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The American Journal of Gastroenterology in 2022 and Beyond: A Vision for “Our” Journal
Long, Millie D. MD, MPH, FACG1,*; Bajaj, Jasmohan S. MD, MS, FACG2,*
doi : 10.14309/ajg.0000000000001579
January 2022 - Volume 117 - Issue 1 - p 1-2
ACG Presidential Address 2021
Greenwald, David MD, FACG
doi : 10.14309/ajg.0000000000001574
January 2022 - Volume 117 - Issue 1 - p 3-6
Diarrhea, Dysbiosis, Dysfunction, and the Disastrous Global Health Consequences: Piecing the Puzzle Together
Frese, Steven PhD1; Riddle, Mark S. MD, DrPH, FISTM2
doi : 10.14309/ajg.0000000000001555
January 2022 - Volume 117 - Issue 1 - p 98-99
The burden of diarrheal infections globally, including the chronic health consequences, is an important problem. Herein we describe a recent paper published by the Journal and describe how it fits within and advances our knowledge in this area.
Obesity: The Forgotten Pandemic
Popov, Violeta B. MD, PhD, FACG1,2; Aytaman, Ayse MD, FACG2,3; Alemán, José O. MD, PhD2,4
doi : 10.14309/ajg.0000000000001553
January 2022 - Volume 117 - Issue 1 - p 7-10
How Your Writing Can Succeed: Getting a Manuscript Accepted by The American Journal of Gastroenterology
Longstreth, George F. MD1; Patton, Heather M. MD1; Lacy, Brian E. MD, PhD2
doi : 10.14309/ajg.0000000000001552
January 2022 - Volume 117 - Issue 1 - p 11-15
Endoscopic Retrieval of a Proximally Migrated 5-Fr Pancreatic Stent Using a Low-Profile Angioplasty Balloon
Soota, Kaartik MD1; Rustagi, Tarun MD1
doi : 10.14309/ajg.0000000000001417
January 2022 - Volume 117 - Issue 1 - p 16
Gastropericardial Fistula After Unconventional Venting Gastrostomy Placement in Encapsulating Peritoneal Sclerosis
Guerrero Vinsard, Daniela MD1; Vinsard, Patrice MD2,3
doi : 10.14309/ajg.0000000000001489
January 2022 - Volume 117 - Issue 1 - p 17
Rectal Mucinous Adenocarcinoma: A Cause of Chronic Anal Fissure
Qian, Steve S. MD1; Mangaru, Zareema DO2; Sandhu, Dalbir MD3; Mouchli, Mohamad A. MD3
doi : 10.14309/ajg.0000000000001534
January 2022 - Volume 117 - Issue 1 - p 18
A Rare Case of (Necrotizing) Fasciitis After Colonoscopy
Fritzsche, Jeska A. MD1; Bachiri, Said MD2; Tol, Suzanne J.M. MD3; Dunker, Mich S. MD, PhD2; van Berkel, Anne-Marie MD, PhD1
doi : 10.14309/ajg.0000000000001493
January 2022 - Volume 117 - Issue 1 - p 19
Acute Renal Failure Related to an Over-the-Scope Clip
Nehme, Fredy MD1; Jonnalagadda, Sreenivasa MD1
doi : 10.14309/ajg.0000000000001494
January 2022 - Volume 117 - Issue 1 - p 20
Salvage Procedure for Double Trouble in Lumen-Apposing Metal Stent Misdeployment During Endoscopic Ultrasound-Guided Gastroenterostomy: Ready to Start Again
Colombo, Matteo MD1,2; Fugazza, Alessandro MD1; Kurihara, Hayato MD3; Preatoni, Paoletta MD4; Repici, Alessandro MD1,2; Anderloni, Andrea MD, PhD1
doi : 10.14309/ajg.0000000000001411
January 2022 - Volume 117 - Issue 1 - p 21-22
Continuing Medical Education Questions: January 2022
Howard, Dominique E. MD, FACG
doi : 10.14309/ajg.0000000000001578
January 2022 - Volume 117 - Issue 1 - p 25
Updates on Age to Start and Stop Colorectal Cancer Screening: Recommendations From the U.S. Multi-Society Task Force on Colorectal Cancer
Continuing Medical Education Questions: January 2022
Shafi, Mehnaz A. MD, FACG
doi : 10.14309/ajg.0000000000001580
January 2022 - Volume 117 - Issue 1 - p 26
