subarachnoid hemorrhage (SAH), but the mechanism is unknown. We hypothesized that cerebrovascular myogenic reactivity is rhythmic and explains the circadian variation in SAH-induced injury.
Impact of Strategy on Clinical Outcome in Large Vessel Occlusion Stroke Successfully Reperfused: ETIS Registry Results
Marian Douarinou, Benjamin Gory, Arturo Consoli, Bertrand Lapergue, Maeva Kyheng, Julien Labreuche, Mohammad Anadani, Raphael Blanc, Gaultier Marnat, Romain Bourcier, Igor Sibon, François Eugène, Stéphane Vannier, Gérard Audibert, Gioia Mione, and Sébastien Richard
doi : 10.1161/STROKEAHA.121.034422
Stroke. 2022;53:e1–e4
Approximately half of the patients with acute ischemic stroke due to anterior circulation large vessel occlusion do not achieve functional independence despite successful reperfusion. We aimed to determine influence of reperfusion strategy (bridging therapy, intravenous thrombolysis alone, or mechanical thrombectomy alone) on clinical outcomes in this population.
Cumulative Concussion and Odds of Stroke in Former National Football League Players
Benjamin L. Brett, Zachary Y. Kerr, Neelum T. Aggarwal, Avinash Chandran, Rebekah Mannix, Samuel Walton, J.D. DeFreese, Ruben J. Echemendia, Kevin M. Guskiewicz, Michael A. McCrea, and William P. Meehan III
doi : 10.1161/STROKEAHA.121.035607
Stroke. 2022;53:e5–e8
Postmortem and experimental studies indicate a potential association between repeated concussions and stroke risk in older contact sport athletes. We examined the relationship between concussion and stroke history in former National Football League players aged ?50 years.
One-Year Outcome After Endovascular Treatment for Acute Basilar Artery Occlusion
Fengli Li, Hongfei Sang, Jiaxing Song, Zhangbao Guo, Shuai Liu, Weidong Luo, Junjie Yuan, Zhongming Qiu, Jiacheng Huang, Luming Chen, Linyu Li, Deping Wu, Wenjie Zi, Raul Gomes Nogueira, Jie Shuai, Qingwu Yang, and for the BASILAR Investigators
doi : 10.1161/STROKEAHA.120.033658
Stroke. 2022;53:e9–e13
The BASILAR registry, a nationwide prospective nonrandomized study conducted in China, enrolled consecutive patients with acute basilar artery occlusion receiving endovascular treatment or conventional-treatment from January 2014 to May 2019. This article aimed to report the results of clinical follow-up at one year among these patients.
Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged Mice
Chen Wang, Verena Börger, Ayan Mohamud Yusuf, Tobias Tertel, Oumaima Stambouli, Florian Murke, Nico Freund, Christoph Kleinschnitz, Josephine Herz, Matthias Gunzer, Aurel Popa-Wagner, Thorsten R. Doeppner, Bernd Giebel, and Dirk M. Hermann
doi : 10.1161/STROKEAHA.121.035821
Stroke. 2022;53:e14–e18
Small extracellular vesicles (sEVs) obtained from mesenchymal stromal cells (MSCs) were shown to induce ischemic neuroprotection in mice by modulating the brain infiltration of leukocytes and, specifically polymorphonuclear neutrophils. So far, effects of MSC-sEVs were only studied in young ischemic rodents. We herein examined the effects of MSC-sEVs in aged mice.
Dual Antiplatelet Therapy Plus Argatroban Prevents Early Neurological Deterioration in Branch Atherosclerosis Disease
Jinghan Xu, Xuejun Xu, Huazedan Wang, Lanying He, Qiu Liu, Yuejun Du, and Jian Wang
doi : 10.1161/STROKEAHA.121.036356
Stroke. 2022;53:e19–e20
Advances in Stroke Recovery Therapeutics
Lorie G. Richards and Steven C. Cramer
doi : 10.1161/STROKEAHA.121.038018
Stroke. 2022;53:260–263
Advances in Stroke: Treatments-Interventional
Bruce C.V. Campbell and Thanh N. Nguyen
doi : 10.1161/STROKEAHA.121.037039
Stroke. 2022;53:264–267
Alternative Payment Models and Associations With Stroke Outcomes, Spending, and Service Utilization: A Systematic Review
Kelby Brown, Nada El Husseini, Rohan Grimley, Annemarei Ranta, Tareq Kass-Hout, Samantha Kaplan, and Brystana G. Kaufman
doi : 10.1161/STROKEAHA.121.033983
Stroke. 2022;53:268–278
Stroke contributes an estimated $28 billion to US health care costs annually, and alternative payment models aim to improve outcomes and lower spending over fee-for-service by aligning economic incentives with high value care. This systematic review evaluates historical and current evidence regarding the impacts of alternative payment models on stroke outcomes, spending, and utilization. Included studies evaluated alternative payment models in 4 categories: pay-for-performance (n=3), prospective payments (n=14), shared savings (n=5), and capitated payments (n=14). Pay-for-performance models were not consistently associated with improvements in clinical quality indicators of stroke prevention. Studies of prospective payments suggested that poststroke spending was shifted between care settings without consistent reductions in total spending. Shared savings programs, such as US Medicare accountable care organizations and bundled payments, were generally associated with null or decreased spending and service utilization and with no differences in clinical outcomes following stroke hospitalizations. Capitated payment models were associated with inconsistent effects on poststroke spending and utilization and some worsened clinical outcomes. Shared savings models that incentivize coordination of care across care settings show potential for lowering spending with no evidence for worsened clinical outcomes; however, few studies evaluated clinical or patient-reported outcomes, and the evidence, largely US-based, may not generalize to other settings.
