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Enzyme-responsive smart nanocarriers for targeted chemotherapy: an overview
Hiral Kapalatiya, Yamini Madav, Varunesh Sanjay Tambe & Sarika Wairkar
doi : 10.1007/s13346-021-01020-6
Volume 12, issue 6, June 2022
Nanocarriers play pivotal roles in the field of biomedical applications, particularly in anticancer therapy. One of the prominent strategies for the transport of anticancer drugs with site-specific release and improved therapeutic efficacy is the use of an enzyme-responsive drug delivery system. There is an emerging class of cancer therapeutics engineered to control the release of a drug via enzymatic degradation. Enzymes, being an essential component of bio-nanotechnology toolbox, hold exceptional biorecognition abilities as well as outstanding catalytic properties. Often, abnormal enzyme expression observed in cancer offers many opportunities in designing nanocarriers modified with enzyme-labile linkage.
The combination of nanotechnology and traditional Chinese medicine (TCM) inspires the modernization of TCM: review on nanotechnology in TCM-based drug delivery systems
Yinghao Zheng, Yun Wang, Mengyu Xia, Ya Gao, Lan Zhang, Yanan Song & Cun Zhang
doi : 10.1007/s13346-021-01029-x
Drug Delivery and Translational Research volume 12, pages 1306–1325 (2022)
Fast development of combination of nanotechnology with traditional Chinese medicine (TCM) broadens the field of application of TCM. Besides, it increases the research ideas and contributes to TCM modernization. As expected, TCM will be developed into the nanodrug delivery system by nanotechnology with careful design, which will enhance the medicinal value of TCM to cure and prevent disease based on benefits brought by nanometer scale. Here, formulations, relevant preparations methods, and characteristics of nano-TCM were introduced. In addition, the main excellent performances of nano-TCM were clearly elaborated. What is more, the review was intended to address the studies committed to application of nanotechnology in TCM over the years, including development of Chinese medicine active ingredients, complete TCM, and Chinese herbal compounds based on nanotechnology. Finally, this review discussed the safety of nano-TCM and presented future development trends in the way to realize the modernization of TCM. Overall, using the emerging nanotechnology in TCM is promising to promote progress of TCM in international platform.
Natural medicine combined with nanobased topical delivery systems: a new strategy to treat psoriasis
Zhiyue Zhao, Tao Liu, Shan Zhu, Jiaxin Pi, Pan Guo, Dongli Qi, Zhidong Liu & Nan Li
doi : 10.1007/s13346-021-01031-3
Drug Delivery and Translational Research volume 12, pages 1326–1338 (2022)
Psoriasis, an autoimmune inflammatory skin disorder, is one of the commonest immune-mediated disease conditions affecting individuals globally. At the moment, the conventional methods applied against psoriasis treatment have various drawbacks involving limited efficacy, skin irritation, immunosuppression, etc. Therefore, it is important for scientists to find a more potent and alternative drug approach towards psoriasis therapeutics. Natural medicine still remains an important source for new drug discovery due to its therapeutical significance in various drug administration routes. However, the traditional formulation of topical therapies for psoriasis is limited in efficacy, which limits the use of natural medicine. Based on the aforementioned limitations, the use of nanocarriers in preparation of these topical herbal products could be tremendously beneficial in enhancing the efficacy of topical medications.
Co-delivery systems: hope for clinical application?
Sepideh Nezhadi & Farid Abedin Dorkoosh
doi : 10.1007/s13346-021-01041-1
Drug Delivery and Translational Research volume 12, pages 1339–1354 (2022)
Cancer is a multidimensional and challenging disease to handle. Current statistics reveal that we are far from satisfying cancer treatment. Taking advantage of different therapeutic agents that affect multiple pathways has been established as highly productive. Nevertheless, owing to several hindrances to conventional combination therapy, such as lack of tumor targeting, non-uniform pharmacokinetic of the combined drugs, and off-target side effects, it is well documented that this treatment approach is unlikely to address all the difficulties observed in monotherapy. Co-delivery systems could enhance the therapeutic efficacy of the combination therapy by targeting cancer cells and improving the pharmacokinetic and physicochemical properties of the therapeutic agents.
