دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Extracorporeal membrane oxygenation for COVID-19 and influenza H1N1 associated acute respiratory distress syndrome: a multicenter retrospective cohort study
Vito Fanelli, Marco Giani, Giacomo Grasselli, Francesco Mojoli, Gennaro Martucci, Lorenzo Grazioli, Francesco Alessandri, Silvia Mongodi, Gabriele Sales, Giorgia Montrucchio, Costanza Pizzi, Lorenzo Richiardi, Luca Lorini, Antonio Arcadipane, Antonio Pesenti, Giuseppe Foti, Nicolò Patroniti, Luca Brazzi & VMarco Ranieri
doi : 10.1186/s13054-022-03906-4
Critical Care volume 26, Article number: 34 (2022)
Extracorporeal membrane oxygenation (ECMO) has become an established rescue therapy for severe acute respiratory distress syndrome (ARDS) in several etiologies including influenza A H1N1 pneumonia. The benefit of receiving ECMO in coronavirus disease 2019 (COVID-19) is still uncertain. The aim of this analysis was to compare the outcome of patients who received veno-venous ECMO for COVID-19 and Influenza A H1N1 associated ARDS.
Detection of cerebral hypoperfusion with a dynamic hyperoxia test using brain oxygenation pressure monitoring
Thomas Gargadennec, Gioconda Ferraro, Rudy Chapusette, Xavier Chapalain, Elisa Bogossian, Morgane Van Wettere, Lorenzo Peluso, Jacques Creteur, Olivier Huet, Niloufar Sadeghi & Fabio Silvio Taccone
doi : 10.1186/s13054-022-03918-0
Critical Care volume 26, Article number: 35 (2022)
Brain multimodal monitoring including intracranial pressure (ICP) and brain tissue oxygen pressure (PbtO2) is more accurate than ICP alone in detecting cerebral hypoperfusion after traumatic brain injury (TBI). No data are available for the predictive role of a dynamic hyperoxia test in brain-injured patients from diverse etiology.
Multidimensional analysis of the host response reveals prognostic and pathogen-driven immune subtypes among adults with sepsis in Uganda
Matthew J. Cummings, Barnabas Bakamutumaho, Adam Price, Nicholas Owor, John Kayiwa, Joyce Namulondo, Timothy Byaruhanga, Moses Muwanga, Christopher Nsereko, Stephen Sameroff, Rafal Tokarz, Wai Wong, Shivang S. Shah, Michelle H. Larsen, W. Ian Lipkin, Julius J. Lutwama & Max R. O’Donnell
doi : 10.1186/s13054-022-03907-3
Critical Care volume 26, Article number: 36 (2022)
The global burden of sepsis is concentrated in sub-Saharan Africa, where severe infections disproportionately affect young, HIV-infected adults and high-burden pathogens are unique. In this context, poor understanding of sepsis immunopathology represents a crucial barrier to development of locally-effective treatment strategies. We sought to determine inter-individual immunologic heterogeneity among adults hospitalized with sepsis in a sub-Saharan African setting, and characterize associations between immune subtypes, infecting pathogens, and clinical outcomes.
Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study
Pedro David Wendel-Garcia, Arantxa Mas, Cristina González-Isern, Ricard Ferrer, Rafael Máñez, Joan-Ramon Masclans, Elena Sandoval, Paula Vera, Josep Trenado, Rafael Fernández, Josep-Maria Sirvent, Melcior Martínez, Mercedes Ibarz, Pau Garro, José Luis Lopera, María Bodí, Joan Carles Yébenes-Reyes, Carles Triginer, Imma Vallverdú, Anna Baró, Fernanda Bodí, Paula Saludes, Mauricio Valencia, Ferran Roche-Campo, Arturo Huerta, Francisco José Cambra, Carme Barberà, Jorge Echevarria, Óscar Peñuelas & Jordi Mancebo for the UCIsCAT study group
doi : 10.1186/s13054-022-03905-5
Critical Care volume 26, Article number: 37 (2022)
Non-invasive oxygenation strategies have a prominent role in the treatment of acute hypoxemic respiratory failure during the coronavirus disease 2019 (COVID-19). While the efficacy of these therapies has been studied in hospitalized patients with COVID-19, the clinical outcomes associated with oxygen masks, high-flow oxygen therapy by nasal cannula and non-invasive mechanical ventilation in critically ill intensive care unit (ICU) patients remain unclear.
