دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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The relationship between cerebral and retinal microbleeds in cerebral amyloid angiopathy (CAA): A pilot study
Jessica Alber,Edmund Arthur,Danielle Goldfarb,...Brian R. Ott,Lenworth N. Johnson,Peter J. Snyder
doi : 10.1016/j.jns.2021.117383
VOLUME 423, 117383, APRIL 15, 2021
The standard in vivo diagnostic imaging technique for cerebral amyloid angiopathy (CAA) is costly and thereby of limited utility for point-of-care diagnosis and monitoring of treatment efficacy. Recent recognition that retinal changes may reflect cerebral changes in neurodegenerative disease provides an ideal opportunity for development of accessible and cost-effective biomarkers for point-of-care use in the detection and monitoring of CAA. In this pilot study, we examined structural and angiographic retinal changes in CAA patients relative to a control group, and compared retinal and cerebral pathology in a group of CAA patients.
Highly sensitive screening of antisense sequences for different types of DMD mutations in patients' urine-derived cells
Hotake Takizawa,Eri Takeshita,Mitsuto Sato,...Yuji Takahashi,Hirofumi Komaki,Yoshitsugu Aoki
doi : 10.1016/j.jns.2021.117337
VOLUME 423, 117337, APRIL 15, 2021
Exon skipping using short antisense oligonucleotides (AONs) is a promising treatment for Duchenne muscular dystrophy (DMD). Several exon-skipping drugs, including viltolarsen (NS-065/NCNP-01), have been approved worldwide. Immortalized human skeletal muscle cell lines, such as rhabdomyosarcoma cells, are frequently used to screen efficient oligonucleotide sequences. However, rhabdomyosarcoma cells do not recapitulate DMD pathophysiology as they express endogenous dystrophin.
Early neuropsychological markers of cognitive involvement in multiple sclerosis
Tehila Eilam-Stock,Michael T. Shaw,Lauren B. Krupp,Leigh E. Charvet
doi : 10.1016/j.jns.2021.117349
VOLUME 423, 117349, APRIL 15, 2021
Cognitive impairment due to multiple sclerosis (MS) is common and often limits occupational functioning, contributes to disability, and reduces quality of life. Early detection of cognitive involvement in MS is critical for treatment planning and intervention, and frequent, regular cognitive monitoring may provide insight into subtle changes in disease progression.
Are there disparities in acute stroke treatment between the Jewish and Arab populations in Israel? Results from the National Acute Stroke Israeli registry
Naaem Simaan,Andrei Filioglo,Asaf Honig,...Reem Habib-Simaan,Jose E. Cohen,Ronen R. Leker
doi : 10.1016/j.jns.2021.117357
VOLUME 423, 117357, APRIL 15, 2021
According to the latest reported data from the National Acute Stroke Israeli Survey (NASIS), around 18,000 strokes occur annually in Israel. Data regarding disparities in stroke care between the Jewish and the Arab populations in Israel are lacking.
Distinct neural circuits are associated with subclinical neuropsychiatric symptoms in Parkinson's disease
Sule Tinaz,Serageldin Kamel,Sai S. Aravala,Mine Sezgin,Mohamed Elfil,Rajita Sinha
doi : 10.1016/j.jns.2021.117365
VOLUME 423, 117365, APRIL 15, 2021
Parkinson's disease (PD) can present with neuropsychiatric symptoms (here, anxiety, depression, and apathy) at any stage of the disease. We investigated the neural correlates of subclinical neuropsychiatric symptoms in relation to motor and cognitive symptoms in a high-functioning PD cohort.
Characteristics and outcomes of 100 consecutive patients with acute stroke and COVID-19
Rajesh Benny,Rakeshsingh K. Singh,Anil Venkitachalam,...Vicky V. Thakkar,Vikas Patel,Kishore V. Shetty
doi : 10.1016/j.jns.2021.117348
VOLUME 423, 117348, APRIL 15, 2021
The coronavirus disease 2019 (COVID-19) pandemic started as a respiratory illness. Now, there are increasing reports of its hypercoagulable and thrombotic complications [[1]] leading to stroke [[2],[3]]. Initial studies suggested strokes to be a feature of severe and late COVID-19 [[2],[4]]; usually occurring in the second week of illness after the onset of typical respiratory symptoms [[4]]. Recent studies identified these even in mild to moderate infection [[5],[6]].
