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Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes
Matthew C Riddle, William T Cefalu, Philip H Evans, Hertzel C Gerstein, Michael A Nauck, William K Oh, Amy E Rothberg, Carel W le Roux, Francesco Rubino, Philip Schauer, Roy Taylor, Douglas Twenefour
doi : 10.1210/clinem/dgab585
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 1–9
Improvement of glucose levels into the normal range can occur in some people living with diabetes, either spontaneously or after medical interventions, and in some cases can persist after withdrawal of glucose-lowering pharmacotherapy. Such sustained improvement may now be occurring more often due to newer forms of treatment. However, terminology for describing this process and objective measures for defining it are not well established, and the long-term risks versus benefits of its attainment are not well understood. To update prior discussions of this issue, an international expert group was convened by the American Diabetes Association to propose nomenclature and principles for data collection and analysis, with the goal of establishing a base of information to support future clinical guidance. This group proposed “remission� as the most appropriate descriptive term, and HbA1c < 6.5% (48 mmol/mol) measured at least 3 months after cessation of glucose-lowering pharmacotherapy as the usual diagnostic criterion. The group also made suggestions for active observation of individuals experiencing a remission and discussed further questions and unmet needs regarding predictors and outcomes of remission.
Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease
Fabienne Langlois, Elena V Varlamov, Maria Fleseriu
doi : 10.1210/clinem/dgab672
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 10–28
Hypophysitis is defined as inflammation of the pituitary gland that is primary or secondary to a local or systemic process. Differential diagnosis is broad (including primary tumors, metastases, and lympho-proliferative diseases) and multifaceted. Patients with hypophysitis typically present with headaches, some degree of anterior and/or posterior pituitary dysfunction, and enlargement of pituitary gland and/or stalk, as determined by imaging. Most hypophysitis causes are autoimmune, but other etiologies include inflammation secondary to sellar tumors or cysts, systemic diseases, and infection or drug-induced causes. Novel pathologies such as immunoglobulin G4-related hypophysitis, immunotherapy-induced hypophysitis, and paraneoplastic pituitary-directed autoimmunity are also included in a growing spectrum of this rare pituitary disease. Typical magnetic resonance imaging reveals stalk thickening and homogenous enlargement of the pituitary gland; however, imaging is not always specific. Diagnosis can be challenging, and ultimately, only a pituitary biopsy can confirm hypophysitis type and rule out other etiologies. A presumptive diagnosis can be made often without biopsy. Detailed history and clinical examination are essential, notably for signs of underlying etiology with systemic manifestations. Hormone replacement and, in selected cases, careful observation is advised with imaging follow-up. High-dose glucocorticoids are initiated mainly to help reduce mass effect. A response may be observed in all auto-immune etiologies, as well as in lymphoproliferative diseases, and, as such, should not be used for differential diagnosis. Surgery may be necessary in some cases to relieve mass effect and allow a definite diagnosis. Immunosuppressive therapy and radiation are sometimes also necessary in resistant cases.
The Emerging Role of Glucagon-like Peptide-1 Receptor Agonists for the Management of NAFLD
Chandani Patel Chavez, Kenneth Cusi, Sushma Kadiyala
doi : 10.1210/clinem/dgab578
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 29–38
The burden of cirrhosis from nonalcoholic fatty liver disease (NAFLD) is reaching epidemic proportions in the United States. This calls for greater awareness among endocrinologists, who often see but may miss the diagnosis in adults with obesity or type 2 diabetes mellitus (T2D) who are at the highest risk. At the same time, recent studies suggest that glucagon-like peptide-1 receptor agonists (GLP-1RAs) are beneficial vs nonalcoholic steatohepatitis (NASH) in this population. This minireview aims to assist endocrinologists to recognize the condition and recent work on the role of GLP-1RAs in NAFLD/NASH.
Changes in Serum Cytokines Throughout Pregnancy in Women With Polycystic Ovary Syndrome
Live Marie T Stokkeland, Guro F Giskeødegård, Mariell Ryssdal, Anders Hagen Jarmund, Bjørg Steinkjer, Torfinn Støve Madssen, Signe N Stafne, Solhild Stridsklev, Tone S Løvvik, Ann-Charlotte Iversen, Eszter Vanky
doi : 10.1210/clinem/dgab684
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 39–52
Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with low-grade inflammation and increased incidence of pregnancy complications, but its influence on the maternal immune system in pregnancy is unknown. Longitudinal serum cytokine profiling is a sensitive measure of the complex immunological dynamics of pregnancy.
Insulin Increases Adipose Adiponectin in Pregnancy by Inhibiting Ubiquitination and Degradation: Impact of Obesity
Irving L M H Aye, Fredrick J Rosario, Anita Kramer, Oddrun Kristiansen, Trond M Michelsen, Theresa L Powell, Thomas Jansson
doi : 10.1210/clinem/dgab680
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 53–66
Circulating adiponectin levels are decreased in pregnant women with obesity or gestational diabetes, and this is believed to contribute to the insulin resistance and increased risk of fetal overgrowth associated with these conditions. However, the molecular mechanisms regulating adiponectin secretion from maternal adipose tissues in pregnancy are poorly understood.
