American Journal of Gastroenterology

Bajaj, Jasmohan S. MD, MS, FACG1; O'Leary, Jacqueline G. MD, MPH, FACG2; Lai, Jennifer C. MD, MBA3; Wong, Florence MD, FACG4; Long, Millie D. MD, MPH, FACG (Methodologist)5; Wong, Robert J. MD, MS, FACG (Methodologist)6; Kamath, Patrick S. MD7

doi : 10.14309/ajg.0000000000001595

February 2022 - Volume 117 - Issue 2 - p 225-252

In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging as a major cause of mortality. These guidelines indicate the preferred approach to the management of patients with acute-on-chronic liver failure and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation process. In instances where the evidence was not appropriate for Grading of Recommendations, Assessment, Development, and Evaluation, but there was consensus of significant clinical merit, key concept statements were developed using expert consensus. These guidelines are meant to be broadly applicable and should be viewed as the preferred, but not only, approach to clinical scenarios.

خرید پکیج و مشاهده آنلاین مقاله

Hepatitis B Virus Infection and Extra-Hepatic Manifestations: A Systemic Disease

Cacoub, Patrice MD, PhD1,2,3,4; Asselah, Tarik MD, PhD5,6

doi : 10.14309/ajg.0000000000001575

February 2022 - Volume 117 - Issue 2 - p 253-263

People living with hepatitis B virus (HBV) chronic infection are exposed to high rates of liver complications including end-stage liver disease and hepatocellular carcinoma. Extrahepatic manifestations of HBV infection have long been underestimated. Several of these extrahepatic syndromes have been well described, including systemic vasculitides, glomerulonephritis, and cutaneous manifestations. Other manifestations have been more recently described such as hematological malignancies and neurological diseases. These extrahepatic manifestations are associated with significant morbidity and mortality. Although not completely understood, underlying mechanisms include HBV-induced local and systemic inflammation. Suppression of HBV replication usually improves extrahepatic manifestations. This review will discuss how HBV induces inflammation and the extrahepatic manifestations of HBV infection to guide clinical management.

خرید پکیج و مشاهده آنلاین مقاله

Responsiveness of a Histologic Scoring System Compared With Peak Eosinophil Count in Eosinophilic Esophagitis

Ma, Christopher MD, MPH1,2,3; Jairath, Vipul MD, PhD3,4,5; Feagan, Brian G. MD3,4,5; Guizzetti, Leonardo PhD3; Zou, Guangyong PhD3,5,6; McFarlane, Stefanie C. BMath3; Shackelton, Lisa M. PhD3; Collins, Margaret H. MD7; Hirano, Ikuo MD8; de Rooij, Willemijn E. MD9; Schaeffer, David F. MD10; Pai, Rish K. MD, PhD11; Bredenoord, Albert J. MD, PhD9; Dellon, Evan S. MD, MPH12

doi : 10.14309/ajg.0000000000001571

February 2022 - Volume 117 - Issue 2 - p 264-271

The optimal instrument for assessing histologic disease activity in patients with eosinophilic esophagitis (EoE) is unclear. We assessed the responsiveness of the EoE Histologic Scoring System (EoE-HSS) when compared with that of the peak eosinophil count (PEC).

خرید پکیج و مشاهده آنلاین مقاله

Development and Validation of Web-Based Tool to Predict Lamina Propria Fibrosis in Eosinophilic Esophagitis

