دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Efficacy of a harvest graft substitute for recession coverage and soft tissue volume augmentation: A randomized controlled trial
Michael K. McGuire, Jim Janakievski, E. Todd Scheyer, Diego Velásquez, John C. Gunsolley, Rick H. Heard, Thiago Morelli
doi : 10.1002/JPER.21-0131
Pages: 333-342 First Published:21 July 2021
The autogenous connective tissue graft (CTG) with coronally advanced flap (CTG+CAF) is the "gold standard" for recession defect coverage; however, researchers continue to pursue lower morbidity, more convenient and unlimited supply harvest graft substitutes, including those that could provide soft tissue volume augmentation.
Volumetric assessment of changes in the alveolar ridge dimension following guided bone regeneration using a combination freeze-dried bone allograft with collagen membrane or novel resorbable scaffold: A prospective two-center clinical trial
Sahar Dowlatshahi, Chia-Yu Chen, Hadar Zigdon-Giladi, Jacob Horwitz, Chiho Ahn, David M. Kim, Eli E. Machtei
doi : 10.1002/JPER.21-0006
Pages: 343-353 First Published:09 July 2021
The aim of this study was to examine osseous changes following lateral bone augmentation using a novel scaffold (OV) alone and compare it to combination therapy using freeze-dried bone allograft (FDBA) and resorbable collagen membrane (FDBA/CM).
Tooth loss and radiographic bone loss in patients without regular supportive care: A retrospective study
Shaima Al-Harthi, Giovanni Barbagallo, Alessandro Psaila, Umberto d'Urso, Luigi Nibali
doi : 10.1002/JPER.21-0415
Pages: 354-363 First Published:26 September 2021
Very few studies have investigated the effect of patient and site factors on periodontal progression and long-term tooth loss in populations with minimal dental care. The aim of this retrospective study was to assess tooth loss and radiographic bone loss over at least 5 years in patients attending a national-health service primary care practice in Sicily and undergoing no regular care.
Periodontitis in patients with systemic lupus erythematosus: A nationwide study of 1,990 patients
Anne Isine Bolstad, Pria Sehjpal, Stein Atle Lie, Bjørg-Tilde Svanes Fevang
doi : 10.1002/JPER.21-0181
Pages: 364-372 First Published:02 June 2021
The aim of this study was to examine the association between systemic lupus erythematosus (SLE) and periodontitis in Norway during a 10-year period from 2008 through 2017.
Economic burden of periodontitis in the United States and Europe: An updated estimation
João Botelho, Vanessa Machado, Yago Leira, LuÃs Proença, Leandro Chambrone, José João Mendes
doi : 10.1002/JPER.21-0111
Pages: 373-379 First Published:30 May 2021
The aim of this study is to estimate the direct and indirect economic burdens of periodontal disease in the US and in Europe.
Autophagy upregulates inflammatory cytokines in gingival tissue of patients with periodontitis and lipopolysaccharide-stimulated human gingival fibroblasts
Won Jae Kim, Sam Young Park, Ok Su Kim, Hoo Sang Park, Ji Yeon Jung
doi : 10.1002/JPER.21-0178
Pages: 380-391 First Published:02 July 2021
Periodontitis is an inflammatory disease caused by multiple disease-associated bacterial species in periodontal tissues. Autophagy is known to modulate various inflammation-driven diseases and inflammatory responses, but the role of autophagy related to the pathogenesis of periodontitis is not fully established. We investigated whether autophagic flux regulated the expression of inflammatory cytokines in the gingiva of periodontitis patients and lipopolysaccharide (LPS)-stimulated human gingival fibroblasts (HGFs) and the underlying mechanism.
Gender differences in immunological response of African-American juveniles with Grade C molar incisor pattern periodontitis
Tamara T. Tavakoli, Fatemeh Gholami, Hong Huang, Patricia Furtado Gonçalves, Alejandro Villasante-Tezanos, Ikramuddin Aukhil, Rubelisa C. G. de Oliveira, Niki Hovencamp, Shannon Wallet, Efthimia Ioannidou, Luciana M. Shaddox
doi : 10.1002/JPER.21-0143
Pages: 392-402 First Published:25 June 2021
Prevalence of Grade C molar incisor periodontitis (C/MIP) in females (F) and males (M) is controversial, although some studies suggest higher prevalence in females. The objective of this study was to evaluate differences in clinical parameters, and levels of cyto/chemokines in gingival crevicular fluid (GCF) and peripheral blood response.
Comparative in vitro study of commercially available products for alveolar ridge preservation
Kirstin Jones, Cortes Williams, Tony Yuan, Ann Marie Digeorge-Foushee, Ramanda Chambers Wilson, Tarea Burton, Nicholas Hamlin, Luis Martinez
doi : 10.1002/JPER.21-0087
Pages: 403-411 First Published:11 June 2021
Ridge preservation is performed by placing a biocompatible product, following tooth extraction, to maintain bone volume. However, current ridge preservation therapies do not always maintain the volume required for future implant placement. Variations in surgical technique and material selection contribute to determining clinical outcomes. The wide variety of grafting materials available and conflicting efficacy reports make selecting the appropriate graft materials challenging. To investigate how different commercially available ridge preservation products might perform clinically: Helistat (collagen control) (Material 1), OsteoGen Plug (Material 2), Bio-Oss Collagen (Material 3), and J-Bone (native bone) (Material 4) were evaluated.