Osteogenesis Imperfecta: The Impact of Genotype and Clinical Phenotype on Adiposity and Resting Energy Expenditure
Kaitlin L Ballenger, Nicol Tugarinov, Sara K Talvacchio, Marianne M Knue, An N Dang Do, Mark A Ahlman, James C Reynolds, Jack A Yanovski, Joan C Marini
doi : 10.1210/clinem/dgab679
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 67–76
Mutations in type I collagen or collagen-related proteins cause osteogenesis imperfecta (OI). Energy expenditure and body composition in OI could reflect reduced mobility or intrinsic defects in osteoblast differentiation increasing adipocyte development.
Colonic Lactulose Fermentation Has No Impact on Glucagon-like Peptide-1 and Peptide-YY Secretion in Healthy Young Men
Charlotte Bayer Christiansen, Simon Veedfald, Bolette Hartmann, Astrid Marie Gauguin, Søren Møller, Thomas Moritz, Sten Madsbad, Jens Juul Holst
doi : 10.1210/clinem/dgab666
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 77–87
The colon houses most of humans’ gut microbiota, which ferments indigestible carbohydrates. The products of fermentation have been proposed to influence the secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) from the many endocrine cells in the colonic epithelium. However, little is known about the colonic contribution to fasting or postprandial plasma levels of L-cell products.
Association of MAFLD With Diabetes, Chronic Kidney Disease, and Cardiovascular Disease: A 4.6-Year Cohort Study in China
Yebei Liang, Hongli Chen, Yuexing Liu, Xuhong Hou, Li Wei, Yuqian Bao, Chunguang Yang, Geng Zong, Jiarui Wu, Weiping Jia Author Notes
doi : 10.1210/clinem/dgab641
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 88–97
In 2020, the terminology of metabolic dysfunction–associated fatty liver disease (MAFLD) was proposed to replace nonalcoholic fatty liver disease (NAFLD).
Vitamin D Supplementation Improves Fasting Insulin Levels and HDL Cholesterol in Infertile Men
Rune Holt, Jørgen Holm Petersen, Elsa Dinsdale, Filip Krag Knop, Anders Juul, Niels Jørgensen, Martin Blomberg Jensen
doi : 10.1210/clinem/dgab667
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 98–108
Vitamin D has been linked with glucose and lipid metabolism. Men with impaired gonadal function have a higher risk of metabolic syndrome and mortality, and vitamin D status may be a reversible modulator.
A Reference Range for Plasma Levels of Inorganic Pyrophosphate in Children Using the ATP Sulfurylase Method
Eva Bernhard, Yvonne Nitschke, Gus Khursigara, Yves Sabbagh, Yongbao Wang, Frank Rutsch
doi : 10.1210/clinem/dgab615
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 109–118
Generalized arterial calcification of infancy, pseudoxanthoma elasticum, autosomal recessive hypophosphatemic rickets type 2, and hypophosphatasia are rare inherited disorders associated with altered plasma levels of inorganic pyrophosphate (PPi). In this study, we aimed to establish a reference range for plasma PPi in the pediatric population, which would be essential to support its use as a biomarker in children with mineralization disorders.
Distinct Lipidomic Signatures in People Living With HIV: Combined Analysis of ACTG 5260s and MACS/WIHS
Jennifer Jao, Lauren C Balmert, Shan Sun, Grace A McComsey, Todd T Brown, Phyllis C Tien, Judith S Currier, James H Stein, Yunping Qiu, Derek LeRoith, Irwin J Kurland
doi : 10.1210/clinem/dgab663
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 119–135
Disentangling contributions of HIV from antiretroviral therapy (ART) and understanding the effects of different ART on metabolic complications in persons living with HIV (PLHIV) has been challenging.
METTL3-mediated RNA m6A Hypermethylation Promotes Tumorigenesis and GH Secretion of Pituitary Somatotroph Adenomas
Mengqi Chang, Zihao Wang, Jun Gao, Chengxian Yang, Ming Feng, Yamei Niu, Wei-Min Tong, Xinjie Bao, Renzhi Wang Author Notes
doi : 10.1210/clinem/dgab652
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 136–149
Pituitary growth hormone-secreting (GH) pituitary adenomas (PAs) cause mass effects and dysregulated hypersecretion of GH. However, somatic mutation burden is low in PAs. While progress has been made in identifying the epigenetic changes involved in GH-PA initiation, the precise details of its tumorigenesis in GH-PA patients remains to be elucidated. As N6-methyladenosine (m6A) has been shown to often play a critical role in various tumors, it represents a possible initiation point for the tumorigenesis of pituitary adenomas. However, the role of RNA methylation in GH adenomas remains unclear.
Glucocorticoid-induced Fingerprints on Visceral Adipose Tissue Transcriptome and Epigenome
Guillermo GarcÃa-Eguren, Mar González-RamÃrez, Pedro Vizán, Oriol Giró, Arturo Vega-Beyhart, Laura Boswell, Mireia Mora, Irene Halperin, Francisco Carmona, Meritxell Gracia, Gregori Casals, Mattia Squarcia, Joaquim Enseñat, Oscar Vidal, Luciano Di Croce, Felicia A Hanzu
doi : 10.1210/clinem/dgab662
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 150–166
Chronic glucocorticoid (GC) overexposure, resulting from endogenous Cushing’s syndrome (CS) or exogenous GC therapy, causes several adverse outcomes, including persistent central fat accumulation associated with a low-grade inflammation. However, no previous multiomics studies in visceral adipose tissue (VAT) from patients exposed to high levels of unsuppressed GC during active CS or after remission are available yet.
