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Treatment of heart failure across the spectrum of left ventricular ejection fraction and an update on cardiac amyloidosis and ischaemic cardiomyopathy
Filippo Crea
doi : 10.1093/eurheartj/ehab906
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 351–354
Taking root: how a fresh approach to nutrition is tackling heart disease amongst South Asian populations
Judith Ozkan
doi : 10.1093/eurheartj/ehab410
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 355–356
The heart of FOIE GRAS and mtFOIE GRAS: fundamental and clinical investigation for training and innovation in non-alcoholic fatty liver disease
Paulo J Oliveira
doi : 10.1093/eurheartj/ehab399
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 357–359
Keeping pace with one of Israel’s leading cardiologists
Mark Nicholls
doi : 10.1093/eurheartj/ehab361
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 360–361
Environmental factors high on congress agenda
Mark Nicholls
doi : 10.1093/eurheartj/ehab439
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 362–364
Therapeutic-dose heparin should integrate the standard of care of moderately ill patients with COVID-19 admitted to hospital
Giovanna Liuzzo, Carlo Patrono
doi : 10.1093/eurheartj/ehab812
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 365–366
The year in cardiovascular medicine 2021: heart failure and cardiomyopathies
Johann Bauersachs, Rudolf A. de Boer, JoAnn Lindenfeld, Biykem Bozkurt
doi : 10.1093/eurheartj/ehab887
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 367–376
In the year 2021, the universal definition and classification of heart failure (HF) was published that defines HF as a clinical syndrome with symptoms and/or signs caused by a cardiac abnormality and corroborated by elevated natriuretic peptide levels or objective evidence of cardiogenic congestion. This definition and the classification of HF with reduced ejection fraction (HFrEF), mildly reduced, and HF with preserved ejection fraction (HFpEF) is consistent with the 2021 ESC Guidelines on HF. Among several other new recommendations, these guidelines give a Class I indication for the use of the sodium–glucose co-transporter 2 (SGLT2) inhibitors dapagliflozin and empagliflozin in HFrEF patients. As the first evidence-based treatment for HFpEF, in the EMPEROR-Preserved trial, empagliflozin reduced the composite endpoint of cardiovascular death and HF hospitalizations. Several reports in 2021 have provided novel and detailed analyses of device and medical therapy in HF, especially regarding sacubitril/valsartan, SGLT2 inhibitors, mineralocorticoid receptor antagonists, ferric carboxymaltose, soluble guanylate cyclase activators, and cardiac myosin activators. In patients hospitalized with COVID-19, acute HF and myocardial injury is quite frequent, whereas myocarditis and long-term damage to the heart are rather uncommon.
The year in cardiovascular medicine 2021: interventional cardiology
Javier Escaned, Farouc A. Jaffer, Julinda Mehilli, Roxana Mehran
doi : 10.1093/eurheartj/ehab884
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 377–386
Since last year’s report in the European Heart Journal, we have witnessed substantial progress in all aspects of interventional cardiology. Of note, the practice of interventional cardiology took place amidst successive waves of the COVID-19 pandemic, which continues to be a major burden for all healthcare professionals around the globe. In our yearly review, we shall revisit the developments in percutaneous coronary intervention (PCI), structural heart interventions, and adjunctive pharmacotherapy.
Myocardial revascularization in ischaemic cardiomyopathy: routine practice vs. scientific evidence
Raffaele De Caterina, Riccardo Liga, William E Boden
doi : 10.1093/eurheartj/ehab680
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 387–390
Transthyretin cardiac amyloidosis in continental Western Europe: an insight through the Transthyretin Amyloidosis Outcomes Survey (THAOS)
Thibaud Damy, Arnt V Kristen, Ole B Suhr, Mathew S Maurer, Violaine Planté-Bordeneuve, Ching-Ray Yu, Moh-Lim Ong, Teresa Coelho, Claudio Rapezzi, THAOS Investigators
doi : 10.1093/eurheartj/ehz173
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 391–400
Transthyretin amyloidosis (ATTR amyloidosis) is a heterogeneous disorder with cardiac, neurologic, and mixed phenotypes. We describe the phenotypic and genotypic profiles of this disease in continental Western Europe as it appears from the Transthyretin Amyloidosis Survey (THAOS).
Transthyretin amyloidosis in Western Europe: a snapshot from the THAOS registry and a call for further perspectives
Enrico Ammirati, Omar F AbouEzzeddine
doi : 10.1093/eurheartj/ehz205
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 401–404
Primary care heart failure service identifies a missed cohort of heart failure patients with reduced ejection fraction
Matthew Kahn, Antony D Grayson, Parminder S Chaggar, Marie J Ng Kam Chuen, Alison Scott, Carol Hughes, Niall G Campbell
doi : 10.1093/eurheartj/ehab629
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 405–412
We explored whether a missed cohort of patients in the community with heart failure (HF) and left ventricular systolic dysfunction (LVSD) could be identified and receive treatment optimization through a primary care heart failure (PCHF) service.
Implementation science and potential for screening in heart failure
Lars H Lund, Camilla Hage, Gianluigi Savarese
doi : 10.1093/eurheartj/ehab751
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 413–415
Effect of empagliflozin in patients with heart failure across the spectrum of left ventricular ejection fraction
Javed Butler, Milton Packer, Gerasimos Filippatos, Joao Pedro Ferreira, Cordula Zeller, Janet Schnee, Martina Brueckmann, Stuart J Pocock, Faiez Zannad, Stefan D Anker
doi : 10.1093/eurheartj/ehab798
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 416–426
No therapy has shown to reduce the risk of hospitalization for heart failure across the entire range of ejection fractions seen in clinical practice. We assessed the influence of ejection fraction on the effect of the sodium–glucose cotransporter 2 inhibitor empagliflozin on heart failure outcomes.
Re-emergence of heart failure with a normal ejection fraction?
Toru Kondo, John J V McMurray
doi : 10.1093/eurheartj/ehab828
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 427–429
Respectful language and putting the person first with obesity
Simar Singh Bajaj, Lucy Tu, Fatima Cody Stanford
doi : 10.1093/eurheartj/ehab837
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Page 430
Investigating the disease is the key to the obesity stigma
Jennifer J Rayner, Oliver J Rider
doi : 10.1093/eurheartj/ehab840
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Page 431
‘Targeting the cardiac myocyte and fibrosis’ in heart failure
Junko Ishiura, Shiro Nakamori, Masaki Ishida, Kaoru Dohi
doi : 10.1093/eurheartj/ehab780
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Page 432
Simultaneous transcatheter aortic mitral and tricuspid valve-in-valve implantation
Deguang Feng, Chi Zhang, Jiaxiang Wang, Bin Lin, Yahua Li, Lai Wei
doi : 10.1093/eurheartj/ehab339
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Page 433
Corrigendum to: AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: the APAF-CRT mortality trial
Michele Brignole, Francesco Pentimalli, Pietro Palmisano, Maurizio Landolina, Fabio Quartieri, Eraldo Occhetta, Leonardo Calò, Giuseppe Mascia, Lluis Mont, Kevin Vernooy, Vincent van Dijk, Cor Allaart, Laurent Fauchier, Maurizio Gasparini, Gianfranco Parati, Davide Soranna, Michiel Rienstra, Isabelle C Van Gelder
doi : 10.1093/eurheartj/ehab831
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Page 386
The correlation of ESC 2016 diastolic guidelines with invasively measured left ventricular filling pressure
A Barakat, A Amar, A,R Alsaadi
doi : 10.1093/eurheartj/ehab849
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Type of funding sources: Public hospital(s). Main funding source(s): Al-mouwasat University Hospital, University Heart Surgery Center in Damascus, Syrian Arab Republic.
Treatment of heart failure across the spectrum of left ventricular ejection fraction and an update on cardiac amyloidosis and ischaemic cardiomyopathy
Filippo Crea
doi : 10.1093/eurheartj/ehab906
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 351–354
Taking root: how a fresh approach to nutrition is tackling heart disease amongst South Asian populations
Judith Ozkan
doi : 10.1093/eurheartj/ehab410
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 355–356
The heart of FOIE GRAS and mtFOIE GRAS: fundamental and clinical investigation for training and innovation in non-alcoholic fatty liver disease
Paulo J Oliveira
doi : 10.1093/eurheartj/ehab399
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 357–359
Keeping pace with one of Israel’s leading cardiologists
Mark Nicholls
doi : 10.1093/eurheartj/ehab361
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 360–361
Environmental factors high on congress agenda
Mark Nicholls
doi : 10.1093/eurheartj/ehab439
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 362–364
Therapeutic-dose heparin should integrate the standard of care of moderately ill patients with COVID-19 admitted to hospital
Giovanna Liuzzo, Carlo Patrono
doi : 10.1093/eurheartj/ehab812
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 365–366
The year in cardiovascular medicine 2021: heart failure and cardiomyopathies
Johann Bauersachs, Rudolf A. de Boer, JoAnn Lindenfeld, Biykem Bozkurt
doi : 10.1093/eurheartj/ehab887
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 367–376
In the year 2021, the universal definition and classification of heart failure (HF) was published that defines HF as a clinical syndrome with symptoms and/or signs caused by a cardiac abnormality and corroborated by elevated natriuretic peptide levels or objective evidence of cardiogenic congestion. This definition and the classification of HF with reduced ejection fraction (HFrEF), mildly reduced, and HF with preserved ejection fraction (HFpEF) is consistent with the 2021 ESC Guidelines on HF. Among several other new recommendations, these guidelines give a Class I indication for the use of the sodium–glucose co-transporter 2 (SGLT2) inhibitors dapagliflozin and empagliflozin in HFrEF patients. As the first evidence-based treatment for HFpEF, in the EMPEROR-Preserved trial, empagliflozin reduced the composite endpoint of cardiovascular death and HF hospitalizations. Several reports in 2021 have provided novel and detailed analyses of device and medical therapy in HF, especially regarding sacubitril/valsartan, SGLT2 inhibitors, mineralocorticoid receptor antagonists, ferric carboxymaltose, soluble guanylate cyclase activators, and cardiac myosin activators. In patients hospitalized with COVID-19, acute HF and myocardial injury is quite frequent, whereas myocarditis and long-term damage to the heart are rather uncommon.
The year in cardiovascular medicine 2021: interventional cardiology
Javier Escaned, Farouc A. Jaffer, Julinda Mehilli, Roxana Mehran
doi : 10.1093/eurheartj/ehab884
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 377–386
Since last year’s report in the European Heart Journal, we have witnessed substantial progress in all aspects of interventional cardiology. Of note, the practice of interventional cardiology took place amidst successive waves of the COVID-19 pandemic, which continues to be a major burden for all healthcare professionals around the globe. In our yearly review, we shall revisit the developments in percutaneous coronary intervention (PCI), structural heart interventions, and adjunctive pharmacotherapy.
Myocardial revascularization in ischaemic cardiomyopathy: routine practice vs. scientific evidence
Raffaele De Caterina, Riccardo Liga, William E Boden
doi : 10.1093/eurheartj/ehab680
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 387–390
Transthyretin cardiac amyloidosis in continental Western Europe: an insight through the Transthyretin Amyloidosis Outcomes Survey (THAOS)
Thibaud Damy, Arnt V Kristen, Ole B Suhr, Mathew S Maurer, Violaine Planté-Bordeneuve, Ching-Ray Yu, Moh-Lim Ong, Teresa Coelho, Claudio Rapezzi, THAOS Investigators
doi : 10.1093/eurheartj/ehz173
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 391–400
Transthyretin amyloidosis (ATTR amyloidosis) is a heterogeneous disorder with cardiac, neurologic, and mixed phenotypes. We describe the phenotypic and genotypic profiles of this disease in continental Western Europe as it appears from the Transthyretin Amyloidosis Survey (THAOS).
Transthyretin amyloidosis in Western Europe: a snapshot from the THAOS registry and a call for further perspectives
Enrico Ammirati, Omar F AbouEzzeddine
doi : 10.1093/eurheartj/ehz205
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 401–404
Primary care heart failure service identifies a missed cohort of heart failure patients with reduced ejection fraction
Matthew Kahn, Antony D Grayson, Parminder S Chaggar, Marie J Ng Kam Chuen, Alison Scott, Carol Hughes, Niall G Campbell
doi : 10.1093/eurheartj/ehab629
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 405–412
We explored whether a missed cohort of patients in the community with heart failure (HF) and left ventricular systolic dysfunction (LVSD) could be identified and receive treatment optimization through a primary care heart failure (PCHF) service.
Implementation science and potential for screening in heart failure
Lars H Lund, Camilla Hage, Gianluigi Savarese
doi : 10.1093/eurheartj/ehab751
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 413–415
Effect of empagliflozin in patients with heart failure across the spectrum of left ventricular ejection fraction
Javed Butler, Milton Packer, Gerasimos Filippatos, Joao Pedro Ferreira, Cordula Zeller, Janet Schnee, Martina Brueckmann, Stuart J Pocock, Faiez Zannad, Stefan D Anker
doi : 10.1093/eurheartj/ehab798
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 416–426
No therapy has shown to reduce the risk of hospitalization for heart failure across the entire range of ejection fractions seen in clinical practice. We assessed the influence of ejection fraction on the effect of the sodium–glucose cotransporter 2 inhibitor empagliflozin on heart failure outcomes.
Re-emergence of heart failure with a normal ejection fraction?
Toru Kondo, John J V McMurray
doi : 10.1093/eurheartj/ehab828
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Pages 427–429
Respectful language and putting the person first with obesity
Simar Singh Bajaj, Lucy Tu, Fatima Cody Stanford
doi : 10.1093/eurheartj/ehab837
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Page 430
Investigating the disease is the key to the obesity stigma
Jennifer J Rayner, Oliver J Rider
doi : 10.1093/eurheartj/ehab840
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Page 431
‘Targeting the cardiac myocyte and fibrosis’ in heart failure
Junko Ishiura, Shiro Nakamori, Masaki Ishida, Kaoru Dohi
doi : 10.1093/eurheartj/ehab780
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Page 432
Simultaneous transcatheter aortic mitral and tricuspid valve-in-valve implantation
Deguang Feng, Chi Zhang, Jiaxiang Wang, Bin Lin, Yahua Li, Lai Wei
doi : 10.1093/eurheartj/ehab339
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Page 433
Corrigendum to: AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: the APAF-CRT mortality trial
Michele Brignole, Francesco Pentimalli, Pietro Palmisano, Maurizio Landolina, Fabio Quartieri, Eraldo Occhetta, Leonardo Calò, Giuseppe Mascia, Lluis Mont, Kevin Vernooy, Vincent van Dijk, Cor Allaart, Laurent Fauchier, Maurizio Gasparini, Gianfranco Parati, Davide Soranna, Michiel Rienstra, Isabelle C Van Gelder
doi : 10.1093/eurheartj/ehab831
European Heart Journal, Volume 43, Issue 5, 1 February 2022, Page 386
The correlation of ESC 2016 diastolic guidelines with invasively measured left ventricular filling pressure
A Barakat, A Amar, A,R Alsaadi
doi : 10.1093/eurheartj/ehab849
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Type of funding sources: Public hospital(s). Main funding source(s): Al-mouwasat University Hospital, University Heart Surgery Center in Damascus, Syrian Arab Republic.
