دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Fortune of Reversals: How Randomized Clinical Trials Shape Medical Practice
Amnon Sonnenberg & Gennadiy Bakis
doi : 10.1007/s10620-021-07240-7
Volume 67, issue 6, June 2022
Functional Disease, Dysbiosis, and Dyspepsia: How Helpful Is Rifaximin?
Sridhar Sundaram & Harish Darak
A Wolf in LAMS Clothing: The Expansion of Off-Label Indications for Lumen-Apposing Metal Stents
Chalapathi Rao Achanta & Sudhanva V. Kinhal
A Better Prep School: Does an Interactive Instruction Video Improve Colon Cleanliness?
Wissam KiwanÂ
In Living Color: Linked Color Imaging for the Detection of Early Gastric Cancer
Mitsuru Esaki, Yosuke Minoda & Eikichi Ihara
Half-Full or Half-Empty: Does Gastroparesis Affect Lung Transplantation Outcomes?
Christopher Vélez & Kyle Staller
Impatience with Inpatients: Are Hospitalization Rates Declining for IBD Patients?
Anand Kumar & Arun Swaminath
Quality Improvement During Gastroenterology Fellowship: The Experience of Improving Inpatient Post-endoscopy Communication
Amy G. Ogurick, Samantha J. Magier & Michelle L. Hughes
Unsedated Transnasal Endoscopy: A Safe, Well-Tolerated and Accurate Alternative to Standard Diagnostic Peroral Endoscopy
Rebecca K. Grant, William M. Brindle, Alexander R. Robertson, Rahul Kalla & John N. Plevris
doi : 10.1007/s10620-022-07432-9
Diagnostic unsedated transnasal endoscopy (uTNE) has been proven to be a safe and well-tolerated procedure. Although its utilization in the United Kingdom (UK) is increasing, it is currently available in only a few centers. Through consideration of recent studies, we aimed to perform an updated review of the technological advances in uTNE, consider their impact on diagnostic accuracy, and to determine the role of uTNE in the COVID-19 era. Current literature has shown that the diagnostic accuracy of uTNE for identification of esophageal pathology is equivalent to conventional esophagogastroduodenoscopy (cEGD). Concerns regarding suction and biopsy size have been addressed by the introduction of TNE scopes with working channels of 2.4 mm. Advances in imaging have improved detection of early gastric cancers. The procedure is associated with less cardiac stress and reduced aerosol production; when combined with no need for sedation and improved rates of patient turnover, uTNE is an efficient and safe alternative to cEGD in the COVID-19 era. We conclude that advances in technology have improved the diagnostic accuracy of uTNE to the point where it could be considered the first line diagnostic endoscopic investigation in the majority of patients. It could also play a central role in the recovery of diagnostic endoscopic services during the COVID-19 pandemic.
Is Ustekinumab Effective in Refractory Crohn’s Disease of the Pouch and Chronic Pouchitis? A Systematic Review
Chiara Rocchi, Youssef Y. Soliman, Marco Massidda, Salvatore F. Vadalà di Prampero, Milutin Bulajic & Dario Sorrentino
doi : 10.1007/s10620-021-07002-5
Crohn’s disease (CD) of the pouch and chronic pouchitis represent the most common long-term complications of total proctocolectomy and ileal pouch anal anastomosis (IPAA) for refractory ulcerative colitis (UC). These conditions are treated with multiple agents, including antibiotics, immunomodulators, and biologics. Among the latter, ustekinumab is approved for both CD and UC. We performed a systematic review to evaluate the efficacy of this anti-IL12/23 in CD of the pouch and chronic refractory pouchitis. Pubmed, Embase, Ovid, and the Cochrane Controlled Trials Register were searched to identify studies published until August 2020 investigating the use of ustekinumab for these conditions. Eighty-six eligible patients with IPAA—51 with CD of the pouch, 35 with chronic pouchitis—were identified from 2 retrospective studies and 5 case reports. Reported clinical response to ustekinumab was 63 and 85% in chronic pouchitis and CD of the pouch after 4–12 and 4–16 weeks, respectively. Clinical remission was reported in 10% of patients with chronic pouchitis and 27% of patients with CD of the pouch after 8–52 and 4–52 weeks of treatment, respectively. Endoscopic response was reported in 60% and 67% of patients with chronic pouchitis and CD of the pouch after 24–32 and 8–24 weeks of treatment respectively. Small sample sizes and large heterogeneity of therapy protocols/outcome definitions were significant studies limitations. In conclusion, there is a limited and inconclusive body of evidence suggesting that ustekinumab may be a therapeutic option for patients with chronic pouchitis and CD of the pouch refractory to other therapies.
Patient Perspectives and Expectations in Inflammatory Bowel Disease: A Systematic Review
Alex Al Khoury, Bhairavi Balram, Talat Bessissow, Waqqas Afif, Lorant Gonczi, Maria Abreu & Peter L. Lakatos
doi : 10.1007/s10620-021-07025-y
In this systematic review, our objective was to assess inflammatory bowel disease (IBD) patient preferences and perspectives relating to their disease diagnosis, treatment, knowledge needs and telemedicine.
Alcohol-Related Liver Disease in the Covid-19 Era: Position Paper of the Italian Society on Alcohol (SIA)
Gianni Testino, Teo Vignoli, Valentino Patussi, Pierluigi Allosio, Maria Francesca Amendola, Sarino Aric?, Aniello Baselice, Patrizia Balbinot, Vito C
doi : 10.1007/s10620-021-07006-1
Coronavirus Disease 2019 (COVID-19), firstly reported in China last November 2019, became a global pandemic. It has been shown that periods of isolation may induce a spike in alcohol use disorder (AUD). In addition, alcohol-related liver disease (ALD) is the most common consequence of excessive alcohol consumption worldwide. Moreover, liver impairment has also been reported as a common manifestation of COVID-19.
Ascites in Acute Pancreatitis: Clinical Implications and Management
Nikhil Bush & Surinder Singh Rana
doi : 10.1007/s10620-021-07063-6
Clinically significant ascites in acute pancreatitis (AP) is rarely encountered and is a result of multifactorial pathogenesis. Early reactionary ascites in AP usually does not require any treatment and resolves spontaneously in majority of patients. A diagnostic analysis should be performed in case of ascites developing in the latter stages with increasing pain or worsening organ failure. Low serum albumin-ascites gradient ascites with amylase > 1000 U/l is highly suggestive of pancreatic ascites that is usually associated with duct disruption. A combination of nasojejunal feeding, subcutaneous octreotide, endoscopic drainage and rarely, surgery are employed in managing this difficult to treat condition. There is a need of further studies to better understand the clinical role of ascites as well as contribution of other factors like hypoalbuminemia and portal hypertension to its development in AP.
Hepatic Encephalopathy-Related Hospitalizations in Cirrhosis: Transition of Care and Closing the Revolving Door
Catherine T. Frenette, Cynthia Levy & Sammy Saab
doi : 10.1007/s10620-021-07075-2
Cirrhosis is associated with substantial morbidity and mortality. Development of complications of cirrhosis, including hepatic encephalopathy (HE), portends poorer outcomes. HE is associated with hospital readmission, impaired patient and caregiver quality of life, risk of falls, and mortality. Guidelines recommend lactulose as first-line therapy for HE and rifaximin in combination with lactulose for reducing the risk of HE recurrence. Improving post-discharge outcomes, including readmissions, is an important aspect in the management of patients with HE. Approaches focused on improving management and prevention of HE, including properly titrating lactulose dosing, overcoming medication-related nonadherence, and incorporating rifaximin as therapy to reduce the risk of recurrence, as well as incorporating supportive care initiatives, may ease the transition from hospital to home. Strategies to decrease readmission rates include using hospital navigators, who can offer patient/caregiver education, post-discharge planning, and medication review; and involving pharmacists in post-discharge planning. Similarly, telemedicine offers providers the opportunity to monitor patients with HE remotely and improves outcomes. Providers offering transitional care management may be reimbursed when establishing contact with patients within 2Â days post-discharge and conducting an outpatient visit within 7Â days or 14Â days. Several approaches have been shown to improve outcomes broadly in patients post-discharge and may also be effective for improving outcomes specifically in patients hospitalized with cirrhosis and HE, thus closing the revolving door on rehospitalizations in this population.
Making It Stick: Management of Gastroesophageal Junction Adenocarcinoma with Poorly-Cohesive Cells (PCC)
Damien Bouriez, Caroline Gronnier, Haythem Najah & Denis Collet
An Analysis of 5Â Years of Randomized Trials in Gastroenterology and Hepatology Reveals 52 Medical Reversals
Margot C. Yopes, Alexander M. Mozeika, Simon Liebling, Alyson Haslam, Vinay Prasad & Benjamin Lebwohl
doi : 10.1007/s10620-021-07199-5
One manifestation of low-value medical practice is the medical reversal, a practice in widespread use that, once subjected to a randomized controlled trial (RCT), is found to be no better—or worse—than a prior established standard of care. We aimed to determine the prevalence of medical reversals in gastroenterology (GI) journals and characterize these reversals.
