Michael J.MackMDaJoAnnLindenfeldMDbWilliam T.AbrahamMDcSaibalKarMDdeD. ScottLimMDfJacob M.MishellMDgBrian K.WhisenantMDhPaul A.GrayburnMDiMichael J.RinaldiMDjSamir R.KapadiaMDkVivekRajagopalMDlIan J.SarembockMBChB, MDmAndreasBriekeMDnJason H.RogersMDoSteven O.MarxMDpDavid J.CohenMD, MScqNeil J.WeissmanMDrsGregg W.StoneMDtCOAPT Investigators
doi : 10.1016/j.jacc.2020.12.047
Volume 77, Issue 8, 2 March 2021, Pages 1029-1040
In the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial, transcatheter mitral valve repair (TMVr) resulted in fewer heart failure hospitalizations (HFHs) and lower mortality at 24 months in patients with heart failure (HF) with mitral regurgitation (MR) secondary to left ventricular dysfunction compared with guideline-directed medical therapy (GDMT) alone.
Jeremiah P.DeptaMD, MPHSaDeepak L.BhattMD, MPHb
doi : 10.1016/j.jacc.2021.01.001
Volume 77, Issue 8, 2 March 2021, Pages 1041-1043
Klaus F.KofoedMD, DmScabThomasEngstr?mMD, DmScaPer E.SigvardsenMDaJesper J.LindeMD, PhDaChristianTorp-PedersenMD, DmSccMartinade KnegtMD, PhDaPeter R.HansenMD, DmSccThomasFritz-HansenMD, PhDcJanBechMD, PhDdMereteHeitmannMD, PhDdOlav W.NielsenMD, DmScdDanH?fstenMD, PhDaJ?rgen T.KühlMD, DmSceIlan E.RaymondMD, PhDeOle P.KristiansenMD, DmScdIda H.SvendsenMD, PhDdM.H.Dom?nguez Vall-LamoraMD, PhDdCharlotteKragelundMD, PhDc…Lars V.K?berMD, DmSca
doi : 10.1016/j.jacc.2020.12.037
Volume 77, Issue 8, 2 March 2021, Pages 1044-1052
Severity and extent of coronary artery disease (CAD) assessed by invasive coronary angiography (ICA) guide treatment and may predict clinical outcome in patients with non–ST-segment elevation acute coronary syndrome (NSTEACS).
Michelle C.WilliamsMBChB, PhDabMarc R.DweckMBChB, PhDaDavid E.NewbyBM, PhDab
doi : 10.1016/j.jacc.2020.12.050
Volume 77, Issue 8, 2 March 2021, Pages 1053-1056
Malamo E.CountourisMDaFlordeliza S.VillanuevaMDaKathryn L.BerlacherMD, MSaJo?o L.CavalcanteMDbW. TonyParksMDcJanet M.CatovPhD, MSd
doi : 10.1016/j.jacc.2020.12.051
Volume 77, Issue 8, 2 March 2021, Pages 1057-1068
Hypertensive disorders of pregnancy (HDP) are associated with short-term cardiac structure and function abnormalities, but later life changes are not well studied.
Melinda B.DavisMD
doi : 10.1016/j.jacc.2021.01.006
Volume 77, Issue 8, 2 March 2021, Pages 1069-1072
GentaroIkedaMD, PhDaMichelle R.SantosoBSaYukoTadaMD, PhDaAlbert M.LiABbEvgeniyaVaskovaPhDaJi-HyeJungPhDaConnorO’BrienMDaElizabethEganMD, PhDcJiangbinYePhDbPhillip C.YangMDa
doi : 10.1016/j.jacc.2020.12.060
Volume 77, Issue 8, 2 March 2021, Pages 1073-1088
Mitochondrial dysfunction results in an imbalance between energy supply and demand in a failing heart. An innovative therapy that targets the intracellular bioenergetics directly through mitochondria transfer may be necessary.
BorjaIb??ezMD, PhDabcRocioVillena-GutierrezBSca
doi : 10.1016/j.jacc.2021.01.017
Volume 77, Issue 8, 2 March 2021, Pages 1089-1092
Bryan H.GoldsteinMDabcdChristopher J.PetitMDeAthar M.QureshiMDfgCourtney E.McCrackenPhDeMichael S.KellemanMS, MSPHeGeorge T.NicholsonMDhMark A.LawMDiJeffery J.MeadowsMDjJeffrey D.ZampiMDkShabanaShahanavazMDlChristopher E.MascioMDmnPaul J.ChaiMDeJennifer C.RomanoMDkSarosh P.BatlivalaMDcdShiraz A.MaskatiaMDopIvor B.AsztalosMD, MSCEmnAlicia M.KamshehMDmnSteven J.HealanMD, MSCIhJustin D.SmithMDkR. AllenLigonMDeJoelle A.PettusMPH, MSeSarinaJumaMPHeJames E.B.RaulstonMDiKrissie M.HockMSN, RN, CNLiAmy L.PajkMBAcdLindsay F.EilersMDfgHala Q.KhanBSfgTaylor C.MerrittRN, BSNlMatthewCanterMETlStephanJuergensenMDjFatuma-AyaanRinderknechtBAjHollyBauser-HeatonMD, PhDeAndrew C.GlatzMD, MSCEmnq
doi : 10.1016/j.jacc.2020.12.048
Volume 77, Issue 8, 2 March 2021, Pages 1093-1106
Neonates with tetralogy of Fallot and symptomatic cyanosis (sTOF) require early intervention.