Reduced Sensitivity to Thyroid Hormone Is Associated with Diabetes and Hypertension
Ladan Mehran, Negar Delbari, Atieh Amouzegar, Mitra Hasheminia, Maryam Tohidi, Fereidoun Azizi
doi : 10.1210/clinem/dgab646
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 167–176
Recently, reduced sensitivity to thyroid hormone as a more common finding in the general population and its possible association with metabolic parameters has been the focus of attention.
The Impact of Long-term Physical Inactivity on Adipose Tissue Immunometabolism
William V Trim, Jean-Philippe Walhin, Francoise Koumanov, Anne Bouloumié, Mark A Lindsay, Rebecca L Travers, James E Turner, Dylan Thompson
doi : 10.1210/clinem/dgab647
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 177–191
Adipose tissue and physical inactivity both influence metabolic health and systemic inflammation, but how adipose tissue responds to chronic physical inactivity is unknown.
Decreased Monocyte Count Is Associated With Gestational Diabetes Mellitus Development, Macrosomia, and Inflammation
Xinmei Huang, Bingbing Zha, Manna Zhang, Yue Li, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Cuijun Gao, Zaoping Chen, Heyuan Ding, Ling Ma, Yanquan Zhang, Shufei Zang, Tie-Ning Zhang, Jun Liu
doi : 10.1210/clinem/dgab657
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 192–204
The immune system plays a central role in the pathophysiology of gestational diabetes mellitus (GDM). Monocytes, the main innate immune cells, are especially important in the maintenance of a normal pregnancy.
Diagnostic Pitfalls in Cushing Disease: Surgical Remission Rates, Test Thresholds, and Lessons Learned in 105 Patients
Regin Jay Mallari, Jai Deep Thakur, Garni Barkhoudarian, Amy Eisenberg, Amanda Rodriguez, Sarah Rettinger, Pejman Cohan, Lynnette Nieman, Daniel F Kelly
doi : 10.1210/clinem/dgab659
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 205–218
Confirming a diagnosis of Cushing disease (CD) remains challenging, yet is critically important before recommending transsphenoidal surgery for adenoma resection.
Dynamic Changes in Serum IGF-I and Growth During Infancy: Associations to Body Fat, Target Height, and PAPPA2 Genotype
Emmie N Upners, Marie Lindhardt Ljubicic, Alexander S Busch, Margit Bistrup Fischer, Kristian Almstrup, Jørgen H Petersen, Rikke Beck Jensen, Casper P Hagen, Anders Juul
doi : 10.1210/clinem/dgab653
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 219–229
IGF-I is important for postnatal growth and may be of diagnostic value in infants suspected of pituitary disease; however, little is known about the impact of IGF-I and its determinants on infant growth. Importantly, detailed reference ranges for IGF-I and IGF binding protein-3 (IGFBP-3) concentrations during infancy are lacking.
Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes
Neda Rasouli, Irwin G Brodsky, Ranee Chatterjee, Sun H Kim, Richard E Pratley, Myrlene A Staten, Anastassios G Pittas, D2d Research Group
doi : 10.1210/clinem/dgab649
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 230–240
Vitamin D regulates glucose homeostasis pathways, but effects of vitamin D supplementation on β-cell function remain unclear.
Approach to the Patient: Pharmacological Management of Trans and Gender-Diverse Adolescents
Michele A O’Connell, Thomas P Nguyen, Astrid Ahler, S Rachel Skinner, Ken C Pang
doi : 10.1210/clinem/dgab634
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 241–257
Internationally, increasing numbers of children and adolescents with gender dysphoria are presenting for care. In response, gender-affirming therapeutic interventions that seek to align bodily characteristics with an individual’s gender identity are more commonly being used. Depending on a young person’s circumstances and goals, hormonal interventions may aim to achieve full pubertal suppression, modulation of endogenous pubertal sex hormone effects, and/or development of secondary sex characteristics congruent with their affirmed gender. This is a relatively novel therapeutic area and, although short-term outcomes are encouraging, longer term data from prospective longitudinal adolescent cohorts are still lacking, which may create clinical and ethical decision-making challenges. Here, we review current treatment options, reported outcomes, and clinical challenges in the pharmacological management of trans and gender-diverse adolescents.
Nonalcoholic Fatty Liver Disease in Women and Girls With Polycystic Ovary Syndrome
Claire Falzarano, Taylor Lofton, Adjoa Osei-Ntansah, Trinitee Oliver, Taylor Southward, Salim Stewart, Stanley Andrisse
doi : 10.1210/clinem/dgab658
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 258–272
Nonalcoholic fatty liver disease (NAFLD) describes a spectrum of liver damage due to excessive hepatic lipid accumulation. Recent research has demonstrated a high prevalence of NAFLD in women with polycystic ovary syndrome (PCOS).
Reproductive Health in First-degree Relatives of Patients With Polycystic Ovary Syndrome: A Review and Meta-analysis
Dan Shan, Jinbiao Han, Yitong Cai, Li Zou, Liangzhi Xu, Yongchun Shen
doi : 10.1210/clinem/dgab640
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages 273–295
Polycystic ovary syndrome (PCOS) is a highly heritable disease. Emerging evidence elucidated the elevated prevalence of reproductive abnormalities in first-degree relatives (FDRs) of patients with PCOS.
Novel Therapies for Kidney Disease in People With Diabetes
Nayana Khurana, Steven James, Melinda T Coughlan, Richard J MacIsaac, Elif I Ekinci
doi : 10.1210/clinem/dgab639
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e1–e24
The increasing burden of diabetic kidney disease (DKD) has led to the discovery of novel therapies.