Virtual Gastroenterology Fellowship Recruitment During COVID-19 and Its Implications for the Future
Nour Hamade, Indira Bhavsar-Burke, Claire Jansson-Knodell, Sachin Wani, Swati G. Patel, Adam C. Ehrlich, Elizabeth Paine, Pegah Hosseini-Carroll, Paul
doi : 10.1007/s10620-021-07014-1
Amid the COVID-19 pandemic, medical education organizations endorsed a virtual recruitment format, representing a stark change from traditional in-person interviews. We aimed to identify the attitudes and perceptions of Gastroenterology Fellowship Program Directors (PDs) and applicants regarding the virtual interview experience and the role of virtual interviews (VI) in the future.
Drivers of Variation in Diagnosis and Management of Eosinophilic Esophagitis: A Survey of Pediatric Gastroenterologists
Talya L. Miller, Arti D. Desai, Michelle M. Garrison, Dale Lee, Amanda Muir & K. Casey Lion
doi : 10.1007/s10620-021-07039-6
Widespread variation in the diagnosis and treatment of eosinophilic esophagitis (EoE) has previously been reported among adult gastroenterologists; however, variation in EoE practice in among pediatric populations is poorly characterized. The study objectives were to describe guideline adherence and understand reasons for variation in EoE practice among pediatric gastroenterologists following publication of the updated 2018 international EoE guidelines.
Patient-Reported Outcomes and Risk of Hospitalization and Readmission in Patients with Inflammatory Bowel Diseases
Nghia H. Nguyen, Xian Zhang, Millie D. Long, William J. Sandborn, Michael D. Kappelman & Siddharth Singh
doi : 10.1007/s10620-021-07082-3
Patient-reported outcome measures (PROMs) provide a wholesome view of patient well-being. We conducted a retrospective cohort study to evaluate whether PROMs inform risk of unplanned healthcare utilization in patients with IBD.
A Short Knowledge Assessment Tool Is Valid and Acceptable for Adults with Inflammatory Bowel Disease
Katrin S. Buerkle, Angharad Vernon-Roberts, Christine Ho, Michael Schultz & Andrew S. Day
doi : 10.1007/s10620-022-07507-7
For people with inflammatory bowel disease, validated knowledge questionnaires are valuable to identify gaps in understanding and explore the impact on disease variables.
Low Subjective Wellbeing Is Associated with Psychological Distress in People Living with Inflammatory Bowel Disease
Catherine Emerson, Matthew Fuller-Tyszkiewicz, Rebecca Orr, Kimina Lyall, Lauren Beswick, Lisa Olive, David Skvarc, Robert A. Cummins & Antonina Mikoc
doi : 10.1007/s10620-021-07065-4
Inflammatory bowel disease (IBD) is a common and debilitating disease of the gastrointestinal tract. Psychological distress is highly comorbid to IBD, especially during periods of active disease. However, a controversy exists on how to best manage its symptoms in the IBD population.
Inflammatory Bowel Disease and COVID-19 Vaccination: A Patients’ Survey
Bénédicte Caron, Elise Neuville & Laurent Peyrin-Biroulet
doi : 10.1007/s10620-021-07040-z
Vaccination against COVID-19 is a major public health challenge, including the community of patients with inflammatory bowel disease. Vaccination coverage is suboptimal in inflammatory bowel disease population. It is of paramount importance to ensure an effective and rapid vaccination program with the adherence of the largest number of well-informed patients.
Analysis of Decreasing Adverse Events with Endoscopic Ultrasound in a New Advanced Endoscopy Program Over Time
Yousef Elfanagely, Chung Sang Tse, Joshua Ray Tanzer, Joao Filipe G. Monteiro, Lawrence Kogan, Harlan Rich & Sarah M. Hyder
doi : 10.1007/s10620-021-07050-x
New innovations and increasing utility of endoscopic ultrasound (EUS) are associated with rare but serious risks. We investigate the rates and risk factors for post-procedural complications over a four-year period at a new advanced endoscopy program.
Recently Graduated Medical Students Lack Exposure to and Comfort with Chronic Liver Diseases
Alexander Y. Pan, Netanel F. Zilberstein, Jeanne M. Farnan, John F. McConville & Adam E. Mikolajczyk
doi : 10.1007/s10620-021-07182-0
The prevalence of chronic liver disease (CLD) is rising, but it remains unclear if medical school curricula are emphasizing CLD to reflect its growing epidemiology.
Concise Commentary: Ill Preparation for Managing Liver Illness Among Incoming Medical Residents
Deborah D. ProctorÂ
Impact of Readmission for Variceal Upper Gastrointestinal Bleeding: A Nationwide Analysis
Simcha Weissman, Sachit Sharma, Muhammad Aziz, Dean Ehrlich, Megan Perumpail, Michael Sciarra & James H. Tabibian
doi : 10.1007/s10620-021-07011-4
Variceal upper gastrointestinal bleeding (VUGIB) is a common and potentially lethal complication of cirrhosis. Population-based data regarding hospital readmission and other outcomes in VUGIB are limited.
Inpatient Gastroenterology Consultation and Outcomes of Cirrhosis-Related Hospitalizations in Two Large National Cohorts
Marina Serper, David E. Kaplan, Menghan Lin, Tamar H. Taddei, Neehar D. Parikh, Rachel M. Werner & Elliot B. Tapper
doi : 10.1007/s10620-021-07150-8
Little is known about use of specialty care among patients admitted with cirrhosis complications.
Concise Commentary: Are We Making a Difference? The Impact of Inpatient Gastroenterology and Hepatology Consultations for Cirrhotic Patients
Sarang Thaker & Adam E. Mikolajczyk
International Classification of Diseases Codes are Useful in Identifying Cirrhosis in Administrative Databases
Monica Dahiya, Ejemai Eboreime, Ashley Hyde, Sholeh Rahman, Meghan Sebastianski, Michelle Carbonneau, Elliot B. Tapper & Puneeta Tandon
doi : 10.1007/s10620-021-07076-1
Health administrative databases are essential to define patient populations, make socioeconomic predictions, and facilitate medical research and healthcare planning. The accuracy of this data is dependent on valid codes/coding algorithms.
Disease Knowledge, Health-Related Quality of Life, and Lifestyle Behavior Change in Patients with Nonalcoholic Fatty Liver Disease: Impact of an Educational Intervention
Lisa Glass, Haila Asefa, Michael Volk, Anna S. Lok & Monica A. Tincopa
doi : 10.1007/s10620-021-07052-9
Lifestyle modification is currently the only treatment for nonalcoholic fatty liver disease (NAFLD). The most effective way to motivate behavior change in this population is not well understood.
LGR5-Expressing Cells in the Healing Process of Post-ESD Ulcers in Gastric Corpus
Yosuke Tobe, Takeshi Uehara, Tomoyuki Nakajima, Mai Iwaya, Yukihiro Kobayashi, Yasuhiro Kinugawa, Yasuhiro Kuraishi & Hiroyoshi Ota
doi : 10.1007/s10620-021-07059-2
LGR5 is a promising stem cell marker in gastric pylorus, but there are few reports on its expression in human gastric corpus.
Fecal Stream Diversion Changes Intestinal Environment, Modulates Mucosal Barrier, and Attenuates Inflammatory Cells in Crohn’s Disease
Yoshifumi Watanabe, Tsunekazu Mizushima, Ryu Okumura, Shiki Fujino, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda,
doi : 10.1007/s10620-021-07060-9
The intestinal environment plays important roles in mucosal barrier homeostasis and intestinal inflammation, as clarified in studies using experimental animals but not in humans.
Circular RNA circ_0006948 Promotes Esophageal Squamous Cell Carcinoma Progression by Regulating microRNA-3612/LASP1 Axis
Rongzhu Tang, Qiang Zhou, Qihua Xu, Lihua Lu & Ying Zhou
doi : 10.1007/s10620-021-07057-4
Esophageal squamous cell carcinoma (ESCC) is the most prevalent malignancy worldwide. Circular RNAs (circRNAs) circ_0006948 is reported to be upregulated in ESCC cells.
Orexin A Suppresses the Expression of Exosomal PD-L1 in Colon Cancer and Promotes T Cell Activity by Inhibiting JAK2/STAT3 Signaling Pathway
Jing Wen, Xiaocen Chang, Bowen Bai, Qian Gao & Yuyan Zhao
doi : 10.1007/s10620-021-07077-0
Colon cancer, ranked third in cancer related mortality, is the most common malignant cancer of digestive tract. Though immune checkpoint inhibitors show promising efficacy in colon cancer, a rather high unresponsive rate and recurrence rate requires further elucidation of the underlying regulatory mechanism of cancer-related immunity.
LncRNA LEF1-AS1/LEF1/FUT8 Axis Mediates Colorectal Cancer Progression by Regulating α1, 6-Fucosylationvia Wnt/β-Catenin Pathway
Yu Qi, Yujia Shan, Shuangda Li, Yiran Huang, Yanru Guo, Tong Huang, Xinyu Zhao & Li Jia
doi : 10.1007/s10620-021-07051-w
Fucosylation alteration is involved in several steps of human cancer pathogenesis. Dysregulated long non-coding RNA (lncRNA) often leads to malignancy in colorectal cancer (CRC).