Implication of current ASE/EACVI left ventricular diastolic function classification in predicting 2-year MACE in asymptomatic patients with diabetes and hypertension
D H P Foo, K H Lam, M Igo, M N A Sulaiman, M Y Ku, T L King, L S Yeo, J Chunggat, S S Ahip, M F Sahiran, M Mustapha, J Michael, A Abdullah, A Y Y Fong
doi : 10.1093/eurheartj/ehab849.001
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Ministry of Health Malaysia
Invasive validation of the different echo parameters and cut-offs among the trilogy of left ventricular filling pressure assessment guidelines: EACVI/ASE 2016, ESC 2016, HFA 2019
A Barakat, A,R Alsaadi
doi : 10.1093/eurheartj/ehab849.002
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Type of funding sources: Public hospital(s). Main funding source(s): Al-mouwasat University Hospital and University Heart Surgery Center in Damascus, Syrian Arab Republic.
The association between transthoracic echocardiographic parameters and severity of COVID-19 in hospitalised adults - a retrospective analysis
R Agarwal, G Priyonugroho, S Hertine, S H Wicaksono, P Almazini, D Zamroni, H S Muliawan
doi : 10.1093/eurheartj/ehab849.003
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The coronavirus disease 2019 (COVID-19) is an ongoing global pandemic with more than 220 million cases and 4.5 million deaths reported worldwide. Its clinical spectrum varies widely, and non-invasive prognostic markers are valuable as they can guide efficient resource allocation. Cardiovascular complications of COVID-19 include myocardial injury, acute heart failure, and arrhythmias. Both de novo cardiovascular complications and pre-existing cardiovascular co-morbidities are associated with a poor prognosis. Transthoracic echocardiography (TTE) can be used to assess cardiovascular structure and function non-invasively.
The association between neutrophil to lymphocyte ratio and echocardiographic parameters in hospitalised adults with COVID-19 - a retrospective analysis
R Agarwal, G Priyonugroho, S Hertine, S H Wicaksono, P Almazini, D Zamroni, H S Muliawan
doi : 10.1093/eurheartj/ehab849.004
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The neutrophil to lymphocyte ratio (NLR) is an inflammatory biomarker with prognostic value in several cardiovascular conditions. Hyperinflammation contributes to severe coronavirus disease 2019 (COVID-19), which is characterized by a multi-organ dysfunction. Cardiovascular complications of COVID-19 include arrhythmias, myocardial damage, acute heart failure, and acute coronary syndrome. Transthoracic echocardiography (TTE) can be used to assess cardiovascular structure and function non-invasively.
Prognostic value of pre-operative left atrial strain on composite endpoint in patients received aortic valve replacement for severe aortic stenosis: a retrospective cohort study
L Tsui, K H Yiu, H F Tse, L Y Lam, C K L Leung, A S Y Yu, M Z Wu, Q W Ren, P F Wong, Y K Tse,S S Y Yu, H L Li, W L Hon
doi : 10.1093/eurheartj/ehab849.005
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Severe aortic stenosis (AS) is the most common primary valvular heart disease, treatable only by aortic valve replacement (AVR). Current literatures have shown that severe AS may precede atrial dysfunction which predicts adverse outcomes.  However, predictive value of pre-operative left atrial (LA) function on post-AVR clinical outcomes is uncertain. The study aims to evaluate the prognostic value of pre-operative LA strain on post AVR all-cause mortality and heart failure.
Incidence of gastrointestinal bleeding after transoesophageal echocardiography in patients with gastro-oesophageal varices: a systematic review and meta-analysis
R W H Hui, C M Leung
doi : 10.1093/eurheartj/ehab849.006
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Transoesophageal echocardiography (TEE) is useful for cardiac assessment and intraoperative monitoring. However, the safety of TEE in cirrhotic patients with gastro-oesophageal varices has remained uncertain.
Accuracy of global longitudinal and territorial longitudinal strain in determining myocardial viability in out of window period Anterior wall myocardial infarction patients
A Batta, Y P Sharma, K Makkar, J Hatwal, T Malhi, P Panda
doi : 10.1093/eurheartj/ehab849.007
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Primary percutaneous intervention remains the principal treatment modality for anterior wall myocardial infarction (AWMI). However, a large fraction of patients especially in the developing countries present outside the window period (OWP) with no chest pain and akinetic left anterior descending (LAD) territory on echocardiography. Revascularization in these patients is primarily guided by viability status.
In patients with paroxysmal atrial fibrillation left atrial strain paramethers, left atrial function index and poor glycaemic control can be predictors of arrhythmia recurrence
H Rus, E Bobescu, I Poinareanu
doi : 10.1093/eurheartj/ehab849.008
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Left atrial (LA) systolic dysfunction is present in early stages of atrial fibrillation (AFib) prior to left anatomical changes and is influenced by left ventricular systolic function. We evaluate weather left atrial function index (LAFI), left atrial strain parameters (LASP) and glycemic control can be a predictor of AFib recurrence after medical or electrical conversion patients with paroxysmal AFib.
Evaluation of subclinical LV systolic dysfunction by global longitudinal strain using 2D-speckle tracking echocardiography in patients having angina with normal epicardial coronary arteries
MD S Hoque, C M Ahmed, DMM F Osmany, S K Banerjee
doi : 10.1093/eurheartj/ehab849.009
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Global longitudinal strain (GLS), assessed by 2D speckle tracking echocardiography would be a trustworthy noninvasive tool to detect subclinical LV systolic dysfunction in patients having angina with normal epicardial coronary arteries.
Comparison of sites of wall thickening and abnormal late enhancement on cardiac CT and magnetic resonance imaging with electrocardiography findings in patients with confirmed cardiac amyloidosis
N Funabashi, Y Kobayashi
doi : 10.1093/eurheartj/ehab849.010
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Left ventricular (LV) wall thickening and diastolic dysfunction on a transthoracic echocardiogram (TTE) without a high voltage R wave on V5 leads on an ECG leads to a diagnosis of cardiac amyloidosis. A final diagnosis is made by endomyocardial biopsy. However, amyloid sometimes invades the right ventricle (RV), and left (LA) and right (RA) atria, causing ECG changes such as sick sinus syndrome (SSS), arrhythmia, and QRS wave axis deviation.
Prevalence and distribution of coronary artery calcium in a southeast asian cohort
C J Wong, H M C Choo, L Baskaran, N S Y Koh, Z Huang, T S J Chua, S Y Tan, W Huang
doi : 10.1093/eurheartj/ehab849.011
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The coronary artery calcium score (CACS) independently predicts the risk of cardiovascular disease and major adverse cardiovascular events. While previous studies have demonstrated regional and ethnic differences in coronary calcification, the distribution of CACS in Southeast Asian (SEA) adults has not been investigated.
Outcomes of cardiac CT investigations in patients from the Rapid Access Chest Pain clinic with consideration to additional CT modalities and individual risk factors
L Juffry, F Lim, S R Ahmad, S Johar
doi : 10.1093/eurheartj/ehab849.012
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Coronary CT is a first line investigation according to NICE guidelines, yet there are still uncertainties in its ability to decrease adverse event rates. The high sensitivity and high negative predictive value of coronary CT only validates low to moderate pre-test probability of attaining significant CAD due to its low positive predictive value. Improving outcomes in coronary CT could avoid events and limit the use of invasive modalities such as invasive coronary angiography. Increased probability of MACE with presence of risk factors could also raise the merit of risk stratification utilization for better classification.
Left main coronary artery dimension and variation in Thai population
T Siriwiwattana
doi : 10.1093/eurheartj/ehab849.013
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Objectives The aim of our study was to determine the length, proximal and distal dimension of the left main coronary artery (LMCA) in Thai population with normal LMCA, from coronary computed tomography angiography (CCTA).
Vascular inflammation in patients with obstructive sleep apnoea and coronary artery disease shown on coronary computed tomography angiography attenuation
J Yuvaraj, W Cameron, J Andrews, A Lin, N Nerlekar, S J Nicholls, G Hamilton, M Issa, Z C Che, E Lim, D T L Wong
doi : 10.1093/eurheartj/ehab849.014
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Obstructive sleep apnoea (OSA) is associated with increased plaque burden in coronary artery disease (CAD), but the role of vascular inflammation in this relationship is unclear. Coronary computed tomography angiography (CTA) enables surrogate assessment of systemic inflammation via subcutaneous adipose tissue attenuation (ScAT-a), and of coronary inflammation via epicardial adipose tissue volume and attenuation (EAT-v and EAT-a) and pericoronary adipose tissue attenuation (PCAT-a).
Identification of hemodynamically significant coronary artery disease with stress myocardial blood flow ratio by dynamic CT perfusion studies
H Maqsood, T Ashraf, S Younus, M W Rasool, A Hameed
doi : 10.1093/eurheartj/ehab849.015
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Coronary computed tomographic angiography (CTA) is an accepted noninvasive tool with high diagnostic accuracy for the evaluation of coronary artery disease (CAD). However, coronary CTA is limited in that it does not provide information on the hemodynamic relevance of coronary artery stenosis. Therefore, to determine the potential benefit of future coronary revascularization, a functional assessment is often required. A protocol combining coronary computed tomographic angiography (CTA) and CTP can provide a simultaneous assessment of both coronary artery ischemia and anatomy.
Correlation of cardiac biomarkers with computed tomography severity score in COVID-19 patients
R Rivera, L Cuenza, T Razon-Cuenza
doi : 10.1093/eurheartj/ehab849.016
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
A vast number of COVID-19 cases have been reported worldwide since the initial outbreak in China, and the disease has since become a global pandemic. Knowledge on this predominantly respiratory illness is evolving with studies suggesting myocardial injury reflected by elevated cardiac enzymes portending to more severe disease. CT scoring indices provide visual, semi-quantitative assessment of lung involvement and have aided in determining extent of COVID-19 pneumonia but, none have been validated for prognostication.
Hemodynamic change in patients with hypertrophic obstructive cardiomyopathy before and after alcohol septal ablation using 4D flow magnetic resonance imaging: a retrospective observational study
K Suwa, K Akita, K Iguchi, T Ushio, Y Maekawa
doi : 10.1093/eurheartj/ehab849.017
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The hemodynamics in the left ventricle (LV) and the ascending aorta (AAO) before and after alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy (HOCM) is elucidated.
OCT-guided left-main PCI, a retrospective single-center analysis
P Jariwala, KARTIK Jadhav, KARTIK Jadhav
doi : 10.1093/eurheartj/ehab849.018
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
It is known that PCI is associated with non-optimal stent implantation utilizing angiography for only left main lesions as well as for bifurcation lesions and is characterised by a high risk of adverse long-term effects. The use of OCT for the left main stent makes it easier to enhance the effective implantation of stents and enhance the results of patients.
High sensitivity C-reactive protein is associated with vulnerable characteristics in non-culprit plaques in patients with ST-segment elevation myocardial infarction
M Katamine, Y Minami, T Nagata, K Asakura, A Katsura, D Kinoshita, T Hashimoto, J Ako
doi : 10.1093/eurheartj/ehab849.019
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Higher level of high sensitivity C-reactive protein (hsCRP) is associated with an increased risk of recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI). However, the association between hsCRP and the characteristics of non-culprit plaques in patients with STEMI remains to be elucidated.
When type 2 diabetes coexists with atrial fibrillation in Middle Eastern patients: Clinical profiles and utilization of oral anticoagulant agents
A Hammoudeh, W Alzyoud, D Ja"ara, M Bahour, R Nasereddin, E Al-Mousa, Y Badaineh
doi : 10.1093/eurheartj/ehab849.020
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Background. Studies from different regions in the world have shown that patients with atrial fibrillation (AF) who have type 2 diabetes mellitus (T2D) have unfavorable baseline clinical profile, higher prevalence of comorbidities and higher risk scores compared with those who do not have T2D. It is largely unknown if this applies to Middle Eastern (ME) patients.Â
ECG education for first-grade medical students detecting Epsilon and J waves in patients with arrhythmogenic right ventricular cardiomyopathy in comparison with specialists for arrhythmia treatment
N Funabashi, K Nakamura, T Sasaki, S Naito, Y Kobayashi
doi : 10.1093/eurheartj/ehab849.021
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Medical students find Epsilon and J wave diagnoses by electrocardiogram (ECG) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) difficult.
Cost-effectiveness of apixaban versus other oral anticoagulants and aspirin for stroke prevention in atrial fibrillation in indian subcontinent
N Kulkarni, S Taur, E Tichy, T Kongnakorn, R Sharma
doi : 10.1093/eurheartj/ehab849.022
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Non-vitamin K antagonist oral anticoagulants (NOACs) are class I recommended by various guidelines for stroke prevention in atrial fibrillation. NOACs are associated with comparable or lower risk of stroke / systemic embolism and significantly lower major bleeding as compared to VKAs. Despite the fact that NOACs have demonstrated safety and efficacy in stroke prevention in AF by various randomized clinical trials and real-world evidences, the pharmacoeconomic data of NOACs in stroke prevention is lacking in India. In view of the higher initial and long-term cost of the NOAC therapy, it is important to analyze the cost effectiveness of such therapy to ensure wider acceptance and compliance to medication since majority of population in India is self-paying.
A fourteen-year experience on treatment of atrial fibrillation with radiofrequency ablation in Thailand: a real-world report from South East Asia
N Tokavanich, P Leelapatana, R Chokesuwattanaskul, S Prechawat, V Rungpradabvong
doi : 10.1093/eurheartj/ehab849.023
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Atrial Fibrillation ablation has been performed for more than 10 years, but the result of the procedure varied across centers. In Western world freedom from AF after ablation with PVI technique was 81.6% at 12 months, 73.8% at 24 months, and 68.1% at 36 months. No earlier report of outcome in South East Asia region. The study sought to report outcome of AF ablation in Thailand.
Learning curve of visually-guided laser balloon ablation of paroxysmal atrial fibrillation
Y Kondo, M Nakano, T Kajiyama, M Nakano, Y Kobayashi
doi : 10.1093/eurheartj/ehab849.024
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The visually-guided laser balloon (VGLB) is a compliant, variable-diameter balloon that delivers laser energy around the pulmonary vein (PV) ostium under real-time endoscopic visualization. However, limited data exist in Japan thus far. Therefore, we determined the safety, efficacy, and learning curve of the VGLB for PV isolation.
Characterizing patients with newly diagnosed atrial fibrillation compared to those with established atrial fibrillation: data from the CODE-AF registry
J M Choi, S R Lee, E K Choi
doi : 10.1093/eurheartj/ehab849.025
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Type of funding sources: Foundation. Main funding source(s): Korean Healthcare Technology R&D project funded by the Ministry of Health & Welfare
The impact of socioeconomic deprivation on the risk of atrial fibrillation in patients with diabetes mellitus: a nationwide population-based study
M J Han, S R Lee, E K Choi, K D Han, G Y H Lip
doi : 10.1093/eurheartj/ehab849.026
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Although the prevalence of atrial fibrillation (AF) is increasing worldwide, little is known about the exact risk factors of AF; and the disease"s association with socioeconomic status (SES) is under debate.
High power short duration (HPSD) versus lower power longer duration (LPLD) atrial fibrillation ablation: a multi-centre randomised controlled trial (HiLo-HEAT study)
D Chieng, H Sugumar, L Segan, A Al-Kaisey, B M Moore, M C Y Nam, S Prabhu, A Voskoboinik, L H Ling, J M Kalman, P M Kistler
doi : 10.1093/eurheartj/ehab849.027
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
 Lower power (25W) longer duration (LPLD) radiofrequency (RF) ablation has conventionally been used on the posterior wall during pulmonary vein isolation (PVI) for atrial fibrillation (AF), to attenuate the risk of esophageal thermal injury (ETI). High power (40-50 W) short duration (HPSD) RF ablation results in shorter procedural times with no increase in ETI. However evidence had been limited by non-randomised studies.
