The Lancet
doi : 10.1016/S0140-6736(21)00348-2
VOLUME 397, ISSUE 10275, P641, FEBRUARY 20, 2021
Ian Jones,Polly Roy
doi : 10.1016/S0140-6736(21)00191-4
VOLUME 397, ISSUE 10275, P642-643, FEBRUARY 20, 2021
Anna K Blakney,Paul F McKay
doi : 10.1016/S0140-6736(21)00258-0
VOLUME 397, ISSUE 10275, P643-645, FEBRUARY 20, 2021
Delphine Borchiellini,Philippe Barthélémy
doi : 10.1016/S0140-6736(21)00316-0
VOLUME 397, ISSUE 10275, P645-647, FEBRUARY 20, 2021
David Blumenthal,Margaret Hamburg
doi : 10.1016/S0140-6736(21)00318-4
VOLUME 397, ISSUE 10275, P647-648, FEBRUARY 20, 2021
Mahomed Said Patel,Christine Beatrice Phillips
doi : 10.1016/S0140-6736(21)00151-3
VOLUME 397, ISSUE 10275, P648-650, FEBRUARY 20, 2021
Germaine Tuyisenge,Shira M Goldenberg
doi : 10.1016/S0140-6736(21)00215-4
VOLUME 397, ISSUE 10275, P650-652, FEBRUARY 20, 2021
Effy Vayena
doi : 10.1016/S0140-6736(21)00203-8
VOLUME 397, ISSUE 10275, P652-653, FEBRUARY 20, 2021
Richard Horton
doi : 10.1016/S0140-6736(21)00431-1
VOLUME 397, ISSUE 10275, P654, FEBRUARY 20, 2021
Rob Hyde
doi : 10.1016/S0140-6736(21)00428-1
VOLUME 397, ISSUE 10275, P655-656, FEBRUARY 20, 2021
Nayanah Siva
doi : 10.1016/S0140-6736(21)00429-3
VOLUME 397, ISSUE 10275, P657, FEBRUARY 20, 2021
Talha Burki
doi : 10.1016/S0140-6736(21)00430-X
VOLUME 397, ISSUE 10275, P658, FEBRUARY 20, 2021
Pamela Das
doi : 10.1016/S0140-6736(21)00365-2
VOLUME 397, ISSUE 10275, P659, FEBRUARY 20, 2021
Michael Marmot
doi : 10.1016/S0140-6736(21)00366-4
VOLUME 397, ISSUE 10275, P660-661, FEBRUARY 20, 2021
Wendy Moore
doi : 10.1016/S0140-6736(21)00260-9
VOLUME 397, ISSUE 10275, P662-663, FEBRUARY 20, 2021
Geoff Watts
doi : 10.1016/S0140-6736(21)00368-8
VOLUME 397, ISSUE 10275, P664, FEBRUARY 20, 2021
Jonathan Pearson-Stuttard,Sally C Davies
doi : 10.1016/S0140-6736(21)00201-4
VOLUME 397, ISSUE 10275, P665, FEBRUARY 20, 2021
Tiago S Jesus,Michel D Landry
doi : 10.1016/S0140-6736(21)00207-5
VOLUME 397, ISSUE 10275, P665-666, FEBRUARY 20, 2021
Nnenaya A Mmonu,Angela Aifah,Deborah Onakomaiya,Gbenga Ogedegbe
doi : 10.1016/S0140-6736(21)00194-X
VOLUME 397, ISSUE 10275, P666-667, FEBRUARY 20, 2021
A Mark Clarfield,Karl Skorecki,Orly Manor,Shimon Glick
doi : 10.1016/S0140-6736(21)00310-X
VOLUME 397, ISSUE 10275, P667-668, FEBRUARY 20, 2021
Bernd Froessler,Elizabeth Murphy,Nicolette Hodyl
doi : 10.1016/S0140-6736(21)00227-0
VOLUME 397, ISSUE 10275, P668, FEBRUARY 20, 2021
Axel Hofmann,Irwin Gross,Domenico Girelli,Matti Aapro,Donat R Spahn
doi : 10.1016/S0140-6736(21)00226-9
VOLUME 397, ISSUE 10275, P668-669, FEBRUARY 20, 2021
Anastazia Keegan,Philip Crispin,Amanda Ormerod,Kristen Brown,Christine Akers,Fiona King
doi : 10.1016/S0140-6736(21)00216-6
VOLUME 397, ISSUE 10275, P669, FEBRUARY 20, 2021
Toby Richards,Ben Clevenger,Darren Dahly,Martin Besser
doi : 10.1016/S0140-6736(21)00214-2
VOLUME 397, ISSUE 10275, P670, FEBRUARY 20, 2021
doi : 10.1016/S0140-6736(21)00369-X
VOLUME 397, ISSUE 10275, P670, FEBRUARY 20, 2021
doi : 10.1016/S0140-6736(21)00398-6
VOLUME 397, ISSUE 10275, P670, FEBRUARY 20, 2021
doi : 10.1016/S0140-6736(21)00387-1
VOLUME 397, ISSUE 10275, P670, FEBRUARY 20, 2021
doi : 10.1016/S0140-6736(21)00386-X
VOLUME 397, ISSUE 10275, P670, FEBRUARY 20, 2021