Distinctive regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative Parkinsonisms
Ryuichi Takahashi,Kazunari Ishii,Kaoru Sousa,...Tetsuo Kashibayashi,Jun Fujita,Kazumasa Yokoyama
doi : 10.1016/j.jns.2021.117363
VOLUME 423, 117363, APRIL 15, 2021
This study aimed to identify regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative parkinsonisms, using dopamine transporter single-photon emission computed tomography images.
Polyneuropathy and monoclonal gammopathy of undetermined significance (MGUS); update of a clinical experience
Sabrina Matà,Sara Torricelli,Alessandro Barilaro,...Paolo Forleo,Monica Del Mastio,Sandro Sorbi
doi : 10.1016/j.jns.2021.117335
VOLUME 423, 117335, APRIL 15, 2021
Polyneuropathies associated with monoclonal gammopathy of undetermined significance (MGUS) encompass a group of phenotypically and immunologically heterogeneous neuropathies. While the best characterized is that associated with anti-myelin glycoprotein (MAG) antibodies, there are phenotypical and immunological neuropathy variants that still lack a clear classification. We analyzed a significant number of patients, in order to better evaluate the distribution of neuropathy phenotypes and to look for some common characteristics.
Evaluating the frequency of positive paraneoplastic antibodies and associated malignancy risk
Moein Amin,Yuebing Li,Thomas M. Daly,Robert J. Marquardt
doi : 10.1016/j.jns.2021.117347
VOLUME 423, 117347, APRIL 15, 2021
To evaluate the association between malignancy and frequently positive paraneoplastic antibodies.
Cerebral thrombi of cardioembolic etiology have an increased content of neutrophil extracellular traps
Angela Genchi,Aurora Semerano,Giorgia Serena Gullotta,...Massimo Filippi,Gianvito Martino,Marco Bacigaluppi
doi : 10.1016/j.jns.2021.117355
VOLUME 423, 117355, APRIL 15, 2021
Inflammation is emerging as an essential trigger for thrombosis. In the interplay between innate immunity and coagulation cascade, neutrophils and neutrophil extracellular traps (NETs) can promote thrombus formation and stabilization. In ischemic stroke, it is uncertain whether the involvement of the inflammatory component may differ in thrombi of diverse etiology. We here aimed to evaluate the presence of neutrophils and NETs in cerebral thrombi of diverse etiology retrieved by endovascular thrombectomy (EVT).
Factors associated with resistance to benzodiazepines in status epilepticus
Arnau Llaurad?,Manuel Quintana,Alejandro Ballvé,...Laura Abraira,Manuel Toledo,Estevo Santamarina
doi : 10.1016/j.jns.2021.117368
VOLUME 423, 117368, APRIL 15, 2021
To investigate factors related to benzodiazepine (BZD) resistance in status epilepticus (SE) with a focus on their relationship with the etiology of the episode.
Increased plasma levels of chitinase 3-like 1 (CHI3L1) protein in patients with idiopathic normal-pressure hydrocephalus
Pan-Woo Ko,Ho-Won Lee,Myunghoon Lee,...Jong-Heon Kim,Kyunghun Kang,Kyoungho Suk
doi : 10.1016/j.jns.2021.117353
VOLUME 423, 117353, APRIL 15, 2021
Idiopathic normal-pressure hydrocephalus (iNPH) is an uncommon neurological disorder with no known pathological hallmarks. INPH may share common degenerative pathways with other neurological diseases, such as Alzheimer's disease (AD). However, the reversible properties of iNPH may share differing pathophysiological mechanisms with other diseases. This study aimed at assessing the diagnostic value of plasma chitinase 3-like 1 (CHI3L1) protein levels as a disease-specific biomarker for iNPH.