Mucin 16 Promotes Colorectal Cancer Development and Progression Through Activation of Janus Kinase 2
Zhining Liu, Yimei Gu, Xianghua Li, Lianbang Zhou, Xiaohu Cheng, Heng Jiang, Yang Huang, Yingfeng Zhang, Tongtong Xu, Wanshui Yang & Qiang Huang
doi : 10.1007/s10620-021-07004-3
Mucin 16 (MUC16), a cell surface-associated mucin, has been implicated to be upregulated in a large repertoire of malignances. However, its function in the pathogenesis of colorectal cancer (CRC) is unknown.
MiR155 Disrupts the Intestinal Barrier by Inducing Intestinal Inflammation and Altering the Intestinal Microecology in Severe Acute Pancreatitis
Xiaoyu Yang, Jianhua Wan, Nianshuang Li, Cong He, Yue Zhang, Yuping Ren, Xueyang Li, Yin Zhu, Fen Liu, Liang Xia & Nonghua Lu
doi : 10.1007/s10620-021-07022-1
Intestinal dysfunction is a common complication of acute pancreatitis. MiR155 may be involved in the occurrence and development of intestinal dysfunction mediated by acute pancreatitis, but the specific mechanism is not clear.
Free Fatty Acid Increases the Expression of NLRP3-Caspase1 in Adipose Tissue Macrophages in Obese Severe Acute Pancreatitis
Tao Xu, Liping Sheng, Xianwen Guo & Zhen Ding
doi : 10.1007/s10620-021-07027-w
Obesity is an important risk factor for severe acute pancreatitis. The necrosis of epididymal adipose tissue occurs in severe acute pancreatitis. Adipose tissue macrophages play an important role in metabolic related inflammation. Therefore, we explored the potential mechanisms between adipose tissue macrophages and obesity-related severe acute pancreatitis.
Adiponectin Alleviates Intestinal Fibrosis by Enhancing AMP-Activated Protein Kinase Phosphorylation
Minghao Xie, Zhizhong Xiong, Shi Yin, Jiaqing Xiong, Xianzhe Li, Longyang Jin, Fengxiang Zhang, Huaxian Chen, Ping Lan & Lei Lian
doi : 10.1007/s10620-021-07015-0
Intestinal fibrosis is a common complication of Crohn’s disease (CD). Adiponectin reportedly exerts anti-inflammatory effects in various disease models, including colitis models.
Lidocaine Suppresses Gastric Cancer Development Through Circ_ANO5/miR-21-5p/LIFR Axis
Enjian Guan, Hongrong Liu & Ning Xu
doi : 10.1007/s10620-021-07055-6
Lidocaine has been manifested to exert anti-tumor role in gastric cancer (GC) progression. However, the action mechanism by which Lidocaine functions in GC has not been fully elucidated.
Circ_0001955 Acts as a miR-646 Sponge to Promote the Proliferation, Metastasis and Angiogenesis of Hepatocellular Carcinoma
Xia Li, Junxu Lv, Liying Hou & Xiaofeng Guo
doi : 10.1007/s10620-021-07053-8
Circular RNA (circRNA) exerts a crucial role in the progression of many cancers, including hepatocellular carcinoma (HCC). However, the function of circ_0001955 in HCC progression has been poorly studied.
Circular RNA Circ-STIL Contributes to Cell Growth and Metastasis in Hepatocellular Carcinoma via Regulating miR-345-5p/AQP3 Axis
Jun Liu, Xionghui He, Yongping Zou & Kaiqiong Wang
doi : 10.1007/s10620-021-07054-7
Circular RNAs (circRNAs) are implicated in the pathogenesis and development of hepatocellular carcinoma (HCC). However, the function and latent mechanism of circ-STIL in HCC have not been elucidated.
Development and Validation of a Novel Circulating miRNA-Based Diagnostic Score for Early Detection of Hepatocellular Carcinoma
Bin Yu, Shujun Zhou, Han Liang, Qifa Ye & Yanfeng Wang
doi : 10.1007/s10620-021-07031-0
With the rise of liquid biopsy in oncology, circulating miRNAs have become one of the most promising noninvasive biomarkers for early detection of hepatocellular carcinoma (HCC). However, a reliable HCC-related circulating miRNA panel and corresponding diagnostic model remain to be explored.
Fortune of Reversals: How Randomized Clinical Trials Shape Medical Practice
Amnon Sonnenberg & Gennadiy Bakis
doi : 10.1007/s10620-021-07240-7
Volume 67, issue 6, June 2022
Functional Disease, Dysbiosis, and Dyspepsia: How Helpful Is Rifaximin?
Sridhar Sundaram & Harish Darak
A Wolf in LAMS Clothing: The Expansion of Off-Label Indications for Lumen-Apposing Metal Stents
Chalapathi Rao Achanta & Sudhanva V. Kinhal
A Better Prep School: Does an Interactive Instruction Video Improve Colon Cleanliness?
Wissam KiwanÂ
In Living Color: Linked Color Imaging for the Detection of Early Gastric Cancer
Mitsuru Esaki, Yosuke Minoda & Eikichi Ihara
Half-Full or Half-Empty: Does Gastroparesis Affect Lung Transplantation Outcomes?
Christopher Vélez & Kyle Staller
Impatience with Inpatients: Are Hospitalization Rates Declining for IBD Patients?
Anand Kumar & Arun Swaminath
Quality Improvement During Gastroenterology Fellowship: The Experience of Improving Inpatient Post-endoscopy Communication
Amy G. Ogurick, Samantha J. Magier & Michelle L. Hughes
Unsedated Transnasal Endoscopy: A Safe, Well-Tolerated and Accurate Alternative to Standard Diagnostic Peroral Endoscopy
Rebecca K. Grant, William M. Brindle, Alexander R. Robertson, Rahul Kalla & John N. Plevris
doi : 10.1007/s10620-022-07432-9
Diagnostic unsedated transnasal endoscopy (uTNE) has been proven to be a safe and well-tolerated procedure. Although its utilization in the United Kingdom (UK) is increasing, it is currently available in only a few centers. Through consideration of recent studies, we aimed to perform an updated review of the technological advances in uTNE, consider their impact on diagnostic accuracy, and to determine the role of uTNE in the COVID-19 era. Current literature has shown that the diagnostic accuracy of uTNE for identification of esophageal pathology is equivalent to conventional esophagogastroduodenoscopy (cEGD). Concerns regarding suction and biopsy size have been addressed by the introduction of TNE scopes with working channels of 2.4 mm. Advances in imaging have improved detection of early gastric cancers. The procedure is associated with less cardiac stress and reduced aerosol production; when combined with no need for sedation and improved rates of patient turnover, uTNE is an efficient and safe alternative to cEGD in the COVID-19 era. We conclude that advances in technology have improved the diagnostic accuracy of uTNE to the point where it could be considered the first line diagnostic endoscopic investigation in the majority of patients. It could also play a central role in the recovery of diagnostic endoscopic services during the COVID-19 pandemic.
Is Ustekinumab Effective in Refractory Crohn’s Disease of the Pouch and Chronic Pouchitis? A Systematic Review
Chiara Rocchi, Youssef Y. Soliman, Marco Massidda, Salvatore F. Vadalà di Prampero, Milutin Bulajic & Dario Sorrentino
doi : 10.1007/s10620-021-07002-5
Crohn’s disease (CD) of the pouch and chronic pouchitis represent the most common long-term complications of total proctocolectomy and ileal pouch anal anastomosis (IPAA) for refractory ulcerative colitis (UC). These conditions are treated with multiple agents, including antibiotics, immunomodulators, and biologics. Among the latter, ustekinumab is approved for both CD and UC. We performed a systematic review to evaluate the efficacy of this anti-IL12/23 in CD of the pouch and chronic refractory pouchitis. Pubmed, Embase, Ovid, and the Cochrane Controlled Trials Register were searched to identify studies published until August 2020 investigating the use of ustekinumab for these conditions. Eighty-six eligible patients with IPAA—51 with CD of the pouch, 35 with chronic pouchitis—were identified from 2 retrospective studies and 5 case reports. Reported clinical response to ustekinumab was 63 and 85% in chronic pouchitis and CD of the pouch after 4–12 and 4–16 weeks, respectively. Clinical remission was reported in 10% of patients with chronic pouchitis and 27% of patients with CD of the pouch after 8–52 and 4–52 weeks of treatment, respectively. Endoscopic response was reported in 60% and 67% of patients with chronic pouchitis and CD of the pouch after 24–32 and 8–24 weeks of treatment respectively. Small sample sizes and large heterogeneity of therapy protocols/outcome definitions were significant studies limitations. In conclusion, there is a limited and inconclusive body of evidence suggesting that ustekinumab may be a therapeutic option for patients with chronic pouchitis and CD of the pouch refractory to other therapies.
Patient Perspectives and Expectations in Inflammatory Bowel Disease: A Systematic Review
Alex Al Khoury, Bhairavi Balram, Talat Bessissow, Waqqas Afif, Lorant Gonczi, Maria Abreu & Peter L. Lakatos
doi : 10.1007/s10620-021-07025-y
In this systematic review, our objective was to assess inflammatory bowel disease (IBD) patient preferences and perspectives relating to their disease diagnosis, treatment, knowledge needs and telemedicine.
