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A comprehensive review on possibilities of treating psoriasis using dermal cyclosporine
Sonia Pandey, Purnima Tripathi, Arti Gupta & Jitendra Singh Yadav
doi : 10.1007/s13346-021-01059-5
Volume 12, issue 7, July 2022
Psoriasis is an autoimmune, chronic proliferative, inflammatory skin disease with high comorbidity. Psoriasis is not a curable disease; it can only be managed. Cyclosporine A (CyA) is one of the FDA-approved immunosuppressant drug used in severe Psoriasis. Till date only oral route is used for its administration. Administration of CyA by this route causes serious side effects such as hypertension and renal toxicity. Due to these side effects, a number of researches have been done and taking place in the current times for the dermal delivery of CyA for the management of psoriasis.
Advances in microneedle-based transdermal delivery for drugs and peptides
Krishanu Aich, Tanya Singh & Shweta Dang
doi : 10.1007/s13346-021-01056-8
Drug Delivery and Translational Research volume 12, pages 1556–1568 (2022)
Transdermal drug delivery is a viable and clinically proven route of administration. This route specifically requires overcoming the mechanical barrier provided by the Stratum Corneum of epidermis and vascular and nervous networks within the dermis. First-generation Transdermal patches and second-generation iontophoretic patches have been translated into commercial clinical products successfully. The current review reports different studies that aim to enhance the transdermal delivery of biopharmaceutical using microneedles and their effect on drug delivery.
A review on multivesicular liposomes for pharmaceutical applications: preparation, characterization, and translational challenges
Akash Chaurasiya, Amruta Gorajiya, Kanan Panchal, Sumeet Katke & Ajeet Kumar Singh
doi : 10.1007/s13346-021-01060-y
Drug Delivery and Translational Research volume 12, pages 1569–1587 (2022)
Multivesicular liposomes (MVLs) are non-concentric, lipid-based micron-sized spherical particles. The usage of MVL for sustained drug delivery has seen progression over the last decade due to successful clinical and commercial applications. It provides attractive characteristics, such as high encapsulation efficiency, variety of sizes, structural stability, and different choices for the route of administration. Drug molecules are encapsulated in internal aqueous compartments of MVL, separated by lipid bilayer septa to form polyhedral structures. The integrity of these entrapped small molecules, peptides, or proteins is maintained throughout the therapy, thus providing sustained drug release on non-vascular administration. Despite the frequent use of unilamellar liposomes, characterization of MVLs is critical due to different puzzling problems, such as real-time size evaluation, initial burst, and in vivo performance.
Polymeric magnetic nanoparticles: a multitargeting approach for brain tumour therapy and imaging
Bhavana Joshi & Abhijeet Joshi
doi : 10.1007/s13346-021-01063-9
Drug Delivery and Translational Research volume 12, pages 1588–1604 (2022)
The most challenging task in targeting the brain is trespassing the blood–brain barrier (BBB) which restricts the movement of about 98% small molecules. Targeting the central nervous system using magnetic nanoparticles may deliver the drug to the target site along with a contrast imaging property. The use of magnetic nanoparticles can become non-invasive drug targeting and a bio-imaging method for brain cancer.
An overview on tumor treating fields (TTFields) technology as a new potential subsidiary biophysical treatment for COVID-19
Ahmad Reza Farmani, Forough Mahdavinezhad, Carolina Scagnolari, Mahsa Kouhestani, Sadegh Mohammadi, Jafar Ai, Mohammad Hasan Shoormeij & Nima Rezaei
doi : 10.1007/s13346-021-01067-5
Drug Delivery and Translational Research volume 12, pages 1605–1615 (2022)
COVID-19 pandemic situation has affected millions of people with tens of thousands of deaths worldwide. Despite all efforts for finding drugs or vaccines, the key role for the survival of patients is still related to the immune system. Therefore, improving the efficacy and the functionality of the immune system of COVID-19 patients is very crucial. The potential new, non-invasive, FDA-approved biophysical technology that could be considered in this regard is tumor treating fields (TTFields) based on an alternating electric field has great biological effects. TTFields have significant effects in improving the functionality of dendritic cell, and cytotoxic T-cells, and these cells have a major role in defense against viral infection.
Lipid-based emulsion drug delivery systems — a comprehensive review
Mori Dhaval, Poonam Vaghela, Kajal Patel, Keshvi Sojitra, Mohini Patel, Sushma Patel, Kiran Dudhat, Sunny Shah, Ravi Manek & Ramesh Parmar
doi : 10.1007/s13346-021-01071-9
Drug Delivery and Translational Research volume 12, pages 1616–1639 (2022)
Lipid-based emulsion system — a subcategory of emulsion technology, has emerged as an enticing option to improve the solubility of the steadily rising water-insoluble candidates. Along with enhancing solubility, additional advantages such as improvement in permeability, protection against pre-systemic metabolism, ease of manufacturing, and easy to scale-up have made lipid-based emulsion technology very popular among academicians and manufacturers. The present article provides a comprehensive review regarding various critical properties of lipid-based emulsion systems, such as microemulsion, nanoemulsion, SMEDDS (self microemulsifying drug delivery system), and SNEDDS (self nanoemulsifying drug delivery system).
