دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Reforming the Process for Deep Brain Stimulation and Neurologic Device Approval in Rare Diseases
Michael S. Okun, MD; James Giordano, PhD
doi : 10.1001/jamaneurol.2020.4232
JAMA Neurol. 2021;78(1):5-6
What Caring for My Aging Parents Taught Me That Medical Education Did Not
David I. Rappaport, MD
doi : 10.1001/jamaneurol.2020.4454
JAMA Neurol. 2021;78(1):7-8
Cerebral Microbleeds and Antithrombotic Treatments—Stop Worrying About Bleeding
Laurent Puy, MD; Charlotte Cordonnier, MD, PhD
doi : 10.1001/jamaneurol.2020.3847
JAMA Neurol. 2021;78(1):9-10
Microbleeds and the Effect of Anticoagulation in Patients With Embolic Stroke of Undetermined SourceAn Exploratory Analysis of the NAVIGATE ESUS Randomized Clinical Trial
Ashkan Shoamanesh, MD; Robert G. Hart, MD; Stuart J. Connolly, MD; et al.
doi : 10.1001/jamaneurol.2020.3836
JAMA Neurol. 2021;78(1):11-20.
Importance The reported associations of cerebral microbleeds with recurrent stroke and intracerebral hemorrhage have raised concerns regarding antithrombotic treatment in patients with a history of stroke and microbleeds on magnetic resonance imaging.
Endovascular Treatment After Stroke Due to Large Vessel Occlusion for Patients Presenting Very Late From Time Last Known Well
Beom Joon Kim, MD, PhD; Bijoy K. Menon, MD, MSc; Jun Yup Kim, MD, MSc; et al.
doi : 10.1001/jamaneurol.2020.2804
JAMA Neurol. 2021;78(1):21-29
Importance Endovascular treatment (EVT) after ischemic stroke due to emergent large vessel occlusion is usually constrained by a specific window of less than 16 to 24 hours from the time the patient was last known well (LKW). Patients with slow progression and tenacious collateral circulation may persist beyond 16 hours.
Skin ?-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease
Zerui Wang, MD, PhD; Katelyn Becker, MS; Vincenzo Donadio, MD, PhD; et al.
doi : 10.1001/jamaneurol.2020.3311
JAMA Neurol. 2021;78(1):30-40
Importance Deposition of the pathological ?-synuclein (?SynP) in the brain is the hallmark of synucleinopathies, including Parkinson disease (PD), Lewy body dementia (LBD), and multiple system atrophy (MSA). Whether real-time quaking-induced conversion (RT-QuIC) and protein misfolding cyclic amplification (PMCA) assays can sensitively detect skin biomarkers for PD and non-PD synucleinopathies remains unknown.
Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients
Kevin N. Sheth, MD; Mercy H. Mazurek, BS; Matthew M. Yuen, BA; et al.
doi : 10.1001/jamaneurol.2020.3263
JAMA Neurol. 2021;78(1):41-47
Importance Neuroimaging is a key step in the clinical evaluation of brain injury. Conventional magnetic resonance imaging (MRI) systems operate at high-strength magnetic fields (1.5-3 T) that require strict, access-controlled environments. Limited access to timely neuroimaging remains a key structural barrier to effectively monitor the occurrence and progression of neurological injury in intensive care settings. Recent advances in low-field MRI technology have allowed for the acquisition of clinically meaningful imaging outside of radiology suites and in the presence of ferromagnetic materials at the bedside.
Efficacy and Safety of 2 Fingolimod Doses vs Glatiramer Acetate for the Treatment of Patients With Relapsing-Remitting Multiple SclerosisA Randomized Clinical Trial
Bruce A. C. Cree, MD, PhD, MAS; Myla D. Goldman, MD, MSc; John R. Corboy, MD; et al.
doi : 10.1001/jamaneurol.2020.2950
JAMA Neurol. 2021;78(1):48-60
Importance Doses of fingolimod lower than 0.5 mg per day were not investigated during the fingolimod clinical development program. Whether lower doses of fingolimod might retain efficacy with fewer safety risks remains unknown.
