دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Exploring new avenues for modifying course of progression of Alzheimer's disease: The rise of natural medicine
Sarah Lye,Caitlin E. Aust,Lyn R. Griffiths,Francesca Fernandez
doi : 10.1016/j.jns.2021.117332
VOLUME 422, 117332, MARCH 15, 2021
With a constantly growing elderly population worldwide, a focus on developing efficient prevention and therapy for Alzheimer's disease (AD) seems timely and topical. Emphasis on natural medicine is increasingly popular in the search for drug candidates that are capable of preventing and treating AD related pathology, particularly where suppression of amyloid accumulation, neurofibrillary tangle formation, neuroinflammation and oxidative stress are equally significant.
Long-term outcomes of endovascular simple coiling versus neurosurgical clipping of unruptured intracranial aneurysms: A systematic review and meta-analysis
Christian H. Krag,Lasse Speiser,Rikke B. Dalby
doi : 10.1016/j.jns.2021.117338
VOLUME 422, 117338, MARCH 15, 2021
Previous studies on ruptured intracranial aneurysms have shown favourable long-term outcomes of patients undergoing endovascular coiling compared to neurosurgical clipping. We aimed to evaluate if these results also apply to patients with unruptured intracranial aneurysms (UIAs).
Management decisions on unruptured intracranial aneurysms before and after implementation of the PHASES score
Laurie J. Hollands,Mervyn D.I. Vergouwen,Jacoba P. Greving,Marieke J.H. Wermer,Gabriël J.E. Rinkel,Annemijn M. Algra
doi : 10.1016/j.jns.2021.117319
VOLUME 422, 117319, MARCH 15, 2021
In management decisions on saccular unruptured intracranial aneurysms (UIAs) the risk of rupture is an important factor. The PHASES score, introduced in 2014, provides absolute 5-year risks of rupture based on six easily retrievable patient and aneurysm characteristics. We assessed whether management decisions on UIAs changed after implementation of the PHASES score.
Single-dose L-dopa increases upper brainstem GABA in Parkinson's disease: A preliminary study
Yulu Song,Tao Gong,Yuanyuan Xiang,Mark Mikkelsen,Guangbin Wang,Richard A.E. Edden
doi : 10.1016/j.jns.2021.117309
VOLUME 422, 117309, MARCH 15, 2021
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder, characterized by the dysfunction between dopaminergic and GABAergic neuronal activities. Dopamine (DA) replacement by its precursor L-dopa remains the primary treatment for PD. In this preliminary study, we test the hypotheses that GABA+ levels would be lower in PD patients than controls, and normalized by L-dopa.
Risk factors and prognosis of adult-onset post-pump chorea
Jong Hyeon Ahn,Joomee Song,Inyoung Choi,Jinyoung Youn,Jin Whan Cho
doi : 10.1016/j.jns.2021.117328
VOLUME 422, 117328, MARCH 15, 2021
Post-pump chorea (PPC), defined as the development of chorea after major cardiac surgery utilizing cardiopulmonary bypass (CPB), has been rarely reported in adults.
Early diagnosis of MECP2 duplication syndrome: Insights from a nationwide survey in Japan
Ryo Takeguchi,Satoru Takahashi,Yuichi Akaba,...Kenji Kurosawa,Toyojiro Matsuishi,Masayuki Itoh
doi : 10.1016/j.jns.2021.117321
VOLUME 422, 117321, MARCH 15, 2021
This study aimed to elucidate the clinical characteristics of MECP2 duplication syndrome (MDS), particularly at initial presentation, and to provide clinical clues for the early diagnosis of this condition. We conducted a nationwide survey for MDS by sending questionnaires to 575 hospitals where board-certified pediatric neurologists were working and 195 residential hospitals for persons with severe motor and intellectual disabilities in Japan. This survey found 65 cases of MDS, and clinical data of 24 cases in which the diagnosis was genetically confirmed were analyzed.
The spiral axis: A comparison of unaffected first-degree relatives of essential tremor cases vs. controls
Elan D. Louis,Hollie N. Dowd,Mazen Elkurd
doi : 10.1016/j.jns.2021.117330
VOLUME 422, 117330, MARCH 15, 2021
We previously observed that during a spiral drawing task, in essential tremor (ET) cases, the tremor wave forms align along a single predominant axis. This interesting clinical feature can distinguish ET from dystonia cases. We now investigate whether the unaffected relatives of ET cases also express this trait, albeit perhaps in a milder form. To address our aim, we assessed the spiral axis in 237 unaffected first-degree relatives of ET cases (FD-ET), comparing them to 105 controls (Co).
