دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Physical restraint precipitates delirium in stroke patients
Eleonora Rollo,Antonio Callea,Valerio Brunetti,Catello Vollono,Jessica Marotta,Giacomo Della Marca
doi : 10.1016/j.jns.2020.117290
VOLUME 421, 117290, FEBRUARY 15, 2021
Assessing neurophobia: A good move
Matthieu Perrenoud
doi : 10.1016/j.jns.2021.117323
VOLUME 421, 117323, FEBRUARY 15, 2021
Inclusion of ethnoracial populations and diversity remains a key challenge in Alzheimer's disease biofluid-based biomarker studies
Ganesh M. Babulal
doi : 10.1016/j.jns.2020.117269
VOLUME 421, 117269, FEBRUARY 15, 2021
Comparing fluid biomarkers of Alzheimer's disease between African American or Black African and white groups: A systematic review and meta-analysis
Aiysha Chaudhry,Mie Rizig
doi : 10.1016/j.jns.2020.117270
VOLUME 421, 117270, FEBRUARY 15, 2021
Biomarker research for Alzheimer's disease (AD) has grown rapidly in recent years, ensuing the integration of the AD fluid biomarker profile: A?1-42, t-tau, and p-tau181, into clinical and research criteria. However, current insights of AD arise almost exclusively from studies on white individuals.
Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease
Vandana Bhatia,Saurabh Sharma
doi : 10.1016/j.jns.2020.117253
VOLUME 421, 117253, FEBRUARY 15, 2021
Alzheimer's disease (AD) is the most common form of dementia. The pathological hallmarks of AD are amyloid plaques [aggregates of amyloid beta (A)] and neurofibrillary tangles (aggregates of tau protein). Growing evidence suggests that tau accumulation is pathologically more relevant to the development of neurodegeneration and cognitive decline in AD patients than A plaques.
Recent advances and remaining questions of autologous hematopoietic stem cell transplantation in multiple sclerosis
Gauruv Bose,Mark S. Freedman
doi : 10.1016/j.jns.2021.117324
VOLUME 421, 117324, FEBRUARY 15, 2021
The judicious use of autologous hematopoietic stem cell transplantation (AHSCT) for MS requires understanding the potential benefits, identifying the most appropriate patient, and acknowledging the risks and differences between different protocols.
Cerebrospinal fluid in COVID-19: A systematic review of the literature
Ariane Lewis,Jennifer Frontera,Dimitris G. Placantonakis,...Steven Galetta,Laura Balcer,Kara R. Melmed
doi : 10.1016/j.jns.2021.117316
VOLUME 421, 117316, FEBRUARY 15, 2021
We sought to review the literature on cerebrospinal fluid (CSF) testing in patients with COVID-19 for evidence of viral neuroinvasion by SARS-CoV-2.
NeuroQ: A neurophobia screening tool assesses how roleplay challenges neurophobia
Eavan McGovern,Céline Louapre,Julien Cassereau,...Yulia Worbe,Bruno Falissard,Emmanuel Roze
doi : 10.1016/j.jns.2021.117320
VOLUME 421, 117320, FEBRUARY 15, 2021
Neurophobia is a chronic disease of medical students and junior doctors. Early detection is needed to facilitate prevention and management as this fear can negatively impact patient care.
The “hypointense substantia nigra” sign. A novel MRI marker of progressive supranuclear palsy
Vasilios C. Constantinides,George P. Paraskevas,Georgios Velonakis,...Efstratios Karavasilis,Leonidas Stefanis,Elisabeth Kapaki
doi : 10.1016/j.jns.2020.117286
VOLUME 421, 117286, FEBRUARY 15, 2021
Diagnosis of multiple sclerosis in times of MOG and AQP4 autoantibody testing – A monocentric study
Juliane Weber,Nora Bernsdorff,Tilman Robinson,Dominique Endres,Sebastian Rauer,Benjamin Berger
doi : 10.1016/j.jns.2020.117289
VOLUME 421, 117289, FEBRUARY 15, 2021
Myelin oligodendrocyte glycoprotein-IgG-associated encephalomyelitis (MOG-EM) and neuromyelitis optica spectrum disorders are challenging differential diagnoses of multiple sclerosis (MS). Hence, there is uncertainty, whether to test all MS patients for corresponding antibodies. Our objective was to provide a systematic study on the frequency of MOG and Aquaporin-4 (AQP4) autoantibodies in MS patients to evaluate a possible risk of misclassification.
