دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Challenges and Opportunities: Using Omics to Generate Testable Insights Into Pathogenic Mechanisms in Preclinical Seropositive Rheumatoid Arthritis
V. Michael Holers
doi : 10.1002/art.41479
Volume73, Issue1,Pages 1-4
Would a ‘Rosendo’ by Another Name Smell as Sweet? Gender Disparity in Academic Rank and Publications in Rheumatology
Janet E. Pope
doi : 10.1002/art.41498
Volume73, Issue1,Pages 5-8
Treat?to?Target From the Patient Perspective Is Bowling for a Perfect Strike
Casper G. Schoemaker Maarten P. T. de Wit
doi : 10.1002/art.41461
Volume73, Issue1,Pages 9-11
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease
Paul M. Lantos Jeffrey Rumbaugh Linda K. Bockenstedt Yngve T. Falck-Ytter Maria E. Aguero-Rosenfeld Paul G. Auwaerter Kelly Baldwin Raveendhara R. Bannuru Kiran K. Belani William R. Bowie John A. Branda David B. Clifford Francis J. DiMario Jr. John J. Halperin Peter J. Krause Valery Lavergne Matthew H. Liang H. Cody Meissner Lise E. Nigrovic James (Jay) J. Nocton Mikala C. Osani Amy A. Pruitt Jane Rips Lynda E. Rosenfeld Margot L. Savoy Sunil K. Sood Allen C. Steere Franc Strle Robert Sundel Jean Tsao Elizaveta E. Vaysbrot Gary P. WormserLawrence S. Zemel
doi : 10.1002/art.41562
Volume73, Issue1,Pages 12-20
Support for this guideline was provided by the Infectious Diseases Society of America, the American Academy of Neurology, and the American College of Rheumatology.
Winners of the 2020 American College of Rheumatology Annual Image Competition
American College of Rheumatology Image Library Subcommittee
doi : 10.1002/art.41556
Volume73, Issue1,Pages 21-22
The Longitudinal Immune Response to Coronavirus Disease 2019: Chasing the Cytokine Storm
Alice S. Chau Andrew G. Weber Naomi I. Maria Sonali Narain Audrey Liu Negin Hajizadeh Prashant Malhotra Ona Bloom Galina Marder Blanka Kaplan
doi : 10.1002/art.41526
Volume73, Issue1,Pages 23-35
The clinical progression of the severe acute respiratory syndrome coronavirus 2 infection, coronavirus 2019 (COVID?19), to critical illness is associated with an exaggerated immune response, leading to magnified inflammation termed the “cytokine storm.” This response is thought to contribute to the pathogenicity of severe COVID?19. There is an initial weak interferon response and macrophage activation that results in delayed neutrophil recruitment leading to impeded viral clearance. This causes prolonged immune stimulation and the release of proinflammatory cytokines. Elevated inflammatory markers in COVID?19 (e.g., d?dimer, C?reactive protein, lactate dehydrogenase, ferritin, and interleukin?6) are reminiscent of the cytokine storm seen in severe hyperinflammatory macrophage disorders. The dysfunctional immune response in COVID?19 also includes lymphopenia, reduced T cells, reduced natural killer cell maturation, and unmitigated plasmablast proliferation causing aberrant IgG levels. The progression to severe disease is accompanied by endotheliopathy, immunothrombosis, and hypercoagulability. Thus, both parts of the immune system—innate and adaptive—play a significant role in the cytokine storm, multiorgan dysfunction, and coagulopathy. This review highlights the importance of understanding the immunologic mechanisms of COVID?19 as they inform the clinical presentation and advise potential therapeutic targets.