ACG Clinical Guideline: Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease
ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease
Katz, Philip O. MD, MACG1; Dunbar, Kerry B. MD, PhD2,3; Schnoll-Sussman, Felice H. MD, FACG1; Greer, Katarina B. MD, MS, FACG4; Yadlapati, Rena MD, MSHS5; Spechler, Stuart Jon MD, FACG6,7
doi : 10.14309/ajg.0000000000001538
January 2022 - Volume 117 - Issue 1 - p 27-56
Gastroesophageal reflux disease (GERD) continues to be among the most common diseases seen by gastroenterologists, surgeons, and primary care physicians. Our understanding of the varied presentations of GERD, enhancements in diagnostic testing, and approach to patient management have evolved. During this time, scrutiny of proton pump inhibitors (PPIs) has increased considerably. Although PPIs remain the medical treatment of choice for GERD, multiple publications have raised questions about adverse events, raising doubts about the safety of long-term use and increasing concern about overprescribing of PPIs. New data regarding the potential for surgical and endoscopic interventions have emerged. In this new document, we provide updated, evidence-based recommendations and practical guidance for the evaluation and management of GERD, including pharmacologic, lifestyle, surgical, and endoscopic management. The Grading of Recommendations, Assessment, Development, and Evaluation system was used to evaluate the evidence and the strength of recommendations. Key concepts and suggestions that as of this writing do not have sufficient evidence to grade are also provided.
Updates on Age to Start and Stop Colorectal Cancer Screening: Recommendations From the U.S. Multi-Society Task Force on Colorectal Cancer
Patel, Swati G. MD, MS1,2; May, Folasade P. MD, PhD, MPhil3,4; Anderson, Joseph C. MD5,6; Burke, Carol A. MD7; Dominitz, Jason A. MD, MHS8; Gross, Seth A. MD9; Jacobson, Brian C. MD, MPH10; Shaukat, Aasma MD, MPH11; Robertson, Douglas J. MD, MPH5
doi : 10.14309/ajg.0000000000001548
January 2022 - Volume 117 - Issue 1 - p 57-69
This document is a focused update to the 2017 colorectal cancer (CRC) screening recommendations from the U.S. Multi-Society Task Force on Colorectal Cancer, which represents the American College of Gastroenterology, the American Gastroenterological Association, and the American Society for Gastrointestinal Endoscopy. This update is restricted to addressing the age to start and stop CRC screening in average-risk individuals and the recommended screening modalities. Although there is no literature demonstrating that CRC screening in individuals under age 50 improves health outcomes such as CRC incidence or CRC-related mortality, sufficient data support the U.S. Multi-Society Task Force to suggest average-risk CRC screening begin at age 45. This recommendation is based on the increasing disease burden among individuals under age 50, emerging data that the prevalence of advanced colorectal neoplasia in individuals ages 45 to 49 approaches rates in individuals 50 to 59, and modeling studies that demonstrate the benefits of screening outweigh the potential harms and costs. For individuals ages 76 to 85, the decision to start or continue screening should be individualized and based on prior screening history, life expectancy, CRC risk, and personal preference. Screening is not recommended after age 85.
