دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Understanding the natural selection of human embryos: Blastocyst quality modulates the inflammatory response during the peri-implantation period
Laura Fernández,Esteban Grasso,Elizabeth Soczewski,Soledad Gori,Guillermina Calo,Vanesa Hauk,Florencia Sabbione,Lucila Gallino,Gustavo Martínez,Marcela Irigoyen,Yesica Bestach,Claudia Pérez Leirós,Rosanna Ramhorst
doi : 10.1111/aji.13423
Volume 87, Issue 1 e13423
Decidualized cells display an active role during embryo implantation sensing blastocyst quality, allowing the implantation of normal developed blastocysts and preventing the invasion of impaired developed ones. Here, we characterized the immune microenvironment generated by decidualized cells in response to soluble factors secreted by blastocysts that shape the receptive milieu.
Reduced innate lymphoid cells in the endometrium of women with endometriosis
Takuya Sugahara,Yukiko Tanaka,Masahide Hamaguchi,Maya Fujii,Koki Shimura,Kanae Ogawa,Taisuke Mori,Izumi Kusuki,Michiaki Fukui,Jo Kitawaki
doi : 10.1111/aji.13502
Volume 87, Issue 1 e13502
Innate lymphoid cells (ILCs), a recently discovered family of innate immune cells, are responsible for the early immune response, and control both innate and adapted immune system via cytokine secretion. The role of ILCs in endometriosis has not been investigated; therefore, here, we aimed to investigate how the proportion of ILCs changes in endometriosis.
A review of key cytokines based on gene polymorphism in the pathogenesis of pre-eclampsia
Chengcheng Guan,Fei Zhao,Zhencui Yang,Qian Tang,Ling Wang,Xueli Li,Lixia Zhang,Ziwen Deng,Huabin Hou,Jingli Wang,Yinglei Xu,Ru Zhang,Yan Lin,Ping Tan,Yan Zhang,Shiguo Liu,Lu Zhang
doi : 10.1111/aji.13503
Volume 87, Issue 1 e13503
Although a number of theories have been suggested, including roles for oxidative stress, an abnormal maternal-fetal interface, and genetic and environmental factors, the etiopathology of pre-eclampsia (PE) remains unclear. Maternal immune tolerance is important for maintaining pregnancy, and researchers have increasingly focused on the critical roles of cytokines in the pathogenesis of PE in recent years. The assessment of candidate genetic polymorphisms in PE could partially elucidate the mechanisms of susceptibility to disease, and contribute to seeking for new diagnosis and treatment methods of PE. PE can lead to severe complications, and even the death of both mother and fetus. Although the complex pathology is not yet clear, some evidence suggested that the occurrence of PE is related to inflammatory factors. We reviewed the current understandings of roles of cytokines in PE, and provided an extensive overview of the role of single nucleotide chain polymorphisms (SNPs) in the genes potentially underlying the pathophysiology of PE.
Longitudinal profile of sHLA-G during pregnancy and its association with small for gestational age births in North Indian pregnant females: A nested case-control study
Shilpi Sehgal,Sushrut Vyawhare,Shinjini Bhatnagar,Pallavi Kshetrapal,GARBH-Ini study group
doi : 10.1111/aji.13504
Volume 87, Issue 1 e13504
Small for gestational age (SGA) neonates are vulnerable to various long and short-term adverse health consequences. The expression of HLA-G in the placenta is crucial for establishment and maintenance of pregnancy. Its aberrant expression could lead to perturbed immunological interactions in the placenta which could be associated with SGA births. The objective of this study was to assess the difference in the trajectories of soluble HLA-G in maternal sera during pregnancy between women delivering SGA and appropriate for gestational age (AGA) neonates.
Glucose/insulin metabolism and vitamin D in women with recurrent pregnancy loss
Silvia D'Ippolito,Anna Capozzi,Giovanni Scambia,Roberto Sorge,Stefano Lello,Nicoletta Di Simone
doi : 10.1111/aji.13505
Volume 87, Issue 1 13505
Glucose/insulin metabolism has been related to recurrent pregnancy loss (RPL) through mechanisms not really clarified. Also, vitamin D deficiency seems to be associated to RPL. The purpose of our study was to evaluate the correlation between glucose/insulin metabolism parameters and vitamin D levels in women with history of RPL.