Hiremath, Girish MD, MPH1; Sun, Lili PhD2; Correa, Hernan MD3; Acra, Sari MD, MPH1; Collins, Margaret H. MD4; Bonis, Peter MD5; Arva, Nicoleta C. MD, PhD6; Capocelli, Kelley E. MD7; Falk, Gary W. MD, MS8; King, Eileen PhD9; Gonsalves, Nirmala MD10; Gupta, Sandeep K. MD11; Hirano, Ikuo MD10; Mukkada, Vincent A. MD12; Martin, Lisa J. PhD12; Putnam, Philip E. MD12; Spergel, Jonathan M. MD, PhD13; Wechsler, Joshua B. MD, MS1; Yang, Guang-Yu MD, PhD14; Aceves, Seema S. MD, PhD15; Furuta, Glenn T. MD1; Rothenberg, Marc. E. MD, PhD16; Koyama, Tatsuki PhD2; Dellon, Evan S. MD, MPH17

doi : 10.14309/ajg.0000000000001587

February 2022 - Volume 117 - Issue 2 - p 272-279

Approximately half of esophageal biopsies from patients with eosinophilic esophagitis (EoE) contain inadequate lamina propria, making it impossible to determine the lamina propria fibrosis (LPF). This study aimed to develop and validate a web-based tool to predict LPF in esophageal biopsies with inadequate lamina propria.

خرید پکیج و مشاهده آنلاین مقاله

Race/Ethnicity and Birthplace as Risk Factors for Gastric Intestinal Metaplasia in a Multiethnic United States Population

Tan, Mimi C. MD, MPH1; Jamali, Taher MD2; Nguyen, Theresa H. MD, MPH1,3; Galvan, Amy MPH1; Sealock, Robert J. MD1; Khan, Anam MD4; Zarrin-Khameh, Neda MD, MPH5; Holloman, Ashley MD5; Kampagianni, Ourania MD5; Ticas, David Henriquez MD5; Liu, Yan MS1,3; El-Serag, Hashem B. MD, MPH2,3; Thrift, Aaron P. PhD6,7

doi : 10.14309/ajg.0000000000001576

February 2022 - Volume 117 - Issue 2 - p 280-287

Several US subgroups have increased risk of gastric cancer and gastric intestinal metaplasia (GIM) and may benefit from targeted screening. We evaluated demographic and clinical risk factors for GIM and examined the interaction between race/ethnicity and birthplace on GIM risk.

خرید پکیج و مشاهده آنلاین مقاله

Episodic Detectable Viremia Does Not Affect Prognosis in Untreated Compensated Cirrhosis With Serum Hepatitis B Virus DNA <2,000 IU/mL

Lee, Hye Won MD, PhD1,2,3,*; Park, Soo Young MD, PhD4,*; Lee, Yu Rim MD, PhD4; Lee, Hyein BS3; Lee, Jae Seung MD1,2,3; Kim, Seung Up MD, PhD1,2,3; Park, Jun Yong MD, PhD1,2,3; Kim, Do Young MD, PhD1,2,3; Ahn, Sang Hoon MD, PhD1,2,3; Kim, Beom Kyung MD, PhD1,2,3

doi : 10.14309/ajg.0000000000001497

February 2022 - Volume 117 - Issue 2 - p 288-294

The necessity of antiviral therapy (AVT) for hepatitis B virus (HBV)-infected compensated cirrhosis with low-level viremia (LLV) is controversial. Herein, we evaluated its natural history.

خرید پکیج و مشاهده آنلاین مقاله

Bristol Stool Scale as a Determinant of Hepatic Encephalopathy Management in Patients With Cirrhosis

Duong, Nikki K. MD1; Shrestha, Shreesh MD1; Park, Dan MD1; Shahab, Omer MD1; Fagan, Andrew BS1; Malpaya, Zenaida NP1; Gallagher, Mary L. NP1; Morris, April NP1; Davis, Brian C. MD1; Bajaj, Jasmohan S. MD, MS, FACG1

doi : 10.14309/ajg.0000000000001550

February 2022 - Volume 117 - Issue 2 - p 295-300

Bowel movement (BM) frequency is used to titrate lactulose for hepatic encephalopathy (HE). However, stool consistency using the Bristol stool scale (BSS, 0–7) is often ignored.