Insulin Resistance and Cardiometabolic Risk Profile Among Nondiabetic American Young Adults: Insights From NHANES
Vibhu Parcha, Brittain Heindl, Rajat Kalra, Peng Li, Barbara Gower, Garima Arora, Pankaj Arora
doi : 10.1210/clinem/dgab645
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e25–e37
The burden of insulin resistance (IR) among young American adults has not been previously assessed. We evaluated (1) the prevalence and trends of IR and cardiometabolic risk factors and (2) the association between measures of adiposity and IR among adults 18 to 44 years of age without diabetes and preexisting cardiovascular disease.
TUBB3 E410K Syndrome With Childhood-Onset Nonalcoholic Steatohepatitis
Jun Mori, Atsushi Umemura, Wataru Satake, Pei-Chieng Cha, Yutaka Suzuki, Kyoko Itoh, Tomohiro Chiyonobu
doi : 10.1210/clinem/dgab628
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e38–e43
Nonalcoholic fatty liver disease (NAFLD) is becoming a major issue worldwide, even in children. Multiple parallel hits hypothesis has been suggested as progress of NAFLD, but the mechanism of NAFLD is not completely understood. β-Tubulin is essential in mitoses, neuronal migration, and axon guidance during neuronal development. Pathogenic variants in the TUBB3 gene were shown to be associated with a wide spectrum of neurological abnormalities, but not accompanied by hepatic complications, such as NAFLD.
Association of Mixed Use of Electronic and Conventional Cigarettes and Exposure to Secondhand Smoke With Prediabetes
Seung Hoon Kim, Minah Park, Gyu Ri Kim, Hye Jin Joo, Sung-In Jang
doi : 10.1210/clinem/dgab558
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e44–e56
Despite previous studies regarding the association between smoking and diabetes, the effects of electronic cigarettes and secondhand smoke (SHS) on glucose metabolism and insulin sensitivity have not been fully elucidated.
LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in Obese Adults With Modest Hypertriglyceridemia
Daniel J Rader, Eleftheria Maratos-Flier, Amanda Nguyen, Doug Hom, Michael Ferriere, Yifang Li, Jill Kompa, Miljen Martic, Markus Hinder, Craig T Basson, David Yowe, John Diener, Allison B Goldfine, CLLF580X2102 Study Team
doi : 10.1210/clinem/dgab624
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e57–e70
To evaluate the safety and potential efficacy of LLF580, a genetically engineered variant of human fibroblast growth factor-21, for triglyceride lowering, weight loss, and hepatic fat reduction.
Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications
Ali Abbara, Maya Al-Memar, Maria Phylactou, Elisabeth Daniels, Bijal Patel, Pei C Eng, Rans Nadir, Chioma Izzi-Engbeaya, Sophie A Clarke, Edouard G Mills, Tia Hunjan, Ewa Pacuszka, Lisa Yang, Paul Bech, Tricia Tan, Alexander N Comninos, Tom W Kelsey, Christopher Kyriacou, Hanine Fourie, Tom Bourne, Waljit S Dhillo
doi : 10.1210/clinem/dgab617
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e71–e83
Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all 3 trimesters in women with antenatal complications.
Individual and Combined Cardiometabolic Morbidities and the Subsequent Risk of Cardiovascular Events in Chinese Adults
Jiao Wang, Zhimin Wang, Feng Guo, Yinghui Zhang, Hongfei Ji, Gang Chen, Qin Wan, Li Yan, Guixia Wang, Yingfen Qin, Zuojie Luo, Xulei Tang, Yanan Huo, Ruying Hu, Zhen Ye, Lixin Shi, Zhengnan Gao, Qing Su, Yiming Mu, Jiajun Zhao, Lulu Chen, Tianshu Zeng, Xuefeng Yu, Qiang Li, Feixia Shen, Li Chen, Yinfei Zhang, Youmin Wang, Huacong Deng, Chao Liu, Shengli Wu, Tao Yang, Mian Li, Yu Xu, Min Xu, Zhiyun Zhao, Tiange Wang, Jieli Lu, Yufang Bi, Weiqing Wang, Guang Ning, Yanyan Zhao, Guijun Qin
doi : 10.1210/clinem/dgab609
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e84–e94
Diabetes, hypertension and dyslipidemia accelerates the incidence of cardiovascular disease (CVD) events. However, data regarding the association between main cardiometabolic morbidities such as diabetes, hypertension, and dyslipidemia and the subsequent risk of CVD events in Chinese adults are still limited.
Interrelationships Between Sclerostin, Secondary Hyperparathyroidism, and Bone Metabolism in Patients on Hemodialysis
Yosuke Nakagawa, Hirotaka Komaba, Naoto Hamano, Hisae Tanaka, Takehiko Wada, Hiroaki Ishida, Michio Nakamura, Hiroo Takahashi, Yuichiro Takahashi, Toru Hyodo, Miho Hida, Takao Suga, Takatoshi Kakuta, Masafumi Fukagawa
doi : 10.1210/clinem/dgab623
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e95–e105
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e95–e105
Catch-up Growth and Discontinuation of Fludrocortisone Treatment in Aldosterone Synthase Deficiency
Busra Gurpinar Tosun, Yasemin Kendir Demirkol, Tuba Seven Menevse, Sare Betul Kaygusuz, Mehmet Nuri Ozbek, Selda Ayca Altincik, Jamala Mammadova, Atilla Cayir, Esra Doger, Elvan Bayramoglu, Ozlem Nalbantoglu, Gul Yesiltepe Mutlu, AghaRza Aghayev, Serap Turan, Abdullah Bereket, Tulay Guran
doi : 10.1210/clinem/dgab619
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e106–e117
Aldosterone synthase deficiency (ASD) caused by mutations in the CYP11B2 gene is characterized by isolated mineralocorticoid deficiency. Data are scarce regarding clinical and biochemical outcomes of the disease in the follow-up.