Demystifying Esophageal Lichen Planus: A Comprehensive Review of a Rare Disease You Will See in Practice
Jacobs, John W. Jr MD1; Kukreja, Keshav MD1; Camisa, Charles MD2; Richter, Joel E. MD1
doi : 10.14309/ajg.0000000000001485
January 2022 - Volume 117 - Issue 1 - p 70-77
Lichen planus (LP) is a chronic inflammatory disorder that often affects the skin, hair, nails, and mucus membranes. Although esophageal involvement has traditionally been felt to be rare, recent reports suggest that it is often unrecognized or misdiagnosed. The diagnoses of esophageal lichen planus can be challenging and is suspected based on patients' endoscopic and histologic findings and in the context of their clinical history and physical examination. Physicians must have an index of suspicion, particularly in older white women and in those patients with an atypical esophagitis or stricturing disease, which do not respond to traditional treatment. Currently, there are limited data on esophageal lichen planus patients, and no formal management guidelines for this disease, which all gastroenterologists will see in practice. This article reviews the etiology and histopathology of LP and provides a comprehensive discussion of the clinical features, diagnosis, and management of esophageal disease from the gastroenterologist's perspective. Finally, we address the esophageal complications of LP.
Digital Health Technologies for Remote Monitoring and Management of Inflammatory Bowel Disease: A Systematic Review
Nguyen, Nghia H. MD, MAS1,*; Martinez, Ivonne MD2,*; Atreja, Ashish MD, MPH2,3; Sitapati, Amy M. MD4,5,6; Sandborn, William J. MD1; Ohno-Machado, Lucila MD, PhD4; Singh, Siddharth MD, MS1,4
doi : 10.14309/ajg.0000000000001545
January 2022 - Volume 117 - Issue 1 - p 78-97
Digital health technologies may be useful tools in the management of chronic diseases. We performed a systematic review of digital health interventions in the management of patients with inflammatory bowel diseases (IBD) and evaluated its impact on (i) disease activity monitoring, (ii) treatment adherence, (iii) quality of life (QoL) measures, and/or (iv) health care utilization.
A Randomized Controlled Trial of Cold Snare Polypectomy Technique: Technique Matters More Than Snare Wire Diameter
Sidhu, Mayenaaz MBBS1-3,*; Forbes, Nauzer MD, MSc4-6,*; Tate, David J. CANTAB, PhD1,2,7,*; Desomer, Lobke MD1,8; Lee, Eric Y.T. MBBS1,3; Burgess, Nicholas MBBS, PhD1-3; van Hattem, Arnout MD, PhD1; Mcleod, Duncan MBBS9; Cheng, Edwin MD5; Cartwright, Shane BA6; Schell, Andrew MD10; Hilsden, Robert J. MD4-6; Heitman, Steven J. MD, MSc4-6,#; Bourke, Michael J. MBBS1,2,#
doi : 10.14309/ajg.0000000000001554
January 2022 - Volume 117 - Issue 1 - p 100
Cold snare polypectomy (CSP) is safe and effective for the removal of small adenomas (?10 mm); however, reported incomplete resection rates (IRRs) vary. The optimal CSP technique, where a wide margin of normal tissue is resected around the target lesion, and snare design have both been hypothesized to reduce the IRR after CSP. We sought to investigate the efficacy of a thin-wire versus thick-wire diameter snare on IRR, using the standardized CSP technique.
Hybrid APC in Combination With Resection for the Endoscopic Treatment of Neoplastic Barrett's Esophagus: A Prospective, Multicenter Study
Knabe, Mate MD1,2,*; Beyna, Torsten MD3,*; Rösch, Thomas MD4; Bergman, Jacques MD5; Manner, Hendrik MD6; May, Andrea MD1,7; Schachschal, Guido MD4; Neuhaus, Horst MD3; Kandler, Jennis MD3,8; Weusten, Bas MD9; Pech, Oliver MD10; Faiss, Siegbert MD11,12; Anders, Mario MD13; Vieth, Michael MD14; Sehner, Susanne MSc15; Bisschops, Raf MD16; Bhandari, Pradeep MD17; Ell, Christian MD1; Ehlken, Hanno MD4
doi : 10.14309/ajg.0000000000001539
January 2022 - Volume 117 - Issue 1 - p 110-119
The current therapy of neoplastic Barrett's esophagus (BE) consists of endoscopic resection plus ablation, with radiofrequency ablation as the best studied technique. This prospective trial assesses a potential alternative, namely hybrid argon plasma ablation.
Relative Adrenal Insufficiency in Decompensated Cirrhotic Children: Does It Affect Outcome?