Effects of hot balloon versus cryoballoon ablation for atrial fibrillation: a systematic review and meta-analysis
X Peng, Y Chen, X X Li
doi : 10.1093/eurheartj/ehab849.028
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Catheter ablation has developed as the most effective therapeutic approach and won the highest-level guideline recommendation in treating atrial fibrillation (AF) in the decades. Several balloon-based catheter ablations, including hot balloon ablation (HBA) and cryoballoon ablation (CBA), have rapidly emerged as alternative modalities to conventional radiofrequency catheter-based AF ablation. However, the differences in characteristics, effectiveness, clinical outcomes, safety, and efficacy between HBA and CBA remain undetermined.Â
Impact of preprocedural upper gastrointestinal endoscopy for pulmonary vein isolation - single-center experience of 400 patients
D Grosse Meininghaus, T Kleemann
doi : 10.1093/eurheartj/ehab849.029
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Mucosal esophageal lesions (ELs) are reported in 10-40% after pulmonary vein isolation (PVI) and may be precursors of (almost always lethal) atrio-esophageal fistula (AEF). Although mechanisms of lesion progression are not completely understood, inflammation (e.g. by acidic reflux) is thought to be a major contributor. However, ELs may also be preexisting or due to mechanical instrumentation rather than ablation-induced, and these lesions are not prone to progression. On the other hand, preexisting reflux-induced esophagitis might facilitate lesion generation during ablation.
Impact of heart rate reduction on recurrence after catheter ablation of persistent atrial fibrillation
M Okada, K Inoue, N Tanaka, M Masuda, Y Furukawa, A Hirata, Y Egami, T Watanabe, H Minamiguchi, M Miyoshi, A Sunaga, Y Sotomi, T Dohi, H Shungo, Y Sakata
doi : 10.1093/eurheartj/ehab849.030
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Predicting heart rate (HR) after restoration of sinus rhythm (SR) remains one of the challenges when performing catheter ablation (CA) of persistent atrial fibrillation (AF).
Validation of HAS-BELD scoring system and risk factors of bleeding with warfarin among non-valvular atrial fibrillation patients
P Wachirapraditporn, N Uaprasert
doi : 10.1093/eurheartj/ehab849.031
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
This study aimed to validate different bleeding scoring systems including HAS-BELD score and other scores and risks of bleeding in Thai patients with non-valvular atrial fibrillation (AF).
Oral antithrombotic prescription patterns among hospitalized adult patients with non-valvular atrial fibrillation
M L Soco, A T Junia
doi : 10.1093/eurheartj/ehab849.032
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Oral anticoagulant (OAC) therapy reduces stroke risk in patients with atrial fibrillation. Despite extensive recommendations regarding the use of non-vitamin K antagonist oral anticoagulants (NOACs), available data shows that they remain underutilized. Additionally, data on OAC prescription patterns in relation to stroke and bleeding risk scores are scarce; more so in low to middle income countries. The aim of this study was to describe the antithrombotic prescription patterns among Filipino patients with non-valvular AF.
Performance of anticoagulation risk scores for predicting ischaemic stroke in dialysis patients with atrial fibrillation
Y W L Liao, TKMW Wang
doi : 10.1093/eurheartj/ehab849.033
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Risk models such as the CHADSâ‚‚ and revised CHAâ‚‚DSâ‚‚-VASc scores are recommended for anticoagulation decision-making in atrial fibrillation (AF) patients. Despite this, their prognostic utilities in dialysis patients with AF are not well established. We evaluated the performance of conventional anticoagulation risk scores at predicting adverse outcomes in dialysis patients with AF.
Bridging to warfarin with apixaban versus conventional heparin: an open label, pilot, randomized controlled trial
T Dangploy, C Wongvipaporn
doi : 10.1093/eurheartj/ehab849.034
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Background : Despite of non-vitamin K antagonist oral anticoagulants (NOACs) is a preferred oral anticoagulant but in limited-resource country, warfarin still be first line drug. Bridging parenteral anticoagulant with warfarin is required in particular circumstances. Since a NOACs contains rapid onset and steady activity characteristics, then the use of NOACs instead of traditional parenteral anticoagulant to bridging with warfarin is intriguing.
Angiographic Profiles in Persistent Non-Valvular Atrial Fibrillation Patients
A Batta, Y P Sharma, K Makkar, P Panda, P Barwad
doi : 10.1093/eurheartj/ehab849.035
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The relationship of atrial fibrillation (AF) with coronary artery disease (CAD) is well established. Atrial ischemia due to obstructive CAD has been identified as one of the key risk factors, leading to AF. However, sufficient evidence exists as to the presence of myocardial ischemia on stress imaging, even without the presence of obstructive CAD in AF patients. Slow flow and coronary tortuosity on angiogram can lead to downstream myocardial ischemia independent of CAD.Â
Alternative method of adenosine administration in paroxysmal supraventricular tachycardia
T Tangsuwanaruk, P Daengbubpha, B Wittayachamnankul, K Sutham, B Chenthanakij
doi : 10.1093/eurheartj/ehab849.036
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
An intravenous adenosine with a double syringe technique is an essential treatment in a patient with paroxysmal supraventricular tachycardia (PSVT). Due to its fast metabolisation (approximate half-life is about 2-5 seconds), it required a fast intravenous injection to make the best outcome in treatment. In some practice, there is an alternative method to administer adenosine by elevating the arm perpendicular to a horizontal plane after injection to facilitate a rapidly injected manner. However, there is no scientific proof of this hypothesis.
J waves reaching to equal or more than 2 of 3 LV inferior wall leads may predict the presence of organized myocardial fibrotic or fat change in survivors of ventricular fibrillation
N Funabashi, Y Kobayashi
doi : 10.1093/eurheartj/ehab849.037
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The distribution of J waves and the presence of organized left ventricular (LV) myocardial damage may be related in survivors of ventricular fibrillation (VF).
A multicentre survey of paediatric out-of-hospital cardiac arrest incidence, aetiology, and survival in New South Wales over an 11-year period
D Youssef, A Singh, J Ayer, C Turner, A Christoff, J Bromage, C Balit, A Numa, J R Skinner
doi : 10.1093/eurheartj/ehab849.038
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Out-of-hospital cardiac arrest (OOHCA) is commonly associated with pulseless ventricular tachycardia and ventricular fibrillation (VT/VF) and cardiac aetiologies. One New South Wales (NSW) ambulance registry reported(1) cardiac aetiologies with a prevalence of 31% among OOHCA cases. Multicentre OOHCA data and NSW’s well-developed services for cardiac genetic predisposition screening motivate us to consider the following study of paediatric OOHCA in this state.
Acute procedural outcomes of his bundle pacing with or without electrophysiology mapping system: a multicenter study
G Loo, J De Leon, S C Seow, E Boey, R Soh, E Tan, H H Gan, J Y Lee, J T L Teo, C Yeo, P Kojodjojo, V H Tan
doi : 10.1093/eurheartj/ehab849.039
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
His bundle pacing (HBP) is associated with improved clinical outcomes compared to right ventricular apical pacing. However, it can be technically challenging and may result in prolonged fluoroscopy and procedural time.
Implantable cardioverter-defibrillators in heart transplant patients: a systematic review and meta-analysis
K Cho, P Lo, R Subbiah
doi : 10.1093/eurheartj/ehab849.040
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Whilst implantable cardioverter-defibrillator (ICD) implantation is beneficial in a select group of patients, heart transplant patients were excluded from landmark clinical trials. Thus, controversy remains about the utility of ICD in high-risk heart transplant patients.
The diagnostic value of different criteria in predicting the response of LBBB patients: a systematic review and meta-analysis
X Peng, C D Cheng, L J Zeng
doi : 10.1093/eurheartj/ehab849.041
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The left bundle branch has emerged as an essential part of the cardiac conduction system. However, many patients with conventional left bundle branch block (LBBB) QRS morphology appeared to have a poor response to cardiac resynchronization therapy (CRT) therapy; these might be due to they were non-LBBB patients who met the conventional diagnostic criteria but failed to meet the strict LBBB standard. There are different criteria to select appropriate CRT patients currently. Several studies have reported that patients with complete LBBB had worse ventricular synchronization and worse prognosis. Thus, it is of great clinical significance to distinguish between complete LBBB and non-LBBB.Â
The first survey on patient needs for remote monitoring of cardiac implantable electronic device in South Korea
Y Hwang
doi : 10.1093/eurheartj/ehab849.042
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Studies showed that remote device monitoring reduced unnecessary outpatient visits and increased patient satisfaction. As there was no local research on remote monitoring (RM) in Korea, there was a lack of evidence for policy or insurance standards due to the lack of domestic data despite high demand by domestic arrhythmia experts. In order to establish the basis for patient satisfaction, economic efficiency, and safety of wireless monitoring, a survey-based study was planned.
Echinacoside inhibited cardiomyocyte apoptosis and improved heart function in heart failure rats induced by isoproterenol via suppressing nadph/ros/atf6/chop associated endoplasmic reticulum stress
Y J Ni, L Gao, W J Zhu
doi : 10.1093/eurheartj/ehab849.043
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Endoplasmic reticulum (ER) stress played an essential role in the development and progression of HF due to it could induce cardiomyocyte apoptosis, ATF6/CHOP was regulated by NADPH and ROS and was the crucial pathway to link ER stress and apoptosis in HF. Our previous study indicated that ECH reversed cardiac remodeling and improves heart function, but the underlying mechanisms are still unclear.
Clustering analysis based on automated electrocardiographic measurements to identify prognostically distinct phenotypes in patients hospitalized for heart failure: a retrospective cohort study
J S K Chan, J Zhou, A Li, M Tan, W T Wong, A Ciobanu, A Gkouziouta, K Letsas, T Liu, Y Liu, Q Zhang, G Tse
doi : 10.1093/eurheartj/ehab849.044
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Heart failure (HF) is a heterogeneous disease with complex structural and electrophysiological derangements of the heart. Attempts to classify HF from the electrophysiological perspective are lacking.
Prediction of in-hospital mortality by using get with the guideline-heart failure (GWTG-HF) risk scores in patients hospitalized with heart failure
M Mahmood, S K Banerjee
doi : 10.1093/eurheartj/ehab849.045
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Prognostic stratification using readily available clinical data can assist clinical decision making in heart failure. Get with the Guideline- Heart Failure (GWTG-HF) score approved by American Heart Association (AHA) can be used to inform hospitals about the expected in-hospital mortality of their patients.
Incidence, clinical correlates and associated outcomes of dementia in heart failure: a population-based cohort study
Q W Ren, T H K Teng, T Wang, Y K Tse, P F Wong, H L Li, S Y Yu, M Z Wu, X L Li, H F Tse, C S P Lam, K H Yiu
doi : 10.1093/eurheartj/ehab849.046
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Dementia, in the setting of heart failure (HF), portends poorer outcomes and poses great challenges in its clinical management.
A short and long-term outcomes of heart failure with midrange and preserved ejection fraction; developing countries perspective
T Leesutipornchai, S Puwanant, S Siwamogsatham, A Aekarach
doi : 10.1093/eurheartj/ehab849.047
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Hospitalization and mortality are common among patients with heart failure (HF). However, evidence of outcomes in HF patients classified by left ejection fraction (LVEF) is limited, especially in Thailand.
Chronic kidney disease begets heart failure and vice versa; temporal associations between heart failure events in relation to incident chronic kidney disease
M Z Wu, T H Teng, W T Tay, Q W Ren, P F Wong, H F Tse, S P Lam, K H Yiu
doi : 10.1093/eurheartj/ehab849.048
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Diabetes, chronic kidney disease (CKD) and heart failure (HF) are fast-growing causes of morbidity and mortality worldwide. Diabetes is an optimal model to study the inter-play of cardiovascular disease and renal disease.
Clinical value of the HATCH score for predicting adverse outcomes in patients with heart failure
N Shibata, T Kondo, R Morimoto, S Kazama, A Sawamura, I Nishiyama, T Kato, H Hiraiwa, T Okumura, T Murohara
doi : 10.1093/eurheartj/ehab849.049
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The HATCH score is employed as a risk assessment tool for atrial fibrillation (AF) development. However, the impact of the HATCH score on the long-term adverse outcomes in patients with acute heart failure (AHF) is unknown.
Prognostic value of machine learning for acute heart failure
M Shimizu, H Miyazaki, S Cho, Y Misu, R Tateishi, M Yamaguchi, Y Yamakami, H Shimada, T Manno, A Isshiki, S Kimura, H Fujii, M Suzuki, M Nishizaki, T Sasano
doi : 10.1093/eurheartj/ehab849.050
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
At onset of acute heart failure (AHF), various clinical fundamental parameters including vital sign, laboratory data, or initial treatment were investigated, and we can roughly estimate the prognosis. However, machine learning method for prediction of the prognosis was not studied.
The influence of physical rehabilitation on bone mineral density in patients with chronic heart failure before and after heart transplantation
V Sujayeva, E V Rudenka, O V Koshlataya, V V Spirina, T A Dubovik
doi : 10.1093/eurheartj/ehab849.051
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
to estimate the influence of physical rehabilitation on bone metabolism density (BMD) in patients with heart failure (HF) before and after heart transplantation (HT).
Cardiac resynchronization therapy in patients with true left bundle branch block : a systematic review and meta-analysis
C Cheng
doi : 10.1093/eurheartj/ehab849.052
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Background  Cardiac resynchronization therapy has been shown to improve clinical outcomes of heart failure. Still, about 30% of the patients had no response to CRT. A stricter LBBB criteria emphasizing notched or slurred R waves was newly proposed by Strauss to select patients for CRT.
Cardiorenal effects of SGLT2i in combination with ARNI for HFrEF: a systematic review and meta-analysis
R A B Cordovez, K Rivera, R A Denila, M Patricio, C Permejo
doi : 10.1093/eurheartj/ehab849.053
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Recent recommendations suggest a combination of Angiotensin receptor neprilysin inhibitor (ARNI) and beta blocker with other classes of medications in heart failure with reduced ejection fraction (HFrEF) (1). Despite currently available treatment options, mortality remains high (2). From the recent robust clinical trials, both SGLT2 inhibitor (SGLT2i) and ARNI have been found to decrease HF hospitalizations and CV death (3-5). This paper aims to determine the efficacy of SGLT2i and ARNI combination versus ARNI alone in the management of HFrEF.
Pulmonary artery pulsatility index and hemolysis during Impella support
M Nakamura, T Imamura, K Kinugawa
doi : 10.1093/eurheartj/ehab849.054
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Impella-related hemolysis is a well-known complication, which we sometimes experience in the clinical practice depending on various hemodynamic status including right ventricular impairment.