Antirheumatic Disease Therapies for the Treatment of COVID?19: A Systematic Review and Meta?Analysis
Michael Putman Yu Pei Eugenia Chock Herman Tam Alfred H. J. Kim Sebastian E. Sattui Francis Berenbaum Maria I. Danila Peter Korsten Catalina Sanchez-Alvarez Jeffrey A. Sparks Laura C. Coates Candace Palmerlee Andrea Peirce Arundathi Jayatilleke Sindhu R. Johnson Adam Kilian Jean Liew Larry J. Prokop M. Hassan Murad Rebecca Grainger Zachary S. Wallace Al? Duarte-Garc?a the COVID?19 Global Rheumatology Alliance … See fewer authors
doi : 10.1002/art.41469
Volume73, Issue1,Pages 36-47
Antirheumatic disease therapies have been used to treat coronavirus disease 2019 (COVID?19) and its complications. We conducted a systematic review and meta?analysis to describe the current evidence.
Susceptibility to COVID?19 in Patients Treated With Antimalarials: A Population?Based Study in Emilia?Romagna, Northern Italy
Carlo Salvarani Pamela Mancuso Federica Gradellini Nilla Viani Paolo Pandolfi Massimo Reta Giuliano Carrozzi Gilda Sandri Gianluigi Bajocchi Elena Galli Francesco Muratore Luigi Boiardi Nicol? Pipitone Giulia Cassone Stefania Croci Anna Maria Marata Massimo Costantini Paolo Giorgi Rossi
doi : 10.1002/art.41475
Volume73, Issue1,Pages 48-52
To evaluate the susceptibility to coronavirus disease 2019 (COVID?19) in patients with autoimmune conditions treated with antimalarials in a population?based study.
Omitted Author Affiliation in the Article by Xu et al (Arthritis Rheumatol, August 2020)
doi : 10.1002/art.41617
Volume73, Issue1,Pages 52-52
Errors in Two Sentences in the Letter by Bertin et al (Arthritis Rheumatol, November 2020)
doi : 10.1002/art.41609
Volume73, Issue1,Pages 52-52
Improvements in Fatigue Lag Behind Disease Remission in Early Rheumatoid Arthritis: Results From the Canadian Early Arthritis Cohort
Melissa Holdren Orit Schieir Susan J. Bartlett Louis Bessette Gilles Boire Glen Hazlewood Carol A. Hitchon Edward Keystone Diane Tin Carter Thorne Vivian P. Bykerk Janet E. Pope on behalf of the Canadian Early Arthritis Cohort investigators
doi : 10.1002/art.41499
Volume73, Issue1,Pages 53-60
To examine the relationship between disease activity and fatigue over time in early rheumatoid arthritis (RA).
Respiratory Diseases as Risk Factors for Seropositive and Seronegative Rheumatoid Arthritis and in Relation to Smoking
Vanessa L. Kronzer Helga Westerlind Lars Alfredsson Cynthia S. Crowson Fredrik Nyberg G?ran Tornling Lars Klareskog Marie Holmqvist Johan Askling
doi : 10.1002/art.41491
Volume73, Issue1,Pages 61-68
The link and interplay between different airway exposures and rheumatoid arthritis (RA) risk are unclear. This study was undertaken to determine whether respiratory disease is associated with development of RA, and specifically to examine this relationship by RA serostatus and smoking exposure.
Mediterranean Diet and Risk of Rheumatoid Arthritis: Findings From the French E3N?EPIC Cohort Study
Yann Nguyen Carine Salliot Amandine Gelot Juliette Gambaretti Xavier Mariette Marie?Christine Boutron?Ruault Raphaèle Seror
doi : 10.1002/art.41487
Volume73, Issue1,Pages 69-77
The Mediterranean diet has been reported to be associated with a significant reduction in risk of noncommunicable diseases. We undertook this study to assess the relationship between adherence to the Mediterranean diet and the risk of rheumatoid arthritis (RA), especially in high?risk individuals.
Association of a Serum Protein Signature With Rheumatoid Arthritis Development
Liam J. O’Neil Victor Spicer Irene Smolik Xiaobo Meng Rishi R. Goel Vidyanand Anaparti John Wilkins Hani S. El?Gabalawy
doi : 10.1002/art.41483
Volume73, Issue1,Pages 78-88
The pathophysiologic events that precede the onset of rheumatoid arthritis (RA) remain incompletely understood. This study was undertaken to identify changes in the serum proteome that precede the onset of RA, with the aim of providing new insights into the pathogenic mechanisms that lead to its development.
Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression
Ming?Feng Hsueh Xin Zhang Samuel S. Wellman Michael P. Bolognesi Virginia B. Kraus
doi : 10.1002/art.41486
Volume73, Issue1,Pages 89-99
To evaluate the role of immune cells and their effector cytokines in the pathogenesis and progression of knee osteoarthritis (OA) in matched OA synovial fluid (SF) and synovial tissue samples.
Multi?Tissue Epigenetic and Gene Expression Analysis Combined With Epigenome Modulation Identifies RWDD2B as a Target of Osteoarthritis Susceptibility
Eleanor Parker Ines M. J. Hofer Sarah J. Rice Lucy Earl Sami A. Anjum David J. Deehan John Loughlin
doi : 10.1002/art.41473
Volume73, Issue1,Pages 100-109
Osteoarthritis (OA) is polygenic, with more than 90 risk loci currently mapped, including at the single?nucleotide polymorphism rs6516886. Previous analysis of OA cartilage DNA identified 6 CpG dinucleotides whose methylation levels correlated with the rs6516886 genotype, forming methylation quantitative trait loci (mQTLs). We undertook this study to investigate these mQTLs and to map expression quantitative trait loci (eQTLs) across joint tissues in order to prioritize a particular gene as a target of the rs6516886 association effect.
Improvement of Signs and Symptoms of Nonradiographic Axial Spondyloarthritis in Patients Treated With Secukinumab: Primary Results of a Randomized, Placebo?Controlled Phase III Study
Atul Deodhar Ricardo Blanco Eva Dokoupilov? Stephen Hall Hideto Kameda Alan J. Kivitz Denis Poddubnyy Marleen van de Sande Anna S. Wiksten Brian O. Porter Hanno B. Richards Sibylle Haemmerle Jürgen Braun
doi : 10.1002/art.41477
Volume73, Issue1,Pages 110-120
To report the primary (1?year) results from PREVENT, the first phase III study evaluating secukinumab in patients with active nonradiographic axial spondyloarthritis (SpA).
Phase II Randomized Trial of Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis
Yemil Atisha?Fregoso Susan Malkiel Kristina M. Harris Margie Byron Linna Ding Sai Kanaparthi William T. Barry Wendy Gao Kristin Ryker Patti Tosta Anca D. Askanase Susan A. Boackle W. Winn Chatham Diane L. Kamen David R. Karp Kyriakos A. Kirou S. Sam Lim Bradley Marder Maureen McMahon Samir V. Parikh William F. Pendergraft III Amber S. Podoll Amit Saxena David Wofsy Betty Diamond Dawn E. Smilek Cynthia Aranow Maria Dall’Era
doi : 10.1002/art.41466
Volume73, Issue1,Pages 121-131
To assess the safety, mechanism of action, and preliminary efficacy of rituximab followed by belimumab in the treatment of refractory lupus nephritis (LN).
Conversion of T Follicular Helper Cells to T Follicular Regulatory Cells by Interleukin?2 Through Transcriptional Regulation in Systemic Lupus Erythematosus
He Hao Shingo Nakayamada Kaoru Yamagata Naoaki Ohkubo Shigeru Iwata Yoshino Inoue Mingzeng Zhang Tong Zhang Yurie Kanda Satoh Yu Shan Takashi Otsuka Yoshiya Tanaka
doi : 10.1002/art.41457
Volume73, Issue1,Pages 132-142
This study was undertaken to identify characteristics of follicular regulatory T (Tfr) cells and elucidate the mechanisms by which follicular helper T (Tfh) cells convert to Tfr cells. We probed the phenotype of T helper cells in patients with systemic lupus erythematosus (SLE) and underlying transcriptional regulation using cytokine?induced STAT family factors.