Association of Maternal Total Cholesterol With SGA or LGA Birth at Term: the Japan Environment and Children’s Study
Kayo Kaneko, Yuki Ito, Takeshi Ebara, Sayaka Kato, Taro Matsuki, Hazuki Tamada, Hirotaka Sato, Shinji Saitoh, Mayumi Sugiura-Ogasawara, Shin Yamazaki, Yukihiro Ohya, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni Inadera, Takeo Nakayama, Hiroyasu Iso, Masayuki Shima, Youichi Kurozawa, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh, Michihiro Kamijima
doi : 10.1210/clinem/dgab618
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e118–e129
Maternal cholesterol is important for fetal development. Whether maternal serum total cholesterol (maternal TC) levels in midpregnancy are associated with small (SGA) or large (LGA) for gestational age independent of prepregnancy body mass index (BMI) and weight gain during pregnancy is inconclusive.
Network Analyses Reveal Negative Link Between Changes in Adipose Tissue GDF15 and BMI During Dietary-induced Weight Loss
Alyssa Imbert, Nathalie Vialaneix, Julien Marquis, Julie Vion, Aline Charpagne, Sylviane Metairon, Claire Laurens, Cedric Moro, Nathalie Boulet, Ondine Walter, Grégory Lefebvre, Jörg Hager, Dominique Langin, Wim H M Saris, Arne Astrup, Nathalie Viguerie, Armand Valsesia
doi : 10.1210/clinem/dgab621
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e130–e142
Adipose tissue (AT) transcriptome studies provide holistic pictures of adaptation to weight and related bioclinical settings changes.
Blastocyst Transfer: A Risk Factor for Gestational Diabetes Mellitus in Women Undergoing In Vitro Fertilization
Huijun Chen, Jian Li, Sufen Cai, Sha Tang, Suimin Zeng, Chang Chu, Carl-Friedrich Hocher, Benjamin Rösing, Bernhard K Krämer, Liang Hu,Ge Lin, Fei Gong, Berthold Hocher
doi : 10.1210/clinem/dgab594
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e143–e152
The risk of developing gestational diabetes mellitus (GDM) is higher in women undergoing assisted reproductive treatment than in women conceiving spontaneously.
Change in Visceral Fat and Total Body Fat and the Effect on Cardiometabolic Risk Factors During Transgender Hormone Therapy
Maartje Klaver, Daan van Velzen, Christel de Blok, Nienke Nota, Chantal Wiepjes, Justine Defreyne, Thomas Schreiner, Alessandra Fisher, Jos Twisk, Jaap Seidell, Guy T’Sjoen, Martin den Heijer, Renée de Mutsert
doi : 10.1210/clinem/dgab616
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e153–e164
Excess visceral fat increases the risk of type 2 diabetes and cardiovascular disease and is influenced by sex hormones. Our aim was to investigate changes in visceral fat and the ratio of visceral fat to total body fat (VAT/TBF) and their associations with changes in lipids and insulin resistance after 1 year of hormone therapy in trans persons.
Age, American Thyroid Association Risk Group, and Response to Therapy Are Prognostic Factors in Children With Differentiated Thyroid Cancer
Antje Redlich, Markus Luster, Kerstin Lorenz, Lienhard Lessel, Tilman R Rohrer, Kurt W Schmid, Michael C Frühwald, Peter Vorwerk, Michaela Kuhlen
doi : 10.1210/clinem/dgab622
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e165–e177
Against the background of increasing incidence, pediatric differentiated thyroid carcinoma (DTC) frequently presents with advanced disease and high recurrence rates while prognosis remains excellent.
Risk of Incident Heart Failure in Individuals With Early-Onset Type 2 Diabetes
Jian-Jun Liu, Sylvia Liu, Jiexun Wang, Janus Lee, Justin I-Shing Tang, Resham L Gurung, Keven Ang, Yi Ming Shao, Subramaniam Tavintharan, Wern Ee Tang, Chee Fang Sum, Su Chi Lim
doi : 10.1210/clinem/dgab620
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e178–e187
Early-onset diabetes has been associated with unfavorable cardiovascular risk but data on heart failure (HF) in this subpopulation are scarce.
Entero-Pancreatic Hormone Secretion, Gastric Emptying, and Glucose Absorption After Frequently Sampled Meal Tests
Simon Veedfald, Jens F Rehfeld, Gerrit van Hall, Lars B Svendsen, Jens J Holst
doi : 10.1210/clinem/dgab610
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e188–e204
Entero-pancreatic hormone secretion has been reported during the pre-absorptive cephalic and gastric meal phases, but never with a blood sampling frequency providing a temporal resolution that allows close scrutiny and correlations with gastric emptying and glucose absorption.
Effects of Dietary Fat and Protein on Glucoregulatory Hormones in Adolescents and Young Adults With Type 1 Diabetes
Amelia J Harray, Sabrina Binkowski, Barbara L Keating, Michael Horowitz, Scott Standfield, Grant Smith, Nirubasini Paramalingam, Timothy Jones, Bruce R King, Carmel E M Smart, Elizabeth A Davis
doi : 10.1210/clinem/dgab614
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e205–e213
Dietary fat and protein impact postprandial hyperglycemia in people with type 1 diabetes, but the underlying mechanisms are poorly understood. Glucoregulatory hormones are also known to modulate gastric emptying and may contribute to this effect.