Appraisal of fluoroquinolone-loaded carubinose-linked hybrid nanoparticles for glycotargeting to alveolar macrophages
Priyanka Maurya, Ravi Saklani, Samipta Singh, Raquibun Nisha, Ravi Raj Pal, Nidhi Mishra, Priya Singh, Abhiram Kumar, Manish K. Chourasia & Shubhini A
doi : 10.1007/s13346-021-01055-9
Drug Delivery and Translational Research volume 12, pages 1640–1658 (2022)
There is a curious case in Alveolar macrophages (AM), the frontline defence recruits that contain the spread of all intruding bacteria. In response to Mycobacterium tuberculosis (M.tb), AM either contain the spread or are modulated by M.tb to create a region for their replication. The M.tb containing granulomas so formed are organised structures with confined boundaries. The limited availability of drugs inside AM aid drug tolerance and poor therapeutic outcomes in diseases like tuberculosis. The present work proves the glycotargeting efficiency of levofloxacin (LVF) to AM. The optimised formulation developed displayed good safety with 2% hemolysis and a viability of 61.14% on J774A.1 cells.
In vitro release, ex vivo penetration, and in vivo dermatokinetics of ketoconazole-loaded solid lipid nanoparticles for topical delivery
Mohhammad Ramzan, Samuel Gourion-Arsiquaud, Afzal Hussain, Jaspreet Singh Gulati, Qihong Zhang, Sonia Trehan, Vinam Puri, Bozena Michniak-Kohn & Indu
doi : 10.1007/s13346-021-01058-6
Drug Delivery and Translational Research volume 12, pages 1659–1683 (2022)
The study focused to evaluate and investigate optimized (using QbD) and novel ketoconazole (KTZ)-loaded solid lipid nanoparticles (KTZ-SLNs; 2% w/v KTZ) for enhanced permeation across skin. KTZ-SLNs were evaluated for size, distribution, zeta potential (ZP), percent entrapment efficiency (%EE), drug release, morphology (HRTEM and FESEM), thermal behaviour (DSC), spectroscopic (FTIR), and solid-state/diffraction characterization (X-ray diffraction, XRD). Moreover, ex vivo permeation and drug deposition into rat skin were conducted using Franz diffusion cell. The same was confirmed using human dermatome skin and fluorescence, confocal Raman, and vibrational ATR-FTIR microscopic methods.
The MEK 1/2 inhibitor PD98059 exhibits synergistic anti-endometrial cancer activity with paclitaxel in vitro and enhanced tissue distribution in vivo when formulated into PAMAM-coated PLGA-PEG nanoparticles
Kanawat Wiwatchaitawee, Aml I. Mekkawy, Juliana C. Quarterman, Youssef W. Naguib, Kareem Ebeid, Sean M. Geary & Aliasger K. Salem
doi : 10.1007/s13346-021-01065-7
Drug Delivery and Translational Research volume 12, pages 1684–1696 (2022)
Endometrial cancer is the most common gynecological cancer that affects the female reproductive organs. The standard therapy for EC for the past two decades has been chemotherapy and/or radiotherapy. PD98059 is a reversible MEK inhibitor that was found in these studies to increase the cytotoxicity of paclitaxel (PTX) against human endometrial cancer cells (Hec50co) in a synergistic and dose-dependent manner. Additionally, while PD98059 arrested Hec50co cells at the G0/G1 phase, and PTX increased accumulation of cells at the G2/M phase, the combination treatment increased accumulation at both the G0/G1 and G2/M phases at low PTX concentrations.
A numerical study of the distribution of chemotherapeutic drug carmustine in brain glioblastoma
Hongyu Chen, Guanghui Hu & Defang Ouyang
doi : 10.1007/s13346-021-01068-4
Drug Delivery and Translational Research volume 12, pages 1697–1710 (2022)
To cure the illness in the brain glioblastoma, the Gliadel wafer, as the first FDA-approved chemotherapy, was available on the market since 1997. Due to the complex studies in vivo, more and more researchers have paid their attention to investigate the dynamic process in the brain by numerical methods. This study aimed to simulate the drug concentration in the cavity after drug releases from Gliadel wafers into the brain tumor by a two-dimensional simulation. The government equations, the parameters, and corresponding initial and boundary conditions are specified.