خرید پکیج و مشاهده آنلاین مقاله

The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study

Morales-Arráez, D. MD, PhD1,2; Ventura-Cots, M. MD, PhD1; Altamirano, J. MD, PhD3; Abraldes, J.G. MD, PhD4; Cruz-Lemini, M. MD5; Thursz, M.R. MD, PhD6; Atkinson, S.R. MD, PhD1,6; Sarin, S.K. MD, PhD7; Kim, W. MD, PhD8; Chavez-Araujo, R. MD9; Higuera-de la Tijera, M.F. MD, PhD10; Singal, A.K. MD11; Shah, V.H. MD12; Kamath, P.S. MD12; Duarte-Rojo, A. MD, PhD13; Charles, E.A. RN1; Vargas, V. MD, PhD14; Jager, M. MD15; Rautou, P.E. MD, PhD15,16; Rincon, D. MD17; Zamarripa, F. MD18; Restrepo-Gutiérrez, J.C. MD, PhD19; Torre, A. MD20; Lucey, M.R. MD21; Arab, J.P. MD22; Mathurin, P. MD, PhD23,24; Louvet, A. MD, PhD23; García-Tsao, G. MD25; González, J.A. MD26; Verna, E.C. MD27; Brown, R.S. Jr MD28; Argemi, J. MD, PhD1,29; Fernández-Carillo, C. MD, PhD1; Clemente, A. MD1,30,31; Alvarado-Tapias, E. MD, PhD1; Forrest, E. MD32; Allison, M. MD, PhD33; Bataller, R. MD, PhD1

doi : 10.14309/ajg.0000000000001596

February 2022 - Volume 117 - Issue 2 - p 301-310

Several scoring systems predict mortality in alcohol-associated hepatitis (AH), including the Maddrey discriminant function (mDF) and model for end-stage liver disease (MELD) score developed in the United States, Glasgow alcoholic hepatitis score in the United Kingdom, and age, bilirubin, international normalized ratio, and creatinine score in Spain. To date, no global studies have examined the utility of these scores, nor has the MELD-sodium been evaluated for outcome prediction in AH. In this study, we assessed the accuracy of different scores to predict short-term mortality in AH and investigated additional factors to improve mortality prediction.

خرید پکیج و مشاهده آنلاین مقاله

Objectively Measured Physical Activity Is Inversely Associated With Nonalcoholic Fatty Liver Disease: The Rotterdam Study

van Kleef, Laurens A. MD1; Hofman, Amy MSc2; Voortman, Trudy PhD2; de Knegt, Robert J. MD, PhD1

doi : 10.14309/ajg.0000000000001584

February 2022 - Volume 117 - Issue 2 - p 311-318

The disease burden of nonalcoholic fatty liver disease (NAFLD) increases rapidly, in line with the obesity pandemic. Physical activity has been linked to a lower risk of NAFLD. However, the impact of different intensities of activity and sedentary behavior and whether their effects on NAFLD are explained by metabolic health remain unclear.

خرید پکیج و مشاهده آنلاین مقاله

Plasma IL-2 and Symptoms Response after Acute Gluten Exposure in Subjects With Celiac Disease or Nonceliac Gluten Sensitivity

Cartee, Amanda K. MD1,2; Choung, Rok Seon MD1; King, Katherine S. MS3; Wang, Suyue PhD4; Dzuris, John L. PhD4; Anderson, Robert P. MD4; Van Dyke, Carol T. CCRP1; Hinson, Chadrick A. BA1; Marietta, Eric PhD1; Katzka, David A. MD1; Nehra, Vandana MD1; Grover, Madhusudan MBBS1; Murray, Joseph A. MD1

doi : 10.14309/ajg.0000000000001565

February 2022 - Volume 117 - Issue 2 - p 319-326

Treated patients with celiac disease (CeD) and nonceliac gluten sensitivity (NCGS) report acute, transient, incompletely understood symptoms after suspected gluten exposure. To determine whether (i) blinded gluten exposure induces symptoms, (ii) subjects accurately identify gluten exposure, and (iii) serum interleukin-2 (IL-2) levels distinguish CeD from NCGS subjects after gluten exposure.