Tripathi, Parijat Ram MD, DM1; Sen Sarma, Moinak MD, DM1; Yachha, Surender Kumar MD, DM1; Aggarwal, Amita MD, DM2; Bhatia, Vijayalakshmi MD3; Kumar, Anup PhD4; Srivastava, Anshu MD, DM1; Poddar, Ujjal MD, DM1
doi : 10.14309/ajg.0000000000001486
January 2022 - Volume 117 - Issue 1 - p 120-128
Relative adrenal insufficiency (RAI) is associated with poor outcome in adult cirrhotics. So far, pediatric studies are not available on the same. We aimed to prospectively study the presence and outcome of RAI in children with decompensated cirrhosis over 180 days.
Increased Cancer Risk in Autoimmune Hepatitis: A Danish Nationwide Cohort Study
Jensen, Morten D. MS1; Jepsen, Peter MD, DSc1,2; Vilstrup, Hendrik MD, DSc1; Grønbæk, Lisbet MD, PhD1,3
doi : 10.14309/ajg.0000000000001525
January 2022 - Volume 117 - Issue 1 - p 129-137
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease and as such may increase the risk of cancer. We examined cancer risks in a nationwide cohort of patients with AIH.
A 2-Step Strategy Combining FIB-4 With Transient Elastography and Ultrasound Predicted Liver Cancer After HCV Cure
Ampuero, Javier MD, PhD1,2,3; Carmona, Isabel MD, PhD4; Sousa, Francisca MD5; Rosales, Jose Miguel MD6; López-Garrido, Ángeles MD7; Casado, Marta MD, PhD8; Figueruela, Banca MD9; Aparicio, Ana MD3,10; Andrade, Raúl MD, PhD3,11; Guerra-Veloz, María Fernanda MD, PhD4; Maraver, Marta MD12; Pascasio, Juan Manuel MD, PhD1; Estévez, Matías MD13; Romero-Gomez, Manuel MD, PhD1,2,3
doi : 10.14309/ajg.0000000000001503
January 2022 - Volume 117 - Issue 1 - p 138-146
Despite the direct-acting antiviral therapy has dramatically decreased the likelihood of having liver-related complications and extrahepatic outcomes, the risk of developing hepatocellular carcinoma (HCC) is not totally eliminated after sustained virological response (SVR). We aimed to develop an easy-to-apply strategy to be adopted in clinical practice for accurately classifying the HCC risk in hepatitis C virus patients after SVR.
Prevalence of Gastrointestinal Symptoms in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Results of the Prospective Controlled Multinational GI-COVID-19 Study
Marasco, Giovanni MD, PhD1,2; Cremon, Cesare MD1,2; Barbaro, Maria Raffaella PhD1; Salvi, Daniele MD2; Cacciari, Giulia MD1,2; Kagramanova, Anna MD3; Bordin, Dmitry MD4,5,6; Drug, Vasile MD7; Miftode, Edgidia MD8; Fusaroli, Pietro MD9; Mohamed, Salem Youssef MD10; Ricci, Chiara MD11; Bellini, Massimo MD12; Rahman, M. Masudur MD13; Melcarne, Luigi MD14; Santos, Javier MD15; Lobo, Beatriz MD15; Bor, Serhat MD16; Yapali, Suna MD17; Akyol, Deniz MD18; Sapmaz, Ferdane Pirincci MD19; Urun, Yonca Yilmaz MD20; Eskazan, Tugce MD21; Celebi, Altay MD22; Kacmaz, Huseyin MD23; Ebik, Berat MD24; Binicier, Hatice Cilem MD25; Bugdayci, Mehmet Sait MD26; Ya?c?, Munkhtsetseg Banzragch MD27; Pullukcu, Husnu MD18; Kaya, Berrin Yal?nbas MD20; Tureyen, Ali MD20; Hatemi, ?brahim MD21; Koc, Elif Sitre MD17; Sirin, Goktug MD22; Cal?skan, Ali Riza MD23; Bengi, Goksel MD25; Al?s, Esra Ergun MD28; Lukic, Snezana MD29; Trajkovska, Meri MD30; Hod, Keren MD31; Dumitrascu, Dan