Diabetes and Outcomes Following Personalized Antiplatelet Therapy in Coronary Artery Disease Patients Who Have Undergone PCI
Ying-Ying Zheng, Ting-Ting Wu, Yi Yang, Xian-Geng Hou, You Chen, Xiang Ma, Yi-Tong Ma, Jin-Ying Zhang, Xiang Xie Author Notes
doi : 10.1210/clinem/dgab612
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e214–e223
A personalized antiplatelet therapy guided by a novel platelet function testing (PFT), PL-12, is considered an optimized treatment strategy in stable coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI). However, the safety and efficacy of any dual-antiplatelet therapy (DAPT) strategy may differ in relation to diabetes status.
Prevalence of Enthesopathies in Adults With X-linked Hypophosphatemia: Analysis of Risk Factors
Julia Herrou, Axelle Salcion Picaud, Louis Lassalle, Laurence Pacot, Catherine Chaussain, Valérie Merzoug, Agathe Hervé, Margaux Gadion, Anya Rothenbuhler, Peter Kamenický, Christian Roux, Agnès Linglart, Martin Biosse Duplan, Karine Briot
doi : 10.1210/clinem/dgab580
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e224–e235
Enthesopathies are the determinant of a poor quality of life in adults with X-linked hypophosphatemia (XLH).
Testicular Microvascular Flow Is Altered in Klinefelter Syndrome and Predicts Circulating Testosterone
Francesco Carlomagno, Carlotta Pozza, Marta Tenuta, Riccardo Pofi, Luigi Tarani, Franz Sesti, Marianna Minnetti, Daniele Gianfrilli, Andrea M Isidori Author Notes
doi : 10.1210/clinem/dgab605
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e236–e245
Experimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no studies investigated in vivo testicular blood flow dynamics in humans with KS.
Continuous Glucose Monitoring in the Management of Neonates With Persistent Hypoglycemia and Congenital Hyperinsulinism
Myat Win, Rowan Beckett, Lynn Thomson, Ajay Thankamony, Kathryn Beardsall
doi : 10.1210/clinem/dgab601
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e246–e253
Persistent hypoglycemia is common in the newborn and is associated with poor neurodevelopmental outcome. Adequate monitoring is critical in prevention, but is dependent on frequent, often hourly blood sampling. Continuous glucose monitoring (CGM) is increasingly being used in children with type 1 diabetes mellitus, but use in neonatology remains limited. We aimed to introduce real-time CGM to provide insights into patterns of dysglycemia and to support the management of persistent neonatal hypoglycemia.
ZSWIM7 Is Associated With Human Female Meiosis and Familial Primary Ovarian Insufficiency
Sinéad M McGlacken-Byrne, Polona Le Quesne Stabej, Ignacio Del Valle, Louise Ocaka, Andrey Gagunashvili, Berta Crespo, Nadjeda Moreno, Chela James, Chiara Bacchelli, Mehul T Dattani,Hywel J Williams, Dan Kelberman, John C Achermann, Gerard S Conway
doi : 10.1210/clinem/dgab597
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e254–e263
Primary ovarian insufficiency (POI) affects 1% of women and is associated with significant medical consequences. A genetic cause for POI can be found in up to 30% of women, elucidating key roles for these genes in human ovary development.
Low Adrenomedullary Function Predicts Acute Illness in Infants With Classical Congenital Adrenal Hyperplasia
Jonathan Weber, Veeraya K Tanawattanacharoen, Amy Seagroves, Mark C Liang, Christina M Koppin, Heather M Ross, Tania A S S Bachega, Mitchell E Geffner, Monica Serrano-Gonzalez, Gagandeep Bhullar, Mimi S Kim
doi : 10.1210/clinem/dgab600
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e264–e271
Youth with classical congenital adrenal hyperplasia (CAH) exhibit abnormal adrenomedullary function with decreased epinephrine levels noted in newborns and young infants. Little is known about how this relates to morbidity during the first year of life.
Production of 11-Oxygenated Androgens by Testicular Adrenal Rest Tumors
Mariska A M Schröder, Adina F Turcu, Patrick O’Day, Antonius E van Herwaarden, Paul N Span, Richard J Auchus, Fred C G J Sweep, Hedi L Claahsen-van der Grinten
doi : 10.1210/clinem/dgab598
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e272–e280
Testicular adrenal rest tumors (TART) are a common complication in males with classic 21-hydroxylase deficiency (21OHD). TART are likely to contribute to the androgen excess in 21OHD patients, but a direct quantification of steroidogenesis from these tumors has not been yet done.
Determinants and Outcomes Associated With Urinary Calcium Excretion in Chronic Kidney Disease
Jing Liu, Maria Clarissa Tio, Ashish Verma, Insa M Schmidt, Titilayo O Ilori, Felix Knauf, Finnian R Mc Causland, Sushrut S Waikar
doi : 10.1210/clinem/dgab574
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e281–e292
Abnormalities in calcium metabolism are common in chronic kidney disease (CKD). Diminished urinary calcium excretion may promote vascular calcification and increased urinary calcium excretion may lead to nephrolithiasis and nephrocalcinosis, conditions associated with CKD.