In vitro dissolution testing models of ocular implants for posterior segment drug delivery
Muhammad Faris Adrianto, Febri Annuryanti, Clive G. Wilson, Ravi Sheshala & Raghu Raj Singh Thakur
doi : 10.1007/s13346-021-01043-z
Drug Delivery and Translational Research volume 12, pages 1355–1375 (2022)
The delivery of drugs to the posterior segment of the eye remains a tremendously difficult task. Prolonged treatment in conventional intravitreal therapy requires injections that are administered frequently due to the rapid clearance of the drug molecules. As an alternative, intraocular implants can offer drug release for long-term therapy. However, one of the several challenges in developing intraocular implants is selecting an appropriate in vitro dissolution testing model. In order to determine the efficacy of ocular implants in drug release, multiple in vitro test models were emerging. While these in vitro models may be used to analyse drug release profiles, the findings may not predict in vivo retinal drug exposure as this is influenced by metabolic and physiological factors. This review considers various types of in vitro test methods used to test drug release of ocular implants. Importantly, it discusses the challenges and factors that must be considered in the development and testing of the implants in an in vitro setup.
Molecular perspective of efficiency and safety problems of chemical enhancers: bottlenecks and recent advances
Lijuan Zeng, Feifei Huang, Qin Zhang, Jianping Liu, Danyi Quan & Wenting Song
doi : 10.1007/s13346-021-01044-y
Drug Delivery and Translational Research volume 12, pages 1376–1394 (2022)
Chemical penetration enhancer (CPE) is a preferred approach to improve drug permeability through the skin, due to its unique advantages of simple use and high compatibility. However, CPEs efficiency and safety problems frequently arise, which greatly restrains the further application in transdermal drug delivery systems (TDDS). To get access to the root of problems, the efficiency and safety of CPEs are reviewed especially from molecular perspectives, which include (1) the possible factors of CPEs low efficiency; (2) the possible contribution of CPEs in the evolution of safety problems such as skin irritation and allergic reaction; (3) the interactive relationship between CPEs efficiency and safety, as well as the bottlenecks of achieving their balance. More importantly, based on these, recent advances are summarized in improving efficiency or safety of CPEs, which offers a guidance of rationally selecting CPEs in future research.
Should local drug delivery systems be used in dentistry?
Joana Vieira Costa, Jaime Portugal, Cristina Bettencourt Neves & Ana F. Bettencourt
doi : 10.1007/s13346-021-01053-x
Drug Delivery and Translational Research volume 12, pages 1395–1407 (2022)
In dentistry, the use of biomaterial-based drug delivery systems (DDS) aiming the release of the active compounds directly to the site of action is slowly getting more awareness among the scientific and medical community. Emerging technologies including nanotechnological platforms are offering novel approaches, but the majority are still in the proof-of-concept stage. This study critically reviews the potential use of DDS in anesthesiology, oral diseases, cariology, restorative dentistry, periodontics, endodontics, implantology, fixed and removable prosthodontics, and orthodontics with a special focus on infections. It also stresses the gaps and challenges faced.
Engineering of 2D nanomaterials to trap and kill SARS-CoV-2: a new insight from multi-microsecond atomistic simulations
Mohammad Khedri, Reza Maleki, Mohammad Dahri, Mohammad Moein Sadeghi, Sima Rezvantalab, Hélder A. Santos & Mohammad-Ali Shahbazi
doi : 10.1007/s13346-021-01054-w
Drug Delivery and Translational Research volume 12, pages 1408–1422 (2022)
In late 2019, coronavirus disease 2019 (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Spike protein is one of the surface proteins of SARS-CoV-2 that is essential for its infectious function. Therefore, it received lots of attention for the preparation of antiviral drugs, vaccines, and diagnostic tools. In the current study, we use computational methods of chemistry and biology to study the interaction between spike protein and its receptor in the body, angiotensin-I-converting enzyme-2 (ACE2).
Simvastatin-loaded nano-niosomes confer cardioprotection against myocardial ischemia/reperfusion injury
Maryam Naseroleslami, Neda Mousavi Niri, Iman Akbarzade, Masoomeh Sharifi & Nahid Aboutaleb
doi : 10.1007/s13346-021-01019-z
Drug Delivery and Translational Research volume 12, pages 1423–1432 (2022)
Although simvastatin (SIM) has been proven to be a powerful agent against myocardial ischemia/reperfusion (MI/R) injury, poor water solubility, short half-life, and low bioavailability have made it futile while using conventional drug delivery system. Hence, this study aims to investigate therapeutic efficacy of SIM-loaded nano-niosomes on MI/R injury. Surface active agent film hydration method was used to synthesize nano-niosomes. The physicochemical properties of nano-niosomes were characterized using dynamic light scattering (DLS) and transmission electron microscopy (TEM). Moreover, niosomes were characterized in entrapment efficiency (EE) and releasing pattern. Male Wistar rats were assigned into five groups (sham, MI/R, SIM, nano-niosomes, and SIM-loaded nano-niosomes). To induce MI/R, left thoracotomy was performed along mid-axillary line.