Impact of angiotensin-receptor neprilysin inhibitor on reverse cardiac remodeling in patients with heart failure with reduced ejection fraction (hfref)
N Atan, ALEX Loch, FIRDAU Hadi
doi : 10.1093/eurheartj/ehab849.055
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Cardiac remodeling is a detrimental consequence of heart failure. The angiotensin-receptor neprilysin inhibitor (ARNI) sacubitril/valsartan has been shown to reverse cardiac remodeling and to improve systolic function in observational studies. There is a lack of local data regarding the effects of ARNI on cardiac remodeling in Asian populations. To determine the impact of ARNI on reverse cardiac remodeling.Â
Yield of surveillance endomyocardial biopsies after heart transplantation: a 10-year experience
A Aekarach, S Sinphurmsukskul, S Siwamogsatham, S Puwanant, P Ongcharit, V Benjacholamas
doi : 10.1093/eurheartj/ehab849.056
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Endomyocardial biopsy (EMB) is recommended as a surveillance procedure for the detection of allograft rejection in all patients after heart transplant. However, the clinical yield of EMB is reported to be low and there are limited evidence in Asian population.
GDF-15: a novel biomarker of heart failure predicts 30-day all-cause mortality and 30-day HF rehospitalization in patients with acute heart failure syndrome
P Kosum, N Mattanapojanat, N Kongruttanachok, A Ariyachaipanich
doi : 10.1093/eurheartj/ehab849.057
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Growth Differentiation Factor-15 (GDF-15) is a distant member of the transforming growth factor-β (TGF-β) cytokine super family. The increased expression of GDF-15 has been observed during various cardiac diseases include heart failure (HF) and may associated with worse outcomes. However, the relationship is still not well understood, and evidences are not existed in Thai patients.
Development and validation of gender specific risk models in prediction of mortality for hospitalized heart failure patients in a multiethnic asian population
W J Quah, M A Sulong, H B Koh, A Afif, S H Ong, C K Teoh, M G Azmee
doi : 10.1093/eurheartj/ehab849.058
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Heart failure carries substantial morbidity and mortality.  Female has different characteristics compared to male which may affect prognosis and are not represented well in many trials. Multiple risk scores for in-hospital mortality have been created and validated such as ADHERE (Acute Decompensated Heart Failure National Registry) and GWTG (Get With The Guidelines). However, these risk scores were in Western population and not gender specific.
In-hospital outcomes of acute heart failure according to left ventricular ejection fraction: a single-center retrospective cohort study
A Han-Gla, K Viriyanukulvong, A Ariyachaipanich
doi : 10.1093/eurheartj/ehab849.059
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Acute heart failure (AHF) is a common cause of hospitalization and associated with high mortality rate. However, the study on outcomes of AHF patients classified by left ventricular ejection fraction (LVEF) in Thailand remains limited.
Do more specific assays for B-type natriuretic peptides better predict heart failure in breathless patients than the currently used assays?
L Lewis, S Raudsepp, J Whitlow, S Appleby, C Pemberton, A M Richards
doi : 10.1093/eurheartj/ehab849.060
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The cardioprotective B-type natriuretic peptide (BNP1-32) and its inactive congener N-terminal proBNP1-76 (NTBNP1-76) are produced from their precursor peptide proBNP, proportionate to cardiac dysfunction, underpinning their now-universal endorsement as markers for heart failure (HF) diagnosis.  ProBNP concentrations are also increased in patients with HF. BNP1-32 is difficult to measure in plasma due to its low concentration and short half-life. Thus, less specific BNP and NT-proBNP assays are routinely used in the diagnosis and prognosis of HF. However, these assays also variably detect proBNP, BNP metabolites, and glycosylated proBNP or glycosylated NT-proBNP. How well these assays compare to highly specific assays that only detect BNP1-32 or NTBNP1-76 has not been assessed.
Machine learning based diagnosis of heart failure with preserved ejection fraction among South Asian patients
R Cherukupalli, A Achanta, A Cherukupalli, S Potukuchi
doi : 10.1093/eurheartj/ehab849.061
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Diagnosis of Heart Failure with preserved Ejection Fraction (HFpEF) remains challenging even for an astute clinician with the current diagnostic tests, algorithms and scoring systems. Â The use of Machine Learning (ML) in cardiovascular research has expanded exponentially in recent years.
Molecular mechanism and therapeutic potential of YiQi FuMai injection in acute heart failure
H Dai, H S Li, J J Zhang, Y Chen, X C Zhang, M Z Hu, Z Y Guan, Y Liu, H C Shang
doi : 10.1093/eurheartj/ehab849.062
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
 Acute heart failure (AHF) is a significant public health problem related to the high mortality and rehospitalization rate of patients. Although drug development is never interrupted, no single drug has been proven to play a decisive role in improving the survival of AHF patients. In China, multi-component traditional Chinese medicine has been widely used to treat AHF. As a Chinese herbal injection included in medical insurance, Yiqi Fumai Injection can reduce the level of NT-proBNP in AHF patients, improve heart function, and alleviate symptoms and signs related to heart failure. To further evaluate the therapeutic effect of Yiqi Fumai Injection on AHF, a multi-center, double-blind, randomized controlled trial that intends to recruit 1270 patients is being carried out in China. However, the mechanism of Yiqi Fumai Injection in the treatment of AHF has not been clarified. To further explore the underlying mechanism, we used systematic pharmacology methods to explore the potential molecular mechanisms of biologically active compounds.
MicroRNA 155:145 ratio as a marker of atherogenic tilt manifested across different age groups and risk factor profiles
A Banerjee, D Roy, H Mazumdar, S Karmakar, R Bhowmik, N Biswas, A Roy, S Dey, K Manna
doi : 10.1093/eurheartj/ehab849.063
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
 Differential expression of microRNAs is critical in the genesis and progression of atherosclerosis. MiR145 has atheroprotective role through improved homeostasis of smooth muscle cells (SMC). MiR155 is pro-atherogenic due to its suppression of Bcl6, which antagonises NF-κB and modulates macrophages.
Association of Body mass index and clinical outcomes in patient with coronary artery disease undergoing percutaneous coronary intervention
T Y Lin, H B Leu
doi : 10.1093/eurheartj/ehab849.064
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Most of the world"s population lives in countries in which overweight status and obesity issues cause more morbidity and mortality than underweight status. Mortality increased as BMI increased above 25 kg/m², and the lowest mortality existed in a population with ideal body weight. Recently, the BMI or obesity paradox was widely discussed. The lower future risk was observed in these overweight subjects, not normal weight or lower BMI population, in patients with cardiovascular disease.
Can paraoxonase activity serve as a comparable marker than high density lipoprotein in the follow-up of patients of coronary artery disease?
S Chatterjee, B Majumder, P Biswas, S Sarkar, P K Sinha, L Mukhopadhyay, I Chakraborty
doi : 10.1093/eurheartj/ehab849.065
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Human serum paraoxonase (PON1) produced by the liver and residing almost exclusively on high density lipoproteins (HDL), has been demonstrated to prevent the oxidation of low density lipoprotein (LDL), which is the central initiating factor in the causation of atherosclerosis. (1,2) Thus, PON1 along with HDL, plays an important role in the pathophysiology of atherosclerosis and consequently coronary artery disease. Statins are commonly used in clinical practice for the management of dyslipidemia , a known risk factor for coronary artery disease (CAD).Keeping this in mind, it was deemed necessary to set up an observational study to explore whether the changes in PON1 activity after 3 months of statin therapy could help in the follow up of CAD patients.
Role of myocardial performance index as predictor of in-hospital cardiac events in patients with acute myocardial infarction
N Dalimunthe
doi : 10.1093/eurheartj/ehab849.066
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Background. Acute myocardial infarction (AMI) remains the leading cause of morbidity and mortality worldwide. Left ventricular dysfunction is a common consequence of acute coronary events and has important prognostic implications. Myocardial performance index (MPI) is an echocardiographic parameter that represent both left ventricular systolic and diastolic function that might provide substantial information essential to guide management and prognosis after AMI.
Prevalence and characteristics of non-ST-segment elevation in acute myocardial infarction with insignificant coronary artery disease
S Sricholwattana, J Chaipromprasit, P Kosum
doi : 10.1093/eurheartj/ehab849.067
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Acute myocardial infarction is mostly associated with obstructive coronary artery disease. 8% to 12% of patients have insignificant coronary artery disease. Prognosis for patients with insignificant coronary artery disease is better than patients with obstructive coronary artery disease who presented with non-ST elevation myocardial infarction (NSTEMI). Prevalence of patients with non-ST elevation myocardial infarction (NSTEMI) related insignificant coronary artery disease in Thailand remains unknown.
The use of bedside haemodynamic parameters to predict risk and in-hospital outcomes in non-ST elevation acute coronary syndromes: data from resource- limited settings in Iraq
Z A Dakhil
doi : 10.1093/eurheartj/ehab849.068
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
There is lack of data on the value of bedside hemodynamic parameters in predicting risk and outcomes in NSTE-ACS. This study aimed to assess if the following bedside haemodynamic tests : mean arterial pressure (MAP) [DBP + 1/3(SBP-DBP)], shock index (SI) [heart rate/SBP], pulse pressure (PP) [SBP-DBP] and proportional PP (PPP) [PP/SBP] can predict risk and adverse in-hospital outcomes in NSTE-ACS.
The correlation between coronary artery disease and left ventricular filling pressure: which correlates more LVEDP or LV pre-A wave?
A Barakat, A Amar, A,R Alsaadi
doi : 10.1093/eurheartj/ehab849.069
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Coronary artery disease (CAD) affects left ventricular (LV) systolic and diastolic function. This  results in high filling pressure which expressed by different waves and may be assessed by invasive and noninvasive methods. Validation and comparing the correlation between CAD and different LV filling pressure waves may add a step forward in CAD diagnosis, prognosis and treatment.
The value of microRNA-122 in the diagnosis of coronary heart disease
O Marchenko, N Rudenko, Y Kyriachenko, A Dzobak, D Krasnienkov
doi : 10.1093/eurheartj/ehab849.070
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Background. Patients with ischemic heart diseases form the majority group of cardiac diseases. Studies on the roles and mechanisms of microRNAs taking part in cardiac pathophysiology have become the focus of research worldwide.
An echocardiographic algorithm for predicting coronary artery disease: is it time to establish one?
A Barakat, A,R Alsaadi
doi : 10.1093/eurheartj/ehab849.071
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Coronary artery disease (CAD) is a major clinical issue. CAD affects left ventricular systolic, diastolic function and LV filling pressure. Echocardiography has been known as the best noninvasive way for the assessment of systolic, diastolic function and LV filling pressure. Finding a correlation between CAD and echocardiographic parameters may help in the early assessment, prognosis and treatment of CAD.
Differential association between significant coronary stenosis and cardiac troponin T serial algorithms in renal dysfunction patients diagnosed with non-ST-segment elevation acute coronary syndromes
P Kotruchin, T Tangpaisarn, N Srimakam, P Phungoen, V Senthong
doi : 10.1093/eurheartj/ehab849.072
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
High-sensitivity cardiac troponin T (hs-cTnT) is recommended for diagnosing non-ST segment elevation acute coronary syndromes (NSTE-ACS). While the standard practice guidelines recommend using the 0,1-hour (hr) and 0,3-hr hs-cTnT algorithms, their efficacy has been not clearly established in chronic kidney disease (CKD) patients.Â
A single-centre analysis of in-stent restenosis after left main stenting
P Jariwala, KARTIK Jadhav
doi : 10.1093/eurheartj/ehab849.073
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Percutaneous coronary interventions (PCI) can be the standard of care for left main (LM) coronary artery disease. In-stent restenosis (ISR) is a rare complication and is associated with patient- and procedure-specific aspects. The aim of our analysis is to evaluate the incidence and the predictors of ISR after left main PCI.
Aspirin vs. Clopidogrel as a Chronic maintenance monotherapy after PCI in patients with high ischemic risk and high bleeding risk: Subgroup analysis of the HOST-EXAM trial
K W Park, J Kang, B K Koo, T M Rhee, H M Yang, K B Won, S W Rha, J W Bae, N H Lee, S H Hur, J K Han, E S Shin, H S Kim
doi : 10.1093/eurheartj/ehab849.074
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The HOST-EXAM randomized clinical trial recently performed a comparison of clopidogrel monotherapy vs. aspirin monotherapy in patients requiring indefinite antiplatelet monotherapy after percutaneous coronary intervention (PCI). This study randomized 5,438 patients who maintained dual antiplatelet therapy without clinical events for 6–18 months after PCI with drug-eluting stents (DES) to receive a monotherapy agent of clopidogrel 75 mg once daily or aspirin 100 mg once daily for 24 months. During the 24-month follow-up, the primary outcome (a composite of all-cause death, non-fatal myocardial infarction, stroke, readmission due to acute coronary syndrome, and Bleeding Academic Research Consortium (BARC) bleeding type 3 or greater) rate was significantly lower in the clopidogrel group (hazard ratio [HR] 0.73 [95% CI 0.59–0.90]; p = 0.0035). However, it is uncertain whether the beneficial effect of clopidogrel will be consistent in patients with high ischemic risk or those with high bleeding risk.
Efficacy and safety of HDL/apoA-1 mimetics on human and mice with atherosclerosis: a systematic review and meta-analysis
A Abudukeremu, H Li, R Sun, X Liu, X Wu, X Xie, J Huang, J Zhang, J Bao, Y Zhang
doi : 10.1093/eurheartj/ehab849.075
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Low high-density lipoprotein cholesterol (HDL-C) level as a residual risk factor of cardiovascular disease (CVD) is still causing concern, although using chemical drugs for raising HDL-C level failed. The effect of high-density lipoprotein/ apolipiproteinA-1(HDL/apoA-1) mimetics on atherosclerosis is controversial.
Primary PCI in the very elderly: A study of outcomes in patients aged > 85 years with STEMI
P Jariwala, KARTIK Jadhav
doi : 10.1093/eurheartj/ehab849.076
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Primary percutaneous coronary intervention (PPCI) as management for acute STEMI is a well-established, evidence-based treatment offered across India. Evidence of benefit in the very elderly is sparse. With an aging population, the demand on PPCI services for STEMI in the elderly is likely to increase. Our aim was to establish real life outcomes in patients aged 85 years and older who receive PPCI for acute STEMI.
Spontaneous coronary artery dissection - case series of a rare disease
S H Hashmani, R G Garrod, F S Shamsi, K Y Hasan, S J Jamal, A B Bafadel, M T Traina, W M Al Mahmeed
doi : 10.1093/eurheartj/ehab849.077
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Spontaneous coronary artery dissection (SCAD) is an important cause of acute coronary syndrome (ACS) particularly in young women. Female sex, pregnancy, emotional stress and fibromuscular dysplasia are known triggering factors for SCAD.
Liver stiffness assessed by Fibrosis-4 index predicts heart failure in AMI patients
T Nunohiro, K Furukawa, M Uchida, S Kuwasaki, S Kusumoto, S Furudono, H Suenaga, M Takeno, S Takeshita
doi : 10.1093/eurheartj/ehab849.078
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
It has been recently reported that the liver stiffness, which reflects increased central venous pressure, measured by transient elastography increases along with decompensated heart failure (HF) developing and decreases with clinical improvement. A simple index for the assessment of liver stiffness and/or impairment of liver reserve may be useful in patients with HF. We calculated each patient´s FIB4 index(F4I) using the following formula: (age (years)× aspartate aminotransferase (IU/L)/platelet count (10９/L)× square root of alanine aminotransferase (IU/L)). Patients with an F4I≥2.67 were classified into the high F4I group and these patients were strongly suspected to have non-alcoholic fatty liver disease (NAFLD). NAFLD is also said to be a form of metabolic syndrome expressed in the liver. And lately NAFLD is associated with increased risk of acute myocardial infarction (AMI) and stroke and cardiovascular surrogate markers. But Little is known about F4I with the influence of AMI prognosis. This study included 167 AMI patients who underwent primary percutaneous coronary intervention within 24h of onset. Consecutive patients were divided into two groups based on their F4I at discharge: First group (2.67 ≤F4I, n = 27), second group (F4I <2.67, n = 140) . And we assessed the association between F4I and CV events including cardiac death, recurrent AMI, recurrent PCI (TLR) and re-hospitalization of heart failure during 13 months. Result: High F4I (2.67≤ F4I ,19% VS F4I <2.67, 6%: P = 0.045) related to the re-hospitalization of heart failure. Univariate odds ratio was 3.45. F4I is significantly related to the re-hospitalization of heart failure. Conclusion: A simple index F4I is significantly related to the prognosis of adverse cardiac events after AMI patients.