Are colored periodontal probes reliable to classify the gingival phenotype in terms of gingival thickness?
Kristina Bertl, Mehdi Al-Hotheiry, David Sun, John Olofsson, Stefan Lettner, Klaus Gotfredsen, Andreas Stavropoulos
doi : 10.1002/JPER.21-0311
Pages: 412-422 First Published:26 July 2021
This cross-sectional study assessed the potential of colored periodontal probes (CPP) to classify gingival phenotype in terms of gingival thickness (GT).
Inhibitory effect of roflumilast on experimental periodontitis
Qifan Liu, Yue Sun, Danying Chen, Kaidi Chen, Baoxin Huang, Zhuofan Chen
doi : 10.1002/JPER.20-0858
Pages: 423-434 First Published:14 June 2021
Phosphodiesterase-4 (PDE4) has been identified as a valid therapeutic target in several inflammatory diseases. In this study, we assessed PDE4 in gingival tissue from patients with chronic periodontitis and evaluated the therapeutic effects of the PDE4 inhibitor, roflumilast, in an experimental rat model of periodontitis.
Genome-wide DNA (hydroxy) methylation reveals the individual epigenetic landscape importance on osteogenic phenotype acquisition in periodontal ligament cells
Rogério S. Ferreira, Rahyza I. F. Assis, Geórgia da S. Feltran, Iasmin Caroline do Rosário Palma, Beatriz G. Françoso, Willian F. Zambuzzi, Denise C. Andia, Rodrigo A. da Silva
doi : 10.1002/JPER.21-0218
Pages: 435-448 First Published:22 July 2021
Mesenchymal cells’ biology has been an important investigative tool to maximize bone regeneration through tissue engineering. Here we used mesenchymal cells from periodontal ligament (PDLCs) with high (h-) and low (l-) osteogenic potential, isolated from different donors, to investigate the impact of the individual epigenetic and transcriptional profiles on the osteogenic potential.
Porphyromonas gingivalis lipopolysaccharide and gingival fibroblast augment MMP-9 expression of monocytic U937 cells through cyclophilin A
Tzu-Ying Chen, Po-Jan Kuo, Chi-Yu Lin, Tsung-Fu Hung, Hsien-Chung Chiu, Cheng-Yang Chiang, Kuang-Chung Shih, Earl Fu
doi : 10.1002/JPER.19-0740
Pages: 449-457 First Published:17 May 2021
Intercellular cross-talking was suggested in matrix metalloproteinase (MMP)-9 expression with unknown mechanisms. Studies showed cyclophilin A (CypA) playing an important role in regulating MMP-9 expression in varied diseases. The aim of the study was to examine the CyPA on the MMP-9 augmentation in monocytic U937 cells after Porphyromonas gingivalis (Pg) lipopolysaccharide (LPS) treatment and human gingival fibroblast (hGF) co-culture.
Nuclear factor-kappa B decoy oligodeoxynucleotide-loaded poly lactic-co-glycolic acid nanospheres promote periodontal tissue healing after tooth replantation in rats
Kai Li, Yuji Ishida, Kasumi Hatano-Sato, Narubhorn Ongprakobkul, Jun Hosomichi, Risa Usumi-Fujita, Sawa Kaneko, Hiroyuki Yamaguchi, Takashi Ono
doi : 10.1002/JPER.21-0134
Pages: 458-470 First Published:28 July 2021
Excessive inflammation in the periodontal tissue after tooth replantation can lead to inflammatory root resorption and interrupt periodontal tissue regeneration. We tested the hypothesis that nuclear factor-κB decoy oligodeoxynucleotide-loaded poly lactic-co-glycolic acid nanospheres (NF-PLGA) inhibit excessive inflammation and promote healing of periodontal tissue after replantation in rats.
Connective tissue growth factor promotes cell-to-cell communication in human periodontal ligament stem cells via MAPK and PI3K pathway
Zuping Wu, Sirui Chen, Yuying He, Demao Zhang, Shujuan Zou, Jing Xie, Chenchen Zhou
doi : 10.1002/JPER.21-0339
Pages: e60-e72 First Published:17 September 2021
Cell–cell communication is an essential process to respond to biological stimuli and sustain the micro environmental homeostasis of human periodontal ligament stem cells (hPDLSCs). Connective tissue growth factor (CTGF), a critical secreted matrix protein, exhibits significant tasks in regulating the cell-cell and cell-matrix interactions. This study aimed to explore the relationship between CTGF and cell communication and the underlying mechanism.