Width of the third ventricle as a highly-sensitive biomarker in chronic progressive neuro-Behçet's disease
Sunao Takahashi,Nobuo Sanjo,Shohei Miyamoto,...Jun Oyama,Ukihide Tateishi,Takanori Yokota
doi : 10.1016/j.jns.2020.117284
VOLUME 421, 117284, FEBRUARY 15, 2021
Chronic progressive neuro-Behçet's disease (CPNBD) is characterized by slowly progressive cognitive decline, cerebellar ataxia, and brainstem atrophy without acute encephalomeningitis. To evaluate the progression of CPNBD during treatment, we conducted a retrospective, longitudinal comparative analysis of the clinical features and brain magnetic resonance imaging (MRI) in patients with CPNBD.
Zuranolone as an oral adjunct to treatment of Parkinsonian tremor: A phase 2, open-label study
Amy Bullock,Inder Kaul,Sigui Li,Christopher Silber,James Doherty,Stephen J. Kanes
doi : 10.1016/j.jns.2020.117277
VOLUME 421, 117277, FEBRUARY 15, 2021
Parkinson's disease (PD) is characterized by both motor and nonmotor deficits. Among cardinal symptoms of this disorder, tremor is the least responsive to dopamine replacement therapy and is often undertreated. Zuranolone (SAGE-217) is an investigational oral neuroactive steroid (NAS) gamma-aminobutyric acid A (GABAA) receptor–positive allosteric modulator (PAM) that has been investigated for its safety and efficacy in patients with PD.
Measuring coping in people with amyotrophic lateral sclerosis using the Coping Index-ALS: A patient derived, Rasch compliant scale
C.A. Young,C.J. McDermott,T.L. Williams,...R.J. Mills,A. TennantOn behalf of the TONiC study group
doi : 10.1016/j.jns.2020.117285
VOLUME 421, 117285, FEBRUARY 15, 2021
The progressively disabling and terminal nature of ALS/MND imposes major coping demands on patients. We wished to improve the psychometric properties of our previously published MND-Coping Scale, so that parametric analyses were valid, and to make it simpler for patients to complete and clinicians to score.
Evaluation of a screening tool for the identification of neurological disorders in rural Uganda
Andy Tran,Kiran T. Thakur,Noeline Nakasujja,...Leah H. Rubin,Ned Sacktor,Deanna Saylor
doi : 10.1016/j.jns.2020.117273
VOLUME 421, 117273, FEBRUARY 15, 2021
Neurological disorders are common in sub-Saharan African, but accurate neuroepidemiologic data are lacking from the region. We assessed a neuroepidemiological screening tool in a rural Ugandan cohort with high HIV prevalence.
Disease course and treatment patterns in progressive supranuclear palsy: A real-world study
John C. Morgan,Xiaolan Ye,Jennifer A. Mellor,...Louis A. Chiodo,Yanjun Bao,Tao Xie
doi : 10.1016/j.jns.2020.117293
VOLUME 421, 117293, FEBRUARY 15, 2021
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder with symptoms including vertical gaze palsy, frequent falls, abnormal gait, and cognitive/language/behavioral changes, making diagnosis and treatment challenging.
Cardiovascular comorbidities in amyotrophic lateral sclerosis
Mariana Pereira,Marta Gromicho,Ana Henriques,...Hilmi Uysal,Michael Swash,Mamede de Carvalho
doi : 10.1016/j.jns.2020.117292
VOLUME 421, 117292, FEBRUARY 15, 2021
The role of cardiovascular risk factors in amyotrophic lateral sclerosis (ALS) is controversial. A favourable profile has been found in ALS patients, but previous studies have not specifically considered the profile in different disease phenotypes.
