The Lancet




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سفارش

Health in the USA: under examination and under repair

The Lancet

doi : 10.1016/S0140-6736(21)00348-2

VOLUME 397, ISSUE 10275, P641, FEBRUARY 20, 2021

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Sputnik V COVID-19 vaccine candidate appears safe and effective

Ian Jones,Polly Roy

doi : 10.1016/S0140-6736(21)00191-4

VOLUME 397, ISSUE 10275, P642-643, FEBRUARY 20, 2021

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Next-generation COVID-19 vaccines: here come the proteins

Anna K Blakney,Paul F McKay

doi : 10.1016/S0140-6736(21)00258-0

VOLUME 397, ISSUE 10275, P643-645, FEBRUARY 20, 2021

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Cabozantinib: a new first-line option for papillary renal cell carcinoma?

Delphine Borchiellini,Philippe Barthélémy

doi : 10.1016/S0140-6736(21)00316-0

VOLUME 397, ISSUE 10275, P645-647, FEBRUARY 20, 2021

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US health and health care are a mess: now what?

David Blumenthal,Margaret Hamburg

doi : 10.1016/S0140-6736(21)00318-4

VOLUME 397, ISSUE 10275, P647-648, FEBRUARY 20, 2021

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COVID-19 and the moral imagination

Mahomed Said Patel,Christine Beatrice Phillips

doi : 10.1016/S0140-6736(21)00151-3

VOLUME 397, ISSUE 10275, P648-650, FEBRUARY 20, 2021

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COVID-19, structural racism, and migrant health in Canada

Germaine Tuyisenge,Shira M Goldenberg

doi : 10.1016/S0140-6736(21)00215-4

VOLUME 397, ISSUE 10275, P650-652, FEBRUARY 20, 2021

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Value from health data: European opportunity to catalyse progress in digital health

Effy Vayena

doi : 10.1016/S0140-6736(21)00203-8

VOLUME 397, ISSUE 10275, P652-653, FEBRUARY 20, 2021

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Offline: What is the UK for?

Richard Horton

doi : 10.1016/S0140-6736(21)00431-1

VOLUME 397, ISSUE 10275, P654, FEBRUARY 20, 2021

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von der Leyen admits to COVID-19 vaccine failures

Rob Hyde

doi : 10.1016/S0140-6736(21)00428-1

VOLUME 397, ISSUE 10275, P655-656, FEBRUARY 20, 2021

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Severe mental illness: reassessing COVID-19 vaccine priorities

Nayanah Siva

doi : 10.1016/S0140-6736(21)00429-3

VOLUME 397, ISSUE 10275, P657, FEBRUARY 20, 2021

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Research Focus: The Cleveland Clinic at 100

Talha Burki

doi : 10.1016/S0140-6736(21)00430-X

VOLUME 397, ISSUE 10275, P658, FEBRUARY 20, 2021

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Sharrelle Barber: at the intersection of place, race, and health

Pamela Das

doi : 10.1016/S0140-6736(21)00365-2

VOLUME 397, ISSUE 10275, P659, FEBRUARY 20, 2021

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Healthy because you deserve it, unhealthy because you don't?

Michael Marmot

doi : 10.1016/S0140-6736(21)00366-4

VOLUME 397, ISSUE 10275, P660-661, FEBRUARY 20, 2021

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Elizabeth Blackwell: breaching the barriers for women in medicine

Wendy Moore

doi : 10.1016/S0140-6736(21)00260-9

VOLUME 397, ISSUE 10275, P662-663, FEBRUARY 20, 2021

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Gordon John McVie

Geoff Watts

doi : 10.1016/S0140-6736(21)00368-8

VOLUME 397, ISSUE 10275, P664, FEBRUARY 20, 2021

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The Health Index for England

Jonathan Pearson-Stuttard,Sally C Davies

doi : 10.1016/S0140-6736(21)00201-4

VOLUME 397, ISSUE 10275, P665, FEBRUARY 20, 2021

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Global need: including rehabilitation in health system strengthening