Demographic analysis and clinical outcomes of COVID-19 and myocardial infarction from a tertiary care centre in south India
R Kongara, RAMESH Sankaran, T R Muralidharan, P Manokar, S Sadhanandham, S Nagendra Boopathy, B Vinod Kumar, J V Balasubramaniyan, K Preetham
doi : 10.1093/eurheartj/ehab849.079
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Back ground – COVID-19  is reported in India from March 2020. It is known to cause  myocarditis , arrythmias and heart failure. COVID-19 infection has been proposed to be associated with myocardial infarction.
Comparison of VWF-ADAMTS13 axis involvement in atrial fibrillation and sinus rhythm in patients with ST-elevation myocardial infarction
T Osawa, Y Ito, K Nakano, Y Yamada, Y Abe, F Tabata, T Koizumi
doi : 10.1093/eurheartj/ehab849.080
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Previous studies have shown that von Willebrand factor (VWF) increases, and a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) decreases in myocardial infarction. Few studies have examined the involvement of the VWF-ADAMTS13 axis in ST-elevation myocardial infarction (STEMI) patients with atrial fibrillation (AF).
Risk scores in predicting adverse events after an acute coronary syndrome
F Duarte, M I Barradas, M I Barradas, L Oliveira, L Oliveira, C Serena, C Serena, A Fontes, A Fontes, A Monteiro, A Monteiro, C Machado, C Machado, R Dourado, R Dourado, E Santos, E Santos, N Pelicano, N Pelicano, M Pacheco, M Pacheco, A Tavares, A Tavares, D Martins, D Martins
doi : 10.1093/eurheartj/ehab849.081
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
ST-segment elevation myocardial infarction (STEMI) is a serious event that usually occur in patients with cardiovascular risk factors and is associated with great morbidity and mortality.
Hemorrhagic risk scores in hospitalized patients with acute coronary syndrome: can they (only) predict bleeding events?
F Duarte, M I Barradas, L Oliveira, C Serena, A Fontes, A Monteiro, C Machado, R Dourado, E Santos, N Pelicano, M Pacheco, A Tavares, D Martins
doi : 10.1093/eurheartj/ehab849.082
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Acute coronary syndrome (ACS) is a life-threatening condition and its therapeutic approach increases the risk of important bleeding events which are associated with a worse prognosis. Along with hemorrhagic events, a drop on hemoglobin level not related to bleeding or the development of anemia could have a negative impact on prognosis.
Association of aVR ST-elevation with outcomes in patients with acute coronary syndrome
R A Cordovez
doi : 10.1093/eurheartj/ehab849.083
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Evaluation of the lead aVR in the diagnosis of acute coronary syndrome has been neglected before.1 However, there is evidence that an ST segment elevation in that lead correlates to a significant coronary artery disease.1,2 This study aimed to determine the association with clinical outcomes of an aVR ST elevation in patients with acute coronary syndrome.
Predictors of elevated follow-up high sensitivity troponin after an initial normal value during acute exacerbations of chronic obstructive pulmonary disease
M S Yew, J A Abisheganaden, H Y Xu
doi : 10.1093/eurheartj/ehab849.084
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Elevation of cardiac troponin (cTn) may be seen in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and is both diagnostic for myocardial injury and confers a poorer prognosis. Serial cTn testing after an initial normal value is often performed even though the yield is low. Â
Influence of ST2 level on the development of acute arrhythmias in NSTEMI
V I Maslovskyi, I A Mezhiievska
doi : 10.1093/eurheartj/ehab849.085
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
To determine the structure and relationship of cardiac arrhythmias in NSTEMI patients based on plasma ST2 level.
Coronary atherosclerotic burden and trimethylamine N-oxide in non-ST-segment myocardial infarction patients: SZ-NSTEMI cohort
K Bin Waleed, LILI Wang, JUNLEI Chang, GARY Tse, Y L Xia, SHULIN Wu, L G Ding
doi : 10.1093/eurheartj/ehab849.086
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Trimethylamine N-oxide (TMAO) is reported to accelerate atherosclerosis and adverse cardiac outcomes. Relationship between coronary atherosclerotic burden and TMAO has linked in stable coronary artery disease and ST-segment elevation myocardial infarction, but not in non-ST-segment elevation myocardial infarction (NSTEMI).
Relationship of mean platelet volume to severity of coronary atherosclerosis in non-ST-segment myocardial infarction
K Bin Waleed, GARY Tse, LILI Wang, JUNLEI Chang, PENG Changnong, X I A Yunlong, SHULIN Wu, L I U Jianghai, YANG Yihang, L I Yicong, L U Yongkang
doi : 10.1093/eurheartj/ehab849.087
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Platelets play a crucial role in thrombotic mechanism. Mean platelet volume (MPV) is primarily indicator of platelet activation and its measurement is easy and time-effective. The MPV is associated with adverse cardiac events in coronary artery disease. However, limited data are available to assess the relationship of MPV to severity of coronary atherosclerosis through multiple indicators including SYNTAX and GENSINI scores and multivessel disease (MVD) in non-ST-segment elevation myocardial infarction (NSTEMI).
Short- and long-term outcomes in patients with right ventricular infarction according to modalities of reperfusion strategies in China: data from China Acute Myocardial Infarction (CAMI) Registry
H Mengjin, YANG Yuejin, G A O Xiaojin
doi : 10.1093/eurheartj/ehab849.088
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Twelfth Five-Year Planning Project of the Scientific and Technological Department of China
Smokers paradox in non-ST elevation acute coronary syndromes: does it exist?
Z A Dakhil, HASAN Farhan
doi : 10.1093/eurheartj/ehab849.089
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
In Iraq; about third of males and 4% of females are smokers. There is no data from  Middle eastern countries including Iraq on impact of smoking on prognosis in ACS
The potential beneficial effects of polysaccharide peptide on oxidative stress and lipid profile in post myocardial infarction patients: a double-blind, randomised controlled trial
L H Adrian, D Sargowo, P Sugita
doi : 10.1093/eurheartj/ehab849.090
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Inflammation, oxidative stress and lipid peroxidation activities contribute to the progression of atherosclerosis leading to myocardial infarction (MI). These sustainable cascade are considered to remain, in fact after the episode of MI. Polysaccharide peptide is renowned to exert anti-oxidative and lipid-lowering effects, thus may impair subsequent post-infarction plaque accumulation.
P2Y12 pre-treatment for NSTE-ACS in a tertiary hospital centre: real world compliance experience with ESC 2020 guidelines
R Kaul, J Khoo, P Pender, A Hopkins, S Lo
doi : 10.1093/eurheartj/ehab849.091
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The 2020 ESC guidelines for managing NSTE-ACS recommend against routine pre-treatment with a P2Y12 receptor inhibitor if coronary anatomy is not known and an early (<24h) invasive management is planned. With delayed (>24h) invasive management, pre-treatment may be considered in selected cases.
Real world outcomes of Thai patient with acute coronary syndrome classified by achieved low-density lipoprotein level
T Leesutipornchai, Y Kunlamas, N Areepium, K Bunditanukul, A Aekarach
doi : 10.1093/eurheartj/ehab849.092
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Although lower low-density lipoprotein (LDL) level is recommended to improves clinical outcomes, little is known about the association between LDL level after treatment and outcomes in developing countries. The aim of the study was to evaluate the impact of LDL level on mortality rate and outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).
Cost and prescription trends of P2Y12 inhibitors in Australia over the last decade
T Abrahams, A Brown, D Pol
doi : 10.1093/eurheartj/ehab849.093
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Coronary artery disease (CAD) remains one of the leading causes of mortality worldwide and in Australia, and places significant burden on healthcare costs. [1,2] Dual antiplatelet therapy (DAPT) is guideline therapy following acute coronary syndrome (ACS).[3] Novel, potent P2Y12 inhibitors have been developed and studied but it is unclear how this evidence has been incorporated into patient care across the spectrum of P2Y12 prescribers.
The effect of remote ischemic post-conditioning on left ventricular ejection fraction in STEMI patients undergoing primary percutaneous coronary intervention
M Fadil
doi : 10.1093/eurheartj/ehab849.094
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Primary Percutaneous Coronary Intervention (PPCI) in ST-Segment Elevation Myocardial Infarction (STEMI) is an effective method to limit the infarct area, reduce clinical symptoms, and improve clinical prognosis. However, it has the potential to creates an acute reperfusion injury which will result in worsening of left ventricular ejection fraction and eventually worsen the prognosis. Remote ischemic post-conditioning (RIPostC) is an additional, non-invasive, and inexpensive protective strategy that has been proved to play an important role in preventing worsening of reperfusion injury and left ventricular ejection fraction.
Left main PCI with second-generation DES: a single-centre experience
P Jariwala, KARTIK Jadhav
doi : 10.1093/eurheartj/ehab849.095
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
To characterise patients and procedures with left main (LM) percutaneous coronary intervention (PCI) and to evaluate their outcomes.
Analysis of clinical features and coronary angiography in 10 patients with de winter syndrome
N I Ni
doi : 10.1093/eurheartj/ehab849.096
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
To investigate the clinical characteristics and electrocardiogram (ECG) changes of patients with de winter syndrome, so as to enhancing the awareness of de Winter ECG pattern and conducting early emergency interventional therapy for the patients.
Prognostic value of GRACE versus TIMI Score for in-hospital outcomes after non-ST-Elevation acute coronary syndrome
DILEEP Kumar, TAHIR Saghir, KAMRAN Ahmed Khan, KHALID Naseeb, GULZAR Ali, M Mahfooz Ali, MUSA Karim, NADEEM Qamar
doi : 10.1093/eurheartj/ehab849.097
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The risk stratification scores are very helpful to categorize high risk patients to plan future management. Therefore, in this study we compared the predictive value of TIMI and GRACE score for predicting in-hospital outcomes after non-ST elevation acute coronary syndrome (NSTE-ACS).
Impact of SARS-CoV2 pandemic onto acute ST-elevation myocardial infarction care and patient outcomes in a large tertiary cardiac center
D Yong, M A Sulong, M Sundarajoo, N Am Haris, M Y Low, K Kaniappan, A A Nuruddin
doi : 10.1093/eurheartj/ehab849.098
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
SARS-CoV2 pandemic has caused major impact on patient care worldwide. We experienced a surge of cases beginning March 2020 leading to the government imposing a movement control order, more commonly known as ‘lockdown’ starting 18th March 2020. As such, various changes were implemented by our center to the clinical pathway for STEMI patients including using thrombolysis as the preferred initial treatment modality.
Clinical manifestation and impact on management of acute coronary syndrome during covid-19 pandemic, lessons learnt from a tertiary care
T Subburaja, K A Sambasivam, R Radhika, P Sankara Thiagarajan
doi : 10.1093/eurheartj/ehab849.099
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The World Health Organization first characterized COVID-19 as a ongoing pandemic since  12th March 2020. Since then, mitigation plans including vaccinations are on the run globally. During this pandemic several restrictions worldwide are being followed , which had major impact on acute coronary syndrome presentation due to various factors.At our tertiary cardiac care centre we analyzed the consecutive acute coronary syndrome admissions and its impact in the management during the pandemic lockdown .
Optimal landmark for chest compression during cardiopulmonary resuscitation derived from a chest computed tomography in arms-down position
P Usawasuraiin, B Wittayachamnankul, J Euathrongchit, P Phinyo, T Tangsuwanaruk
doi : 10.1093/eurheartj/ehab849.100
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Recently evidence, compression at the maximal left ventricular diameter on sternum (LVmax) maximises cardiac output, stroke volume and rate of return of spontaneous circulation. However, there is insufficient evidence for the specific landmark on the chest for high-quality chest compression. Although cardiac arrest patients are usually in the arms-down position, previous studies used chest computed tomography (CCT) of the patient with arms-up position. It might alter the left ventricular position.
Greater mitral valve area in obese patients with rheumatic heart disease: a new evidence of obesity paradox ?
A N Lestari, M R Akbar, I R Alie
doi : 10.1093/eurheartj/ehab849.101
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The existence of obesity paradox’s been proposed this past decade, suggesting obese individuals may have survival benefit when there"s acute cardiovascular decompensation or congestive heart failure. Adiponectin, a residual protein from fat, has a cardioprotective role against inflammation.
Prognostic implications of the proportionality of tricuspid regurgitation in tricuspid annuloplasty
Y K Stephanie, H L Li, Q W Ren, M Z Wu, K H Yiu
doi : 10.1093/eurheartj/ehab849.102
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Patients with secondary tricuspid regurgitation (TR) represent a heterogeneous group that benefits differentially from tricuspid annuloplasty. We hypothesized that TR severity may be proportional or disproportional to right ventricular (RV) remodeling and investigated the prognostic implications of this novel paradigm.
Clinical implications of troponin-T elevations following TAVR
T Imamura, A Oshima, H Onoda, S Tanaka, R Ushijima, M Sobajima, N Fukuda, H Ueno, K Kinugawa
doi : 10.1093/eurheartj/ehab849.104
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Baseline and post-procedural elevations in serum troponin-T levels are associated with increased morbidity and mortality following transcatheter aortic valve replacement (TAVR). However, the prognostic impact of change in serum troponin-T level following TAVR remains unknown.
Single center experience of transcatheter aortic valve implantation in severe aortic stenosis: study of mid-term clinical outcome
Y S Tey, F A Aris, M S Jalaluddin, W F Wan Rahimi Shah, A Ashari, J Kolanthai Velu, K G Ganesan, J J Dillon, S Kadiman, M A Sulong, S A Yahaya
doi : 10.1093/eurheartj/ehab849.105
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Transcatheter Aortic Valve Implantation (TAVI) had revolutionized the treatment and outcome of symptomatic severe aortic stenosis (AS) since its introduction. In 2009, our center performed the first TAVI in Malaysia and since then it has provided an alternative treatment for severe AS patients. The objective of the study is to evaluate the clinical outcome of severe AS patients who had undergone TAVI in our center.
Knowledge and attitudes amongst internal medicine clinicians in referring valvular heart disease patients : a multi-centre survey study
R Raja Shariff, K S Ibrahim, H A Zainal Abidin, A B Md Radzi, M H Muhmad Hamidi, H Sani, S Kasim
doi : 10.1093/eurheartj/ehab849.106
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
With advancement in valvular interventions, outcomes of valvular heart disease (VHD) patients have improved dramatically. However, very little is known regarding levels of knowledge and attitudes amongst non-cardiology clinicians in managing VHD.Â
Infective endocarditis post-transcatheter aortic valve replacement: a systematic review of epidemiology, clinical findings and prognosis
VIKASH Jaiswal, AKASH Jaiswal, ANGELA Ishak, RUCHIKA Kumar, ADITI Ujjawal, NITYA Batra, ZOUINA Sarfraz, AZZA Sarfraz, PRACHI Sharma, JACK Michel, GAURAV Chaudhary
doi : 10.1093/eurheartj/ehab849.107
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Transcatheter aortic valve replacement (TAVR) is a minimally invasive, catheter-based procedure to replace calcified narrow aortic valves. Available data on prosthetic valve endocarditis (PVE) post TAVR is limited to small subject populations in the form of case reports and case series. This systematic review aims to evaluate first the incidence of infective endocarditis post TAVR, second the microorganism profile and clinical findings, and third associated mortality/morbidity.