Are lipid nanoparticles really superior? A holistic proof of concept study
Sabrina Wiemann & Cornelia M. Keck
doi : 10.1007/s13346-021-01021-5
Drug Delivery and Translational Research volume 12, pages 1433–1444 (2022)
Lipid nanoparticles are a successful carrier system for dermal drug delivery. They possess various beneficial properties, i.e., increased chemical stability for chemically labile compounds, increased dermal penetration of active compounds, or skin carrying properties after dermal application due to the formation of a so-called “invisible patch.� Despite manifold studies showing these properties individually, a study that investigates if one lipid nanoparticle formulation can really combine all the above-mentioned benefits at once is not yet available.
An evaluation of a novel nanoformulation of imatinib mesylate in a mouse model of lupus nephritis
Uma Fogueri, Georgia Charkoftaki, Gavriel Roda, Stacey Tuey, Mustafa Ibrahim, Indushekhar Persaud, Michael F. Wempe, Jared M. Brown, Joshua M. Thurman
doi : 10.1007/s13346-021-01022-4
Drug Delivery and Translational Research volume 12, pages 1445–1454 (2022)
Studies have suggested imatinib mesylate (ImM) as a potential treatment for systemic lupus erythematosus nephritis (SLEN). However, ImM has limited renal excretion. The goal of the current research was to develop an ImM containing nanoformulation, conduct studies to evaluate pharmacokinetics, and determine whether kidney deposition can be enhanced in a mouse model of SLEN. A fish oil–based ImM oil-in-water nanoemulsion was developed and characterized for particle size, zeta potential, pH, and stability. MRL/MpJ-Faslrp (model of SLEN) and MRL/MpJ (control) mice (12–13 weeks) received one dose of ImM as either a nanoemulsion or naked drug. Pharmacokinetics and kidney deposition studies were performed.
Development of a novel nanoemulgel formulation containing cumin essential oil as skin permeation enhancer
Katayoun Morteza-Semnani, Majid Saeedi, Jafar Akbari, Mohammad Eghbali, Amirhossein Babaei, Seyyed Mohammad Hassan Hashemi & Ali Nokhodchi
doi : 10.1007/s13346-021-01025-1
Drug Delivery and Translational Research volume 12, pages 1455–1465 (2022)
Essential oils have been proposed as promising non-toxic transdermal permeation enhancers. Their use is limited because of their low water solubility. The use of nanotechnology-based strategies is one of the ways to overcome this limitation. This study aimed to explore the transdermal permeation enhancing capability of cumin essential oil in nanoemulgel systems containing diclofenac sodium. Cumin essential oil nanoemulsion was produced by high-pressure homogenization technique. The formulation was optimized by changing HLB values in a range of 9.65–16.7 using different surfactant mixtures, namely, Tween 20, Tween 80, and Span 80. Preparations were characterized by polydispersity index, droplet size, and zeta potential.
Pressure pulsations enhance penetration index in COPD
Noam Gavriely, Olga Volkov, Gershon Fink, Isaac Shpirer & Haim Golan
doi : 10.1007/s13346-021-01027-z
Drug Delivery and Translational Research volume 12, pages 1466–1474 (2022)
This study was done in order to evaluate the effect of a novel pressure pulsation device (Pulsehaler™, Respinova Ltd., Israel) on the deposition pattern of inhaled aerosol in the lungs of COPD patients. Fifteen COPD patients were recruited to undergo spirometry and SPECT-CT lung scan following nebulization of radioactively labeled albuterol in saline solution with a jet nebulizer (“NEB�) and with a combined Pulsehaler™/jet nebulizer (“PH + NEB�) treatment. Central and peripheral segments of the coronal and transverse SPECT scans were evaluated for total counts and for the ratios between peripheral counts and central counts (penetration Index, “PI�).