Tiago S Jesus,Michel D Landry

doi : 10.1016/S0140-6736(21)00207-5

VOLUME 397, ISSUE 10275, P665-666, FEBRUARY 20, 2021

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Why the global health community should support the EndSARS movement in Nigeria

Nnenaya A Mmonu,Angela Aifah,Deborah Onakomaiya,Gbenga Ogedegbe

doi : 10.1016/S0140-6736(21)00194-X

VOLUME 397, ISSUE 10275, P666-667, FEBRUARY 20, 2021

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A COVID-19 jab in the right direction

A Mark Clarfield,Karl Skorecki,Orly Manor,Shimon Glick

doi : 10.1016/S0140-6736(21)00310-X

 VOLUME 397, ISSUE 10275, P667-668, FEBRUARY 20, 2021

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Iron deficiency in PREVENTT

Bernd Froessler,Elizabeth Murphy,Nicolette Hodyl

doi : 10.1016/S0140-6736(21)00227-0

VOLUME 397, ISSUE 10275, P668, FEBRUARY 20, 2021

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Iron deficiency in PREVENTT

Axel Hofmann,Irwin Gross,Domenico Girelli,Matti Aapro,Donat R Spahn

doi : 10.1016/S0140-6736(21)00226-9

VOLUME 397, ISSUE 10275, P668-669, FEBRUARY 20, 2021

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Iron deficiency in PREVENTT

Anastazia Keegan,Philip Crispin,Amanda Ormerod,Kristen Brown,Christine Akers,Fiona King

doi : 10.1016/S0140-6736(21)00216-6

VOLUME 397, ISSUE 10275, P669, FEBRUARY 20, 2021

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Iron deficiency in PREVENTT – Authors' reply

Toby Richards,Ben Clevenger,Darren Dahly,Martin Besser

doi : 10.1016/S0140-6736(21)00214-2

 VOLUME 397, ISSUE 10275, P670, FEBRUARY 20, 2021

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Department of Error

doi : 10.1016/S0140-6736(21)00369-X

VOLUME 397, ISSUE 10275, P670, FEBRUARY 20, 2021

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Department of Error

doi : 10.1016/S0140-6736(21)00398-6

VOLUME 397, ISSUE 10275, P670, FEBRUARY 20, 2021

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Department of Error

doi : 10.1016/S0140-6736(21)00387-1

VOLUME 397, ISSUE 10275, P670, FEBRUARY 20, 2021

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Department of Error

doi : 10.1016/S0140-6736(21)00386-X

VOLUME 397, ISSUE 10275, P670, FEBRUARY 20, 2021

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Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

Denis Y Logunov,Inna V Dolzhikova,Dmitry V Shcheblyakov,Amir I Tukhvatulin,Olga V Zubkova,Alina S Dzharullaeva,Anna V Kovyrshina,Nadezhda L Lubenets,Daria M Grousova,Alina S Erokhova,Andrei G Botikov,Fatima M Izhaeva,Olga Popova,Tatiana A Ozharovskaya,Ilias B Esmagambetov,Irina A Favorskaya,Denis I Zrelkin,Daria V Voronina,Dmitry N Shcherbinin,Alexander S Semikhin,Yana V Simakova,Elizaveta A Tokarskaya,Daria A Egorova,Maksim M Shmarov,Natalia A Nikitenko,Vladimir A Gushchin,Elena A Smolyarchuk,Sergey K Zyryanov,Sergei V Borisevich,Boris S Naroditsky,Alexander L Gintsburgand the Gam-COVID-Vac Vaccine Trial Group

doi : 10.1016/S0140-6736(21)00234-8

VOLUME 397, ISSUE 10275, P671-681, FEBRUARY 20, 2021

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Safety and immunogenicity of S-Trimer (SCB-2019), a protein subunit vaccine candidate for COVID-19 in healthy adults: a phase 1, randomised, double-blind, placebo-controlled trial