Post-stroke dementia and permanent institutionalization
Gerli Sibolt,Sami Curtze,Hanna Jokinen,...Timo Erkinjuntti,Susanna Melkas,Niku K.J. Oksala
doi : 10.1016/j.jns.2020.117307
VOLUME 421, 117307, FEBRUARY 15, 2021
Dementia is among the most frequent causes of institutionalization. To serve the purpose of preventive strategies, there are no follow-up studies that have evaluated the actual impact of post-stroke dementia on institutionalization. We therefore compared the institutionalization rate and length of stay in an institutional care facility of patients with post-stroke dementia with stroke patients without dementia.
Two distinct mechanisms of neuropathy in immunoglobulin light chain (AL) amyloidosis
Haruki Koike,Naohiro Mouri,Yuki Fukami,...Fumiaki Tanaka,Gen Sobue,Masahisa Katsuno
doi : 10.1016/j.jns.2020.117305
VOLUME 421, 117305, FEBRUARY 15, 2021
Although polyneuropathy in patients with immunoglobulin light chain (AL) amyloidosis has been considered to be attributable to axonal degeneration resulting from amyloid deposition, patients with nerve conduction parameters indicating demyelination that mimics chronic inflammatory demyelinating polyneuropathy (CIDP) have also been reported anecdotally.
Predictors and outcomes of hemorrhagic stroke in reversible cerebral vasoconstriction syndrome
Aayushi Garg,Marcelo Rocha,Matthew Starr,Santiago Ortega-Gutierrez
doi : 10.1016/j.jns.2021.117312
VOLUME 421, 117312, FEBRUARY 15, 2021
Intracranial hemorrhage (ICH) is the most common neurologic complication of reversible cerebral vasoconstriction syndrome (RCVS). In this study, we compared hemorrhagic and non-hemorrhagic RCVS with an aim to evaluate the risk factors and short-term clinical outcomes of hemorrhagic lesions.
Posterior reversible encephalopathy syndrome after induced hypertension therapy for delayed cerebral ischemia after subarachnoid hemorrhage: A case-control study
Maike Angermann,Fidaa Jablawi,Annika Keulers,...Arno Reich,Martin Wiesmann,Omid Nikoubashman
doi : 10.1016/j.jns.2021.117313
VOLUME 421, 117313, FEBRUARY 15, 2021
Posterior reversible encephalopathy syndrome (PRES) is associated with arterial hypertension. Our aim was to investigate whether induced hypertension (IH) as therapy for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is associated with PRES and to identify risk factors for PRES.
Peri-hematoma corticospinal tract integrity in intracerebral hemorrhage patients: A diffusion-tensor imaging study
Rebecca McCourt,Ehsan Misaghi,Wei Tu,...Sarah Treit,Christian Beaulieu,Ken S. Butcher
doi : 10.1016/j.jns.2021.117317
VOLUME 421, 117317, FEBRUARY 15, 2021
The impact of perihematoma edema in Intracerebral Hemorrhage (ICH) on white matter integrity is uncertain. Fractional Anisotropy (FA), as measured with Diffusion Tensor Imaging (DTI), can be used to assess white matter microstructure. We tested the hypotheses that sections of the Corticospinal Tract (CST) passing through perihematoma edema would 1) have low FA relative to the contralateral CST and 2) would predict NIHSS motor score in ICH patients.
Parcellation-based modeling of the supplementary motor area
John R. Sheets,Robert G. Briggs,Isabella M. Young,...Cordell M. Baker,Chad A. Glenn,Michael E. Sughrue
doi : 10.1016/j.jns.2021.117322
VOLUME 421, 117322, FEBRUARY 15, 2021
The supplementary motor area (SMA) plays an important role in the initiation and coordination of internally and externally cued movements. Such movements include reaching, grasping, speaking, and bilateral hand coordination. While many studies discuss the SMA and its relationship to other parts of the motor network, there is minimal literature examining the connectivity of the SMA outside of the motor network. Using region-based fMRI studies, we built a neuroanatomical model to account for these extra-motor connections.
Impulse control behavior in GBA-mutated parkinsonian patients
Paolo Amami,Tiziana De Santis,Federica Invernizzi,Barbara Garavaglia,Alberto Albanese
doi : 10.1016/j.jns.2020.117291
VOLUME 421, 117291, FEBRUARY 15, 2021
To assess the prevalence and phenomenology of Impulse control behavior (ICB) in Parkinson's disease (PD) patients carrying mutations in the ?-glucocerebrosidase (GBA) gene.
Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19
John Conklin,Matthew P. Frosch,Shibani S. Mukerji,...M. Brandon Westover,Susie Y. Huang,Brian L. Edlow
doi : 10.1016/j.jns.2021.117308
VOLUME 421, 117308, FEBRUARY 15, 2021
We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive patients admitted to the intensive care unit with severe COVID-19 undergoing brain MRI for evaluation of coma or neurologic deficits were retrospectively identified. Eleven patients had punctate susceptibility-weighted imaging (SWI) lesions in the subcortical and deep white matter, eight patients had >10 SWI lesions, and four patients had lesions involving the corpus callosum.
Reversible mixed perfusion on 123I-IMP SPECT in anti-AMPA receptor encephalitis: A case report
Tatsuya Fukumoto,Ryosuke Miyamoto,Koji Fujita,Nagahisa Murakami,Naoko Matsui,Yuishin Izumi
doi : 10.1016/j.jns.2020.117306
VOLUME 421, 117306, FEBRUARY 15, 2021
Mechanical thrombectomy in acute ischemic stroke patients with left ventricular assist device: More information, more evidence
Zi-yang Sun,Xiao-yan Meng
doi : 10.1016/j.jns.2020.117192
VOLUME 421, 117192, FEBRUARY 15, 2021
Author response: Mechanical thrombectomy in acute ischemic stroke patients with left ventricular assist device: More information, more evidence
Takaya Kitano,Kenich Todo
doi : 10.1016/j.jns.2020.117191
VOLUME 421, 117191, FEBRUARY 15, 2021
Tropical Neurology Education: A World Federation of Neurology outstanding priority
Marco T. Medina,Chandrashekar Meshram,John England,Raad Shakir
doi : 10.1016/j.jns.2020.117281
VOLUME 421, 117281, FEBRUARY 15, 2021
Central nervous system tuberculosis
Sarosh M. Katrak
doi : 10.1016/j.jns.2020.117278
VOLUME 421, 117278, FEBRUARY 15, 2021
The purpose of this article is to review the many facets of central nervous system tuberculosis (CNS-TB). The entities described are tuberculous meningitis (TBM) and its complications, spinal cord disorders, tuberculomas and co-infection with the human immune-deficiency virus (HIV).
Environmental neurology in the tropics
J. Reis,P.S. Spencer,G.C. Rom?n,A. Buguet
doi : 10.1016/j.jns.2020.117287
VOLUME 421, 117287, FEBRUARY 15, 2021
We address the impact of the tropical environment on the human nervous system using the multifaceted approach characteristic of environmental neurology. First, environmental factors are examined according to their nature (physical, chemical and biological) and in relation to human activity and behavior. Some factors are specific to the tropics (climate and infections), while others are non-specific (chemicals, human communities and their way of life).
Ebola: A review and focus on neurologic manifestations
Olukemi Adekanmbi,Olayinka Ilesanmi,Sulaiman Lakoh
doi : 10.1016/j.jns.2021.117311
VOLUME 421, 117311, FEBRUARY 15, 2021
Ebolavirus disease (EVD) is a severe, highly contagious, and often fatal systemic disease in human and non-human primates. Zoonotic and human-to-human transmission have been well documented. Ebolaviruses are endemic to Equatorial and West Africa and there have been over 20 outbreaks in sub-Saharan Africa since 1976. The largest known outbreak of EVD occurred between 2013 and 2016 across several West African countries. It resulted in 28,646 suspected and confirmed cases and 11,323 deaths.
Onchocerciasis in tropical neurology: A scoping review
Jaime Luna,Salvatore Metanmo,Farid Boumediene,...Emilie Auditeau,Daniel Ajzenberg,Pierre-Marie Preux
doi : 10.1016/j.jns.2021.117314
VOLUME 421, 117314, FEBRUARY 15, 2021
Onchocerciasis is a serious problem in tropical areas. The role of the parasite as a factor associated with neurological diseases needs to be addressed because it might involve a reduction of the risk via elimination strategies. We performed a systematic scoping review to identify available studies on this association and put into perspective the different methodological approaches for interpreting the evidence.