Low efficiency of leucocyte plugging-based drug delivery to cancer in mice
Baifeng Qian, Andreas Termer, Christof M. Sommer, Arianeb Mehrabi & Eduard Ryschich
doi : 10.1007/s13346-021-01028-y
Drug Delivery and Translational Research volume 12, pages 1475–1487 (2022)
Cells of the immune system were proposed for use as Trojan horse for tumour-specific drug delivery. The efficacy of such cell-based drug delivery depends on the site-specific cell homing. This present study was aimed to investigate the potential of leucocytes for intratumoural site-specific enrichment using a locoregional application route in experimental liver tumours. Human neutrophils were isolated from peripheral blood and directly labelled with calcein AM or loaded with doxorubicin. The neutrophil loading and release of doxorubicin and the migration and adhesion to ICAM-1 were analysed in vitro. Macrophages were isolated and activated in vitro.
Design of ophthalmic micelles loaded with diclofenac sodium: effect of chitosan and temperature on the block-copolymer micellization behaviour
Sarra Aicha Koummich, Ikram Mustapha Zoukh, Filip Gorachinov, Nikola Geskovski, Petre Makreski, Marija Glavas Dodov & Katerina Goracinova
doi : 10.1007/s13346-021-01030-4
Drug Delivery and Translational Research volume 12, pages 1488–1507 (2022)
Diclofenac sodium 0.1% is a commonly used NSAID with well-documented clinical efficacy in reducing postoperative inflammation; however, its corneal tolerability and ophthalmic tissue bioavailability require further improvement. Advanced micellar delivery systems composed of block-copolymers and chitosan showing fine balance between the mucoadhesion and mucus permeation, capable to slip through the mucus barrier and adhere to the epithelial ocular surface, may be used to tackle both challenges. The aggregation behaviour of the block-copolymers in the presence of different additives will dramatically influence the quality attributes like particle size, particle size distribution, drug-polymer interaction, zeta potential, drug incorporation, important for the delicate balance among mucoadhesion and permeation, as well as safety and efficacy of the ophthalmic micelles.
A novel method for the development of plasmid DNA-loaded nanoliposomes for cancer gene therapy
Behzad Baradaran, Ali Mohammadi, Sara Shamekhi, Nikoo Majidazar, Azita Dilmaghani, Saiedeh Razi Soofiyani, Nigel AJ McMillan, Farzaneh Lotfipour & Som
doi : 10.1007/s13346-021-01034-0
Drug Delivery and Translational Research volume 12, pages 1508–1520 (2022)
We aimed to develop a simple yet novel method to prepare plasmid DNA-loaded nanoliposomes for cancer gene therapy. Murine interleukin-12 (mIL-12) pDNA-loaded nanoliposomes were prepared via novel freeze-drying of a monophase solution method. The physicochemical characteristics, cytotoxicity, and transfection efficiency of the prepared nanoliposomes in murine CT-26 colon carcinoma cells were evaluated. Furthermore, tumor progression and survival rate in CT-26 colon carcinoma-bearing BALB/c mice subsequent to direct intratumoral injections were investigated over a period of 40 days. Using this preparation method, nanoliposomes with particle size of around 300 nm and zeta potential of 96.5 mV were obtained. The transmission electron microscope results showed that the liposomes were nano-sized and almost spherical.
QbD enabled optimization of solvent shifting method for fabrication of PLGA-based nanoparticles for promising delivery of Capecitabine for antitumor activity
Goutam Kumar Jena, Ch Niranjan Patra, Kahnu Charan Panigrahi, Jammula Sruti, Parameswar Patra & Rabinarayan Parhi
doi : 10.1007/s13346-021-01042-0
Drug Delivery and Translational Research volume 12, pages 1521–1539 (2022)
The key objective of the current research was to fabricate and optimize Capecitabine (Cap)-loaded [poly(lactic-co-glycolic acid)] PLGA-based nanoparticles (NPs) by enabling quality by design (QbD) approach for enhancing antitumor activity by promising delivery of the drug at the colonic site. The current research was based on fabricating PLGA-based nanoparticles along with Eudragit S100 as enteric polymer employing solvent shifting method followed by optimization using QbD approach. This approach was found to be useful for understanding the multiple factors and their interaction influencing the product by utilizing Design of Experiment (DOE).
Correction to: Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting
Ruchika Goyal, Gaurav Jerath, Aneesh Chandrasekharan, Yvonne Christian, T. R. Santhosh Kumar & Vibin Ramakrishnan
doi : 10.1007/s13346-021-01051-z
Drug Delivery and Translational Research volume 12, page 1540 (2022)