High-resolution MR imaging of cranial neuropathy in patients with anti-GQ1b antibody syndrome
Boeun Lee,Jeong Hyun Lee,Young-Min Lim,...Jung Youn Kim,Young Jun Choi,Jung Hwan Baek
doi : 10.1016/j.jns.2021.117380
VOLUME 423, 117380, APRIL 15, 2021
The value of conventional MRI in patients anti-GQ1b antibody syndrome is subject to debate. Our purpose was to evaluate the diagnostic accuracy of high-resolution MRI for detecting cranial nerve abnormalities in patients with anti-GQ1b antibody syndrome.
A novel diagnostic marker for progressive supranuclear palsy targeting atrophy of the subthalamic nucleus
Shinsuke Fujioka,Takashi Morishita,Koichi Takano,...Midori Suenaga,Yoichi Matsunaga,Yoshi Tsuboi
doi : 10.1016/j.jns.2021.117366
VOLUME 423, 117366, APRIL 15, 2021
Despite great progress in radiological diagnostic tools for neurodegenerative disorders, their diagnostic accuracy has been unsatisfactory. One of the pathological hallmarks of progressive supranuclear palsy (PSP) is atrophy of the subthalamic nucleus, which has not attracted much attention for imaging analysis.
Hepatitis E virus and neurological manifestations
Yunlong Li,Maikel P. Peppelenbosch
doi : 10.1016/j.jns.2021.117388
VOLUME 423, 117388, APRIL 15, 2021
Acute CNS infections – Expanding the spectrum of neurological manifestations of hepatitis E virus?
Miriam Fritz-Weltin,Nora Isenmann,Estelle Frommherz,...Dominique Endres,Marcus Panning,Benjamin Berger
doi : 10.1016/j.jns.2021.117387
VOLUME 423, 117387, APRIL 15, 2021
Central nervous system (CNS) infections can be caused by a variety of viruses, but in a significant number of patients no viral or other pathogen can be identified using routine diagnostic work-up. Interestingly, several case reports and series described Hepatitis E virus (HEV) as a potential pathogen. However, systematic studies have not been conducted so far.
HERV-K inactive or potential pathogens from within?
Yousra Khalfallah,Angela Genge
doi : 10.1016/j.jns.2021.117359
VOLUME 423, 117359, APRIL 15, 2021
Inhibition of HERV-K (HML-2) in amyotrophic lateral sclerosis patients on antiretroviral therapy
M. Garcia-Montojo,S. Fathi,G. Norato,...A. Al-Chalabi,J. Gold,A. Nath
doi : 10.1016/j.jns.2021.117358
VOLUME 423, 117358, APRIL 15, 2021
Reactivation of Human Endogenous Retrovirus K (HERV-K), subtype HML-2, has been associated with pathophysiology of amyotrophic lateral sclerosis (ALS). We aimed to assess the efficacy of antiretroviral therapy in inhibiting HML-2 in patients with ALS and a possible association between the change in HML-2 levels and clinical outcomes. We studied the effect of 24-weeks antiretroviral combination therapy with abacavir, lamivudine, and dolutegravir on HML-2 levels in 29 ALS patients. HML-2 levels decreased progressively over 24 weeks (P = 0.001) and rebounded within a week of stopping medications (P = 0.02).
Prognostic significance of early pyrexia in acute intracerebral haemorrhage: The INTERACT2 study
Alejandra Malavera,Shoujiang You,Danni Zheng,Candice Delcourt,Craig S. Andersonon behalf of the INTERACT2 Investigators
doi : 10.1016/j.jns.2021.117364
VOLUME 423, 117364, APRIL 15, 2021
Uncertainty exists over the prognostic significance of pyrexia in acute intracerebral haemorrhage (ICH). We aimed to determine the association of elevated body temperature with clinical and imaging outcomes among participants of the main Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2).
