دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Raphael J. DeHoratius, MD, 1942–2020
Lawrence H. Brent
doi : 10.1002/art.41636
Arthritis & RheumatologyVolume 73, Issue 4 p. 551-552
Expert Perspective: Immune Checkpoint Inhibitors and Rheumatologic Complications
Laura C. Cappelli Clifton O. Bingham III
doi : 10.1002/art.41587
Arthritis & RheumatologyVolume 73, Issue 4 p. 553-565
Rheumatologists increasingly receive consults for patients treated with immune checkpoint inhibitors (ICIs) for cancer. ICIs can cause inflammatory syndromes known as immune?related adverse events (IRAEs). Several rheumatic IRAEs have been reported, including inflammatory arthritis, polymyalgia rheumatica, and myositis. For patients who present with musculoskeletal symptoms while receiving ICI therapy, it is important to have an algorithm for evaluation. The differential diagnosis includes a range of musculoskeletal syndromes, such as crystalline arthritis, mechanical issues, and osteoarthritis, in addition to IRAEs. After diagnosing a rheumatic IRAE, rheumatologists must work with the patient and the oncologist to form a treatment plan. Treatment of IRAEs is guided by severity. Evidence for management is limited to observational studies. Inflammatory arthritis and polymyalgia rheumatica are treated with nonsteroidal antiinflammatory drugs in mild cases, glucocorticoids for moderate?to?severe cases, and sometimes require other disease?modifying antirheumatic drugs. Myositis due to ICIs can be accompanied by myocarditis or myasthenia gravis. Glucocorticoids and withholding the ICI are usually required to treat myositis; some patients with severe myositis require intravenous immunoglobulin or plasmapheresis. Further research is needed to optimize treatment of IRAEs that does not compromise the antitumor effect of ICIs.
American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV?2 and Hyperinflammation in Pediatric COVID?19: Version 2
Lauren A. Henderson Scott W. Canna Kevin G. Friedman Mark Gorelik Sivia K. Lapidus Hamid Bassiri Edward M. Behrens Anne Ferris Kate F. Kernan Grant S. Schulert Philip Seo Mary Beth F. Son Adriana H. Tremoulet Rae S. M. Yeung Amy S. Mudano Amy S. Turner David R. Karp Jay J. MehtaLauren A. Henderson Scott W. Canna Kevin G. Friedman Mark Gorelik Sivia K. Lapidus Hamid Bassiri Edward M. Behrens Anne Ferris Kate F. Kernan Grant S. Schulert Philip Seo Mary Beth F. Son Adriana H. Tremoulet Rae S. M. Yeung Amy S. Mudano Amy S. Turner David R. Karp Jay J. Mehta … See fewer authors
doi : 10.1002/art.41616
Arthritis & RheumatologyVolume 73, Issue 4 p. e13-e29
To provide guidance on the management of Multisystem Inflammatory Syndrome in Children (MIS?C), a condition characterized by fever, inflammation, and multiorgan dysfunction that manifests late in the course of severe acute respiratory syndrome coronavirus 2 (SARS–CoV?2) infection. Recommendations are also provided for children with hyperinflammation during coronavirus disease 2019 (COVID?19), the acute, infectious phase of SARS–CoV?2 infection.
Consequences of a Great Crisis on Chronic Diseases: How Childhood Exposures May Shape Future Health
Jason J. Lee Zumin Shi
doi : 10.1002/art.41599
Arthritis & RheumatologyVolume 73, Issue 4 p. 566-567
Associations of Antibodies Targeting Periodontal Pathogens With Subclinical Coronary, Carotid, and Peripheral Arterial Atherosclerosis in Rheumatoid Arthritis
Jon T. Giles Jesper Reinholdt Felipe Andrade Maximilian F. Konig
doi : 10.1002/art.41572
Arthritis & RheumatologyVolume 73, Issue 4 p. 568-575
Both periodontal disease and cardiovascular disease (CVD) are overrepresented in rheumatoid arthritis (RA). This study was undertaken to investigate the contribution of periodontal pathogens to CVD in RA.
Distinct Expression of Coinhibitory Molecules on Alveolar T Cells in Patients With Rheumatoid Arthritis–Associated and Idiopathic Inflammatory Myopathy–Associated Interstitial Lung Disease
Maho Nakazawa Katsuya Suzuki Masaru Takeshita Jun Inamo Hirofumi Kamata Makoto Ishii Yoshitaka Oyamada Hisaji Oshima Tsutomu Takeuchi
doi : 10.1002/art.41554
Arthritis & RheumatologyVolume 73, Issue 4 p. 576-586
To identify immunologic factors in the lungs of patients with rheumatoid arthritis–associated interstitial lung disease (RA?ILD) and patients with idiopathic inflammatory myopathy–associated ILD (IIM?ILD) and to examine their pathologic mechanisms.