خرید پکیج و مشاهده آنلاین مقاله

Effect of Different Modalities of Purgative Preparation on the Diagnostic Yield of Small Bowel Capsule for the Exploration of Suspected Small Bowel Bleeding: A Multicenter Randomized Controlled Trial

Rahmi, Gabriel MD, PhD1; Cholet, Franck MD2; Gaudric, Marianne MD3; Filippi, Jérôme MD4; Duburque, Clotilde MD5; Bramli, Slim MD6; Quentin, Vincent MD7; Alavi, Zarrin MSc, MEng8; Nowak, Emmanuel PhD8; Saurin, Jean Christophe MD, PhD9; Cellier, Christophe MD, PhD1; Quénéhervé, Lucille MD, PhD2; PREPINTEST working group

doi : 10.14309/ajg.0000000000001597

February 2022 - Volume 117 - Issue 2 - p 327-335

The aim of our study was to compare clear liquid diet with 2 different polyethylene glycol (PEG)-based bowel preparation methods regarding diagnostic yield of small bowel capsule endoscopy (SBCE) in patients with suspected small bowel bleeding (SBB).

خرید پکیج و مشاهده آنلاین مقاله

Cancer Risk in Patients With and Relatives of Serrated Polyposis Syndrome and Sporadic Sessile Serrated Lesions

Kanth, Priyanka MD, MS1,2; Yu, Zhe MS2; Keener, Megan B. MS2; Koptiuch, Cathryn MS, CGC2; Kohlmann, Wendy K. MS, CGC2; Neklason, Deborah W. PhD2,3; Westover, Michelle MS4; Curtin, Karen PhD, MStat2,3

doi : 10.14309/ajg.0000000000001572

February 2022 - Volume 117 - Issue 2 - p 336-342

Patients with serrated polyposis syndrome (SPS) and their first-degree relatives (FDRs) have increased colorectal cancer (CRC) risk. Patients with sporadic sessile serrated lesion (SSL) have risk for progression to CRC. Yet familial risks of common extracolonic cancers and even CRC in these cohorts are poorly understood. Our aim was to examine cancer risk for patients with SPS and sporadic SSL and their close and more distant relatives using a large population database.

خرید پکیج و مشاهده آنلاین مقاله

Validation of the Endoscopic Part of the Spigelman Classification for Evaluating Duodenal Adenomatosis in Familial Adenomatous Polyposis: A Prospective Study of Interrater and Intrarater Reliability

Karstensen, John Gásdal MD, PhD1,2; Bülow, Steffen MD, DMSci1; Burisch, Johan MD, PhD3; Ellebæk, Mark Bremholm MD, PhD4; Ostapiuk, Marcin MD, PhD5; Pommergaard, Hans Christian MD, PhD6; Schmidt, Palle Nordblad MD, PhD3

doi : 10.14309/ajg.0000000000001582

February 2022 - Volume 117 - Issue 2 - p 343-345

In patients with familial adenomatous polyposis, the Spigelman classification is recommended for staging and risk stratification of duodenal adenomatosis. Although the classification has been used for decades, it has never been formally validated.

خرید پکیج و مشاهده آنلاین مقاله

Associations Between Sleep Position and Nocturnal Gastroesophageal Reflux: A Study Using Concurrent Monitoring of Sleep Position and Esophageal pH and Impedance

Schuitenmaker, Jeroen M. MD; van Dijk, Mitch MD; Oude Nijhuis, Renske A.B. MD; Smout, André J.P.M. MD, PhD; Bredenoord, Albert J. MD, PhD

doi : 10.14309/ajg.0000000000001588

February 2022 - Volume 117 - Issue 2 - p 346-351

The aim of this study was to investigate the effect of spontaneous sleep positions on the occurrence of nocturnal gastroesophageal reflux.

