R. Alta Charo, J.D.
doi : 10.1056/NEJMp2114886
N Engl J Med 2021; 385:1441-1443
Katie Moran-McCabe, J.D., and Scott Burris, J.D.
doi : 10.1056/NEJMp2031947
N Engl J Med 2021; 385:1443-1445
Mirat Shah, M.D., Atiqur Rahman, Ph.D., Marc R. Theoret, M.D., and Richard Pazdur, M.D.
doi : 10.1056/NEJMp2109826
N Engl J Med 2021; 385:1445-1447
Stefan D. Anker, M.D., Ph.D., Javed Butler, M.D., Gerasimos Filippatos, M.D., Ph.D., João P. Ferreira, M.D., Edimar Bocchi, M.D., Michael Böhm, M.D., Ph.D., Hans-Peter Brunner–La Rocca, M.D., Dong-Ju Choi, M.D., Vijay Chopra, M.D., Eduardo Chuquiure-Valenzuela, M.D., Nadia Giannetti, M.D., Juan Esteban Gomez-Mesa, M.D., Stefan Janssens, M.D., Ph.D., James L. Januzzi, M.D., Jose R. Gonzalez-Juanatey, M.D., Bela Merkely, M.D., Stephen J. Nicholls, M.D., Sergio V. Perrone, M.D., Ileana L. Piña, M.D., Piotr Ponikowski, M.D., Michele Senni, M.D., David Sim, M.D., Jindrich Spinar, M.D., Iain Squire, M.D., Stefano Taddei, M.D., Hiroyuki Tsutsui, M.D., Subodh Verma, M.D., Dragos Vinereanu, M.D., Jian Zhang, M.D., Ph.D., Peter Carson, M.D., Carolyn Su Ping Lam, M.D., Nikolaus Marx, M.D., Cordula Zeller, Dipl.Math., Naveed Sattar, M.D., Waheed Jamal, M.D., Sven Schnaidt, M.Sc., Janet M. Schnee, M.D., Martina Brueckmann, M.D., Stuart J. Pocock, Ph.D., Faiez Zannad, M.D., Ph.D., and Milton Packer, M.D. for the EMPEROR-Preserved Trial Investigators*
doi : 10.1056/NEJMoa2107038
N Engl J Med 2021; 385:1451-1461
Sodium–glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure in patients with heart failure and a reduced ejection fraction, but their effects in patients with heart failure and a preserved ejection fraction are uncertain.
Linmarie Sikich, M.D., Alexander Kolevzon, M.D., Bryan H. King, M.D., Christopher J. McDougle, M.D., Kevin B. Sanders, M.D., Soo-Jeong Kim, M.D., Marina Spanos, Ph.D., Tara Chandrasekhar, M.D., M.D. Pilar Trelles, M.D., Carol M. Rockhill, M.D., Michelle L. Palumbo, M.D., Allyson Witters Cundiff, M.D., Alicia Montgomery, M.B., B.S., Paige Siper, Ph.D., Mendy Minjarez, Ph.D., Lisa A. Nowinski, Ph.D., Sarah Marler, M.A., Lauren C. Shuffrey, Ph.D., Cheryl Alderman, B.S., Jordana Weissman, B.A., Brooke Zappone, B.S., Jennifer E. Mullett, R.N., Hope Crosson, B.S.W., Natalie Hong, M.S., Stephen K. Siecinski, B.S., Stephanie N. Giamberardino, Sc.M., Sheng Luo, Ph.D., Lilin She, Ph.D., Manjushri Bhapkar, M.S., Russell Dean, M.S., Abby Scheer, M.S.I.S., Jacqueline L. Johnson, Dr.P.H., Simon G. Gregory, Ph.D., and Jeremy Veenstra-VanderWeele, M.D.
doi : 10.1056/NEJMoa2103583
N Engl J Med 2021; 385:1462-1473
Experimental studies and small clinical trials have suggested that treatment with intranasal oxytocin may reduce social impairment in persons with autism spectrum disorder. Oxytocin has been administered in clinical practice to many children with autism spectrum disorder.