The physiological foundations of critical care medicine: the contribution of Joseph Milic-Emili, a physiologist “by hook or by crook”
V. Marco Ranieri & Claude Guérin
doi : 10.1186/s13054-022-03919-z
Critical Care volume 26, Article number: 38 (2022)
Prone position during venovenous extracorporeal membrane oxygenation: survival analysis needed for a time-dependent intervention
Akram M. Zaaqoq, Adrian G. Barnett, Silver Heinsar, Matthew J. Griffee, Graeme MacLaren, Jeffrey P. Jacobs, Jacky Y. Suen, Gianluigi Li Bassi, John F. Fraser, Heidi J. Dalton, Giles J. Peek on behalf of the COVID-19 Critical Care Consortium (COVID Critical)
doi : 10.1186/s13054-022-03923-3
Critical Care volume 26, Article number: 39 (2022)
Tracheostomy timing and clinical outcomes in ventilated COVID-19 patients: a systematic review and meta-analysis
Yun Ji, Yumin Fang, Baoli Cheng, Libin Li & Xiangming Fang
doi : 10.1186/s13054-022-03904-6
Critical Care volume 26, Article number: 40 (2022)
The association of tracheostomy timing and clinical outcomes in ventilated COVID-19 patients remains controversial. We performed a meta-analysis to evaluate the impact of early tracheostomy compared to late tracheostomy on COVID-19 patients’ outcomes.
Study find that COVID ARDS was associated with a low risk for possible or proven PCP: still true after dexamethasone use
Patrick M. Honore, Sebastien Redant, Thierry Preseau, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Rachid Attou, Andrea Gallerani & David De Bels
doi : 10.1186/s13054-022-03886-5
Critical Care volume 26, Article number: 41 (2022)
Correction to: Association between hospital and ICU structural factors and patient outcomes in China: a secondary analysis of the National Clinical Improvement System Data in 2019
Zhen Li, Xudong Ma, Sifa Gao, Qi Li, Hongbo Luo, Jianhua Sun, Wei Du, Longxiang Su, Lu Wang, Qing Zhang, Zunzhu Li, Xiang Zhou, Dawei Liu on behalf of China National Critical Care Quality Control Center Group
doi : 10.1186/s13054-022-03920-6
Critical Care volume 26, Article number: 42 (2022)
Relationship between time of emergency department admission and adherence to the Surviving Sepsis Campaign bundle in patients with septic shock
Je Sung You, Yoo Seok Park, Sung Phil Chung, Hye Sun Lee, Soyoung Jeon, Won Young Kim, Tae Gun Shin, You Hwan Jo, Gu Hyun Kang, Sung Hyuk Choi, Gil Joon Suh, Byuk Sung Ko, Kap Su Han, Jong Hwan Shin, Taeyoung Kong on behalf of Korean Shock Society (KoSS) Investigators
doi : 10.1186/s13054-022-03899-0
Critical Care volume 26, Article number: 43 (2022)
Nighttime hospital admission is often associated with increased mortality risk in various diseases. This study investigated compliance rates with the Surviving Sepsis Campaign (SSC) 3-h bundle for daytime and nighttime emergency department (ED) admissions and the clinical impact of compliance on mortality in patients with septic shock.
Timing of intubation, beds in intensive care and inter-hospital transfer: rings of a complex chain during pandemic conditions
Filippo Sanfilippo, Luigi La Via, Giuseppe Carpinteri & Marinella Astuto
doi : 10.1186/s13054-022-03925-1
Critical Care volume 26, Article number: 44 (2022)
Inspiratory and peripheral muscle strength as predictors for extubation failure in COVID-19 patients
Shraddha Shah
doi : 10.1186/s13054-022-03926-0
Critical Care volume 26, Article number: 45 (2022)
Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial
Lu Ke, Jiajia Lin, Gordon S. Doig, Arthur R. H. van Zanten, Yang Wang, Juan Xing, Zhongheng Zhang, Tao Chen, Lixin Zhou, Dongpo Jiang, Qindong Shi, Jiandong Lin, Jun Liu, Aibin Cheng, Yafeng Liang, Peiyang Gao, Junli Sun, Wenming Liu, Zhenyu Yang, Rumin Zhang, Wei Xing, An Zhang, Zhigang Zhou, Tingfa Zhou, Yang Liu, Fei Tong, Qiuhui Wang, Aijun Pan, Xiaobo Huang, Chuming Fan, Weihua Lu, Dongwu Shi, Lei Wang, Wei Li, Liming Gu, Yingguang Xie, Rongqing Sun, Feng Guo, Lin Han, Lihua Zhou, Xiangde Zheng, Feng Shan, Jianbo Liu, Yuhang Ai, Yan Qu, Liandi Li, Hailing Li, Zhiguo Pan, Donglin Xu, Zhiqiang Zou, Yan Gao, Chunli Yang, Qiuye Kou, Xijing Zhang, Jinglan Wu, Chuanyun Qian, Weixing Zhang, Minjie Zhang, Yuan Zong, Bingyu Qin, Fusen Zhang, Zhe Zhai, Yun Sun, Ping Chang, Bo Yu, Min Yu, Shiying Yuan, Yijun Deng, Liyun Zhao, Bin Zang, Yuanfei Li, Fachun Zhou, Xiaomei Chen, Min Shao, Weidong Wu, Ming Wu, Zhaohui Zhang, Yimin Li, Qiang Guo, Zhiyong Wang, Yuanqi Gong, Yunlin Song, Kejian Qian, Yongjian Feng, Baocai Fu, Xueyan Liu, Zhiping Li, Chuanyong Gong, Cheng Sun, Jian Yu, Zhongzhi Tang, Linxi Huang, Biao Ma, Zhijie He, Qingshan Zhou, Rongguo Yu, Zhihui Tong & Weiqin Li for the Chinese Critcal Care Nutrition Trials Group (CCCNTG)
doi : 10.1186/s13054-022-03921-5
Critical Care volume 26, Article number: 46 (2022)
Previous cluster-randomized controlled trials evaluating the impact of implementing evidence-based guidelines for nutrition therapy in critical illness do not consistently demonstrate patient benefits. A large-scale, sufficiently powered study is therefore warranted to ascertain the effects of guideline implementation on patient-centered outcomes.