Denis Y Logunov,Inna V Dolzhikova,Dmitry V Shcheblyakov,Amir I Tukhvatulin,Olga V Zubkova,Alina S Dzharullaeva,Anna V Kovyrshina,Nadezhda L Lubenets,Daria M Grousova,Alina S Erokhova,Andrei G Botikov,Fatima M Izhaeva,Olga Popova,Tatiana A Ozharovskaya,Ilias B Esmagambetov,Irina A Favorskaya,Denis I Zrelkin,Daria V Voronina,Dmitry N Shcherbinin,Alexander S Semikhin,Yana V Simakova,Elizaveta A Tokarskaya,Daria A Egorova,Maksim M Shmarov,Natalia A Nikitenko,Vladimir A Gushchin,Elena A Smolyarchuk,Sergey K Zyryanov,Sergei V Borisevich,Boris S Naroditsky,Alexander L Gintsburgand the Gam-COVID-Vac Vaccine Trial Group
doi : 10.1016/S0140-6736(21)00234-8
VOLUME 397, ISSUE 10275, P671-681, FEBRUARY 20, 2021
Peter Richmond,Lara Hatchuel,Min Dong,Brenda Ma,Branda Hu,Igor Smolenov,Ping Li,Peng Liang,Htay Htay Han,Joshua Liang,Ralf Clemens
doi : 10.1016/S0140-6736(21)00241-5
VOLUME 397, ISSUE 10275, P682-694, FEBRUARY 20, 2021
Sumanta K Pal,Catherine Tangen,Ian M Thompson Jr,Naomi Balzer-Haas,Daniel J George,Daniel Y C Heng,Brian Shuch,Mark Stein,Maria Tretiakova,Peter Humphrey,Adebowale Adeniran,Vivek Narayan,Georg A Bjarnason,Ulka Vaishampayan,Ajjai Alva,Tian Zhang,Scott Cole,Melissa Plets,John Wright,Primo N Lara Jr
doi : 10.1016/S0140-6736(21)00152-5
VOLUME 397, ISSUE 10275, P695-703, FEBRUARY 20, 2021
MET (also known as hepatocyte growth factor receptor) signalling is a key driver of papillary renal cell carcinoma (PRCC). Given that no optimal therapy for metastatic PRCC exists, we aimed to compare an existing standard of care, sunitinib, with the MET kinase inhibitors cabozantinib, crizotinib, and savolitinib for treatment of patients with PRCC.
Grigorios Christidis,Frank Lammert,Marcin Krawczyk
doi : 10.1016/S0140-6736(21)00204-X
VOLUME 397, ISSUE 10275, P704, FEBRUARY 20, 2021
Steffie Woolhandler,David U Himmelstein,Sameer Ahmed,Zinzi Bailey,Mary T Bassett,Michael Bird,Jacob Bor,David Bor,Olveen Carrasquillo,Merlin Chowkwanyun,Samuel L Dickman,Samantha Fisher,Adam Gaffney,Sandro Galea,Richard N Gottfried,Kevin Grumbach,Gordon Guyatt,Helena Hansen,Philip J Landrigan,Michael Lighty,Martin McKee,Danny McCormick,Alecia McGregor,Reza Mirza,Juliana E Morris,Joia S Mukherjee,Marion Nestle,Linda Prine,Altaf Saadi,Davida Schiff,Martin Shapiro,Lello Tesema,Atheendar Venkataramani
doi : 10.1016/S0140-6736(20)32545-9
VOLUME 397, ISSUE 10275, P705-753, FEBRUARY 20, 2021
Kamran Ghoreschi,Anna Balato,Charlotta Enerb?ck,Robert Sabat
doi : 10.1016/S0140-6736(21)00184-7
VOLUME 397, ISSUE 10275, P754-766, FEBRUARY 20, 2021
Psoriasis is a chronic inflammatory disease characterised by sharply demarcated erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by WHO as one of the most serious non-infectious diseases, psoriasis affects 2–3% of the global population. Mechanistically, psoriatic lesions result from hyperproliferation and disturbed differentiation of epidermal keratinocytes that are provoked by immune mediators of the IL-23 and IL-17 pathway. Translational immunology has had impressive success in understanding and controlling psoriasis. Psoriasis is the first disease to have been successfully treated with therapeutics that directly block the action of the cytokines of this pathway; in fact, therapeutics that specifically target IL-23, IL-17, and IL-17RA are approved for clinical use and show excellent efficacy. Furthermore, inhibitors of IL-23 and IL-17 intracellular signalling, such as TYK2 or ROR?t, are in clinical development. Although therapies that target the IL-23 and IL-17 pathway also improve psoriatic arthritis symptoms, their effects on long-term disease modification and psoriasis-associated comorbidities still need to be explored.
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