Moriah Bergwerk, M.B., B.S., Tal Gonen, B.A., Yaniv Lustig, Ph.D., Sharon Amit, M.D., Marc Lipsitch, Ph.D., Carmit Cohen, Ph.D., Michal Mandelboim, Ph.D., Einav Gal Levin, M.D., Carmit Rubin, N.D., Victoria Indenbaum, Ph.D., Ilana Tal, R.N., Ph.D., Malka Zavitan, R.N., M.A., Neta Zuckerman, Ph.D., Adina Bar-Chaim, Ph.D., Yitshak Kreiss, M.D., and Gili Regev-Yochay, M.D.
doi : 10.1056/NEJMoa2109072
N Engl J Med 2021; 385:1474-1484
Despite the high efficacy of the BNT162b2 messenger RNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rare breakthrough infections have been reported, including infections among health care workers. Data are needed to characterize these infections and define correlates of breakthrough and infectivity.
Terence Nolan, M.B., B.S., Ph.D., Alexandre C. Fortanier, Ph.D., Brett Leav, M.D., Airi Põder, M.D., Lulu C. Bravo, M.D., Henryk T. Szyma?ski, M.D., Marten Heeringa, Ph.D., Wim Vermeulen, Ph.D., Vince Matassa, Ph.D., Igor Smolenov, M.D., Ph.D., and Jonathan M. Edelman, M.D.
doi : 10.1056/NEJMoa2024848
N Engl J Med 2021; 385:1485-1495
Cell-culture–derived influenza vaccines may enable a closer antigenic match to circulating strains of influenza virus by avoiding egg-adapted mutations.
George R. Thompson, III, M.D., and Jo-Anne H. Young, M.D.
doi : 10.1056/NEJMra2027424
N Engl J Med 2021; 385:1496-1509
David Hao, M.D., Daniel Saddawi-Konefka, M.D., Sarah Low, M.D., Paul Alfille, M.D., and Keith Baker, M.D., Ph.D.
doi : 10.1056/NEJMvcm2026684
N Engl J Med 2021; 385:e52
Lakshman Meena, M.D., and Ranjan Gupta, M.D., D.M.
doi : 10.1056/NEJMicm2103503
N Engl J Med 2021; 385:1510
Yi-Wei Lee, M.D., and Hsin-Yi Liu, M.D.
doi : 10.1056/NEJMicm2104629
N Engl J Med 2021; 385:e53
Hanno Hock, M.D., Ph.D., Hillary R. Kelly, M.D., Eric A. Meyerowitz, M.D., Matthew J. Frigault, M.D., and Lucas R. Massoth, M.D.
doi : 10.1056/NEJMcpc2027096
N Engl J Med 2021; 385:1511-1520
Mark H. Drazner, M.D.
doi : 10.1056/NEJMe2113008
N Engl J Med 2021; 385:1522-1524
Daniel H. Geschwind, M.D., Ph.D.
doi : 10.1056/NEJMe2110158
N Engl J Med 2021; 385:1524-1525
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Katherine J. Wu, Ph.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2115837
N Engl J Med 2021; 385:e66
Satchit Balsari, M.D., M.P.H., Mathew V. Kiang, Sc.D., and Caroline O. Buckee, D.Phil.
doi : 10.1056/NEJMms2104654
N Engl J Med 2021; 385:1526-1530
doi : 10.1056/NEJMc2112411
N Engl J Med 2021; 385:1531-1533
doi : 10.1056/NEJMc2113891
N Engl J Med 2021; 385:1533-1535
doi : 10.1056/NEJMc2113516
N Engl J Med 2021; 385:1535-1536
doi : 10.1056/NEJMc2113384
N Engl J Med 2021; 385:e55
doi : 10.1056/NEJMc2110095
N Engl J Med 2021; 385:e56
doi : 10.1056/NEJMc2112688
N Engl J Med 2021; 385:e57
doi : 10.1056/NEJMx210016
N Engl J Med 2021; 385:1536
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