دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Using Policy Tools to Improve Population Health — Combating the U.S. Opioid Crisis
Colleen L. Barry, Ph.D., M.P.P., and Brendan Saloner, Ph.D.
doi : 10.1056/NEJMp2102323
N Engl J Med 2021; 385:2113-2116
Decarbonizing the U.S. Health Sector — A Call to Action
Victor J. Dzau, M.D., Rachel Levine, M.D., George Barrett, M.B.A., and Andrew Witty, B.A.
doi : 10.1056/NEJMp2115675
N Engl J Med 2021; 385:2117-2119
Is It Finally Time for a Medicare Dental Benefit?
Lisa Simon, M.D., D.M.D., and William V. Giannobile, D.D.S., D.M.Sc.
doi : 10.1056/NEJMp2115048
N Engl J Med 2021; 385:e80
Randomized Trial of Cytoreductive Surgery for Relapsed Ovarian Cancer
Philipp Harter, M.D., Ph.D., Jalid Sehouli, M.D., Ph.D., Ignace Vergote, M.D., Ph.D., Gwenael Ferron, M.D., Ph.D., Alexander Reuss, M.Sc., Werner Meier, M.D., Ph.D., Stefano Greggi, M.D., Ph.D., Berit J. Mosgaard, M.D., Ph.D., Frederic Selle, M.D., Ph.D., Frédéric Guyon, M.D., Ph.D., Christophe Pomel, M.D., Ph.D., Fabrice Lécuru, M.D., Ph.D., Rongyu Zang, M.D., Ph.D., Elisabeth Avall-Lundqvist, M.D., Ph.D., Jae-Weon Kim, M.D., Ph.D., Jordi Ponce, M.D., Ph.D., Francesco Raspagliesi, M.D., Ph.D., Gunnar Kristensen, M.D., Ph.D., Jean-Marc Classe, M.D., Ph.D., Peter Hillemanns, M.D., Ph.D., Pernille Jensen, M.D., Ph.D., Annette Hasenburg, M.D., Ph.D., Sadaf Ghaem-Maghami, M.D., Ph.D., Mansoor R. Mirza, M.D., Ph.D., Bente Lund, M.D., Ph.D., Alexander Reinthaller, M.D., Ph.D., Ana Santaballa, M.D., Ph.D., Adeola Olaitan, M.D., Ph.D., Felix Hilpert, M.D., Ph.D., and Andreas du Bois, M.D., Ph.D. for the DESKTOP III Investigators*
doi : 10.1056/NEJMoa2103294
N Engl J Med 2021; 385:2123-2131
Treatment for patients with recurrent ovarian cancer has been mainly based on systemic therapy. The role of secondary cytoreductive surgery is unclear.
Myocarditis after Covid-19 Vaccination in a Large Health Care Organization
Guy Witberg, M.D., Noam Barda, M.D., Ph.D., Sara Hoss, M.D., Ilan Richter, M.D., M.P.H., Maya Wiessman, M.D., Yaron Aviv, M.D., Tzlil Grinberg, M.D., Oren Auster, M.Sc., Noa Dagan, M.D., Ph.D., M.P.H., Ran D. Balicer, M.D., Ph.D., M.P.H., and Ran Kornowski, M.D.
doi : 10.1056/NEJMoa2110737
N Engl J Med 2021; 385:2132-2139
Reports have suggested an association between the development of myocarditis and the receipt of messenger RNA (mRNA) vaccines against coronavirus disease 2019 (Covid-19), but the frequency and severity of myocarditis after vaccination have not been extensively explored.
Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel
Dror Mevorach, M.D., Emilia Anis, M.D., M.P.H., Noa Cedar, M.P.H., Michal Bromberg, M.D., M.P.H., Eric J. Haas, M.D., M.S.C.E., Eyal Nadir, M.D., Sharon Olsha-Castell, M.D., Dana Arad, R.N., M.S.N., Tal Hasin, M.D., Nir Levi, M.D., Rabea Asleh, M.D., Ph.D., Offer Amir, M.D., Karen Meir, M.D., Dotan Cohen, M.D., Rita Dichtiar, M.P.H., Deborah Novick, M.Sc., Yael Hershkovitz, M.Sc., Ron Dagan, M.D., Iris Leitersdorf, M.D., M.H.A., Ronen Ben-Ami, M.D., Ian Miskin, M.D., Walid Saliba, M.D., M.P.H., Khitam Muhsen, Ph.D., Yehezkel Levi, M.D., Manfred S. Green, M.B., Ch.B., Ph.D., Lital Keinan-Boker, M.D., Ph.D., and Sharon Alroy-Preis, M.D., M.P.H.