Alcohol-Related Liver Disease in the Covid-19 Era: Position Paper of the Italian Society on Alcohol (SIA)
Gianni Testino, Teo Vignoli, Valentino Patussi, Pierluigi Allosio, Maria Francesca Amendola, Sarino Aric?, Aniello Baselice, Patrizia Balbinot, Vito C
doi : 10.1007/s10620-021-07006-1
Coronavirus Disease 2019 (COVID-19), firstly reported in China last November 2019, became a global pandemic. It has been shown that periods of isolation may induce a spike in alcohol use disorder (AUD). In addition, alcohol-related liver disease (ALD) is the most common consequence of excessive alcohol consumption worldwide. Moreover, liver impairment has also been reported as a common manifestation of COVID-19.
Ascites in Acute Pancreatitis: Clinical Implications and Management
Nikhil Bush & Surinder Singh Rana
doi : 10.1007/s10620-021-07063-6
Clinically significant ascites in acute pancreatitis (AP) is rarely encountered and is a result of multifactorial pathogenesis. Early reactionary ascites in AP usually does not require any treatment and resolves spontaneously in majority of patients. A diagnostic analysis should be performed in case of ascites developing in the latter stages with increasing pain or worsening organ failure. Low serum albumin-ascites gradient ascites with amylase > 1000 U/l is highly suggestive of pancreatic ascites that is usually associated with duct disruption. A combination of nasojejunal feeding, subcutaneous octreotide, endoscopic drainage and rarely, surgery are employed in managing this difficult to treat condition. There is a need of further studies to better understand the clinical role of ascites as well as contribution of other factors like hypoalbuminemia and portal hypertension to its development in AP.
Hepatic Encephalopathy-Related Hospitalizations in Cirrhosis: Transition of Care and Closing the Revolving Door
Catherine T. Frenette, Cynthia Levy & Sammy Saab
doi : 10.1007/s10620-021-07075-2
Cirrhosis is associated with substantial morbidity and mortality. Development of complications of cirrhosis, including hepatic encephalopathy (HE), portends poorer outcomes. HE is associated with hospital readmission, impaired patient and caregiver quality of life, risk of falls, and mortality. Guidelines recommend lactulose as first-line therapy for HE and rifaximin in combination with lactulose for reducing the risk of HE recurrence. Improving post-discharge outcomes, including readmissions, is an important aspect in the management of patients with HE. Approaches focused on improving management and prevention of HE, including properly titrating lactulose dosing, overcoming medication-related nonadherence, and incorporating rifaximin as therapy to reduce the risk of recurrence, as well as incorporating supportive care initiatives, may ease the transition from hospital to home. Strategies to decrease readmission rates include using hospital navigators, who can offer patient/caregiver education, post-discharge planning, and medication review; and involving pharmacists in post-discharge planning. Similarly, telemedicine offers providers the opportunity to monitor patients with HE remotely and improves outcomes. Providers offering transitional care management may be reimbursed when establishing contact with patients within 2Â days post-discharge and conducting an outpatient visit within 7Â days or 14Â days. Several approaches have been shown to improve outcomes broadly in patients post-discharge and may also be effective for improving outcomes specifically in patients hospitalized with cirrhosis and HE, thus closing the revolving door on rehospitalizations in this population.
Making It Stick: Management of Gastroesophageal Junction Adenocarcinoma with Poorly-Cohesive Cells (PCC)
Damien Bouriez, Caroline Gronnier, Haythem Najah & Denis Collet
An Analysis of 5Â Years of Randomized Trials in Gastroenterology and Hepatology Reveals 52 Medical Reversals
Margot C. Yopes, Alexander M. Mozeika, Simon Liebling, Alyson Haslam, Vinay Prasad & Benjamin Lebwohl
doi : 10.1007/s10620-021-07199-5
One manifestation of low-value medical practice is the medical reversal, a practice in widespread use that, once subjected to a randomized controlled trial (RCT), is found to be no better—or worse—than a prior established standard of care. We aimed to determine the prevalence of medical reversals in gastroenterology (GI) journals and characterize these reversals.
Virtual Gastroenterology Fellowship Recruitment During COVID-19 and Its Implications for the Future
Nour Hamade, Indira Bhavsar-Burke, Claire Jansson-Knodell, Sachin Wani, Swati G. Patel, Adam C. Ehrlich, Elizabeth Paine, Pegah Hosseini-Carroll, Paul
doi : 10.1007/s10620-021-07014-1
Amid the COVID-19 pandemic, medical education organizations endorsed a virtual recruitment format, representing a stark change from traditional in-person interviews. We aimed to identify the attitudes and perceptions of Gastroenterology Fellowship Program Directors (PDs) and applicants regarding the virtual interview experience and the role of virtual interviews (VI) in the future.
Drivers of Variation in Diagnosis and Management of Eosinophilic Esophagitis: A Survey of Pediatric Gastroenterologists
Talya L. Miller, Arti D. Desai, Michelle M. Garrison, Dale Lee, Amanda Muir & K. Casey Lion
doi : 10.1007/s10620-021-07039-6
Widespread variation in the diagnosis and treatment of eosinophilic esophagitis (EoE) has previously been reported among adult gastroenterologists; however, variation in EoE practice in among pediatric populations is poorly characterized. The study objectives were to describe guideline adherence and understand reasons for variation in EoE practice among pediatric gastroenterologists following publication of the updated 2018 international EoE guidelines.
Patient-Reported Outcomes and Risk of Hospitalization and Readmission in Patients with Inflammatory Bowel Diseases
Nghia H. Nguyen, Xian Zhang, Millie D. Long, William J. Sandborn, Michael D. Kappelman & Siddharth Singh
doi : 10.1007/s10620-021-07082-3
Patient-reported outcome measures (PROMs) provide a wholesome view of patient well-being. We conducted a retrospective cohort study to evaluate whether PROMs inform risk of unplanned healthcare utilization in patients with IBD.
A Short Knowledge Assessment Tool Is Valid and Acceptable for Adults with Inflammatory Bowel Disease
Katrin S. Buerkle, Angharad Vernon-Roberts, Christine Ho, Michael Schultz & Andrew S. Day
doi : 10.1007/s10620-022-07507-7
For people with inflammatory bowel disease, validated knowledge questionnaires are valuable to identify gaps in understanding and explore the impact on disease variables.
Low Subjective Wellbeing Is Associated with Psychological Distress in People Living with Inflammatory Bowel Disease
Catherine Emerson, Matthew Fuller-Tyszkiewicz, Rebecca Orr, Kimina Lyall, Lauren Beswick, Lisa Olive, David Skvarc, Robert A. Cummins & Antonina Mikoc
doi : 10.1007/s10620-021-07065-4
Inflammatory bowel disease (IBD) is a common and debilitating disease of the gastrointestinal tract. Psychological distress is highly comorbid to IBD, especially during periods of active disease. However, a controversy exists on how to best manage its symptoms in the IBD population.
Inflammatory Bowel Disease and COVID-19 Vaccination: A Patients’ Survey
Bénédicte Caron, Elise Neuville & Laurent Peyrin-Biroulet
doi : 10.1007/s10620-021-07040-z
Vaccination against COVID-19 is a major public health challenge, including the community of patients with inflammatory bowel disease. Vaccination coverage is suboptimal in inflammatory bowel disease population. It is of paramount importance to ensure an effective and rapid vaccination program with the adherence of the largest number of well-informed patients.
Analysis of Decreasing Adverse Events with Endoscopic Ultrasound in a New Advanced Endoscopy Program Over Time
Yousef Elfanagely, Chung Sang Tse, Joshua Ray Tanzer, Joao Filipe G. Monteiro, Lawrence Kogan, Harlan Rich & Sarah M. Hyder
doi : 10.1007/s10620-021-07050-x
New innovations and increasing utility of endoscopic ultrasound (EUS) are associated with rare but serious risks. We investigate the rates and risk factors for post-procedural complications over a four-year period at a new advanced endoscopy program.
Recently Graduated Medical Students Lack Exposure to and Comfort with Chronic Liver Diseases
Alexander Y. Pan, Netanel F. Zilberstein, Jeanne M. Farnan, John F. McConville & Adam E. Mikolajczyk
doi : 10.1007/s10620-021-07182-0
The prevalence of chronic liver disease (CLD) is rising, but it remains unclear if medical school curricula are emphasizing CLD to reflect its growing epidemiology.
Concise Commentary: Ill Preparation for Managing Liver Illness Among Incoming Medical Residents
Deborah D. ProctorÂ
Impact of Readmission for Variceal Upper Gastrointestinal Bleeding: A Nationwide Analysis
Simcha Weissman, Sachit Sharma, Muhammad Aziz, Dean Ehrlich, Megan Perumpail, Michael Sciarra & James H. Tabibian
doi : 10.1007/s10620-021-07011-4
Variceal upper gastrointestinal bleeding (VUGIB) is a common and potentially lethal complication of cirrhosis. Population-based data regarding hospital readmission and other outcomes in VUGIB are limited.