Efficacy and Safety of E6011, an Anti?Fractalkine Monoclonal Antibody, in Patients With Active Rheumatoid Arthritis With Inadequate Response to Methotrexate: Results of a Randomized, Double?Blind, Placebo?Controlled Phase II Study
Yoshiya Tanaka Tsutomu Takeuchi Hisashi Yamanaka Toshihiro Nanki Hisanori Umehara Nobuyuki Yasuda Fumitoshi Tago Yasumi Kitahara Makoto Kawakubo Kentaro Torii Seiichiro Hojo Tetsu Kawano Toshio Imai
doi : 10.1002/art.41555
Arthritis & RheumatologyVolume 73, Issue 4 p. 587-595
To evaluate the efficacy and safety of E6011, a humanized IgG2 monoclonal antibody against human fractalkine (FKN), in a phase II, double?blind, placebo?controlled study in rheumatoid arthritis (RA) patients.
In Utero and Early Life Exposure to the Great Chinese Famine and Risk of Rheumatoid Arthritis in Adulthood
Hannah VanEvery Wen?hao Yang Nancy Olsen Xinyuan Zhang Rong Shu Bing Lu Shouling Wu Liufu Cui Xiang Gao
doi : 10.1002/art.41601
Arthritis & RheumatologyVolume 73, Issue 4 p. 596-603
To investigate whether early life exposure to the Great Chinese Famine of 1959?1961 is associated with the risk of RA development in adulthood.
Efficacy and Safety of Guselkumab, an Interleukin?23p19–Specific Monoclonal Antibody, Through One Year in Biologic?Naive Patients With Psoriatic Arthritis
Iain B. McInnes Proton Rahman Alice B. Gottlieb Elizabeth C. Hsia Alexa P. Kollmeier Soumya D. Chakravarty Xie L. Xu Ramanand A. Subramanian Prasheen Agarwal Shihong Sheng Yusang Jiang Bei Zhou Yanli Zhuang Désirée van der Heijde Philip J. Mease
doi : 10.1002/art.41553
Arthritis & RheumatologyVolume 73, Issue 4 p. 604-616
Guselkumab, a human monoclonal antibody specific to interleukin?23p19, demonstrated efficacy and safety versus placebo through week 24 of the phase III DISCOVER?2 trial in biologic?naive patients with psoriatic arthritis (PsA). Here we report 1?year DISCOVER?2 findings.
Hospitalized Infections in Lupus: A Nationwide Study of Types of Infections, Time Trends, Health Care Utilization, and In?Hospital Mortality
Jasvinder A. Singh John D. Cleveland
doi : 10.1002/art.41577
Arthritis & RheumatologyVolume 73, Issue 4 p. 617-630
To examine the time trends in hospitalized infections in patients with systemic lupus erythematosus (SLE), and the factors associated with health care utilization and in?hospital mortality.
Wong?Type Dermatomyositis in an African American Patient
Christina E. Bax Madison Grinnell Josef Symon S. Concha Victoria P. Werth
doi : 10.1002/art.41629
Arthritis & RheumatologyVolume 73, Issue 4 p. 630-630
Interleukin?7/Interferon Axis Drives T Cell and Salivary Gland Epithelial Cell Interactions in Sj?gren’s Syndrome
Elodie Rivière Juliette Pascaud Alexandre Virone Anastasia Dupré Bineta Ly Audrey Paoletti Raphaèle Seror Nicolas Tchitchek Michael Mingueneau Nikaïa Smith Darragh Duffy Lydie Cassard Nathalie Chaput Sabrina Pengam Vanessa Gauttier Nicolas Poirier Xavier Mariette Gaetane Nocturne
doi : 10.1002/art.41558
Arthritis & RheumatologyVolume 73, Issue 4 p. 631-640
Primary Sj?gren’s syndrome (SS) is characterized by a lymphocytic infiltration of salivary glands (SGs) and the presence of an interferon (IFN) signature. SG epithelial cells (SGECs) play an active role in primary SS pathophysiology. We undertook this study to examine the interactions between SGECs and T cells in primary SS and the role of the interleukin?7 (IL?7)/IFN axis.
Sustained Remission of Granulomatosis With Polyangiitis After Discontinuation of Glucocorticoids and Immunosuppressant Therapy: Data From the French Vasculitis Study Group Registry
Xavier Puéchal Michele Iudici Christian Pagnoux Alexandre Karras Pascal Cohen François Maurier Thomas Quéméneur François Lifermann Mohamed Hamidou Luc Mouthon Benjamin Terrier Loïc Guillevin for the French Vasculitis Study Group
doi : 10.1002/art.41551
Arthritis & RheumatologyVolume 73, Issue 4 p. 641-650
Data on sustained remission of granulomatosis with polyangiitis (GPA) after discontinuation of therapy (referred to as GPA with sustained remission off?therapy [SROT]) are scarce. In the present study, SROT among GPA patients from the French Vasculitis Study Group Registry was evaluated to identify factors associated with its occurrence and durability.