doi : 10.1056/NEJMoa2109730
N Engl J Med 2021; 385:2140-2149
Approximately 5.1 million Israelis had been fully immunized against coronavirus disease 2019 (Covid-19) after receiving two doses of the BNT162b2 messenger RNA vaccine (Pfizer–BioNTech) by May 31, 2021. After early reports of myocarditis during adverse events monitoring, the Israeli Ministry of Health initiated active surveillance.
Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR
Nicolas M. Van Mieghem, M.D., Ph.D., Martin Unverdorben, M.D., Ph.D., Christian Hengstenberg, M.D., Helge Möllmann, M.D., Roxana Mehran, M.D., Diego López-Otero, M.D., Ph.D., Luis Nombela-Franco, M.D., Ph.D., Raul Moreno, M.D., Ph.D., Peter Nordbeck, M.D., Holger Thiele, M.D., Irene Lang, M.D., José L. Zamorano, M.D., Fayaz Shawl, M.D., Masanori Yamamoto, M.D., Ph.D., Yusuke Watanabe, M.D., Ph.D., Kentaro Hayashida, M.D., Ph.D., Rainer Hambrecht, M.D., Felix Meincke, M.D., Pascal Vranckx, M.D., Ph.D., James Jin, Ph.D., Eric Boersma, Ph.D., Josep Rodés-Cabau, M.D., Patrick Ohlmann, M.D., Ph.D., Piera Capranzano, M.D., Ph.D., Hyo-Soo Kim, M.D., Ph.D., Thomas Pilgrim, M.D., Richard Anderson, M.D., Usman Baber, M.D., Anil Duggal, M.D., Petra Laeis, Ph.D., Hans Lanz, M.D., Cathy Chen, M.D., Marco Valgimigli, M.D., Ph.D., Roland Veltkamp, M.D., Shigeru Saito, M.D., and George D. Dangas, M.D., Ph.D. for the ENVISAGE-TAVI AF Investigators*
doi : 10.1056/NEJMoa2111016
N Engl J Med 2021; 385:2150-2160
The role of direct oral anticoagulants as compared with vitamin K antagonists for atrial fibrillation after successful transcatheter aortic-valve replacement (TAVR) has not been well studied.
Milvexian for the Prevention of Venous Thromboembolism
Jeffrey I. Weitz, M.D., John Strony, M.D., Walter Ageno, M.D., David Gailani, M.D., Elaine M. Hylek, M.D., Michael R. Lassen, M.D., Kenneth W. Mahaffey, M.D., Ravi S. Notani, M.B.A., Robin Roberts, M.S., Annelise Segers, M.D., and Gary E. Raskob, Ph.D. for the AXIOMATIC-TKR Investigators*
doi : 10.1056/NEJMoa2113194
N Engl J Med 2021; 385:2161-2172
Factor XIa inhibitors for the prevention and treatment of venous and arterial thromboembolism may be more effective and result in less bleeding than conventional anticoagulants. Additional data are needed regarding the efficacy and safety of milvexian, an oral factor XIa inhibitor.
REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19
David M. Weinreich, M.D., Sumathi Sivapalasingam, M.D., Thomas Norton, M.D., Shazia Ali, Pharm.D., Haitao Gao, Ph.D., Rafia Bhore, Ph.D., Jing Xiao, Ph.D., Andrea T. Hooper, Ph.D., Jennifer D. Hamilton, Ph.D., Bret J. Musser, Ph.D., Diana Rofail, Ph.D., Mohamed Hussein, Ph.D., Joseph Im, B.S., Dominique Y. Atmodjo, B.A., Christina Perry, M.B.A., Cynthia Pan, B.Pharm., Adnan Mahmood, M.D., Romana Hosain, M.D., M.P.H., John D. Davis, Ph.D., Kenneth C. Turner, Ph.D., Alina Baum, Ph.D., Christos A. Kyratsous, Ph.D., Yunji Kim, Pharm.D., Amanda Cook, B.S., Dip.Reg.Aff., Wendy Kampman, M.D., Lilia Roque-Guerrero, M.D., Gerard Acloque, M.D., Hessam Aazami, M.D., Kevin Cannon, M.D., J. Abraham Simón-Campos, M.D., Joseph A. Bocchini, M.D., Bari Kowal, M.S., A. Thomas DiCioccio, Ph.D., Yuhwen Soo, Ph.D., Gregory P. Geba, M.D., Dr.P.H., Neil Stahl, Ph.D., Leah Lipsich, Ph.D., Ned Braunstein, M.D., Gary Herman, M.D., and George D. Yancopoulos, M.D., Ph.D. for the Trial Investigators*
doi : 10.1056/NEJMoa2108163
N Engl J Med 2021; 385:e81
In the phase 1–2 portion of an adaptive trial, REGEN-COV, a combination of the monoclonal antibodies casirivimab and imdevimab, reduced the viral load and number of medical visits in patients with coronavirus disease 2019 (Covid-19). REGEN-COV has activity in vitro against current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.
Spontaneous Intracranial Hypotension
Wouter I. Schievink, M.D.
doi : 10.1056/NEJMra2101561
N Engl J Med 2021; 385:2173-2178
Morel–Lavallée Lesion
Young-Hoon Kim, M.D., Ph.D., and Hyung-Youl Park, M.D.
doi : 10.1056/NEJMicm2111332
N Engl J Med 2021; 385:2179
Ectopic Tooth in the Nose
Sagar Khanna, B.D.S., D.D.S., and Michael Turner, D.D.S., M.D.
doi : 10.1056/NEJMicm2112363
N Engl J Med 2021; 385:e82
A “Fluid” Diagnosis
Owen Albin, M.D., John P. Mills, M.D., Sanjay Saint, M.D., M.P.H., Michele Swanson, Ph.D., and Jane C. Deng, M.D.
doi : 10.1056/NEJMcps2108991
N Engl J Med 2021; 385:2180-2185
Recurrent Ovarian Cancer — Sculpting a Promising Future with Surgery
Ginger J. Gardner, M.D., and Dennis S. Chi, M.D.
doi : 10.1056/NEJMe2116353
N Engl J Med 2021; 385:2187-2188
Receipt of mRNA Vaccine against Covid-19 and Myocarditis
Alida L.P. Caforio, M.D., Ph.D.
doi : 10.1056/NEJMe2116493
N Engl J Med 2021; 385:2189-2190
Audio Interview: The Omicron Variant of SARS-CoV-2
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Salim S. Abdool Karim, M.B., Ch.B., Ph.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2118839
N Engl J Med 2021; 385:e96
Predicting Proteome-Scale Protein Structure with Artificial Intelligence
Stephen K. Burley, M.D., D.Phil., Wadih Arap, M.D., Ph.D., and Renata Pasqualini, Ph.D.
doi : 10.1056/NEJMcibr2113027
N Engl J Med 2021; 385:2191-2194
BNT162b2 and ChAdOx1 nCoV-19 Vaccine Effectiveness against Death from the Delta Variant
doi : 10.1056/NEJMc2113864
N Engl J Med 2021; 385:2195-2197
Toxic Effects from Ivermectin Use Associated with Prevention and Treatment of Covid-19
doi : 10.1056/NEJMc2114907
N Engl J Med 2021; 385:2197-2198
Benefits and Risks of Iron Interventions in Infants in Bangladesh
doi : 10.1056/NEJMc2116125
N Engl J Med 2021; 385:2198-2199
Mycophenolate Mofetil for Immune Thrombocytopenia
doi : 10.1056/NEJMc2115772
N Engl J Med 2021; 385:2200-2202
Convalescent Plasma for Outpatients with Covid-19
doi : 10.1056/NEJMc2114591
N Engl J Med 2021; 385:2205-2207
Triple Therapy for Cystic Fibrosis Phe508del–Gating and –Residual Function Genotypes
doi : 10.1056/NEJMc2115966
N Engl J Med 2021; 385:2207-2208