MD32; Pietrangelo, Antonello MD33; Corradini, Elena MD33; Simren, Magnus MD34; Sjolund, Jessica MD34; Tornkvist, Navkiran MD34; Ghoshal, Uday C. MD35; Kolokolnikova, Olga MD36; Colecchia, Antonio MD37; Serra, Jordi MD38; Maconi, Giovanni MD39; De Giorgio, Roberto MD, PhD40; Danese, Silvio MD41; Portincasa, Pietro MD42; Di Stefano, Michele MD43; Maggio, Marcello MD44; Philippou, Elena MD45; Lee, Yeong Yeh MD46; Venturi, Alessandro MD1; Borghi, Claudio MD1,2; Zoli, Marco MD1,2; Gionchetti, Paolo MD1,2; Viale, Pierluigi MD1,2; Stanghellini, Vincenzo MD1,2; Barbara, Giovanni MD1,2; and the GI-COVID19 Study Group
doi : 10.14309/ajg.0000000000001541
January 2022 - Volume 117 - Issue 1 - p 147-157
Gastrointestinal (GI) symptoms in coronavirus-19 disease (COVID-19) have been reported with great variability and without standardization. In hospitalized patients, we aimed to evaluate the prevalence of GI symptoms, factors associated with their occurrence, and variation at 1 month.
Long-Term Statin Use, Total Cholesterol Level, and Risk of Colorectal Cancer: A Prospective Cohort Study
Zhang, Yin MD, MPH1,2,3; Wu, Kana MD, PhD3; Chan, Andrew T. MD, MPH4,5,6,7; Meyerhardt, Jeffrey A. MD, MPH1; Giovannucci, Edward L. MD, MSc2,3,8
doi : 10.14309/ajg.0000000000001543
January 2022 - Volume 117 - Issue 1 - p 158-166
Statin use has been examined as a potential chemopreventive strategy against colorectal cancer (CRC). Previous studies have not been able to investigate this topic with adequate follow-up time or disentangle the effects of statin use and total cholesterol level. We investigated prospectively this topic.
Small Intestine Bacterial Overgrowth in Bangladeshi Infants Is Associated With Growth Stunting in a Longitudinal Cohort
Donowitz, Jeffrey R. MD1,2; Pu, Zhen BS3; Lin, Ye PhD3; Alam, Masud MBBS4; Ferdous, Tahsin MBBS4; Shama, Talat MBBS4; Taniuchi, Mami PhD2,5,6; Islam, Md Ohedul BS4; Kabir, Mamun MSc4; Nayak, Uma PhD7,8; Faruque, Abu S.G. MD9; Haque, Rashidul MBBS, PhD4; Ma, Jennie Z. PhD8; Petri, William A. Jr MD, PhD2
doi : 10.14309/ajg.0000000000001535
January 2022 - Volume 117 - Issue 1 - p 167-175
Small intestine bacterial overgrowth (SIBO) is common in children from low-income countries and has been cross-sectionally associated with growth stunting. We sought to determine whether SIBO was associated with poor growth and neurodevelopmental in a longitudinal analysis.
Humoral Immunogenicity of mRNA COVID-19 Vaccines Among Patients With Inflammatory Bowel Disease and Healthy Controls
Caldera, Freddy DO, MS1; Knutson, Keith L. PhD2; Saha, Sumona MD, MS1; Wald, Arnold MD1; Phan, Hiep S. MD3; Chun, Kelly PhD4; Grimes, Ian MD1; Lutz, Megan MD1; Hayney, Mary S. PharmD, MPH5,*; Farraye, Francis A. MD, MSc6,*
doi : 10.14309/ajg.0000000000001570
January 2022 - Volume 117 - Issue 1 - p 176-179
Patients with inflammatory bowel disease (IBD) on immune-modifying therapies may have a lower vaccine response to certain vaccines. The aim of our study was to evaluate humoral immunogenicity of mRNA coronavirus disease 2019 (COVID-19) vaccines among patients with IBD and healthy controls (HCs).