Circulatory dipeptidyl peptidase 3 (cDPP3) is a potential biomarker for early detection of secondary brain injury after aneurysmal subarachnoid hemorrhage
Felix Neumaier,Christian Stoppe,Michael Veldeman,...Gernot Marx,Hans Clusmann,Walid Albanna
doi : 10.1016/j.jns.2021.117333
VOLUME 422, 117333, MARCH 15, 2021
Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) that can culminate in secondary brain damage. Although it remains one of the main preventable causes of aSAH-related morbidity, there is still a lack of prognostic criteria for identification of patients at risk of developing DCI. Because elevated circulatory levels of the enzyme dipeptidyl peptidase 3 (cDPP3) were recently identified as a potential biomarker for outcome prediction in critically ill patients, we evaluated the time-course of changes in cDPP3 levels after aSAH.
Modulatory effects of cognitive exertion on regional functional connectivity of the salience network in women with ME/CFS: A pilot study
Riccardo Manca,Katija Khan,Micaela Mitolo,...Rosemary Varley,Iain D. Wilkinson,Annalena Venneri
doi : 10.1016/j.jns.2021.117326
VOLUME 422, 117326, MARCH 15, 2021
A common symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is post-exertional malaise (PEM). Various brain abnormalities have been observed in patients with ME/CFS, especially in insular and limbic areas, but their link with ME/CFS symptoms is still unclear. This pilot study aimed at investigating the association between PEM in ME/CFS and changes in functional connectivity (FC) of two main networks: the salience network (SN) and the default-mode network (DMN).
Trends in ischemic stroke outcomes in a rural population in the United States
Durgesh Chaudhary,Ayesha Khan,Shima Shahjouei,...Jiang Li,Vida Abedi,Ramin Zand
doi : 10.1016/j.jns.2021.117339
VOLUME 422, 117339, MARCH 15, 2021
The stroke mortality rate has gradually declined due to improved interventions and controlled risk factors. We investigated the associated factors and trends in recurrence and all-cause mortality in ischemic stroke patients from a rural population in the United States between 2004 and 2018.
Value of next-generation sequencing in early diagnosis of patients with tuberculous meningitis
Aiqing Lin,Baotao Cheng,Xiaochun Han,Hong Zhang,Xiaoli Liu,Xueping Liu
doi : 10.1016/j.jns.2021.117310
VOLUME 422, 117310, MARCH 15, 2021
To assess the value of next-generation sequencing (NGS) technology in early diagnosis of patients with tuberculous meningitis (TBM).
Detection of varicella zoster virus antigen and DNA in two cases of cerebral amyloid angiopathy
Teresa Mescher,Philip J. Boyer,Andrew N. Bubak,James E. Hassell Jr,Maria A. Nagel
doi : 10.1016/j.jns.2021.117315
VOLUME 422, 117315, MARCH 15, 2021
Varicella zoster virus (VZV) vasculopathy and cerebral amyloid angiopathy (CAA) have similar clinical presentations: both affect cerebrovasculature in the elderly, produce hemorrhage, and can have a protracted course of cognitive decline and other neurological deficits. The cause of CAA is unknown, but amyloid-beta (A?) is found within arterial walls. Recent studies show that VZV induces A? and amylin expression and an amyloid-promoting environment. Thus, we determined if VZV was present in CAA-affected arteries.
Neuropathy associated with IgA monoclonal Gammopathy. A harbinger of AL amyloidosis
Pitcha Chompoopong,Bayan Almarwani,Bashar Katirji
doi : 10.1016/j.jns.2021.117336
VOLUME 422, 117336, MARCH 15, 2021
Peripheral neuropathy is seen in 15% of patients with IgA monoclonal gammopathy. Treatment and prognosis of dysproteinemic neuropathy is usually guided by the underlying plasma cell disorders, which could be either benign or malignant. The true incidence of hematologic malignancy in patients with neuropathy associated with IgA monoclonal gammopathy is not known.
More prominent fibrosis of the cricopharyngeal muscle in inclusion body myositis
Kenichiro Taira,Madoka Mori-Yoshimura,Toshiyuki Yamamoto,...Takaharu Nito,Ichizo Nishino,Yuji Takahashi
doi : 10.1016/j.jns.2021.117327
VOLUME 422, 117327, MARCH 15, 2021
Parkinson's disease after COVID-19
Karim Makhoul,Joseph Jankovic
doi : 10.1016/j.jns.2021.117331
VOLUME 422, 117331, MARCH 15, 2021
Case report of a complicated neurologically manifesting acute porphyria treated successfully with Givosiran
Tim Steinberg,Mustafa Kilic,Kornelius Fuchs,...Ralf A. Linker,Felix Schlachetzki,Bernhard Neumann
doi : 10.1016/j.jns.2021.117334
VOLUME 422, 117334, MARCH 15, 2021
CNS fungal infections: A review
Cody L. Nathan,Brian E. Emmert,Ernest Nelson,Joseph R. Berger
doi : 10.1016/j.jns.2021.117325
VOLUME 422, 117325, MARCH 15, 2021