Inpatient Gastroenterology Consultation and Outcomes of Cirrhosis-Related Hospitalizations in Two Large National Cohorts
Marina Serper, David E. Kaplan, Menghan Lin, Tamar H. Taddei, Neehar D. Parikh, Rachel M. Werner & Elliot B. Tapper
doi : 10.1007/s10620-021-07150-8
Little is known about use of specialty care among patients admitted with cirrhosis complications.
Concise Commentary: Are We Making a Difference? The Impact of Inpatient Gastroenterology and Hepatology Consultations for Cirrhotic Patients
Sarang Thaker & Adam E. Mikolajczyk
International Classification of Diseases Codes are Useful in Identifying Cirrhosis in Administrative Databases
Monica Dahiya, Ejemai Eboreime, Ashley Hyde, Sholeh Rahman, Meghan Sebastianski, Michelle Carbonneau, Elliot B. Tapper & Puneeta Tandon
doi : 10.1007/s10620-021-07076-1
Health administrative databases are essential to define patient populations, make socioeconomic predictions, and facilitate medical research and healthcare planning. The accuracy of this data is dependent on valid codes/coding algorithms.
Disease Knowledge, Health-Related Quality of Life, and Lifestyle Behavior Change in Patients with Nonalcoholic Fatty Liver Disease: Impact of an Educational Intervention
Lisa Glass, Haila Asefa, Michael Volk, Anna S. Lok & Monica A. Tincopa
doi : 10.1007/s10620-021-07052-9
Lifestyle modification is currently the only treatment for nonalcoholic fatty liver disease (NAFLD). The most effective way to motivate behavior change in this population is not well understood.
LGR5-Expressing Cells in the Healing Process of Post-ESD Ulcers in Gastric Corpus
Yosuke Tobe, Takeshi Uehara, Tomoyuki Nakajima, Mai Iwaya, Yukihiro Kobayashi, Yasuhiro Kinugawa, Yasuhiro Kuraishi & Hiroyoshi Ota
doi : 10.1007/s10620-021-07059-2
LGR5 is a promising stem cell marker in gastric pylorus, but there are few reports on its expression in human gastric corpus.
Fecal Stream Diversion Changes Intestinal Environment, Modulates Mucosal Barrier, and Attenuates Inflammatory Cells in Crohn’s Disease
Yoshifumi Watanabe, Tsunekazu Mizushima, Ryu Okumura, Shiki Fujino, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda,
doi : 10.1007/s10620-021-07060-9
The intestinal environment plays important roles in mucosal barrier homeostasis and intestinal inflammation, as clarified in studies using experimental animals but not in humans.
Circular RNA circ_0006948 Promotes Esophageal Squamous Cell Carcinoma Progression by Regulating microRNA-3612/LASP1 Axis
Rongzhu Tang, Qiang Zhou, Qihua Xu, Lihua Lu & Ying Zhou
doi : 10.1007/s10620-021-07057-4
Esophageal squamous cell carcinoma (ESCC) is the most prevalent malignancy worldwide. Circular RNAs (circRNAs) circ_0006948 is reported to be upregulated in ESCC cells.
Orexin A Suppresses the Expression of Exosomal PD-L1 in Colon Cancer and Promotes T Cell Activity by Inhibiting JAK2/STAT3 Signaling Pathway
Jing Wen, Xiaocen Chang, Bowen Bai, Qian Gao & Yuyan Zhao
doi : 10.1007/s10620-021-07077-0
Colon cancer, ranked third in cancer related mortality, is the most common malignant cancer of digestive tract. Though immune checkpoint inhibitors show promising efficacy in colon cancer, a rather high unresponsive rate and recurrence rate requires further elucidation of the underlying regulatory mechanism of cancer-related immunity.
LncRNA LEF1-AS1/LEF1/FUT8 Axis Mediates Colorectal Cancer Progression by Regulating α1, 6-Fucosylationvia Wnt/β-Catenin Pathway
Yu Qi, Yujia Shan, Shuangda Li, Yiran Huang, Yanru Guo, Tong Huang, Xinyu Zhao & Li Jia
doi : 10.1007/s10620-021-07051-w
Fucosylation alteration is involved in several steps of human cancer pathogenesis. Dysregulated long non-coding RNA (lncRNA) often leads to malignancy in colorectal cancer (CRC).
Mucin 16 Promotes Colorectal Cancer Development and Progression Through Activation of Janus Kinase 2
Zhining Liu, Yimei Gu, Xianghua Li, Lianbang Zhou, Xiaohu Cheng, Heng Jiang, Yang Huang, Yingfeng Zhang, Tongtong Xu, Wanshui Yang & Qiang Huang
doi : 10.1007/s10620-021-07004-3
Mucin 16 (MUC16), a cell surface-associated mucin, has been implicated to be upregulated in a large repertoire of malignances. However, its function in the pathogenesis of colorectal cancer (CRC) is unknown.
MiR155 Disrupts the Intestinal Barrier by Inducing Intestinal Inflammation and Altering the Intestinal Microecology in Severe Acute Pancreatitis
Xiaoyu Yang, Jianhua Wan, Nianshuang Li, Cong He, Yue Zhang, Yuping Ren, Xueyang Li, Yin Zhu, Fen Liu, Liang Xia & Nonghua Lu
doi : 10.1007/s10620-021-07022-1
Intestinal dysfunction is a common complication of acute pancreatitis. MiR155 may be involved in the occurrence and development of intestinal dysfunction mediated by acute pancreatitis, but the specific mechanism is not clear.
Free Fatty Acid Increases the Expression of NLRP3-Caspase1 in Adipose Tissue Macrophages in Obese Severe Acute Pancreatitis
Tao Xu, Liping Sheng, Xianwen Guo & Zhen Ding
doi : 10.1007/s10620-021-07027-w
Obesity is an important risk factor for severe acute pancreatitis. The necrosis of epididymal adipose tissue occurs in severe acute pancreatitis. Adipose tissue macrophages play an important role in metabolic related inflammation. Therefore, we explored the potential mechanisms between adipose tissue macrophages and obesity-related severe acute pancreatitis.
Adiponectin Alleviates Intestinal Fibrosis by Enhancing AMP-Activated Protein Kinase Phosphorylation
Minghao Xie, Zhizhong Xiong, Shi Yin, Jiaqing Xiong, Xianzhe Li, Longyang Jin, Fengxiang Zhang, Huaxian Chen, Ping Lan & Lei Lian
doi : 10.1007/s10620-021-07015-0
Intestinal fibrosis is a common complication of Crohn’s disease (CD). Adiponectin reportedly exerts anti-inflammatory effects in various disease models, including colitis models.
Lidocaine Suppresses Gastric Cancer Development Through Circ_ANO5/miR-21-5p/LIFR Axis
Enjian Guan, Hongrong Liu & Ning Xu
doi : 10.1007/s10620-021-07055-6
Lidocaine has been manifested to exert anti-tumor role in gastric cancer (GC) progression. However, the action mechanism by which Lidocaine functions in GC has not been fully elucidated.
Circ_0001955 Acts as a miR-646 Sponge to Promote the Proliferation, Metastasis and Angiogenesis of Hepatocellular Carcinoma
Xia Li, Junxu Lv, Liying Hou & Xiaofeng Guo
doi : 10.1007/s10620-021-07053-8
Circular RNA (circRNA) exerts a crucial role in the progression of many cancers, including hepatocellular carcinoma (HCC). However, the function of circ_0001955 in HCC progression has been poorly studied.
Circular RNA Circ-STIL Contributes to Cell Growth and Metastasis in Hepatocellular Carcinoma via Regulating miR-345-5p/AQP3 Axis
Jun Liu, Xionghui He, Yongping Zou & Kaiqiong Wang
doi : 10.1007/s10620-021-07054-7
Circular RNAs (circRNAs) are implicated in the pathogenesis and development of hepatocellular carcinoma (HCC). However, the function and latent mechanism of circ-STIL in HCC have not been elucidated.
Development and Validation of a Novel Circulating miRNA-Based Diagnostic Score for Early Detection of Hepatocellular Carcinoma
Bin Yu, Shujun Zhou, Han Liang, Qifa Ye & Yanfeng Wang
doi : 10.1007/s10620-021-07031-0
With the rise of liquid biopsy in oncology, circulating miRNAs have become one of the most promising noninvasive biomarkers for early detection of hepatocellular carcinoma (HCC). However, a reliable HCC-related circulating miRNA panel and corresponding diagnostic model remain to be explored.
Frequency, Intensity, and Partner of Exercise Habit Is Inversely Associated with Functional Dyspepsia in Young Japanese Population
Shinya Furukawa, Yasunori Yamamoto, Junichi Watanabe, Aki Kato, Katsunori Kusumoto, Eiji Takeshita, Yoshio Ikeda, Naofumi Yamamoto, Katsutoshi Okada,
doi : 10.1007/s10620-021-07017-y
Functional dyspepsia (FD) has a high prevalence worldwide and reduces patients’ quality of life. The etiology of FD is likely multifactorial. Although two studies showed an inverse association between exercise habits and FD, evidence regarding the association between exercise habits and FD remains scarce.