AEPEI scoring system to predict mortality among patients diagnosed with infective endocarditis after surgery at the philippine heart center: a retrospective analytical cross-sectional study
M Gatuz, L Cuenza
doi : 10.1093/eurheartj/ehab849.108
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Infective endocarditis (IE) is a life-threatening disease which continues to pose significant challenges in clinical practice. Surgery for IE while curative can be associated with considerable morbidity and mortality. We sought to determine the utility of a French based risk score in determining outcomes of patients with IE undergoing surgery.
Symptomatology, prognosis and clinical findings of myocarditis as an adverse event of COVID-19 mRNA vaccine: a systematic review
VIKASH Jaiswal, AKASH Jaiswal, NITYA Batra, D Mukherjee, R Ruchika, ANGELA Ishak, U Maskey, GAZALA Hitawala, DAVID Song, YASAR Sattar
doi : 10.1093/eurheartj/ehab849.109
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Myocarditis, an inflammation of the myocardium in the absence of ischemic injury, may be caused by viruses, drugs, and vaccines. The Myocarditis following COVID-19 vaccinations is most commonly seen in young adult males and commonly after the second dose of the mRNA vaccine. It usually presents with chest pain, dyspnoea, palpitations but has a diverse clinical presentation and varied therapeutic response. We aim to systematically collate the symptomatology, prognosis, and clinical findings of COVID-19 vaccine adverse events causing Myocarditis.
Arrhythmogenic right ventricular cardiomyopathy patients with a markedly enlarged RV compressing LV to left side have an atypical distribution of epsilon waves and elevated plasma BNP
N Funabashi, M Okamoto, K Nakamura, T Sasaki, S Naito, Y Kobayashi
doi : 10.1093/eurheartj/ehab849.110
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Epsilon waves on V1-3 leads are specific ECG findings in patients with arrhythmogenic right ventricular (RV) cardiomyopathy (ARVC) suggesting RV conduction delay. Four dimensional (4D) cardiac CT visualizes ARVC characteristics, such as fibro-fatty invasion into RV and left ventricular (LV) myocardium (RVM, LVM), an enlarged RV, reduced RV motion, and bulging.
Predictions of arrhythmic, heart failure and mortality outcomes in pericarditis using automatic electrocardiogram analysis: a retrospective cohort study
I Lakhani, J Z Zhou, A L Li, S L Lee, T L Liu, Q Z Zhang, G T Tse
doi : 10.1093/eurheartj/ehab849.111
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Pericarditis is a relatively rare disease with a global burden. Despite its strong association with adverse cardiovascular outcomes, identification of patients at risk of future heart failure or arrhythmic events is difficult. In the following study, automated electrocardiogram (ECG) variables were used to predict new onset ventricular tachycardia/fibrillation (VT/VF), atrial fibrillation (AF) and heart failure with reduced ejection fraction (HF) in an Asian cohort of pericarditis patients.
Pericardiocentesis over 3 years at a tertiary referral Australian hospital
J Ramachandran, P Pender, J Assad, A Wang, A Faour, D Leung, R Rajaratnam, C Mussap, C Juergens, S Lo
doi : 10.1093/eurheartj/ehab849.112
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Pericardiocentesis is a lifesaving intervention performed both percutaneously or surgically. We analysed 3 years of experience in a major tertiary hospital in Sydney Australia.Â
Diagnostic delay in congenital heart disease related pulmonary arterial hypertension: insights from the single tertiary hospital center of pulmonary hypertension registry in East-Java Indonesia
I C M I Icmi Dian Rochmawati, FADLAN Muhamad Rizki Fadlan, HENY Heny Martini
doi : 10.1093/eurheartj/ehab849.113
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
CHD-Pulmonary arterial hypertension (PAH) is a progressive and fatal disorder. Â There could be more severe, permanent pathological changes and right ventricular failure in patients diagnosed in later stages, contributing to worse prognosis.
Clinical manifestation of coronary pulmonary arterial fistula diagnosed by cardiac computed tomography
N Funabashi, Y Kobayashi
doi : 10.1093/eurheartj/ehab849.114
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
 Coronary pulmonary arterial fistula (CPAF) may cause enlargement of an aneurysm, which may rupture or compress other organs, or occurrence of steal phenomenon of coronary arterial (CA) blood flow. We hypothesize that there are various clinical characteristics of CPAF including patient age at diagnosis, method of diagnosis, observed symptoms, complications, and surgical interventions
Risk stratification and prognosis in pulmonary arterial hypertension: the Singapore experience
J Teoh, J L J Yap, Z Y P Ong, J D B Lee, R Wen, A B Ismail, D W Sewa, G C Phua, C H Y Fong, A H L Low, S T Lim, J L Tan
doi : 10.1093/eurheartj/ehab849.115
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Aims & Background: Guidelines recommend the risk stratification of patients with pulmonary arterial hypertension (PAH) at baseline and on follow-up, so as to guide the management and titration of therapy in these patients. This approach has been validated in various pulmonary hypertension registries in the West.  We aim to study the value of risk stratification on the prognosis of PAH patients in Asia.
Intravenous epoprostenol therapy in the treatment of pulmonary arterial hypertension: the Singapore experience
J Choo, J Yap, AIDILA Ismail, C L Lim, P Sumathy, W Ruan, D W Sewa, G C Phua, C Hong, A H L Low, S T Lim, J L Tan
doi : 10.1093/eurheartj/ehab849.116
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Pulmonary arterial hypertension (PAH) is a progressive disease with significant morbidity and mortality. While intravenous (IV) Epoprostenol, a prostacyclin analogue, has been shown to improve exercise tolerance, symptoms, hemodynamics and survival, there are challenges with initiation and maintenance of this IV therapy.
The Clinical Experience of Macitentan in pulmonary hypertension in Indian cohort: 12-months follow-up
PANKAJ Jariwala, KARTIK Jadhav
doi : 10.1093/eurheartj/ehab849.117
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Macitentan, an endothelin receptor antagonist, has been shown to be effective and safe in the treatment of pulmonary arterial hypertension (PAH) in multiple randomized clinical trials, including SERAPHIN, focusing on morbidity and mortality reduction. The goal of this study was to show the clinical and echocardiographic improvement with macitentan in Indian patients with PAH.
Direct oral anticoagulant vs low molecular weight heparin for the treatment of venous thromboembolism associated with malignancy: a meta- analysis
H Lastimosa
doi : 10.1093/eurheartj/ehab849.118
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Venous thromboembolism (VTE) is a major cause of morbidity and mortality in cancer patients and treatment of cancer associated thromboembolism is challenging. Low molecular weight heparin (LMWH) has been the standard of care treatment for cancer-associated VTE yet the use of direct oral anticoagulant (DOACs) has been promising.
Anticoagulation practices and venous thromboembolism in COVID-19 patients in a Philippine tertiary hospital
M Ramos
doi : 10.1093/eurheartj/ehab849.119
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
COVID-19 poses an increased risk for thrombosis and initiation of prophylactic anticoagulation has been shown to have mortality benefit in earlier studies. However, the use of full dose anticoagulation as prophylaxis and evidence of the efficacy and safety of anticoagulation on COVID-19 patients remains to be a topic of interest. This study aimed to explore the aspects of anticoagulation applied in a tertiary hospital in the Philippines and to further elucidate on its outcomes and development of complications among COVID-19 patients.
The effects of Kaatsu training on an acute angiogenic response in post-interventional rehabilitation of peripheral arterial disease patients
A Wlodarczyk, A Wachsmann-Maga, M Schonborn, A Trynkiewicz, M Cebenko, P Maga, R Nowobilski, M Maga
doi : 10.1093/eurheartj/ehab849.120
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Atherosclerosis as the main cause of death in adults is one of the greatest challenges of modern medicine. Peripheral arterial disease (PAD) is a condition with worldwide increasing occurrence affecting more than 20% of Europeans and North Americans in the age group> 55 years, and in the group> 70 years of age affects as much as 60% of the population. Among many treatment forms the endovascular treatment remains the most common treatment method, however the most non-invasive, but still effective is rehabilitation by physical training. Recently, innovative solutions have been introduced concerning this form of treatment by combining anaerobic interval exercises with venous blood flow restriction (BFR) and cooling.
The impact of blood pressure variation on mortality and symptomatic intracerebral hemorrhage in stroke patients after thrombolytic therapy
P Kotruchin, H Kliangsa-Ard, T Mitsungnern, S Imoun, K Kongbunkiat
doi : 10.1093/eurheartj/ehab849.121
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Introduction Blood pressure variation (BPV) was one of the risk factors for unfavorable stokes outcomes. However, the association between BPV and short-term outcomes in stroke patients after received thrombolysis (recombinant tissue plasminogen activator; rt-PA) was limited.
Performance and 12 month outcomes of a wire free fractional flow reserve system for assessment of coronary artery disease, first experience in south east asia
C D Bhavnani, A Y Y Fong, K T Koh, Y Y Oon, C T Tan, L S Chen, I X Pang, A B Said, K H Ho, F E P Shu, H S Ling, Y L Cham, L K Thien, B K Chung, T K Ong
doi : 10.1093/eurheartj/ehab849.122
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Fractional flow reserve (FFR) using an invasive pressure wire has a Class 1A recommendation for guiding coronary revascularization in stable coronary artery disease (CAD). Angiography based ‘wire free’ FFR is an emerging technique which determines the physiological significance of a coronary lesion without requirement of a pressure wire or induction of hyperemia. It also eliminates potential complications associated with introduction of wires into the coronary arteries.
Three year clinical outcomes of fractional flow reserve guided coronary revascularization using a monorail pressure sensor microcatheter
C D Bhavnani, K T Koh, Y Y Oon, I X Pang, C T Tan, L S Chen, F E P Shu, K H Ho, Y L Cham, H S Ling, A Said, L K Thien, B K Chung, A Y Y Fong, T K Ong
doi : 10.1093/eurheartj/ehab849.123
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Fractional flow reserve (FFR) has a Class 1A recommendation for guiding coronary revascularization in stable coronary artery disease. Deferral of revascularization for coronary stenosis of FFR >0.80 has shown favorable long-term outcomes, yet the adoption in real-world practice is limited. To date, there is no study on FFR guided PCI in the Malaysian population.
Instantaneous wave-free ratio and fractional flow reserve: effect of variation in left ventricular end diastolic pressure
P Sharma, S Vohra, M Bhandari, A Sharma, P Vishwakarma, G Chaudhary, A Pradhan, S Chandra, S K Dwivedi, R Sethi
doi : 10.1093/eurheartj/ehab849.124
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Among patients with intermediate coronary artery stenosis (50-90%), assessment of functional significance of the lesion by instantaneous wave free ratio (iFR)/ fractional flow reserve (FFR) is recommended in latest guidelines. Though iFR is not much affected by change in hemodynamics compared to FFR, the change in iFR vs FFR due to various hemodynamic factors need a validation. Left ventricular end-diastolic pressure (LVEDP) is one of the hemodynamic factors whose variation and effect on FFR vs iFR is largely unknown. In the present study we evaluated the association of change in LVEDP on the changing pattern of iFR/FFR which may hold a clinical significance especially with percutaneous coronary intervention in heart failure patients.
Safety and efficacy of percutaneous coronary interventions performed via anatomical snuffbox access in elderly patients
K Berezhnoi, A Vanyukov, L Kokov
doi : 10.1093/eurheartj/ehab849.125
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Radial artery thrombosis is a potential complication of transradial catheterization. For elderly patients greater attention should be paid to preserve radial arteries due to rather common comorbidities, such as renal failure and systemic atherosclerosis. Radial arteries in such cases may be required for hemodialysis, coronary artery bypass grafting and vascular reconstruction surgery. Presumably, the distal radial access can provide additional benefits in reducing the incidence of radial artery occlusion.
Standardized LocSSIPs improves risk prevention for in-patient angioplasty in tertiary care hospital
K Kyaw
doi : 10.1093/eurheartj/ehab849.126
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
There are no established ESC/NICE guidelines for acceptable Safety Checklists in invasive coronary angiogram. A lack of Quality Assurance Checklists that is indicated by WHO guidelines for coronary angiogram can lead to potentially serious or life-threatening implications such as acute pulmonary and venous thromboembolism, stent thrombosis due to delays in anti-platelet therapy and thromboprophylaxis.
Anatomical obstacles and their impact on the sheath to balloon time while intervening through a trans-radial approach in patients undergoing primary percutaneous coronary intervention
DILEEP Kumar, SYED Abdul Bari, TAHIR Saghir, NASIR Khan, ROMANA Awan, VICKY Kumar, NADEEM Qamar
doi : 10.1093/eurheartj/ehab849.127
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Trans-radial approach has been considered a safe and useful vascular access site for cardiac catheterization in comparison with the conventional trans-femoral approach. However, radial access has many challenges, such as access difficulty related to anatomical variations, radial artery spasm, occlusion, loops, tortuosities, and aberrant origin of radial and subclavian arteries. These factors were ignored in the large randomized trials that might have a significant impact on the outcome.
Randomized comparison of proximal and distal radial access for coronary angiography and interventions
A Dadarwal, N Garg, A Kapoor, S Tewari, S Kumar, R Khanna, A Sahu, P K Goel
doi : 10.1093/eurheartj/ehab849.128
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Vascular access for coronary procedures is of paramount important not only for successful procedure but also to prevent complications. In comparison to femoral access, proximal radial artery (PRA) access at wrist is associated with decreased bleeding complications and mortality. The most important complication of PRA access is radial artery occlusion Use of the proximal radial artery (PRA) approach at wrist has several limitations: the need to supinate the hand, which can exacerbate chronic joint pain, the depth of the radial artery in large arms, which could make arterial puncture challenging even under ultrasound guidance, the risk of sporadic bleeding in the forearm, and the risk of radial artery occlusion. All above limitations can be overcome by distal radial artery (DRA) access in anatomical snuff box. Randomized Studies are lacking for the comparison between DRA and PRA approach in coronary procedures.
Optical coherence tomography versus angiography to guide percutaneous intervention: a real-world single center propensity-matched analysis
A Dadarwal, S Roy, A K Sharma, K K Sharma
doi : 10.1093/eurheartj/ehab849.129
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Optical coherence tomography (OCT) with its superior resolution has several benefits over coronary angiography (CA) to guide percutaneous coronary intervention (PCI). Despite the benefits of OCT in comparison with angiography, it is not widely used in developing countries like India data is limited in India specifically in all comer population to meet unmet need.
Intravascular lithotripsy during percutaneous coronary intervention for calcified coronary lesions: analysis of patient and procedural characteristics and clinical outcomes
J Leung, P Pender, J French, D Leung, C Mussap, K Asrress, D Taylor, T Naguib Badie, K Kadappu, O Gibbs, K Kachwalla, P Nguyen, A Hopkins, S Lo
doi : 10.1093/eurheartj/ehab849.130
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Coronary artery calcification is frequently encountered during percutaneous coronary intervention (PCI). It can reduce PCI success and increase intra-procedural and post-procedural complications, including stent embolization, under-expansion and mal-apposition. Intravascular lithotripsy (IVL) is a new tool developed to treat calcified coronary lesions.