Abnormal movements in hospitalized COVID-19 patients: A case series
Jeffrey R. Clark,Eric M. Liotta,Nicholas J. Reish,...Patrick H. Lim,Igor J. Koralnik,Ayush Batra
doi : 10.1016/j.jns.2021.117377
VOLUME 423, 117377, APRIL 15, 2021
Abnormal movements in Covid-19 patients have been reported with varying degree of frequency, prompting neurologic consultation and additional diagnostic evaluation. We sought to evaluate the frequency and etiology of abnormal movements among hospitalized Covid-19 patients undergoing neurologic consultation.
Perampanel in brain tumor and SMART-syndrome related epilepsy – A single institutional experience
Johanna Heugenhauser,Sarah Iglseder,Armin Muigg,...Guenther Stockhammer,Martha Nowosielski,Iris Unterberger
doi : 10.1016/j.jns.2021.117386
VOLUME 423, 117386, APRIL 15, 2021
Epilepsy is common in patients with brain tumors and frequently presents as the first clinical manifestation of an underlying tumor. Despite a number of available antiepileptic drugs (AED), brain tumor related epilepsy (BTRE) may still be difficult to control.
The neuropsychology needs of a hyper-acute stroke unit
Naomi H. Martin,Bronwyn Cornish,Simone Browning,...David J. Werring,Lisa Cipolotti,Edgar Chan
doi : 10.1016/j.jns.2021.117382
VOLUME 423, 117382, APRIL 15, 2021
Guidelines recommend routine assessment and management of mood and cognition after stroke, but little is known about the value or feasibility of providing neuropsychology input during the hyper-acute period. We aimed to identify and describe the extent and nature of neuropsychological needs and to investigate the feasibility of providing direct neuropsychology input within a hyper-acute setting.
Electronic health record derived-impact of COVID-19 on myasthenia gravis
Bhaskar Roy,Sukanthi Kovvuru,Krishna Nalleballe,Sanjeeva Reddy Onteddu,Richard J. Nowak
doi : 10.1016/j.jns.2021.117362
VOLUME 423, 117362, APRIL 15, 2021
Significance of concurrent ipsilateral intracranial carotid artery stenosis in carotid revascularization
Riwaj Bhagat,Allison Muha
doi : 10.1016/j.jns.2021.117354
VOLUME 423, 117354, APRIL 15, 2021
The entity of asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on magnetic resonance imaging?
Halil Onder
doi : 10.1016/j.jns.2021.117329
VOLUME 423, 117329, APRIL 15, 2021
Clinical utility of serial systemic immune inflammation indices (SSIIi) in the context of post covid-19 neurological syndrome (PCNS)
Tissa Wijeratne,Chanith Wijeratne
doi : 10.1016/j.jns.2021.117356
VOLUME 423, 117356, APRIL 15, 2021
Delayed-onset motor aphasia succeeds Holmes' tremor and neuropathic pain after left thalamic hemorrhage
Tomoyo Shimada,Wataru Uchida,Atsuhiko Shindo,Koji Kamagata,Nobutaka Hattori,Taiji Tsunemi
doi : 10.1016/j.jns.2021.117367
VOLUME 423, 117367, APRIL 15, 2021
“Establishment of an acute headache infusion clinic as an alternative for emergency department care”
Olivia Reese,Candice Wright,Anny Sandoval,...Jennifer Viamille,Rimas V. Lukas,Katherine Carroll
doi : 10.1016/j.jns.2021.117384
VOLUME 423, 117384, APRIL 15, 2021
Numerous patients receive acute migraine care in the Emergency Department (ED) setting. A shift of this care to the outpatient Neurology Clinic and outpatient Infusion Center setting has the potential to optimize clinical management while decreasing resource utilization.
Neurological presentations of COVID-19: Findings from the Spanish Society of Neurology neuroCOVID-19 registry
David Garc?a-Azor?n,Mar?a José Abenza Abild?a,Mar?a Elena Erro Aguirre,...José Miguel L?inez Andrés,David EzpeletaSpanish neuroCOVID registry group
doi : 10.1016/j.jns.2020.117283
VOLUME 423, 117283, APRIL 15, 2021
We report the findings from the Spanish Society of Neurology's NeuroCOVID-19 Registry.