Concomitant Irritable Bowel Syndrome Does Not Influence the Response to Antimicrobial Therapy in Patients with Functional Dyspepsia
Ayesha Shah, Saravana Ruban Gurusamy, Teressa Hansen, Gavin Callaghan, Nicholas J. Talley, Natasha Koloski, Marjorie M. Walker, Michael P. Jones, Mark
doi : 10.1007/s10620-021-07149-1
Antimicrobial therapy improves symptoms in patients with irritable bowel syndrome (IBS), but the efficacy in functional dyspepsia (FD) is largely unknown. While FD and IBS frequently overlap, it is unknown if concomitant IBS in FD alters the response to antimicrobial therapy in FD. Thus, we aimed to assess and compare the effect of antimicrobial therapy on visceral sensory function and symptom improvement in FD patients with and without IBS.
Endoscopy Is Not Associated with Infectious Adverse Events After Hematopoietic Cell Transplantation: A Retrospective Cohort Study
Abraham Segura, Rahul S. Dalal, Meghana Golla, James N. Gerson, Nadim Mahmud, James D. Lewis & Ravy K. Vajravelu
doi : 10.1007/s10620-021-07062-7
Patients with recent hematopoietic cell transplantation (HCT) are considered high risk for gastrointestinal endoscopy due to the potential for procedural bacterial translocation. Prior studies investigating these risks do not account for the higher baseline rate of infectious complications among those who are immunocompromised. We performed a retrospective cohort study of patients with recent HCT who underwent endoscopy and their matched controls who did not undergo endoscopy.
Outcomes of Radiofrequency Ablation Compared to Liquid Nitrogen Spray Cryotherapy for the Eradication of Dysplasia in Barrett’s Esophagus
Matthew Fasullo, Tilak Shah, Milan Patel, Pritesh Mutha, Alvin Zfass, Robert Lippman & George Smallfield
doi : 10.1007/s10620-021-06991-7
Current guidelines recommend endoscopic eradication therapy (EET) for Barrett’s esophagus (BE) with dysplasia and intramucosal adenocarcinoma using either radiofrequency ablation (RFA) or liquid nitrogen spray cryotherapy (LNSC). The aims of this multicenter study are to compare the rate and number of treatment sessions of RFA vs. LNSC to achieve CE-D and CE-IM and assess outcomes for those who switched therapy.
Effectiveness and Safety of Lumen-Apposing Metal Stents in Endoscopic Interventions for Off-Label Indications
Jun-Ho Choi, Richard A. Kozarek, Michael C. Larsen, Andrew S. Ross, Joanna K. Law, Rajesh Krishnamoorthi & Shayan Irani
doi : 10.1007/s10620-021-07270-1
Although released only for drainage of pseudocyst and walled-off necrosis (WON) with ≤ 30% solid debris, the utilization of lumen-apposing metal stent (LAMS) in “real-world� practice has deviated from approved indications. We evaluated the contemporary use of LAMS and associated clinical, procedural outcomes in the setting of a tertiary referral center in the USA.
“Innocent as a LAMS�: Does Spontaneous Fistula Closure (Secondary Intention), After EUS-Directed Transgastric ERCP (EDGE) via 20-mm Lumen-Apposing Metal Stent, Confer an Increased Risk of Persistent Fistula and Unintentional Weight Gain?
Matthew Richard Krafft, Alyssa Lorenze, Michael P. Croglio, Wei Fang, Todd H. Baron & John Y. Nasr
doi : 10.1007/s10620-021-07003-4
Persistent gastrogastric or jejunogastric fistula is theoretically a concerning sequela of EUS-directed transgastric ERCP/EUS (EDGE), as it may functionally reverse the malabsorptive mechanism of Roux-en-Y gastric bypass (RYGB). Prior EDGE studies, using predominantly 15-mm (diameter) lumen-apposing metal stents (LAMS) and fistula closure by primary intent, collectively report 9% persistent fistula rate, without a clear weight gain association. Our study determines the incidence of persistent fistula, and its association with unintentional weight gain, among recipients of EDGE via 20-mm LAMS followed by spontaneous fistula closure (secondary intent).
An Interactive Video Educational Tool Does Not Improve the Quality of Bowel Preparation for Colonoscopy: A Randomized Controlled Study
Ted B. Walker, Tricia A. Hengehold, Kevin Garza, Benjamin D. Rogers & Dayna Early
doi : 10.1007/s10620-021-07215-8
Inadequate bowel preparation leads to poor outcomes in colonoscopy. Prior investigations have demonstrated improved bowel preparation with pre-procedural educational videos. We aimed to determine whether an interactive, online educational video could improve bowel preparation scores in an outpatient population.
Single-Day Low-Residue Diet Prior to Colonoscopy Demonstrates Improved Bowel Preparation Quality and Patient Tolerance over Clear Liquid Diet: A Randomized, Single-Blinded, Dual-Center Trial
Jason B. Samarasena, Nabil El Hage Chehade, Alexander Abadir, Allen Yu, Elise Tran, Daniel Mai, Daniel Thieu, Gregory Albers, Nimisha K. Parekh, Willi
doi : 10.1007/s10620-021-07023-0
Patients often refer to bowel preparation and associated dietary restrictions as the greatest deterrents to having a colonoscopy completed or performed. Large studies comparing a low-residue diet (LRD) and a clear liquid diet (CLD) are still limited. The aim of this study is to compare LRD and CLD with regard to bowel preparation quality, tolerance, and satisfaction among a diverse patient population.
Enhanced Visibility in Evaluating Gastric Cancer and Helicobacter pylori-Associated Gastritis Using Linked Color Imaging with a Light-Emitting Diode Light Source
Tsugitaka Ishida, Osamu Dohi, Naohisa Yoshida, Takeshi Yasuda, Takuma Yoshida, Yuka Azuma, Hiroaki Kitae, Shinya Matsumura, Toshifumi Doi, Ryohei Hiro
doi : 10.1007/s10620-021-07234-5
In Japan, laser light source (Laser) endoscopy is widely available, and the characteristics of light-emitting diode light source (LED) endoscopy have not been clarified.
Linked Color Imaging (LCI) Emphasizes the Color Changes in the Gastric Mucosa After Helicobacter pylori Eradication
Hiroyuki Sakae, Hiromitsu Kanzaki, Takuya Satomi, Shotaro Okanoue, Yuka Obayashi, Kenta Hamada, Makoto Abe, Yoshiyasu Kono, Ko Miura, Masaya Iwamuro,
doi : 10.1007/s10620-021-07030-1
Diffuse redness is a characteristic endoscopic finding that indicates current infection of Helicobacter pylori, which is reduced after successful eradication. Linked color imaging (LCI) has been reported to improve the visibility of diffuse redness compared to white light imaging (WLI); however, quantitative evaluation has not been reported.
Risk Factors and Outcomes for Gastroparesis After Lung Transplantation
John W. Blackett, Luke Benvenuto, Miguel M. Leiva-Juarez, Frank D’Ovidio, Selim Arcasoy & Daniela Jodorkovsky
doi : 10.1007/s10620-021-07249-y
Gastroparesis is common after lung transplantation and is associated with worse transplant outcomes, including the development of chronic lung allograft dysfunction (CLAD). This study sought to identify the prevalence, risk factors, and outcomes associated with a new diagnosis of gastroparesis after lung transplantation.
Rebamipide for the Improvement of Gastric Atrophy and Intestinal Metaplasia: A Prospective, Randomized, Pilot Study
Joon Seop Lee, Seong Woo Jeon, Hyun Seok Lee, Yong Hwan Kwon, Su Youn Nam, Han Ik Bae & An Na Seo
doi : 10.1007/s10620-021-07038-7
The presence of atrophic gastritis (AG) and intestinal metaplasia (IM) is associated with an increased risk of gastric cancer (GC). Thus, the development of new strategies to improve AG/IM is essential for reducing the incidence of GC.
Colchicine as an Alternative First-Line Treatment of Sclerosing Mesenteritis: A Retrospective Study
Pedro Cortés, Hassan M. Ghoz, Obaie Mzaik, Muhamad Alhaj Moustafa, Yan Bi, Bhaumik Brahmbhatt, Nader Daoud & Maoyin Pang
doi : 10.1007/s10620-021-07081-4
Sclerosing mesenteritis is a rare condition characterized by chronic inflammation and fibrotic changes of the mesentery.
Increased Fecal Bile Acid Excretion in a Significant Subset of Patients with Other Inflammatory Diarrheal Diseases
Priya Vijayvargiya, Daniel Gonzalez Izundegui, Gerardo Calderon, Sarah Tawfic, Sarah Batbold, Hiba Saifuddin, Patrick Duggan, Valeria Melo, Taylor Tho
doi : 10.1007/s10620-021-06993-5
Increased fecal bile acid excretion (IBAX) occurs in a third of patients with functional diarrhea.