Association of Selective Serotonin Reuptake Inhibitor Use After Intracerebral Hemorrhage With Hemorrhage Recurrence and Depression Severity
Patryk Kubiszewski, BA; Lansing Sugita, BS; Christina Kourkoulis, BS; et al.
doi : 10.1001/jamaneurol.2020.3142
JAMA Neurol. 2021;78(1):61-67
Importance Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat poststroke depression but are associated with increased incidence of first-ever intracerebral hemorrhage (ICH) in the general population. The decision to treat ICH survivors with SSRIs must therefore balance potential risks of ICH recurrence with presumed benefits on depressive symptoms.
Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS)Bayesian Adaptive Comparative Effectiveness Randomized Trial
Richard J. Barohn, MD; Byron Gajewski, PhD; Mamatha Pasnoor, MD; et al.
doi : 10.1001/jamaneurol.2020.2590
JAMA Neurol. 2021;78(1):68-76
Importance Cryptogenic sensory polyneuropathy (CSPN) is a common generalized slowly progressive neuropathy, second in prevalence only to diabetic neuropathy. Most patients with CSPN have significant pain. Many medications have been tried for pain reduction in CSPN, including antiepileptics, antidepressants, and sodium channel blockers. There are no comparative studies that identify the most effective medication for pain reduction in CSPN.
A 5-Decade Analysis of Incidence Trends of Ischemic Stroke After Transient Ischemic AttackA Systematic Review and Meta-analysis
Shima Shahjouei, MD, MPH; Alireza Sadighi, MD; Durgesh Chaudhary, MD; et al.
doi : 10.1001/jamaneurol.2020.3627
JAMA Neurol. 2021;78(1):77-87
Importance Management of transient ischemic attack (TIA) has gained significant attention during the past 25 years after several landmark studies indicated the high incidence of a subsequent stroke.
Assessment of Emergency Department and Inpatient Use and Costs in Adult and Pediatric Functional Neurological Disorders
Christopher D. Stephen, MB ChB, MRCP(UK), MS; Vicki Fung, PhD; Codrin I. Lungu, MD; et al.
doi : 10.1001/jamaneurol.2020.3753
JAMA Neurol. 2021;78(1):88-101
Importance There is limited information about health care use and costs in patients with functional neurological disorders (FNDs).
Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources PanelA Meta-analysis
Brian W. Kunkle, PhD, MPH; Michael Schmidt, PhD; Hans-Ulrich Klein, PhD; et al.
doi : 10.1001/jamaneurol.2020.3536
JAMA Neurol. 2021;78(1):102-113
Importance Compared with non-Hispanic White individuals, African American individuals from the same community are approximately twice as likely to develop Alzheimer disease. Despite this disparity, the largest Alzheimer disease genome-wide association studies to date have been conducted in non-Hispanic White individuals. In the largest association analyses of Alzheimer disease in African American individuals, ABCA7, TREM2, and an intergenic locus at 5q35 were previously implicated.
Ultrasonography Evaluation of Bilateral Focal Auricular Dyskinesia
Yiding Li, MBBS, MRCP; Kappaganthu V. Prasanna, MBBS, MRCS; Tze Chao Wee, MBBS
doi : 10.1001/jamaneurol.2020.3352
JAMA Neurol. 2021;78(1):114
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy With the Detection of Anti-GM3 and Anti-GM4 IgG Antibodies, Masquerading as Brown-Sequard Syndrome
Zhi-Hua Zhou, PhD; Qing-Yun Yu, MD; Ming-Fan Hong, MD
doi : 10.1001/jamaneurol.2020.3828
JAMA Neurol. 2021;78(1):115-116
Disparities Across Sexual Orientation in Migraine Among US Adults
Jason M. Nagata, MD, MSc; Kyle T. Ganson, PhD, MSW; Jennifer Tabler, PhD; et al.
doi : 10.1001/jamaneurol.2020.3406
JAMA Neurol. 2021;78(1):117-118
Biotinidase Deficiency as a Mimic of Neuromyelitis Optica Spectrum Disorder in Childhood
Jonathan D. Santoro, MD; Kelli C. Paulsen, RN
doi : 10.1001/jamaneurol.2020.3558
JAMA Neurol. 2021;78(1):118-120
Correction to Author’s Academic Degrees
doi : 10.1001/jamaneurol.2020.4087
JAMA Neurol. 2021;78(1):120
Error in P Value in Abstract and Results
doi : 10.1001/jamaneurol.2020.4698
JAMA Neurol. 2021;78(1):120