Molecular Biomarkers and Drug Targets in Brain Arteriovenous and Cavernous Malformations: Where Are We?
Vani Venugopal and S. Sumi
doi : 10.1161/STROKEAHA.121.035654
Stroke. 2022;53:279–289
Vascular malformations of the brain (VMB) comprise abnormal development of blood vessels. A small fraction of VMBs causes hemorrhages with neurological morbidity and risk of mortality in patients. Most often, they are symptomatically silent and are detected at advanced stages of disease progression. The most common forms of VMBs are arteriovenous and cavernous malformations in the brain. Radiopathological features of these diseases are complex with high phenotypic variability. Early detection of these malformations followed by preclusion of severe neurological deficits such as hemorrhage and stroke is crucial in the clinical management of patients with VMBs. The technological advances in high-throughput omics platforms have currently infused a zest in translational research in VMBs. Besides finding novel biomarkers and therapeutic targets, these studies have withal contributed significantly to the understanding of the etiopathogenesis of VMBs. Here we discuss the recent advances in predictive and prognostic biomarker research in sporadic and familial arteriovenous malformations as well as cerebral cavernous malformations. Furthermore, we analyze the clinical applicability of protein and noncoding RNA-based molecular-targeted therapies which may have a potentially key role in disease management.
Carotid Artery Plaque Calcifications: Lessons From Histopathology to Diagnostic Imaging
Luca Saba, Valentina Nardi, Riccardo Cau, Ajay Gupta, Hooman Kamel, Jasjit S. Suri, Antonella Balestrieri, Terenzio Congiu, Anthony P.H. Butler, Steven Gieseg, Daniela Fanni, Giulia Cerrone, Roberto Sanfilippo, Josep Puig, Qi Yang, Lorenzo Mannelli, Gavino Faa, and Giuseppe Lanzino
doi : 10.1161/STROKEAHA.121.035692
Stroke. 2022;53:290–297
The role of calcium in atherosclerosis is controversial and the relationship between vascular calcification and plaque vulnerability is not fully understood. Although calcifications are present in ?50% to 60% of carotid plaques, their association with cerebrovascular ischemic events remains unclear. In this review, we summarize current understanding of carotid plaque calcification. We outline the role of calcium in atherosclerotic carotid disease by analyzing laboratory studies and histopathologic studies, as well as imaging findings to understand clinical implications of carotid artery calcifications. Differences in mechanism of calcium deposition express themselves into a wide range of calcification phenotypes in carotid plaques. Some patterns, such as rim calcification, are suggestive of plaques with inflammatory activity with leakage of the vasa vasourm and intraplaque hemorrhage. Other patterns such as dense, nodular calcifications may confer greater mechanical stability to the plaque and reduce the risk of embolization for a given degree of plaque size and luminal stenosis. Various distributions and patterns of carotid plaque calcification, often influenced by the underlying systemic pathological condition, have a different role in affecting plaque stability. Modern imaging techniques afford multiple approaches to assess geometry, pattern of distribution, size, and composition of carotid artery calcifications. Future investigations with these novel technologies will further improve our understanding of carotid artery calcification and will play an important role in understanding and minimizing stroke risk in patients with carotid plaques.
Vessels Sing Their ARIAs: The Role of Vascular Amyloid in the Age of Aducanumab
Lukas Sveikata, Andreas Charidimou, and Anand Viswanathan
doi : 10.1161/STROKEAHA.121.036873
Stroke. 2022;53:298–302
We review the implications of the recently approved aducanumab amyloid-? immunotherapy for treating Alzheimer disease with comorbid cerebral amyloid angiopathy. In clinical trials, amyloid-? immunotherapy has been associated with a high rate of amyloid-related imaging abnormalities, potentially driven by coexisting cerebral amyloid angiopathy. Therefore, immunotherapy’s efficacy in patients may be modified by coexisting cerebrovascular pathology. We discuss the contributions of cerebral amyloid angiopathy on the development of amyloid-related imaging abnormalities and propose strategies to identify cerebral amyloid angiopathy in patients considered for immunotherapy.
European Stroke Organisation Conference 2021 Plenary Highlights
Ho-Yan Yvonne Chun, Tolga Dittrich, Halvor Øygarden, and Linxin Li
doi : 10.1161/STROKEAHA.121.037634
Stroke. 2022;53:e21–e22
Paid Parental Leave: Different Scenarios Around the World
Ana Claudia de Souza, Leonardo Augusto Carbonera, and Eva Rocha
doi : 10.1161/STROKEAHA.121.035919
Stroke. 2022;53:e23–e25
Bow Hunter’s Syndrome
Robert W. Regenhardt, Mariel G. Kozberg, Adam A. Dmytriw, Justin E. Vranic, Christopher J. Stapleton, Scott B. Silverman, and Aman B. Patel
doi : 10.1161/STROKEAHA.121.037253
Stroke. 2022;53:e26–e29