Gut Dysbiosis Associated with Antibiotics and Disease Severity and Its Relation to Mortality in Critically Ill Patients
Masahiro Ojima, Kentaro Shimizu, Daisuke Motooka, Takuma Ishihara, Shota Nakamura, Ayumi Shintani, Hiroshi Ogura, Tetsuya Iida, Kazuhisa Yoshiya & Tak
doi : 10.1007/s10620-021-07000-7
The gut microbiota are reported to be altered in critical illness. The pattern and impact of dysbiosis on prognosis has not been thoroughly investigated in the ICU setting.
Microscopic Colitis Patients Possess a Perturbed and Inflammatory Gut Microbiota
Sandra Hertz, Juliana Durack, Karina Frahm Kirk, Hans Linde Nielsen, Din L. Lin, Douglas Fadrosh, Kole Lynch, Yvette Piceno, Ole Thorlacius-Ussing, He
doi : 10.1007/s10620-021-07045-8
Microscopic colitis (MC), an inflammatory disease of the colon, is characterized by chronic non-bloody diarrhea with characteristic inflammation and for some, collagen deposits in mucosal biopsies. The etiology of MC is unclear, although previous findings implicate luminal factors and thus the gut microbiome. However, the relationships between fecal microbiota and MC are relatively unexplored.
UK IBD Twin Registry: Concordance and Environmental Risk Factors of Twins with IBD
Hannah Gordon, William Blad, Frederik Trier M?ller, Timothy Orchard, Alan Steel, Gareth Trevelyan, Siew Ng & Marcus Harbord
doi : 10.1007/s10620-021-07080-5
Twin studies have long been used to infer heritability. Within the ‘omics era, twin cohorts have even greater research potential. This study describes the formation of the UK IBD Twin Registry and analysis of concordance and environmental factors.
Systematic Review and Meta-Analysis: Risk of Hospitalization in Patients with Ulcerative Colitis and Crohn’s Disease in Population-Based Cohort Studies
Lester Tsai, Nghia H. Nguyen, Christopher Ma, Larry J. Prokop, William J. Sandborn & Siddharth Singh
doi : 10.1007/s10620-021-07200-1
Inflammatory bowel diseases (IBD) lead to high morbidity and unplanned healthcare utilization. We conducted a systematic review with meta-analysis to estimate the cumulative incidence of IBD-related (and all-cause) hospitalization in patients with ulcerative colitis (UC) and Crohn’s disease (CD).
Role of Cross-Sectional Imaging in Pediatric Inflammatory Bowel Disease
Aurélie Grandmougin, Ferdinando D’Amico, Thomas Remen, Silvio Danese, Marjorie Bonneton, Marie Agnes Galloy, Laurent Peyrin-Biroulet & Valérie Laurent
doi : 10.1007/s10620-021-07016-z
The association between radiological remission and natural history of disease in children with inflammatory bowel diseases (IBD) is poorly known.
Surgery and the Subtype of Inflammatory Bowel Disease Impact the Risk of Venous Thromboembolism After Hospital Discharge
Jeffrey D. McCurdy, M. Ellen Kuenzig, Sarah Spruin, Oliver W. Fung, Ranjeeta Mallik, Lara Williams, Sanjay K. Murthy, Marc Carrier, Geoff Nguyen & Eri
doi : 10.1007/s10620-021-07064-5
Surgery for inflammatory bowel disease (IBD) is associated with an increased risk of venous thromboembolism (VTE) during hospitalization. It is unclear whether this association persists after hospital discharge.
Prior Immunogenicity to Anti-TNF Biologics Is Not Associated with Increased Anti-drug Antibodies to Vedolizumab or Ustekinumab
Nicholas J. Costable, Zachary A. Borman, Jiayi Ji, Marla C. Dubinsky & Ryan C. Ungaro
doi : 10.1007/s10620-021-07046-7
Patients with inflammatory bowel disease (IBD) on biologic therapy may lose response to anti-tumor necrosis factor agents (anti-TNFs) due to the development of anti-drug antibodies (ADAs). A history of anti-TNF ADA increases the risk of developing ADA to subsequent anti-TNFs; however, it is not known whether ADA to anti-TNFs increases the risk of ADA development to vedolizumab (VDZ) or ustekinumab (UST). We aimed to investigate whether prior history of ADA to anti-TNF increases the risk of ADA to VDZ and UST.
Serum Zinc and Selenium in Children with Inflammatory Bowel Disease: A Multicenter Study in Japan
Jun Ishihara, Katsuhiro Arai, Takahiro Kudo, Ryusuke Nambu, Hitoshi Tajiri, Tomoki Aomatsu, Naoki Abe, Toshihiko Kakiuchi, Kunio Hashimoto, Tsuyoshi S
doi : 10.1007/s10620-021-07078-z
Reports of zinc and selenium deficiencies accompanying inflammatory bowel disease (IBD) mostly have originated from Western countries and concerned adult patients. Whether Japanese children with IBD have similar deficiencies remained unclear.
Intestinal Conventional Ultrasonography, Contrast-Enhanced Ultrasonography and Magnetic Resonance Enterography in Assessment of Crohn’s Disease Activity: A Comparison with Surgical Histopathology Analysis
L. Servais, G. Boschetti, C. Meunier, C. Gay, E. Cotte, Y. François, A. Rozieres, J. Fontaine, L. Cuminal, M. Chauvenet, A. L. Charlois, S. Isaac, A.
doi : 10.1007/s10620-021-07074-3
Contrast-enhanced ultrasonography (CEUS) is a potential interesting method for assessing accurately Crohn’s disease (CD) activity. We compared the value of intestinal ultrasonography (US) coupled with contrast agent injection with that of magnetic resonance enterography (MRE) in the assessment of small bowel CD activity using surgical histopathology analysis as reference.
Fecal Microbiota Transplantation Is Safe for Clostridiodies difficile Infection in Patients with Solid Tumors Undergoing Chemotherapy
Robin B. Mendelsohn, Anna Kaltsas, Stephanie King, Connie Hwang, Zain Kassam, Audrey M. Abend, Elisabeth Kramer & Mini Kamboj
doi : 10.1007/s10620-021-07024-z
Recurrent Clostridiodies difficile infection (CDI) contributes to morbidity and mortality in cancer patients. Fecal microbiota transplantation (FMT) has been proven to be effective in treatment of recurrent CDI, but immunocompromised patients have been excluded from prospective studies due to safety concerns. The aim of this study was to investigate the safety of FMT for recurrent CDI in immunocompromised patients with solid tumor malignancy undergoing chemotherapy.
Risk of Malignancy with Vedolizumab Versus Tumor Necrosis Factor-α Antagonists in Patients with Inflammatory Bowel Diseases
Siddharth Singh, Herbert C. Heien, Lindsey Sangaralingham, Nilay D. Shah & William J. Sandborn
doi : 10.1007/s10620-021-07073-4
We conducted a retrospective cohort study comparing the risk of malignancy between patients treated with vedolizumab vs. tumor necrosis factor-α (TNFα) antagonists in patients with inflammatory bowel diseases (IBD).
Bile Acid Malabsorption in Patients with Neuroendocrine Tumors
Lehar Khanna, Thorvardur R. Halfdanarson, Mohamad B. Sonbol, Rachel Eiring, Teresa Prond & Michael Camilleri
doi : 10.1007/s10620-021-07189-7
Chronic diarrhea in patients with neuroendocrine tumors (NET) may be caused by bioactive products of NET, bile acid malabsorption (BAM), ileal resection (IR) or steatorrhea.
Ten or More Cumulative Lifetime Adenomas Are Associated with Increased Risk for Advanced Neoplasia and Colorectal Cancer
Brian A. Sullivan, Thomas S. Redding IV, Xuejun Qin, Ziad F. Gellad, Elizabeth R. Hauser, Meghan C. O’Leary, Christina D. Williams, Laura W. Musselwhi
doi : 10.1007/s10620-021-07069-0
Colorectal cancer (CRC) screening guidelines recommend frequent colonoscopies and consideration of genetic testing in individuals with ≥10 cumulative adenomas. However, it is unclear how these guidelines apply to routine practice.
Hunger-Based Versus Conventional Oral Feeding in Moderate and Severe Acute Pancreatitis: A Randomized Controlled Trial
Ashwin Rai, Amaranathan Anandhi, Sathasivam Sureshkumar & Vikram Kate
doi : 10.1007/s10620-021-06992-6
The length of hospitalization is prolonged in patients with acute pancreatitis due to delay in feeding. The present study aimed at evaluating hunger-based early feeding for its efficacy in reducing length of hospitalisation.
Coexistent Alcohol-Related Liver Disease and Alcohol-Related Pancreatitis: Analysis of a Large Health Care System Cohort
Gavin E. Arteel, Ajay Singhvi, Robert Feldman, Andrew D. Althouse, Ramon Bataller, Melissa Saul & Dhiraj Yadav
doi : 10.1007/s10620-021-07010-5
Although coexistence of alcohol-related liver disease (ALD) and pancreatitis (ALP) is seen in clinical practice, a clear understanding of the overlap between these diseases is lacking. Moreover, the relative risks for certain population groups have not been studied. We determined the prevalence and coexistence of ALD and ALP in patients with an alcohol use disorder using retrospective analysis of a large patient cohort from Western Pennsylvania. We specifically emphasized the analysis of underrepresented populations, including women and blacks.