Gastroenterology Clinical Trials Transparency: An Analysis of Publication Rates From the ClinicalTrials.gov Database
Garg, Shashank MBBS1; Rizvi, Anam MD2; Wee, Diana MD3; Sreenivasan, Aditya MD2; Suchman, Kelly MD3; Thomas, Sheila Louise BS4; Inamdar, Sumant MBBS1; Trindade, Arvind J. MD2
doi : 10.14309/ajg.0000000000001517
January 2022 - Volume 117 - Issue 1 - p 180-183
There is limited information on the transparency of gastroenterology clinical trials.
Increasing Incidence of Cirrhosis Over the Past 2 Decades Among Children in Ontario, Canada
Kehar, Mohit MBBS, DNB1; Griffiths, Rebecca MSc2; Flemming, Jennifer A. MD, MAS2-4
doi : 10.14309/ajg.0000000000001564
January 2022 - Volume 117 - Issue 1 - p 189-192
We describe the incidence of cirrhosis in the general pediatric population.
Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating
Staller, Kyle MD, MPH1; Hinson, Jimmy PharmD2; Kerstens, René MSc3; Spalding, William MS2; Lembo, Anthony MD4
doi : 10.14309/ajg.0000000000001521
January 2022 - Volume 117 - Issue 1 - p 184-188
This post hoc analysis evaluated the effect of prucalopride on abdominal bloating in participants with chronic idiopathic constipation (CIC) who had moderate to very severe bloating at baseline.
Study of Association of Genetic Risk Loci for Anxiety and PTSD With Pain in Pancreatitis Needs More Discussion
Liu, Yu MD1,2,*; Shi, Zheng MD3,*; Hu, Liang-Hao MD2
doi : 10.14309/ajg.0000000000001522
January 2022 - Volume 117 - Issue 1 - p 193
Response to Liu et al.
Dunbar, Ellyn MS1; Whitcomb, David C. MD, PhD1
doi : 10.14309/ajg.0000000000001556
January 2022 - Volume 117 - Issue 1 - p 193-195
Herpes Zoster Meningoencephalitis: A Novel, Rare, Potentially Fatal Side Effect to Tofacitinib
Steenholdt, Casper MD, PhD, DMSc1; Kristensen, Lars Erik MD, PhD2; Brynskov, Jørn MD, DMSc1
doi : 10.14309/ajg.0000000000001510
January 2022 - Volume 117 - Issue 1 - p 195-196
Cholangiopathy in Early Rehabilitation After Intensive Care Treatment of Patients With COVID-19
Linneweber, Lutz MD1,*; Mann, Alexander Bernd MD1,*; Denk, Gerald MD2; Kraft, Eduard MD1; Weber, Sabine MD2
doi : 10.14309/ajg.0000000000001511
January 2022 - Volume 117 - Issue 1 - p 197-198
Calendar of Courses, Symposiums and Conferences
doi : 10.14309/ajg.0000000000001581
January 2022 - Volume 117 - Issue 1 - p 199
Correction to: Anticoagulation and Transjugular Intrahepatic Portosystemic Shunt for the Management of Portal Vein Thrombosis in Cirrhosis: A Prospective Observational Study
Lv, Yong MD, PhD1; Bai, Wei MD1,2; Li, Kai MD, PhD1; Wang, Zhengyu MD1,2; Guo, Wengang MD1,2; Luo, Bohan MD1,2; Wang, Jianhong MD, PhD3; Wang, Qiuhe MD1; Wang, Enxin MD, PhD1; Xia, Dongdong MD1; Li, Xiaomei MD1,2; Yuan, Jie MD1; Han, Na MD1; Niu, Jing MD1; Yin, Zhanxin MD, PhD1,2; Fan, Daiming MD, PhD4; Han, Guohong MD, PhD1,2
doi : 10.14309/ajg.0000000000001573
January 2022 - Volume 117 - Issue 1 - p 200