Initial clinical experience with a new sheathless guiding catheter designed for direct insertion
A Borrie, S Fairley, S A Harding
doi : 10.1093/eurheartj/ehab849.131
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Radial access for percutaneous coronary intervention (PCI) is growing rapidly as this approach has been shown to improve patient comfort and reduce complications. Use of a sheathless guiding catheter for transradial PCI has the potential reduce trauma to the radial artery and to further expand the type of cases where this approach can be utilised. The new Sheathless Hyperion system allows direct insertion of the Sheathless Hyperion guiding catheter using a 20 G needle or IV cannula, a 0.25" Silverway wire and a custom dilator.
Platinum chromium everolimus-eluting stent versus cobalt chromium zotarolimus-eluting stent in very late stent thrombosis: a meta-analysis of randomized controlled trials
J J Baterna, A Susanto, F Cheng
doi : 10.1093/eurheartj/ehab849.132
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Very late stent thrombosis is a rare but potentially lethal outcome for drug-eluting stents used in percutaneous coronary intervention. There is limited research currently on the occurrence of very late stent thrombosis as a complication of two most used second-generation drug-eluting stents, i.e. platinum chromium everolimus-eluting stent (PtCR-EES) and cobalt chromium zotarolimus-eluting stent (CoCr-ZES).
Refined balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension: a prospective multicenter registry
Y-P Zhou, Y-P Wei, Y-J Yang, F-H Peng, B-X Wu, C Hong, Q Tong, X-P Cui, G-C Zhang, Y-S Cao, D-L Wang, X-Q Xu, X Jiang, Z-C Jing
doi : 10.1093/eurheartj/ehab849.133
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening disease with a poor prognosis if left untreated. Pulmonary endarterectomy is the standard treatment for CTEPH, but around 40% of CTEPH patients are non-eligible for surgery.
Transit time flow measurement (TTFM) as a predictor of graft failure and major adverse cardiac events following coronary artery bypass grafting (CABG)
H J Yong, M A Lim, K Kok, N Juanda, S Johar
doi : 10.1093/eurheartj/ehab849.134
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Post coronary artery bypass grafting (CABG), coronary angiography (CAG) is the gold standard for graft assessment to check the presence of occlusion or stenosis. Despite this, CAGs after a CABG in the nation are only conducted if patients show ischemic signs. Alternative to CAG, transit time flow measurement (TTFM) can be utilized to determine overall quality of blood flow in grafts. TTFM has yet been utilized to assess graft patency despite its availability in the nation.
The association of preoperative dialysis with troponin trends and short term outcomes among advanced kidney disease patients undergoing coronary artery bypass grafting
Y Manla, M Hogan, G Bhatnagar, N Khan, F Alsindi, Y Aljabery, S Sanger, L Gobolos
doi : 10.1093/eurheartj/ehab849.135
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Coronary artery disease continues to be the leading cause of death in patients with stage IV-V chronic kidney disease (CKD IV-V). However, the prognosis and early outcomes for advanced CKD patients undergoing coronary artery bypass grafting (CAB) worsen as the estimated glomerular filtration rate (eGFR) deteriorates. Therefore, we compared postoperative clinical outcomes and troponin trends in patients having advanced CKD according to preoperative dialysis status in a single centre experience.
Sex-specific differences in mortality after first time, isolated coronary artery bypass graft surgery: a systematic review and meta-analysis of randomized controlled trials
S Matthews, A O"neil, J Sanders, A Buttery, S Maraosco, S Fredericks, G Martorella, N Keenan, A Ganes, R Wynne
doi : 10.1093/eurheartj/ehab849.136
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Evidence quantifying sex-specific differences in cardiac surgical outcomes is scant.
Early impact of COVID-19 pandemic on heart transplant volumes in Asia and Oceania: results from the Global Observatory on Donation and Transplantation (GODT)
Y Manla, N Bader, G Bajwa, L Gobolos, F Alsindi, I Hamour, H Ghalib, F Al Badarin
doi : 10.1093/eurheartj/ehab849.137
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Massive demand for healthcare services worldwide following the emergence of coronavirus disease 2019 (COVID-19) has limited the availability of healthcare resources needed for certain high-complexity procedures, including orthotopic heart transplantation (OHT). Whereas the negative impact of COVID-19 pandemic on several elective procedures has been well-documented, data on regional changes in OHT volumes after COVID-19 are limited. Therefore, we aimed to quantify the impact of COVID-19 pandemic on OHT volumes in Asia and Oceania.
Effect of profilin-1 on the asymmetric dimethylarginine-induced vascular lesion associated hypertension
G Ni
doi : 10.1093/eurheartj/ehab849.138
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Previous studies have demonstrated that the levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthesis, are strongly associated with hypertension, diabetes, and cardiovascular diseases. Pro�lin-1, an actin-binding protein, has been documented to be involved in endothelial injury and in the proliferation of vascular smooth muscle cells (VSMCs) resulting from hypertension. However, the role of profilin-1 in ADMA-induced vascular injury in hypertension remains largely unknown.
Association of body mass index with systolic and diastolic blood pressure in rural Indians
Aniket Inamdar
doi : 10.1093/eurheartj/ehab849.139
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Body mass index (BMI) is positively and independently associated with morbidity and mortality from hypertension, cardiovascular disease, type II diabetes mellitus, and other chronic diseases. In Caucasian and Asian populations, a strong association has been depicted between BMI and mortality. Globally, high blood pressure is estimated to cause 7.1 million deaths, about 13% of the total. About 62% of cerebrovascular disease and 49% of ischemic heart disease are attributable to suboptimal BP (systolic > 115 mm Hg). Overweight and obesity increase the risks of high BP, coronary heart disease, ischemic stroke, type II diabetes mellitus, and certain cancers. Worldwide, about 58% of diabetes mellitus and 21% of ischemic heart disease are attributable to BMI above 21 kg/m2. The combination of blood pressure and Body Mass Index (BMI) contribute more than 60% cases of cardiovascular disease.
Prevalence and predictors for high blood pressure during covid-19 vaccination in Thailand
S Patamatamkul
doi : 10.1093/eurheartj/ehab849.140
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The Thai government mandates BP measurement prior to COVID-19 vaccination to ensure safety for all vaccinees. However, there is neither large study regarding the prevalence of high BP nor CV complication during COVID-19 vaccination.Â
Evaluation of outcome of Coronavirus disease 2019 patients receiving RAAS inhibitors (OCRAS study): a prospective observational study of Bangladeshi hypertensive patients
A B D Majumder, M T Rahman, A K M Islam, M Ullah, M K Zaman, M A Reza, M S Islam, R C Khan, M Z Rahman, M M Rahman, M A Awal, S Kabir, G K Paul, S Nasrin, S Zaman
doi : 10.1093/eurheartj/ehab849.141
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The fact that SAARS-Cov2 virus enters cells through ACE2 receptors and the Renin-Angiotensin-Aldosterone System Inhibitors (RAASi) upregulate the ACE2 receptors, there was speculation that use of RAASi may lead increased cellular entry of the virus. There was a pause for a brief period of the use of RAASi in COVID 19 patients. But clinically the speculation has been found to be incorrect. Different professional societies come up with the assertion to continue to use RAASi. As the hesitancy among the clinicians appears to continue and there is no first hand data regarding the safety of the use of RAASi in Bangladeshi population, the study was undertaken to evaluate the safety of RAASi in COVID 19 patients.
Blood pressure variability in hypertension patients in Indian clinical settings
M Abhyankar, A K Jinghan, C Das, S Datta, A D Goswami, S Silki
doi : 10.1093/eurheartj/ehab849.142
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
 Blood pressure variability (BPV) is a potential predictor for complications such as coronary artery disease, heart failure, stroke, and all-cause death, independently of mean blood pressure (BP) in patients with hypertension.(1)
The safety and efficacy of efonidipine, an L- and T-Type dual calcium channel blocker, on heart rate and blood pressure in indian patients with mild-to-moderate essential hypertension
P Jariwala, KARTIK Jadhav
doi : 10.1093/eurheartj/ehab849.143
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Efonidipine hydrochloride, an L- and T-type dual calcium channel blocker, have a heart rate (HR)-slowing action in addition to a blood pressure (BP)-lowering effect. Many younger Indian hypertensive patients has sinus tachycardia. Beta blockers are not first line of antihypertensive agents. The aim of this study was to determine the effect of efonidipine on HR and BP in Indian patients with mild-to-moderate hypertension.
Circulating extracellular vesicles correlate with nocturnal blood pressure and vascular organ damage and may serve as an integrative biomarker of vascular health.
L M Lugo Gavidia, D Burger, S Robinson, J Nolde, R Carnagarin, V B Matthews, M P Schlaich
doi : 10.1093/eurheartj/ehab849.144
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
 Elevated blood pressure (BP) has been associated with increased levels of circulating extracellular vesicles (EVs) which could potentially serve as a novel integrative biomarker for vascular health.
Study on the correlation between ambulatory blood pressure and left atrial diameter in patients with treated and controlled office hypertension
LIJIAO Zhang, X U Zhang, W E I Song, YING Zhang, YINONG Jiang, PENG Qu
doi : 10.1093/eurheartj/ehab849.145
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
 Patients suffered from different kinds of target organ damage even after years of standardized treatment in clinic.Â
Serum uric acid is positively associated with systolic and diastolic blood pressure in young adults
T Correa, I O De Oliveira
doi : 10.1093/eurheartj/ehab849.146
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Uric acid is the final product of purine metabolism, and its increase can be related to excessive production or decreased renal excretion. Serum uric acid (SUA) has been positively and independently associated with inflammatory markers, insulin resistance, and cardiometabolic diseases in observational studies, but causal roles remain unclear.1,2
A survey-based comparison of cardiovascular health risk behaviours in Indian men and women during the pandemic
P Chockalingam, V Natarajan, T Sekar
doi : 10.1093/eurheartj/ehab849.147
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Cardiovascular disease (CVD), the leading cause of mortality globally, is caused by a combination of behavioral, clinical and genetic risk factors. The rising prevalence of unhealthy diet, inadequate exercise, psychosocial factors and tobacco use in urban and rural populations of India has posed a major epidemiological and healthcare threat in the recent past.
The association of liver enzymes with systolic and diastolic blood pressure in young adults
T Correa, D F Freitas, C B Brum, I O De Oliveira
doi : 10.1093/eurheartj/ehab849.148
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Nonalcoholic fatty liver (NAFLD) disease has been associated with metabolic syndrome and cardiovascular risk factors including cholesterol, type 2 diabetes, obesity, and hypertension. Patients with NAFLD also have increased risk of coronary artery disease and major adverse cardiovascular events.
Impact of the anti-hypertensive diets virtual education towards knowledge, attitude, practice, and reduction of blood pressure during covid-19 pandemic
A Andrianto, M Ardiana, A Yutha, B P D Khrisna, R A Nugraha, T S Putra, A R Shahab, H Andrianto, I H Kikuko, A N Puspitasari, M R Hajjrin
doi : 10.1093/eurheartj/ehab849.149
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Background. One of the efforts to reduce hypertension rates in the community is through dietary changes that refer to the Dietary Approach to Stop Hypertension guidelines or abbreviated as DASH. However, in the COVID-19 pandemic, there is a significant obstacle regarding the most effective way to transfer knowledge, skill, and attitude towards society.Â
Clinical significance of epicardial fat in suspected angina pectoris: an observational study
A Dadarwal, N Garg, A Kapoor, S Tewari, S Kumar, R Khanna, A Sahu, P K Goel
doi : 10.1093/eurheartj/ehab849.150
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Epicardial adipose tissue (EAT) is the visceral fat between pericardium and visceral epicardium and is the source of several endocrine and inflammatory mediators. It also has paracrine affects in the neighboring coronary arteries.
Homocysteine predicts vascular target organ damage in hypertension and may serve as guidance for first-line antihypertensive therapy
R Carnagarin, MARKUS Schlaich
doi : 10.1093/eurheartj/ehab849.151
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Homocysteine is an independent risk factor for cardiovascular and cerebrovascular disease and has been proposed to contribute to vascular dysfunction. We sought to determine in a real-world clinical setting whether homocysteine levels were associated with hypertension mediated organ damage (HMOD) and could guide treatment choices in hypertension.
Effectiveness and safety of combined direct oral anticoagulant and antiplatelet among high-risk peripheral arterial disease: a meta-analysis
S Solano, G Obrado, K Balcos, M Heidari, M Gotohio
doi : 10.1093/eurheartj/ehab849.152
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Peripheral arterial disease (PAD) is a common manifestation of systemic atherosclerosis which strongly correlates to cardiovascular morbidity and mortality and increased risk of limb loss, and despite the wide use of guideline-based antiplatelet therapy, patients remain at high risk for cardiovascular and limb events. There has been increasing interest in novel anticoagulants to improve prevention of complications secondary to PAD.
High visit-to-visit cholesterol variability predicts new-onset heart failure and adverse cardiovascular events: a retrospective population-based cohort study
J S K Chan, J Zhou, D I Satti, T T L Lee, O H I Chou, A K C Wai, A Ciobanu, Y Liu, T Liu, Q Zhang, G Tse
doi : 10.1093/eurheartj/ehab849.153
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Hyperlipidaemia is associated with adverse cardiovascular outcomes. However, the long-term prognostic value of visit-to-visit cholesterol variability is less certain, particularly regarding the risks of new-onset heart failure (HF). We investigated the associations between visit-to-visit cholesterol variability and adverse cardiovascular events.
Can cord blood lipid and lipoprotein levels inform LDL targets?
J W C Tan, K K Yeo, S K Phua, J J B Lee, N S Y Koh, T C Aw
doi : 10.1093/eurheartj/ehab849.154
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
 Current ESC dyslipidemia guidelines recommend lowering LDL targets to 1.4mmol/L (55mg/dL) for very high risk individuals. Lipid levels of newborns may provide insights into physiologic levels at the time of birth. There is limited data on cord blood lipids/lipoprotein levels in Asian populations. This study aims to describe cord blood lipid levels in a multi-ethnic Asian population.
Normal weight central obesity among Filipinos and its association with cardiovascular diseases: a cross-sectional study
B Toledano, E M Yap, G Vilela
doi : 10.1093/eurheartj/ehab849.155
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Normal weight central obesity reflects an increased visceral fat and low lean mass hence its association with cardiovascular diseases
Effectiveness of a home-based cardiovascular disease prevention program during the COVID-19 pandemic
P Chockalingam, V Natarajan, T Sekar, A Rajaram, M M Yusuf, S Gunasekaran, P G Nayar, V Chockalingam
doi : 10.1093/eurheartj/ehab849.156
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Home-based cardiovascular disease (CVD) primary prevention (HBPP) and cardiac rehabilitation (HBCR) programs which occupied a small proportion of the overall Preventive Cardiology work in the past have become mainstream during the COVID-19 pandemic.