Circ_0037078 promotes trophoblast cell proliferation, migration, invasion and angiogenesis by miR-576-5p/IL1RAP axis
Hong Zou,Qinghua Mao
doi : 10.1111/aji.13507
Volume 87, Issue 1 e13507
Preeclampsia (PE) is a common hypertensive disorder of pregnancy. Recent studies have suggested that circular RNAs (circRNAs) play a pathological role in PE. Herein, this study aimed to investigate the action and mechanism of circ_0037078 in PE process.
Advancing research on recurrent pregnancy loss: Overcoming obstacles and opportunities for translation
Guillermina Girardi,Andrew A. Bremer
doi : 10.1111/aji.13508
Volume 87, Issue 1 e13508
Recurrent pregnancy loss (RPL) is one of the most complex and challenging scenarios in reproductive medicine. New theories about the mechanisms behind RPL have recently emerged, highlighting the multifactorial nature of this serious pregnancy complication. Unfortunately, these preclinical observations are rarely validated in the human scenario, where treatment remains ineffective and empirical. New technologies such as organoids, organ-on-a-chip, and 3D printing can be used to characterize the molecular cross talk between the uterine environment with its unique inflammatory cells and the developing embryo. Understanding the mechanisms behind RPL and identifying mediators and effectors and validating these targets for prevention and therapy in humans will have a profound impact on women's health.
Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome
Juan J. Fierro,Manuela Velásquez,Angela P. Cadavid,Karina de Leeuw
doi : 10.1111/aji.13509
Volume 87, Issue 1 e13509
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by venous, arterial, or small-vessel thrombosis and/or pregnancy-related morbidity, associated with persistent positivity of antiphospholipid antibodies (aPL). Pregnancy-related morbidity in APS patients is characterized by unexplained fetal deaths, premature birth of morphologically normal newborns, and/or consecutive pregnancy losses before the 10th week of gestation. Beta 2-glycoprotein 1 (ß2GP1) is the main antigen recognized by aPL and plays an essential role in the pathogenesis of APS. Antibodies against ß2GP1 (aß2GP1) are involved in damage-generating mechanisms in APS due to their interaction with trophoblasts, decidua, and endothelial cells. aß2GP1 might be used as a prognostic tool for obstetric risk stratification and ß2GP1 could be a target for molecular-targeted treatment to prevent pregnancy morbidity in APS. This review describes these aspects of aß2GP1, including effects on different cellular targets, its association with the severity of obstetric manifestations and the potential of ß2GP1-targeted therapies for APS.
Uncomplicated oocyte donation pregnancies display an elevated CD163-positive type 2 macrophage load in the decidua, which is associated with fetal-maternal HLA mismatches
Xuezi Tian,Kaveri T. S. Aiyer,Johanna M. Kapsenberg,Dave L. Roelen,Marie-Louise van der Hoorn,Michael Eikmans
doi : 10.1111/aji.13511
Volume 87, Issue 1 e13511
The embryo of an oocyte donation (OD) pregnancy is completely allogeneic to the mother, which may challenge the maternal immune system to tolerize the fetus. Decidual macrophages are essential in maintaining a healthy pregnancy, and type 2 macrophages may exhibit immune suppressive activity. We hypothesized that the composition of decidual macrophages is different between uncomplicated OD pregnancies and non-OD in vitro fertilization (IVF) pregnancies, and is related to fetal-maternal incompatibility.
Interaction among extracellular nicotinamide phosphoribosyltransferase, toll-like receptor-4, and inflammatory cytokines in pre-eclampsia
Priscila R. Nunes,Carla S. Ceron,Marcelo R. Luizon,Valeria C. Sandrim
doi : 10.1111/aji.13514
Volume 87, Issue 1 e13514