خرید پکیج و مشاهده آنلاین مقاله

Tis Not a Leiomyoma! Two Cases of Postendoscopic Full-Thickness Resection Leiomyomatous Pseudopolyps

Tan, Chin Kimg MD1,2; Wang, Lai Mun MB, BCh, BAO3,4; Goh, Lynne MBBS3,4; Li, James Weiquan MBBS1,2,5; Lin, Jinlin MBBS6; Ang, Tiing Leong MBBS1,2,5

doi : 10.14309/ajg.0000000000001583

February 2022 - Volume 117 - Issue 2 - p 352-354

خرید پکیج و مشاهده آنلاین مقاله

A Case of Esophageal Mucormycosis

Rajarajen, Arun Prabhahar MD1; Sethi, Jasmine MD, DM1; Shaji, Alan MBBS2; Singh, Anupam Kumar MD, DM3; Mitra, Saikat MD4; Vaiphei, Kim MD4

doi : 10.14309/ajg.0000000000001592

February 2022 - Volume 117 - Issue 2 - p 355

خرید پکیج و مشاهده آنلاین مقاله

Esophageal Functional Lumen Imaging Probe Panometry Vs High-Resolution Manometry—The Jury Is Still Out

Sanagapalli, Santosh MBBS, PhD, FRACP1,2; Sweis, Rami MD, PhD3

doi : 10.14309/ajg.0000000000001600

February 2022 - Volume 117 - Issue 2 - p 356

خرید پکیج و مشاهده آنلاین مقاله

Response to Sanagapalli and Sweis

Carlson, Dustin A. MD, MS1; Pandolfino, John E. MD, MS1

doi : 10.14309/ajg.0000000000001599

February 2022 - Volume 117 - Issue 2 - p 356-357

خرید پکیج و مشاهده آنلاین مقاله

Correction to: ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections

Kelly, Colleen R. MD, AGAF, FACG1; Fischer, Monika MD, MSc, AGAF, FACG2; Allegretti, Jessica R. MD, MPH, FACG3; LaPlante, Kerry PharmD, FCCP, FIDSA4; Stewart, David B. MD, FACS, FASCRS5; Limketkai, Berkeley N. MD, PhD, FACG6; Stollman, Neil H. MD, FACG7

doi : 10.14309/ajg.0000000000001529

February 2022 - Volume 117 - Issue 2 - p 358

خرید پکیج و مشاهده آنلاین مقاله

Correction to: Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain

Dunbar, Ellyn K. MS1,2; Greer, Phil J. MS1,3; Amann, Stephen T. MD4; Alkaade, Samer MD5,6; Banks, Peter MD7; Brand, Randall MD1; Conwell, Darwin L. MD, MSc7,8; Forsmark, Christopher E. MD9; Gardner, Timothy B. MD10; Guda, Nalini M. MD11,12; Lewis, Michele D. MD13; Machicado, Jorge D. MD1,14; Muniraj, Thiruvengadam MD, PhD1,15; Papachristou, Georgios I. MD, PhD1,8; Romagnuolo, Joseph MD16,17; Sandhu, Bimaljit S. MD18,19; Sherman, Stuart MD20; Slivka, Adam MD, PhD1; Wilcox, C. Mel MD21; Yadav, Dhiraj MD, MPH1; Whitcomb, David C. MD, PhD1,2,22; for the NAPS2 Consortium

doi : 10.14309/ajg.0000000000001549

February 2022 - Volume 117 - Issue 2 - p 359

خرید پکیج و مشاهده آنلاین مقاله

Calendar of Courses, Symposiums and Conferences

doi : 10.14309/ajg.0000000000001620

February 2022 - Volume 117 - Issue 2 - p 360

خرید پکیج و مشاهده آنلاین مقاله