Referral rates and patient characteristics of the inpatient cardiac rehabilitation program of a philippine tertiary cardiovascular referral center
R D Agustin, A L Samson, A Dela Cruz, M M Pipo, F E Punzalan
doi : 10.1093/eurheartj/ehab849.157
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
International guidelines recommend effective cardiac rehabilitation programs to decrease mortality and morbidity and improve health-related quality of life. However, cardiac rehabilitation remains underutilized with low referral rates. Data on referral rates and factors affecting referral are lacking in our setting.
Correlation between fasting heart rate and fasting plasma glucose level in rural Indians
Aniket Inamdar
doi : 10.1093/eurheartj/ehab849.158
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Diabetes mellitus is associated with abnormal autonomic function. Diabetes and impaired fasting glucose are associated with increased mortality, particularly from cardiovascular causes. Several factors, including fast heart rate, have been identified to be associated with an increased likelihood of having diabetes. Heart rate is a crude index of the autonomic nervous system tone, reflecting a balance of sympathetic and parasympathetic inputs, and correlates with muscle sympathetic nerve activity and noradrenaline serum levels . Examining its potential role in diabetes risk could improve our understanding of the pathogenesis of diabetes.
Impact of perioperative interruption of antithrombotic therapy on thrombotic and bleeding events in non-cardiac surgery
K Saito, Y Saito, T Muramatsu, H Kitahara, Y Fujimoto, S Isono, Y Kobayashi
doi : 10.1093/eurheartj/ehab849.159
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Antithrombotic therapy including antiplatelet agents and anticoagulants are prescribed for secondary prevention in patients with established cardiovascular disease. Although antithrombotic therapy is often interrupted before non-cardiac surgery with or without perioperative bridging anticoagulation, the impact on thrombotic and bleeding events remains uncertain.Â
Epidemiology of obstructive sleep apnea in older patients with stable cardiovascular disease and chronic kidney disease
E Efremova, A M Shutov, V A Serov, O V Gabriel"
doi : 10.1093/eurheartj/ehab849.160
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Obstructive sleep apnea (OSA) is diagnosed late, especially in older people. The presence of chronic hypoxia and glomerular hypertension decrease renal function in patients with OSAS, which causes the progression of chronic kidney disease (CKD) [3]. The aim of the study was to investigate epidemiological aspects of OSA in older patients with stable cardiovascular disease and chronic kidney disease.
Programmed Cell Death 1 (PD-1) and Programmed Cell Death Ligand 1 (PD-L1) inhibitors and adverse cardiovascular events: a population-based study
S Lee, J Zhou, I Lakhani, L Yang, T Liu, Y Zhang, Y Xia, W T Wong, E W Y Chan, I C K Wong, G Tse, Q Zhang
doi : 10.1093/eurheartj/ehab849.161
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) inhibitors are major classes of immune checkpoint inhibitors that are increasingly used for cancer treatment. However, they are associated with adverse cardiovascular events.
Serial echocardiography assessment and clinical outcomes among pregnant women with Tetralogy of Fallot
N W L Hon, M Z Wu, S Y Yu, P F Wong, Y K Tse, H L Li, L H Tsui, S Y Yu, K H Yiu
doi : 10.1093/eurheartj/ehab849.162
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Following advancements in intracardiac repair of Tetralogy of Fallot (TOF), a greater proportion of patients survive well beyond child-bearing age. Pulmonary regurgitation (PR) and subsequent progressive right ventricular dilatation occur frequently as an intrinsic complication of surgical repair of TOF. High-output states such as pregnancy may exacerbate these late complications. The advocation of pre-pregnancy pulmonary valve replacement to mitigate pregnancy-related cardiac burden has remained controversial. This study aims to delineate the outcomes of pregnancy among women with repaired TOF.
Role of prenatal cardiovascular magnetic resonance imaging in determining pregnancy risk in repaired Tetralogy of Fallot patients
N W L Hon, M Z Wu, S Y Yu, P F Wong, Y K Tse, H L Li, L H Tsui, S Y Yu, K H Yiu
doi : 10.1093/eurheartj/ehab849.163
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Addressing pregnancy risks poses as a new challenge among women with repaired tetralogy of Fallot (TOF). The high-output state of pregnancy may predispose women to late complications of repaired TOF. However, guidelines regarding antenatal and or perinatal cardiovascular assessment has not been outlined. Noninvasive modalities such as cardiac magnetic resonance imaging (CMR) that do not require the utilization of ionizing radiation are feasible methods of assessment. Risk stratification of baseline CMR parameters has been sparsely investigated among repaired TOF cohorts. This study aims to identify baseline CMR parameters that may predict adverse outcomes of pregnancy among women with repaired TOF.
A four year experience of peripartum cardiomyopathy in a rural public hospital in south india
R A Kanakasabapathy, N Annamalai
doi : 10.1093/eurheartj/ehab849.164
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Peripartum cardiomyopathy (PPCM), as defined by the study group on PPCM of Heart Failure Association of the European Society of Cardiology (ESC), is an idiopathic Cardiomyopathy with systolic heart failure occurring towards the end of pregnancy or in the months following delivery, in previously healthy women. The current diagnostic criteria are:
Comorbidity and quality of life in older patients with chronic cardiorenal syndrome and obstructive sleep apnea
E Efremova, A M Shutov, V A Serov, N V Igonina
doi : 10.1093/eurheartj/ehab849.165
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Comorbidity increases with age, including the presence of cardiovascular disease, chronic kidney disease (CKD) and obstructive sleep apnea (OSA). OSA is considered as a risk factor for the progression of CKD.
Awareness and cognitive status of older patients with chronic cardiorenal syndrome in terms of patient-centered approach
E Efremova, A M Shutov
doi : 10.1093/eurheartj/ehab849.166
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
A patient-centered approach is the basis for older patients with cardiovascular comorbidity. Collaborative decision making is especially important for older patients with chronic kidney disease (СKD).
Prognostic indicators for the onset of ischaemic versus haemorrhagic stroke in stable coronary artery disease
W T Wang
doi : 10.1093/eurheartj/ehab849.167
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The incidence of stroke may be increased in patients with coronary artery disease (CAD). We aimed to investigate the specific risk factors for the development of ischaemic and haemorrhagic stroke in stable CAD patients.
ECG changes in psychiatric patients on psychotropic medications
S Wong, M Soliman, A Cunningham, H Ho, S Johar
doi : 10.1093/eurheartj/ehab849.168
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Suicide and euthanasia accounts for 14.3% of deaths in those with psychiatric conditions. The rest are attributed to preventable causes such as cardiovascular disease, respiratory disease, and infections. Several psychotropic medications have been associated with sudden death due to their effect on prolonging QT interval, resulting in the development of a polymorphic ventricular arrhythmia, Torsades de Pointes (TdP). TdP may be self-limiting or lead to sudden cardiac arrest and death.
Efficacy and safety of fondaparinux versus unfractionated heparin in patients hospitalised with severe COVID-19 pneumonia and coagulopathy: a randomised, open-label clinical trial
L H Adrian, S A Hutomo, A D S Negari
doi : 10.1093/eurheartj/ehab849.169
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The use of unfractionated heparin (UFH) has been renowned to reduce mortality in COVID-19. There are no data about the efficacy and safety of fondaparinux (FPX) in COVID-19.
How to bridge residual distance to target low-density-lipoprotein cholesterol in acute coronary syndrome patients after initial statin therapy?
B Yan, A Lai, H Sun
doi : 10.1093/eurheartj/ehab849.170
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Current guidelines recommend intensive low-density-lipoprotein cholesterol (LDL-C) lowering by ≥50% to target LDL-C <1.4mmol/L after acute coronary syndrome (ACS). Residual distance to LDL-C target can help select treatment strategy after initial statin therapy.
Pharmacological evaluation of the use of dexrazoxane in preventing anthracycline induced cardiotoxicity in breast cancer
H Maqsood, T Ashraf, S Younus, M W Rasool, A Hameed
doi : 10.1093/eurheartj/ehab849.171
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Anthracyclines and trastuzumab are extensively used for the treatment of breast cancer but are associated with an increased risk of dilated cardiomyopathy. Dexrazoxane is an iron-chelating agent used to reduce the risk of cardiotoxicity, but it is seldom used in clinical practice.
Palliative care for patients with cardiovascular disease and COVID-19 in a major referral hospital
T Correa, A M S Simao, J V B Sobreira, F Yarshell, F B Anbar, R T De Carvalho
doi : 10.1093/eurheartj/ehab849.172
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
COVID-19 disease has a wide spectrum of severity, ranging from asymptomatic to severe acute respiratory syndrome. Although the estimated mortality is around 3% in the general population, individuals with comorbidities such as cardiovascular disease (CVD) may develop worse virus-related outcomes and have higher mortality rates. Furthermore, triage systems in pandemics may have low sensitivity to the need for palliative care, leaving many patients without appropriate end-of-life support.
The effect of high intensity interval training on patients with heart transplantation: a systematic review
T Rajandekar, G John
doi : 10.1093/eurheartj/ehab849.173
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Exercise rehabilitation after heart transplant is of major importance in order to improve physical capacity and prognosis.High-intensity interval training (HIIT) has repeatedly proven to be a highly efficient form of exercise for improving the physical capacity of both normal subjects and patients with coronary artery diseases (CAD) and heart failure. In contrast to the chronotropic response of a normal heart to exercise, a newly transplanted heart is denervated, which causes higher resting heart rate (HR) and reduced heart response (chronotropic incompetence). The HR response during exercise is mainly controlled by catecholamine’s from the adrenal glands, resulting in a significantly slower increase of the HR at onset of exercise, a reduced peak HR, and a delayed return towards resting values after cessation of exercise. A study conducted in 2013 concluded that high-intensity, aerobic training, especially interval-based training, is a favourable type of exercise that yields improvements in both peripheral and central factors.The review was conducted to determine the effect of HIIT on heart transplant patients.I
Differing radiation exposure in scrub technicians and rotating staff in cardiac catheterization laboratory: occupation matters
M Javed, N Rahman, G Adnan, Z Nizar, I Shah
doi : 10.1093/eurheartj/ehab849.174
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Radiation exposure of cardiac catheterization lab personnel is an evolving area of concern, due to long term, repetitive exposure causing deterministic and stochastic effects(1,2). Current radiation protection measures are based on increasing distance, shielding from fluoroscopy source and depend on primary operator behavior(3)
The role of STEMI integrated networking system based on tele-cardiology for reducing ischemic time and crossing wire time delayed during COVID 19 pandemic
M Rizki Fadlan, S Anjarwani, M Saifur Rohman
doi : 10.1093/eurheartj/ehab849.175
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
During a public health emergency, such as outbreak of COVID-19, delayed for reperfusion become even more challenging to predict. Telecardiology has the advantage of reducing STEMI patient"s access time to the emergency units and reduces the delayed for reperfusion.
Machine learning to predict in-hospital mortality risk among heterogenous STEMI patients with diabetes
S Kasim, S Malek, M F Aziz, K S Ibrahim
doi : 10.1093/eurheartj/ehab849.176
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Diabetes has become a major public health concern in Asia. In Malaysia, the prevalence of diabetes has escalated in adults above the age of 18, affecting 3.9  million individuals. Patients with diabetes and coronary heart disease have worse outcomes, compared with patients without diabetes who have coronary heart disease. Conventional Risk scores such as TIMI and GRACE were derived from a Western Caucasian cohort with limited data from Asian countries, despite Asia hosting 60% of the world’s population.
Remission of T2DM by digital twin technology with reduction of cardiovascular risk: interim results of randomised controlled clinical trial
P Shamanna, S Joshi, L Shah, M Dharmalingam, A Vadavi, S Damodaran, J Mohammed, M Mohamed, T Poon, A Keshavamurthy, T Mohamed, S Bhonsley
doi : 10.1093/eurheartj/ehab849.177
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
 Twin Precision Treatment (TPT) is a novel intervention designed to improve glycemia and reverse T2D using a Whole-Body Digital Twin (WBDT) platform powered by Artificial Intelligence and the Internet of Things. Technology enabled precision nutrition, a combination of macro, micro and biota nutrients, along with Continuous Glucose Monitoring (CGM) have been demonstrated to be a key for reversal of diabetes. WBDT platform captures 174 health markers and 3000 daily data points through a panel of blood tests and connected devices that measure weight, physical activity, sleep and BP. CGM is used initially and then the algorithm predicts personalized glucose responses from multiple inputs. Nutritional, physical activity and sleep counseling is through an app or phone to provide individualized meal plans that balance 87 macro, micro and probiotic nutrients to reduce glucotoxicity and lipotoxicity. Program physicians titrate medications and monitor metabolic outcomes.Â
Impact of Covid-19 on cardiovascular clinics: are we ready for tele-medicine?
M Mujtaba, Sapna, FAISAL Khanzada, DANISH Qayyum, TAHIR Saghir, SHARF Buraro
doi : 10.1093/eurheartj/ehab849.178
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
World is facing Coronavirus disease (COVID-19) pandemic since December 2019. [1, 2]. COVID-19 has significantly decreased the influx of patients presenting with cardiovascular diseases at hospitals. The aim of this study was to determine the difficulties faced by patients in visiting the cardiac outpatient department during COVID-19 era and to assess the awareness regarding telemedicine and wiliness to adopt if offered in future.
Virtual medical research mentoring and collaboration: breaking the bounds of nationality during the COVID-19 pandemic
J S K Chan, D H H Lau, E King, Y K L Shum, L Roever, T Liu, K Ng, E C Dee, A Ciobanu, G Bazoukis, E Mahmoudi, D I Satti, K Jeevaratnam, A Baranchuk, G Tse
doi : 10.1093/eurheartj/ehab849.179
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Medical research is critical to professional advancement, and mentoring is an important means of early research engagement in medical training. In contrast to international research collaborations, research mentoring programs are often locally limited. With the COVID-19 pandemic causing drifts to virtual classes and conferences, virtual international medical research mentoring may be viable. We hereby describe our experience with a virtual, international mentorship group for cardiovascular research.
Impact of the COVID-19 pandemic on cardiology services in the second year at a South Asian cardiac centre
F A Cader, M M Haq, S R Khan
doi : 10.1093/eurheartj/ehab849.180
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Little has been reported on the impact of the COVID-19 pandemic and the new delta variant, on cardiology services and catheterization volumes in South Asia, during the second year of the pandemic.
Thromboembolic complication among COVID-19 patients in the intensive care unit (ICU): a single-centre study from a Malaysian perspective
H Zulkifly, F Mansor, I Abdul Halim Zaki, K S Eng, L C Kiok, T Ravi, M Pathmanathan, S Abd Wahab, R Muda
doi : 10.1093/eurheartj/ehab849.181
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
The emerging complications of thromboembolism (TE) in COVID-19 patients have led to severe consequence such as death. Nonetheless, the prevalence of TE complications among COVID-19 patients in the Intensive Care Unit (ICU) in Malaysia is unknown.
Measuring the arterial phase of the right coronary artery in the patients suspected of coronary artery disease: a dual study by dynamic angiography and deep learning program
T Truyen, L Vu, D Pham, Q Do, T Huynh, D Ho, T Nguyen
doi : 10.1093/eurheartj/ehab849.182
European Heart Journal, Volume 43, Issue Supplement_1, February 2022
Background. In the diagnosis of coronary artery disease (CAD), coronary angiography (CA) plays a crucial role in determining the location and severity of the stenosis, the anatomical aspect of a lesion. It does not accurately reflect the flow dynamics in the coronary artery. This study aimed to evaluate the coronary flow abnormalities based on our new angiographic technique and Deep Learning (DL) program in patients suspected of CAD.