Endoscopic Ultrasound Guided Fine-Needle Aspiration for Solid Lesions in Chronic Pancreatitis: A Systematic Review and Meta-Analysis
Mohamed A. Abdallah, Khalid Ahmed, Wesam Taha, Abdullahi Musa, Erin E. Reardon, Abubaker O. Abdalla & Guru Trikudanathan
doi : 10.1007/s10620-021-07066-3
Patients with chronic pancreatitis (CP) are at a higher risk of developing pancreatic adenocarcinoma compared the general population with an estimated 5% risk of developing pancreatic cancer in 20 years. Endoscopic ultrasound fine needle aspiration (EUS-FNA) of solid pancreatic lesions (SPL) has an excellent sensitivity (85–90%) and specificity (98–100%) for diagnosing pancreatic malignancy. However, data on the performance characteristics of EUS-FNA in CP are mixed.
Intracystic Glucose Levels Appear Useful for Diagnosis of Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis
Edson Guzm?n-Calder?n, Belen Martinez-Moreno MD, Juan A. Casellas & José Ram?n Aparicio
doi : 10.1007/s10620-021-07035-w
Carcinoembryonic antigen (CEA) in the pancreatic cystic fluid is the most important biomarker for differentiating mucinous from non-mucinous pancreatic cystic lesions (PCLs). However, recent studies have shown that glucose levels in pancreatic cystic fluid can discriminate mucinous from non-mucinous cysts.
A Preliminary Study on the Efficacy of Single-Operator Cholangioscopy with a New Basket for Residual Stone Retrieval After Mechanical Lithotripsy
Tae Hoon Lee, Jong Ho Moon, Yun Nah Lee, Hae Won Yoo, Jae Kook Yang, Sang-Woo Cha, Young Deok Cho & Sang-Heum Park
doi : 10.1007/s10620-021-07068-1
The detection of residual or fragmented common bile duct (CBD) stones after lithotripsy can be improved by the high-resolution imaging quality of digital, single-operator cholangioscopy (SOC). However, therapeutic interventions for the removal of residual CBD stones are limited by the lack of appropriate tools. We retrospectively evaluated the role of SOC and the newly developed Dormia basket for the evaluation and removal of stones remaining after lithotripsy.
Increased Morbidity and Mortality in COVID-19 Patients with Liver Injury
Mohammad Arsalan Siddiqui, Suraj Suresh, Stephen Simmer, Mouhanna Abu-Ghanimeh, Megan Karrick, Faisal Nimri, Maher Musleh, Vivek Mediratta, Mustafa Al
doi : 10.1007/s10620-021-07007-0
There is a high prevalence of liver injury (LI) in patients with coronavirus disease 2019 (COVID-19); however, few large-scale studies assessing risk factors and clinical outcomes in these patients have been done.
Comorbidities Are Associated with Fibrosis in NAFLD Subjects: A Nationwide Study (NASH-CO Study)
Oumarou Nabi, Jerome Boursier, Karine Lacombe, Philippe Mathurin, Victor de Ledinghen, Marcel Goldberg, Marie Zins & Lawrence Serfaty
doi : 10.1007/s10620-021-07032-z
The relationship between the severity of NAFLD and extra-hepatic events such as cardiovascular disease (CVD), extra-hepatic cancer (EHC) or chronic kidney diseases (CKD) has not been clearly investigated in the general population.
Patients with Autoimmune Hepatitis Report Lower Lifetime Coffee Consumption
Craig Lammert, Sai N. Chalasani, Kelsey Green, Elizabeth Atkinson, Bryan McCauley & Konstantinos N. Lazaridis
doi : 10.1007/s10620-021-06989-1
Coffee drinking has been associated with decreased risk of some autoimmune diseases as well liver disease and outcomes. Environmental factors, such as coffee consumption, are yet to be assessed among patients with autoimmune hepatitis (AIH).
Characteristics Associated with Monitoring and Treatment of Chronic Hepatitis B in a Large Cohort of Australian Adults
Wen-Qiang He, Gail V. Matthews & Bette Liu
doi : 10.1007/s10620-021-07008-z
Regular monitoring and treatment of chronic hepatitis B (CHB) are known to reduce the risk of hepatocellular carcinoma. We sought to describe patterns of monitoring and treatment among adults diagnosed with CHB in Australia.
Liver Fibrosis in the Natural Course of Chronic Hepatitis B Viral Infection: A Systematic Review with Meta-Analysis
Mei-Hong Lin, Hai-Qiong Li, Lin Zhu, Hai-Ying Su, Li-Shan Peng, Chuang-Yuan Wang, Cai-Ping He, Xie-Er Liang & Yan Wang
doi : 10.1007/s10620-021-07009-y
Quantitative data are limited on the natural course of liver fibrosis in patients with chronic HBV infection (CHB).
Diagnostic Value of FibroTouch and Non-invasive Fibrosis Indexes in Hepatic Fibrosis with Different Aetiologies
Xuebin Peng, Aiping Tian, Junfeng Li, Yongwu Mao, Ni Jiang, Ting Li & Xiaorong Mao
doi : 10.1007/s10620-021-07049-4
Liver biopsy is the gold standard for staging liver fibrosis, but it has numerous drawbacks, mainly associated with bleeding and bile fistula risks. A number of non-invasive techniques have been investigated, but they all have their own disadvantages. To avoid the risks mentioned above and to improve the diagnostic value, we still need to search for a more accurate non-invasive method to evaluate the degree of liver fibrosis.
Safety and Effectiveness of Tenofovir Alafenamide in Usual Clinical Practice Confirms Results of Clinical Trials: TARGET-HBV
David E. Bernstein, Huy N. Trinh, Eugene R. Schiff, Coleman I. Smith, Andrea R. Mospan, Richard C. Zink, Michael W. Fried & Anna S. Lok
doi : 10.1007/s10620-021-07033-y
Nucleos(t)ide analogues, with a proven record of safety and efficacy, have been the therapy of choice for over a decade for the treatment of chronic hepatitis B. The approval of tenofovir alafenamide (TAF) in 2016 provided an additional treatment option.
Prevalence of Latent Tuberculosis Infection Among Persons with Chronic Hepatitis B Virus Infection: A Systematic Review and Meta-Analysis
Jennie Chen, Ashley Hubbard, Laurie Bagley, Rita Shiau, Robert J. Wong & Amit S. Chitnis
doi : 10.1007/s10620-021-07056-5
Tuberculosis (TB) and chronic hepatitis B virus infection (HBV) can be prevented through latent tuberculosis infection (LTBI) treatment and HBV vaccination, respectively. Prevalence of LTBI and HBV are six- and ninefold higher among non-US-born compared to US-born persons, respectively. Few studies have described the prevalence of LTBI-HBV co-infection.
Cirrhotic Patients with Bacterial Infection and Negative Cultures Have a More Advanced Disease and an Increased Short-Term Mortality Rate
Gaia Caccamo, Maria Stella Franzè, Francesca Saffioti, Concetta Pitrone, Serena Porcari, Angela Alibrandi, Roberto Filomia, Placido Mondello, Irene Ca
doi : 10.1007/s10620-021-07047-6
The negative clinical impact of bacterial infections (BI) in patients with cirrhosis is well documented. In cirrhotic patients, failure to isolate the pathogen is a frequent event, occurring in 30–40% of cases.
High Neutrophil–Lymphocyte Ratio and Delta Neutrophil–Lymphocyte Ratio Are Associated with Increased Mortality in Patients with Hepatocellular Cancer
Nicole E. Rich, Aarthi Parvathaneni, Ahana Sen, Mobolaji Odewole, Ana Arroyo, Arjmand R. Mufti, Thomas A. Kerr, Lafaine Grant, Shannan R. Tujios, Marl
doi : 10.1007/s10620-021-07001-6
The neutrophil–lymphocyte ratio (NLR) has been proposed as a prognostic biomarker for cirrhosis and non-liver malignancies. We aimed to evaluate the prognostic value of NLR in a diverse cohort of patients with hepatocellular carcinoma (HCC).
Hepatocellular Carcinoma in Patients Without Cirrhosis: The Fibrosis Stage Distribution, Characteristics and Survival
Kanokwan Pinyopornpanish, Wael Al-Yaman, Srinivasan Dasarathy, Carlos Romero-Marrero & Arthur McCullough
doi : 10.1007/s10620-021-07048-5
The data on hepatocellular carcinoma (HCC) patients without liver cirrhosis is scarce.
Diabetic Hepatosclerosis in a Woman with Maturity-Onset Diabetes of the Young Type 3
Chau To, Li Liu, Rohit S. Satoskar & Paul J. Thuluvath
Correction to: Gastrointestinal Endoscopy‑Associated Infections: Update on an Emerging Issue
Anasua Deb, Abhilash Perisetti, Hemant Goyal, Mark M. Aloysius, Sonali Sachdeva, Dushyant Dahiya, Neil Sharma & Nirav Thosani
Correction to: Advances in Endoscopic Techniques and Technology: Old Problems, New Frontiers
Phillip S. Ge & Linda S. Lee