Peter Richmond,Lara Hatchuel,Min Dong,Brenda Ma,Branda Hu,Igor Smolenov,Ping Li,Peng Liang,Htay Htay Han,Joshua Liang,Ralf Clemens

doi : 10.1016/S0140-6736(21)00241-5

VOLUME 397, ISSUE 10275, P682-694, FEBRUARY 20, 2021

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A comparison of sunitinib with cabozantinib, crizotinib, and savolitinib for treatment of advanced papillary renal cell carcinoma: a randomised, open-label, phase 2 trial

Sumanta K Pal,Catherine Tangen,Ian M Thompson Jr,Naomi Balzer-Haas,Daniel J George,Daniel Y C Heng,Brian Shuch,Mark Stein,Maria Tretiakova,Peter Humphrey,Adebowale Adeniran,Vivek Narayan,Georg A Bjarnason,Ulka Vaishampayan,Ajjai Alva,Tian Zhang,Scott Cole,Melissa Plets,John Wright,Primo N Lara Jr

doi : 10.1016/S0140-6736(21)00152-5

VOLUME 397, ISSUE 10275, P695-703, FEBRUARY 20, 2021

MET (also known as hepatocyte growth factor receptor) signalling is a key driver of papillary renal cell carcinoma (PRCC). Given that no optimal therapy for metastatic PRCC exists, we aimed to compare an existing standard of care, sunitinib, with the MET kinase inhibitors cabozantinib, crizotinib, and savolitinib for treatment of patients with PRCC.

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Amiodarone and hypothyroidism

Grigorios Christidis,Frank Lammert,Marcin Krawczyk

doi : 10.1016/S0140-6736(21)00204-X

VOLUME 397, ISSUE 10275, P704, FEBRUARY 20, 2021

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Public policy and health in the Trump era

Steffie Woolhandler,David U Himmelstein,Sameer Ahmed,Zinzi Bailey,Mary T Bassett,Michael Bird,Jacob Bor,David Bor,Olveen Carrasquillo,Merlin Chowkwanyun,Samuel L Dickman,Samantha Fisher,Adam Gaffney,Sandro Galea,Richard N Gottfried,Kevin Grumbach,Gordon Guyatt,Helena Hansen,Philip J Landrigan,Michael Lighty,Martin McKee,Danny McCormick,Alecia McGregor,Reza Mirza,Juliana E Morris,Joia S Mukherjee,Marion Nestle,Linda Prine,Altaf Saadi,Davida Schiff,Martin Shapiro,Lello Tesema,Atheendar Venkataramani

doi : 10.1016/S0140-6736(20)32545-9

VOLUME 397, ISSUE 10275, P705-753, FEBRUARY 20, 2021

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Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis

Kamran Ghoreschi,Anna Balato,Charlotta Enerb?ck,Robert Sabat

doi : 10.1016/S0140-6736(21)00184-7

VOLUME 397, ISSUE 10275, P754-766, FEBRUARY 20, 2021

Psoriasis is a chronic inflammatory disease characterised by sharply demarcated erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by WHO as one of the most serious non-infectious diseases, psoriasis affects 2–3% of the global population. Mechanistically, psoriatic lesions result from hyperproliferation and disturbed differentiation of epidermal keratinocytes that are provoked by immune mediators of the IL-23 and IL-17 pathway. Translational immunology has had impressive success in understanding and controlling psoriasis. Psoriasis is the first disease to have been successfully treated with therapeutics that directly block the action of the cytokines of this pathway; in fact, therapeutics that specifically target IL-23, IL-17, and IL-17RA are approved for clinical use and show excellent efficacy. Furthermore, inhibitors of IL-23 and IL-17 intracellular signalling, such as TYK2 or ROR?t, are in clinical development. Although therapies that target the IL-23 and IL-17 pathway also improve psoriatic arthritis symptoms, their effects on long-term disease modification and psoriasis-associated comorbidities still need to be explored.

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