Improvement of Severe Fatigue Following Nuclease Therapy in Patients With Primary Sj?gren’s Syndrome: A Randomized Clinical Trial
James Posada Saba Valadkhan Daniel Burge Kristen Davies Jessica Tarn John Casement Kerry Jobling Peter Gallagher Douglas Wilson Francesca Barone Benjamin A. Fisher Wan?Fai Ng
doi : 10.1002/art.41489
Volume73, Issue1,Pages 143-150
To assess the safety and efficacy of RSLV?132, an RNase Fc fusion protein, in a phase II randomized, double?blind, placebo?controlled clinical trial in patients with primary Sj?gren’s syndrome (SS).
Phase II Open Label Study of Anakinra in Intravenous Immunoglobulin–Resistant Kawasaki Disease
Isabelle Koné?Paut Stéphanie Tellier Alexandre Belot Karine Brochard Corinne Guitton Isabelle Marie Ulrich Meinzer Bilade Cherqaoui Caroline Galeotti Nadja Boukhedouni Helene Agostini Moshe Arditi Virginie Lambert Céline Piedvache
doi : 10.1002/art.41481
Volume73, Issue1,Pages 151-161
Anakinra has been shown to be successful in preventing and treating cardiovascular lesions both in experimental murine models of Kawasaki disease (KD) and in several studies on intravenous immunoglobulin (IVIG)– and steroid?resistant patients with KD. This study was undertaken to determine the safety of blocking interleukin?1 in patients with IVIG?resistant KD.
Representation of Women as Authors of Rheumatology Research Articles
Ekta Bagga Sarah Stewart Gregory D. Gamble Janine Hill Andrew Grey Nicola Dalbeth
doi : 10.1002/art.41490
Volume73, Issue1,Pages 162-167
To determine the potential association between physician gender and academic advancement among US rheumatologists.
The Association Between Physician Gender and Career Advancement Among Academic Rheumatologists in the United States
April Jorge Marcy Bolster Xiaoqing Fu Daniel M. Blumenthal Nate Gross Kimberly G. Blumenthal Zachary Wallace
doi : 10.1002/art.41492
Volume73,Issue1,Pages 168-172
To determine the potential association between physician gender and academic advancement among US rheumatologists.
Reality Check on Antiphospholipid Antibodies in COVID?19–Associated Coagulopathy
Elena Gkrouzman Medha Barbhaiya Doruk Erkan Michael D. Lockshin
doi : 10.1002/art.41472
Volume73,Issue1,Pages 173-174
Determinants of Morning Stiffness in Rheumatoid Arthritis: Comment on the Article by Orange et al
Siddharth Jain Debashish Mishra Varun Dhir
doi : 10.1002/art.41459
Volume73, Issue1,Pages 174-175
Reply
Dana E. Orange Nathalie E. Blachere Mayu O. Frank Salina Parveen Edward F. DiCarlo Serene Mirza Tania Pannellini Caroline S. Jiang Mark P. Figgie Vivian P. Bykerk Ellen M. Gravallese Ana-Maria Orbai Sarah L. Mackie Susan M. Goodman
doi : 10.1002/art.41463
Volume73, Issue1,Pages 175-176
Examining the Role of NF?E2–Related Factor 2 in Lupus: Comment on the Article by Han et al
Wang-Dong Xu An-Fang Huang
doi : 10.1002/art.41482
Volume73, Issue1,Pages 176-176
Reply
Shuhong Han Haoyang Zhuang Mingjia Li Lijun Yang Pui Y. Lee Peter A. Nigrovic Westley H. Reeves
doi : 10.1002/art.41478
Volume73, Issue1,Pages 176-178
Dipeptidylpeptidase 4 as a Marker of Fibrosis in Systemic Sclerosis: Comment on the Article by Soare et al
Michael R. Liebling
doi : 10.1002/art.41470
Volume73, Issue1,Pages 178-179
Erosive Costovertebral Joint Arthritis—An Uncommon Manifestation of Ankylosing Spondylitis
Tal Gazitt Najwan Nassrallah Devy Zisman
doi : 10.1002/art.41514
Volume73, Issue1,Pages 180-180