The Unfavorable Impact of DR9/DR9 Genotype on the Frequency and Quality of Partial Remission in Type 1 Diabetes
Yan Chen, Ying Xia, Zhiguo Xie, Ting Zhong, Rong Tang, Xia Li, Zhiguang Zhou
doi : 10.1210/clinem/dgab589
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e293–e302
Partial remission (PR) is a specific stage in type 1 diabetes (T1D). Although human leukocyte antigen (HLA) class II loci are the strongest genetic determinants in T1D, the relationship between PR and HLA remains unclear.
Associations of Endogenous Hormones With HDL Novel Metrics Across the Menopause Transition: The SWAN HDL Study
Samar R El Khoudary, Alexis Nasr, Jeffrey Billheimer, Maria M Brooks, Dan McConnell, Sybil Crawford, Trevor J Orchard, Daniel J Rader, Karen A Matthews
doi : 10.1210/clinem/dgab595
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e303–e314
Novel metrics of high-density lipoprotein (HDL) (subclasses, lipid content, and function) may improve characterization of the anti-atherogenic features of HDL. In midlife women, changes in these metrics vary by time relative to the final menstrual period (FMP), supporting a contribution of estradiol (E2) and follicle-stimulating hormone (FSH).
Maternal Body Mass Index, Early-Pregnancy Metabolite Profile, and Birthweight
Rama J Wahab, Vincent W V Jaddoe, Ellis Voerman, George J G Ruijter, Janine F Felix, Linda Marchioro, Olaf Uhl, Engy Shokry, Berthold Koletzko, Romy Gaillard
doi : 10.1210/clinem/dgab596
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e315–e327
Maternal prepregnancy body mass index (BMI) has a strong influence on gestational metabolism, but detailed metabolic alterations are unknown.
Inhibiting Kiss1 Neurons With Kappa Opioid Receptor Agonists to Treat Polycystic Ovary Syndrome and Vasomotor Symptoms
Elizabeth A McCarthy, Daniel Dischino, Caroline Maguire, Silvia Leon, Rajae Talbi, Eugene Cheung, Claudio D Schteingart, Pierre J M Rivière, Susan D Reed, Robert A Steiner, Victor M Navarro
doi : 10.1210/clinem/dgab602
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e328–e347
Recent evidence suggests that vasomotor symptoms (VMS) or hot flashes in the postmenopausal reproductive state and polycystic ovary syndrome (PCOS) in the premenopausal reproductive state emanate from the hyperactivity of Kiss1 neurons in the hypothalamic infundibular/arcuate nucleus (KNDy neurons).
Vitamin D Levels Are Associated With Blood Glucose and BMI in COVID-19 Patients, Predicting Disease Severity
Luigi di Filippo, Agnese Allora, Mauro Doga, Anna Maria Formenti, Massimo Locatelli, Patrizia Rovere Querini, Stefano Frara, Andrea Giustina
doi : 10.1210/clinem/dgab599
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e348–e360
A high prevalence of vitamin D (VD) deficiency in COVID-19 patients has been reported and hypothesized to increase COVID-19 severity likely because of its negative impact on immune and inflammatory responses. Furthermore, clear associations between hypovitaminosis D and fat body mass excess and diabetes, factors associated with COVID-19 severity, have been widely recognized.
Low Levels of Serum Sclerostin in Adult Patients With Tumor-Induced Osteomalacia Compared With X-linked Hypophosphatemia
Xiaolin Ni, Qi Zhang, Xiang Li, Qianqian Pang, Yiyi Gong, Ou Wang, Mei Li, Xiaoping Xing, Yan Jiang, Weibo Xia
doi : 10.1210/clinem/dgab579
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e361–e371
Sclerostin inhibits Wnt-β-catenin signaling, regulating bone formation. Circulating sclerostin was reported to be elevated in X-linked hypophosphatemia (XLH) patients, and sclerostin antibody (Scl-Ab) increased bone mass and normalized circulating phosphate in Hyp mice. However, circulating sclerostin levels in patients with acquired hypophosphatemia due to tumor-induced osteomalacia (TIO) are rarely reported.
PaTH Forward: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial of TransCon PTH in Adult Hypoparathyroidism
Aliya A Khan, Lars Rejnmark, Mishaela Rubin, Peter Schwarz, Tamara Vokes, Bart Clarke, Intekhab Ahmed, Lorenz Hofbauer, Claudio Marcocci, Uberto Pagotto, Andrea Palermo, Erik Eriksen, Meryl Brod, Denka Markova, Alden Smith, Susanne Pihl, Sanchita Mourya, David B Karpf, Aimee D Shu
doi : 10.1210/clinem/dgab577
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e372–e385
Hypoparathyroidism is characterized by insufficient levels of parathyroid hormone (PTH). TransCon PTH is an investigational long-acting prodrug of PTH(1-34) for the treatment of hypoparathyroidism.
Timing of Pubertal Development and Midlife Blood Pressure in Men and Women: A Mendelian Randomization Study
Io Ieong Chan, Man Ki Kwok, C Mary Schooling
doi : 10.1210/clinem/dgab561
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e386–e393
Observational studies suggest earlier puberty is associated with higher adulthood blood pressure (BP), but these findings have not been replicated using Mendelian randomization (MR). We examined this question sex-specifically using larger genome-wide association studies (GWAS) with more extensive measures of pubertal timing.