A pharmacological approach assessing the role of mast cells in insulin infusion site inflammation
Shereen Kesserwan, Li Mao, Roshanak Sharafieh, Donald L. Kreutzer & Ulrike Klueh
doi : 10.1007/s13346-021-01070-w
Drug Delivery and Translational Research volume 12, pages 1711–1718 (2022)
Background Extending the lifespan of subcutaneous insulin administration sets and infusion pumps requires overcoming unreliable insulin delivery induced by dermal reactions. All commercially available insulin formulations contain insulin phenolic preservatives (IPP), which stabilize the insulin molecule but result in unwanted cell and tissue toxicity. Mast cells, which are the first line of defense once the epithelium is breached, are particularly abundant beneath the skin surface. Thus, we hypothesize a sequence of events initiated by device insertion that activates skin mast cells (MC) that subsequently trigger neutrophil and monocyte/macrophage recruitment.
Preclinical assessment of nanostructured liquid crystalline particles for the management of bacterial keratitis: in vivo and pharmacokinetics study
Shreya Kaul, Upendra Nagaich & Navneet Verma
doi : 10.1007/s13346-021-01072-8
Drug Delivery and Translational Research volume 12, pages 1719–1737 (2022)
The research work was driven to develop, optimize, and characterize novel nanostructured liquid crystalline particles as carriers for the ocular delivery of vancomycin. The formulations were developed by fragmenting the cubic crystalline phase of glycerol monooleate, water, and poloxamer 407. A four-factor, three-level Taguchi statistical experimental design was constructed to optimize the formulation. Formulations exhibited internal-cubic structure of the vesicles with particle size in the range of 51.11 ± 0.96 nm to 158.73 ± 0.46 nm and negative zeta potential.
Liposomal formulations of oxybutynin and resiniferatoxin for the treatment of urinary diseases: improvement of drug tolerance upon intravesical
Lorena M. D. Cirino, Daviane M. C. Vergne, Gabrielle B. Novais, Amanda Cano, Francine F. Padilha, Patr?cia Severino, Ricardo L. C. de Albuquerque J?ni
doi : 10.1007/s13346-021-01082-6
Drug Delivery and Translational Research volume 12, pages 1738–1752 (2022)
The use of liposomes for drug release has demonstrated to be a promising therapeutic platform for biomedical applications. In this study, intravesical administration of OXI (1.5Â mM) and RTX (100Â nM) was used to compare histological changes caused in Wistar female rats by the drugs both unloaded and loaded in liposomes. After instillation of formulations by intravesical catheter, bladders were removed and histological analysis carried out at pre-determined time intervals over a period of 60Â days. Urinalysis was performed to verify the presence of infection and of liposomes.
Development of ritonavir-loaded nanostructured lipid carriers employing quality by design (QbD) as a tool: characterizations, permeability, and bioavailability studies
Vishal C. Gurumukhi & Sanjaykumar B. Bari
doi : 10.1007/s13346-021-01083-5
Drug Delivery and Translational Research volume 12, pages 1753–1773 (2022)
The objective of the present work was to optimize ritonavir (RTV)-loaded nanostructured lipid carriers (NLCs) to improve bioavailability using a quality by design (QbD)-based technique. Risk assessment was studied using “cause and effect� diagram followed by failure mode effect analysis (FMEA) to identify the effective high-risk variables for the formulation development. Quality target product profile (QTPP) and critical quality attributes (CQAs) were initially assigned for the proposed product. Central composite rotatable design (CCRD) was used to identify the individual and combined interactions of formulation variables. RTV-loaded NLC (RTV-NLC) was prepared using emulsification-ultrasonication method.
Hybridization of tumor homing and mitochondria-targeting peptide domains to design novel dual-imaging self-assembled peptide nanoparticles for theranostic applications
Syed Faheem Askari Rizvi, Samiah Shahid, Shuai Mu & Haixia Zhang
doi : 10.1007/s13346-021-01066-6
Drug Delivery and Translational Research volume 12, pages 1774–1785 (2022)
A novel hybridized dual-targeting peptide-based nanoprobe was successfully designed by using the cyclic heptapeptide. This peptide has Arg-Gly-Asp-Lys-Leu-Ala-Lys sequence, in which the RGD homing motif and KALK mitochondria-targeting motif were linked via amide bond. The designed peptide probe was further modified through covalent linkage to induce dual-imaging functionality, and self-assembled to form spherical nanoparticles. The novel Cy5.5-SAPD-99mTc nanoparticles were tested for in vitro cytotoxicity, cellular uptake, and apoptosis-inducing functionalities. The cellular internalization, enhanced cytotoxicity and selective receptor binding capabilities against U87MG cells, excellent dual-imaging potential, improved apoptosis-inducing feature by damaging mitochondria, and in vivo preclinical investigations suggested that our newly designed novel hybridized peptide-based dual-imaging nanoparticles may serve as an admirable theranostic probe to treat brain tumor glioblastoma multiforme.