Multimorbidity in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Results From a Longitudinal, Multicenter Data Linkage Study
Shifa H. Sarica Peter J. Gallacher Neeraj Dhaun Jan Sznajd John Harvie John McLaren Lucy McGeoch Vinod Kumar Nicole Amft Lars Erwig Angharad Marks Laura Bruno York Z?llner Corri Black Neil Basu
doi : 10.1002/art.41557
Arthritis & RheumatologyVolume 73, Issue 4 p. 651-659
Antineutrophil cytoplasmic antibody–associated vasculitis (AAV) is considered a chronic, relapsing condition. To date, no studies have investigated multimorbidity in AAV nationally. This study was undertaken to characterize temporal trends in multimorbidity and report excess health care expenditures associated with multimorbidities in a national AAV cohort from Scotland.
Large?Scale Characterization of Systemic Sclerosis Serum Protein Profile: Comparison to Peripheral Blood Cell Transcriptome and Correlations With Skin/Lung Fibrosis
Chiara Bellocchi Jun Ying Ellen A. Goldmuntz Lynette Keyes?Elstein John Varga Monique E. Hinchcliff Marka A. Lyons Peter McSweeney Daniel E. Furst Richard Nash Leslie J. Crofford Beverly Welch Jonathan G. Goldin Ashley Pinckney Maureen D. Mayes Keith M. Sullivan Shervin Assassi
doi : 10.1002/art.41570
Arthritis & RheumatologyVolume 73, Issue 4 p. 660-670
To provide a large?scale assessment of serum protein dysregulation in diffuse cutaneous systemic sclerosis (dcSSc) and to investigate serum protein correlates of SSc fibrotic features.
Effect of Nintedanib on Lung Function in Patients With Systemic Sclerosis?Associated Interstitial Lung Disease: Further Analyses of a Randomized, Double?Blind, Placebo?Controlled Trial
Toby M. Maher Maureen D. Mayes Michael Kreuter Elizabeth R. Volkmann Martin Aringer Ivan Castellvi Maurizio Cutolo Christian Stock Nils Schoof Margarida Alves Ganesh Raghu the SENSCIS Trial Investigators
doi : 10.1002/art.41576
Arthritis & RheumatologyVolume 73, Issue 4 p. 671-676
In the SENSCIS trial in subjects with systemic sclerosis–associated interstitial lung disease (SSc?ILD), nintedanib reduced the rate of decline in forced vital capacity (FVC) over 52 weeks by 44% versus placebo. This study was undertaken to investigate the effects of nintedanib on categorical changes in FVC and other measures of ILD progression.
Risk Prediction Modeling Based on a Combination of Initial Serum Biomarker Levels in Polymyositis/Dermatomyositis–Associated Interstitial Lung Disease
Takahisa Gono Kenichi Masui Naoshi Nishina Yasushi Kawaguchi Atsushi Kawakami Kei Ikeda Yohei Kirino Yumiko Sugiyama Yoshinori Tanino Takahiro Nunokawa Yuko Kaneko Shinji Sato Katsuaki Asakawa Taro Ukichi Shinjiro Kaieda Taio Naniwa Yutaka Okano Masataka Kuwana and the Multicenter Retrospective Cohort of Japanese Patients with Myositis?Associated ILD (JAMI) Investigators
doi : 10.1002/art.41566
Arthritis & RheumatologyVolume 73, Issue 4 p. 677-686
To establish predictive models for mortality in patients with polymyositis/dermatomyositis–associated interstitial lung disease (PM/DM?ILD) using a combination of initial serum biomarker levels.
Can Dual?Energy Computed Tomography Be Used to Identify Early Calcium Crystal Deposition in the Knees of Patients With Calcium Pyrophosphate Deposition?
Jean?François Budzik Claire Marzin Julie Legrand Laurène Norberciak Fabio Becce Tristan Pascart
doi : 10.1002/art.41569
Arthritis & RheumatologyVolume 73, Issue 4 p. 687-692
To assess the ability of dual?energy computed tomography (DECT) in identifying early calcium crystal deposition in menisci and articular cartilage of the knee, depending on the presence/absence of chondrocalcinosis seen on conventional CT.