Primary Adrenal Insufficiency Due to Bilateral Adrenal Infarction in COVID-19
Iza F R Machado, Isabel Q Menezes, Sabrina R Figueiredo, Fernando M A Coelho, Debora R B Terrabuio, Davi V Ramos, Gustavo F C Fagundes, Ana Alice W Maciel, Ana Claudia Latronico, Maria Candida B V Fragoso, Eduardo L R Cancado, Berenice B Mendonca, Madson Q Almeida
doi : 10.1210/clinem/dgab557
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e394–e400
Coronavirus disease 2019 (COVID-19) is a proinflammatory and prothrombotic condition, but its impact on adrenal function has not been adequately evaluated.
Growth Hormone Receptor (GHR) 6Ω Pseudoexon Activation: A Novel Cause of Severe Growth Hormone Insensitivity
Emily Cottrell, Avinaash Maharaj, Jack Williams, Sumana Chatterjee, Grazia Cirillo, Emanuele Miraglia del Giudice, Adalgisa Festa, Stefania Palumbo, Donatella Capalbo, Mariacarolina Salerno, Claudio Pignata, Martin O Savage, Katharina Schilbach, Martin Bidlingmaier, Vivian Hwa, Louise A Metherell, Anna Grandone, Helen L Storr
doi : 10.1210/clinem/dgab550
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e401–e416
Severe forms of growth hormone insensitivity (GHI) are characterized by extreme short stature, dysmorphism, and metabolic anomalies.
Another Kid on the Block: Long-acting FGF21 Analogue to Treat Dyslipidemia and Fatty Liver
Ranyao Yang, Aimin Xu, Alexei Kharitonenkov
doi : 10.1210/clinem/dgab686
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e417–e419
Are Branched Chain Amino Acids the Potential Targets for Lifestyle Interventions in Youth?
Lu Qi
doi : 10.1210/clinem/dgab631
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e420–e422
Block and Replace—a New Therapeutic Concept in Congenital Adrenal Hyperplasia?
Nicole Reisch
doi : 10.1210/clinem/dgab555
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e423–e425
Bariatric Interventions in Craniopharyngioma Patients—Best Choice or Last Option for Treatment of Hypothalamic Obesity?
Hermann L Müller
doi : 10.1210/clinem/dgab567
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e426–e428
A Deeper Understanding of the Causal Relationships Between Thyroid Function and Atrial Fibrillation
Aleksander KuÅ›, Alexander Teumer, Marco Medici
doi : 10.1210/clinem/dgab525
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e429–e431
Letter to the Editor from Speeckaert et al: “Vitamin D Deficiency Is Associated With Higher Hospitalization Risk from COVID-19: a Retrospective Case-control Study�
Marijn M Speeckaert, Joris R Delanghe
doi : 10.1210/clinem/dgab606
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e432–e433
Letter to the Editor from Soghomonian et al.: “Epicardial and Pericardial Adiposity Without Myocardial Steatosis in Cushing Syndrome�
Astrid Soghomonian, Anne Dutour, Flavia Maurice, Frédéric Castinetti, Bénédicte Gaborit
doi : 10.1210/clinem/dgab677
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e434–e435
Letter to the Editor From Jee: “Familial Short Stature—A Novel Phenotype of Growth Plate Collagenopathies�
Youn Hee Jee
doi : 10.1210/clinem/dgab664
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e436–e437
Letter to the Editor from Viola et al.: “Diminishing Value from Multiple Serial Bone Densitometry in Women Receiving Antiresorptive Medication for Osteoporosis�
Viola Viola, Flavia Tramontana, Giulia Leanza
doi : 10.1210/clinem/dgab584
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e438–e439
Letter to the Editor from Giovanelli and Quinton: “Erythrocytosis in a Large Cohort of Trans Men Using Testosterone: a Long-Term Follow-up Study on Prevalence, Determinants, and Exposure Years�
Luca Giovanelli, Richard Quinton
doi : 10.1210/clinem/dgab603
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e440–e441
Response to Letter to the Editor from Speeckaert et al: “Vitamin D Deficiency Is Associated With Higher Hospitalisation Risk from COVID-19: A Retrospective Case-Control Study�
Edward B Jude
doi : 10.1210/clinem/dgab607
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Page e442
Response to Letter to the Editor from Soghomonian: “Epicardial and Pericardial Adiposity Without Myocardial Steatosis in Cushing Syndrome�
Peter Wolf, Benjamin Marty, Khaoula Bouazizi, Nadjia Kachenoura, Céline Piedvache, Anne Blanchard, Sylvie Salenave, Mikaël Prigent, Christel Jublanc, Christiane Ajzenberg, Céline Droumaguet, Jacques Young, Anne-Lise Lecoq, Emmanuelle Kuhn, Helene Agostini, Severine Trabado, Pierre G Carlier, Bruno Fève, Alban Redheuil, Philippe Chanson, Peter Kamenický
doi : 10.1210/clinem/dgab678
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e443–e444
Response to Letter to the Editor from Youn Hee Jee: “Familial Short Stature - A Novel Phenotype of Growth Plate Collagenopathies�
Lukas Plachy, Petra Dusatkova, Lenka Elblova, Lenka Petruzelkova, Zdenek Sumnik, Jan Lebl, Stepanka Pruhova
doi : 10.1210/clinem/dgab665
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Pages e445–e446
Corrigendum to: “Thigh Muscle Fat Infiltration Is Associated With Impaired Physical Performance Despite Remission in Cushing’s Syndrome�
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 1, January 2022, Page e447
doi : 10.1210/clinem/dgab590