Repeated endo-tracheal tube disconnection generates pulmonary edema in a model of volume overload: an experimental study
Bhushan H. Katira, Doreen Engelberts, Sheena Bouch, Jordan Fliss, Luca Bastia, Kohei Osada, Kim A. Connelly, Marcelo B. P. Amato, Niall D. Ferguson, Wolfgang M. Kuebler, Brian P. Kavanagh, Laurent J. Brochard & Martin Post
doi : 10.1186/s13054-022-03924-2
Critical Care volume 26, Article number: 47 (2022)
An abrupt lung deflation in rodents results in lung injury through vascular mechanisms. Ventilator disconnections during endo-tracheal suctioning in humans often cause cardio-respiratory instability. Whether repeated disconnections or lung deflations cause lung injury or oedema is not known and was tested here in a porcine large animal model.
Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial
Antoine Monsel, Caroline Hauw-Berlemont, Miryam Mebarki, Nicholas Heming, Julien Mayaux, Otriv Nguekap Tchoumba, Jean-Luc Diehl, Alexandre Demoule, Djillali Annane, Clémence Marois, Sophie Demeret, Emmanuel Weiss, Guillaume Voiriot, Muriel Fartoukh, Jean-Michel Constantin, Bruno Mégarbane, Gaëtan Plantefève, Stéphanie Malard-Castagnet, Sonia Burrel, Michelle Rosenzwajg, Nicolas Tchitchek, Hélène Boucher-Pillet, Guillaume Churlaud, Audrey Cras, Camille Maheux, Chloé Pezzana, Mamadou Hassimiou Diallo, Jacques Ropers, Philippe Menasché, Jérôme Larghero & APHP STROMA–CoV-2 Collaborative Research Group
doi : 10.1186/s13054-022-03930-4
Critical Care volume 26, Article number: 48 (2022)
Severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2)-induced acute respiratory distress syndrome (ARDS) causes high mortality. Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have potentially relevant immune-modulatory properties, whose place in ARDS treatment is not established. This phase 2b trial was undertaken to assess the efficacy of UC-MSCs in patients with SARS–CoV-2-induced ARDS.
Impact of platelet transfusion on outcomes in trauma patients
S. R. Hamada, D. Garrigue, H. Nougue, A. Meyer, M. Boutonnet, E. Meaudre, A. Culver, E. Gaertner, G. Audibert, B. Vigué, J. Duranteau, A. Godier & and the TraumaBase Group
doi : 10.1186/s13054-022-03928-y
Critical Care volume 26, Article number: 49 (2022)
Trauma-induced coagulopathy includes thrombocytopenia and platelet dysfunction that impact patient outcome. Nevertheless, the role of platelet transfusion remains poorly defined. The aim of the study was 1/ to evaluate the impact of early platelet transfusion on 24-h all-cause mortality and 2/ to describe platelet count at admission (PCA) and its relationship with trauma severity and outcome.
The role of cell-free hemoglobin and haptoglobin in acute kidney injury in critically ill adults with ARDS and therapy with VV ECMO
Jan A. Graw, Philip Hildebrandt, Alexander Krannich, Felix Balzer, Claudia Spies, Roland C. Francis, Wolfgang M. Kuebler, Steffen Weber-Carstens, Mario Menk & Oliver Hunsicker
doi : 10.1186/s13054-022-03894-5
Critical Care volume 26, Article number: 50 (2022)
Increased plasma concentrations of circulating cell-free hemoglobin (CFH) are supposed to contribute to the multifactorial etiology of acute kidney injury (AKI) in critically ill patients while the CFH-scavenger haptoglobin might play a protective role. We evaluated the association of CFH and haptoglobin with AKI in patients with an acute respiratory distress syndrome (ARDS) requiring therapy with VV ECMO.
Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial
Hendrik Rüddel, Daniel O. Thomas-Rüddel, Konrad Reinhart, Friedhelm Bach, Herwig Gerlach, Matthias Lindner, John C. Marshall, Philipp Simon, Manfred Weiss, Frank Bloos, Daniel Schwarzkopf & the MEDUSA study group
doi : 10.1186/s13054-022-03901-9
Critical Care volume 26, Article number: 51 (2022)
Timely antimicrobial treatment and source control are strongly recommended by sepsis guidelines, however, their impact on clinical outcomes is uncertain.