Platelet Glycoprotein Ib ??Chain as a Putative Therapeutic Target for Juvenile Idiopathic Arthritis: A Mendelian Randomization Study
Shan Luo Sarah L. N. Clarke Athimalaipet V. Ramanan Susan D. Thompson Carl D. Langefeld Miranda C. Marion Alexei A. Grom C. Mary Schooling Tom R. Gaunt Shiu Lun Au Yeung Jie Zheng
doi : 10.1002/art.41561
Arthritis & RheumatologyVolume 73, Issue 4 p. 693-701
To ascertain the role of platelet glycoprotein Ib ??chain (GPIb?) plasma protein levels in cardiovascular, autoimmune, and autoinflammatory diseases and whether its effects are mediated by platelet count.
Errors in Figure 6B of the Article by Ciccia et al (Arthritis Rheumatol, December 2018)
Francesco Ciccia MD, PhD Giuliana Guggino MD, PhD Michael Zeng PhD Ranjeny Thomas MBBS, MD Vidya Ranganathan Arifur Rahman BSc, MS Riccardo Alessandro PhD Aroldo Rizzo MD Laura Saieva PhD Federica Macaluso MD Sergio Peralta MD Diana Di Liberto PhD Francesco Dieli MD, PhD Paola Cipriani MD, PhD Roberto Giacomelli MD, PhD Dominique Baeten MD, PhD Nigil Haroon MD, PhD, DM
doi : 10.1002/art.41680
Arthritis & RheumatologyVolume 73, Issue 4 p. 701-701
Prevalence, Deaths, and Disability?Adjusted Life Years Due to Musculoskeletal Disorders for 195 Countries and Territories 1990–2017
Saeid Safiri Ali?Asghar Kolahi Marita Cross Catherine Hill Emma Smith Kristin Carson?Chahhoud Mohammad Ali Mansournia Amir Almasi?Hashiani Ahad Ashrafi?Asgarabad Jay Kaufman Mahdi Sepidarkish Seyed Kazem Shakouri Damian Hoy Anthony D. Woolf Lyn March Gary Collins Rachelle Buchbinder
doi : 10.1002/art.41571
Arthritis & RheumatologyVolume 73, Issue 4 p. 702-714
To report the levels and trends of prevalence, deaths, and disability?adjusted life years (DALYs) due to musculoskeletal disorders, categorized as low back pain, neck pain, osteoarthritis (OA), rheumatoid arthritis (RA), gout, and other musculoskeletal disorders, across 195 countries and territories from 1990 to 2017 according to age, sex, and Sociodemographic Index (SDI; a composite of sociodemographic factors).
Different Control Populations May Lead to Different Understanding of Hydroxychloroquine Blood Levels as a Risk Factor for Retinopathy: Comment on the Article by Petri et al
Tiphaine Lenfant Gaëlle Leroux Nathalie Costedoat?Chalumeau
doi : 10.1002/art.41588
Arthritis & RheumatologyVolume 73, Issue 4 p. 715-715
Lenabasum for Systemic Sclerosis—Are Cannabinoids the Missing Link? Comment on the Article by Spiera et al
Sakshi Mittal Shefali Sharma
doi : 10.1002/art.41578
Arthritis & RheumatologyVolume 73, Issue 4 p. 715-716
Reply
Robert Spiera Lorinda Chung Tracy Frech Robyn Domsic Vivien Hsu Daniel E. Furst Robert Simms Maureen Mayes Viktor Martyanov Michael L. Whitfield Nancy Dgetluck Quinn Dinh Barbara White
doi : 10.1002/art.41579
Arthritis & RheumatologyVolume 73, Issue 4 p. 716-717
Should the Biopsychosocial Model Be Considered in Systemic Autoimmune Diseases? Comment on the Article by Posada et al
Laurent Chiche Noémie Jourde?Chiche Divi Cornec
doi : 10.1002/art.41582
Arthritis & RheumatologyVolume 73, Issue 4 p. 717-718
Reply
James Posada Benjamin A. Fisher Wan?Fai Ng
doi : 10.1002/art.41581
Arthritis & RheumatologyVolume 73, Issue 4 p. 718-719
Recognition of Rare, Atypical Manifestations Is Important for Diagnosis and Management of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Comment on the Article by Delaval et al
Mitsuhiro Akiyama
doi : 10.1002/art.41590
Arthritis & RheumatologyVolume 73, Issue 4 p. 719-719
Reply
Laure Delaval Benjamin Terrier
doi : 10.1002/art.41592
Arthritis & RheumatologyVolume 73, Issue 4 p. 719-720
Omitted Author in the Article by Bernstein et al (Arthritis Rheumatol, November 2020)
Elana J. Bernstein Sara Jaafar Shervin Assassi Robyn T. Domsic Tracy M. Frech Jessica K. Gordon Rachel J. Broderick Faye N. Hant Monique E. Hinchcliff Ami A. Shah Victoria K. Shanmugam Virginia D. Steen Dinesh Khanna
doi : 10.1002/art.41681
Arthritis & RheumatologyVolume 73, Issue 4 p. 720-720