Christoph P.HornikMD, PhD, MPH
doi : 10.1016/j.jacc.2020.12.043
Volume 77, Issue 8, 2 March 2021, Pages 1107-1109
ShylaGuptaaNaomiGazendamaJuan Mar?aFarinaMDbClaraSaldarriagaMDcIvanMendozaMDdRicardoL?pez-SantiMDeGonzalo EmanuelPérezMDbManuelMart?nez-SellésMDfAdrianBaranchukMDa
doi : 10.1016/j.jacc.2020.12.042
Volume 77, Issue 8, 2 March 2021, Pages 1110-1121
As one of the tropical diseases, malaria is endemic in developing countries. Severe malaria, mainly caused by the Plasmodium falciparum parasite, can result in life-threatening complications. Traditionally, cardiac involvement has not been included as a frequent cause of morbidity and mortality. This could be due to under-reporting or underdiagnosing. Specific cardiovascular (CV) complications include electrocardiogram abnormalities, myocarditis, pericarditis, pericardial effusion, ischemic disease, and heart failure. According to the data analyzed, CV manifestations can lead to severe consequences. Possible theories related to the pathophysiological mechanisms related to CV compromise include an imbalanced pro-inflammatory cytokine response and/or erythrocyte sequestration by increased cytoadherence to endothelium. Although there is a paucity of data regarding cardiac manifestations of malaria, an algorithm for appropriate use of diagnostic tools to assess cardiac involvement has been developed in this paper. Furthermore, it is important to note that typical antimalarial treatment regimens can have fatal cardiac side-effects.
VigyanBangMDa?SarjuGanatraMDa?Sachin P.ShahMDaSourbha S.DaniMDaTomas G.NeilanMD, MPHbPaaladineshThavendiranathanMD, SMcFrederic S.ResnicMDaThomas C.PiemonteMDaAnaBaracMDdRushinPatelMBBSaAjaySharmaMDaRohanParikhMDaGhulam M.ChaudhryMDaMarkVeselyMDeSalim S.HayekMDfMonikaLejafDavidVenesyMDaRichardPattenMDaDanielLenihanMDgAnjuNohriaMDhLeslie T.CooperMDi
doi : 10.1016/j.jacc.2020.11.074
Volume 77, Issue 8, 2 March 2021, Pages 1122-1134
Giant cell myocarditis is a rare, often rapidly progressive and potentially fatal, disease due to T-cell lymphocyte-mediated inflammation of the myocardium that typically affects young and middle-aged adults. Frequently, the disease course is marked by acute heart failure, cardiogenic shock, intractable ventricular arrhythmias, and/or heart block. Diagnosis is often difficult due to its varied clinical presentation and overlap with other cardiovascular conditions. Although cardiac biomarkers and multimodality imaging are often used as initial diagnostic tests, endomyocardial biopsy is required for definitive diagnosis. Combination immunosuppressive therapy, along with guideline-directed medical therapy, has led to a paradigm shift in the management of giant cell myocarditis resulting in an improvement in overall and transplant-free survival. Early diagnosis and prompt management can decrease the risk of transplantation or death, which remain common in patients who present with cardiogenic shock.
Emily S.LauMDaSharonne N.HayesMDbAnnabelle SantosVolgmanMDcKathrynLindleyMDdCarl J.PepineMDeMalissa J.WoodMDaAmerican College of Cardiology Cardiovascular Disease in Women Section
doi : 10.1016/j.jacc.2020.12.031
Volume 77, Issue 8, 2 March 2021, Pages 1135-1138
ValentinFusterMD, PhD
doi : 10.1016/j.jacc.2021.01.022
Volume 77, Issue 8, 2 March 2021, Pages 1139-1140
JianhuaWuPhDMamas A.MamasDPhilMark A.de BelderMDJohn E.DeanfieldPhDChris P.GalePhD
doi : 10.1016/j.jacc.2020.12.039
Volume 77, Issue 8, 2 March 2021, Pages 1141-1143
LeonardoCal?MDRobertaDella BonaMD, PhDAnnamariaMartinoMD, PhDCinziaCrescenziMDGermanaPanattoniMD, PhDGiuliad’AmatiMD, PhDFiorenzoGaitaMDRuggieroMangoMD, PhDLuigiSciarraMDMikaelLaredoMD, MSc
doi : 10.1016/j.jacc.2020.12.033
Volume 77, Issue 8, 2 March 2021, Pages 1143-1145
NishitaSinghMDJohannaOspelMDMayankGoyalMD, PhD
doi : 10.1016/j.jacc.2020.11.075
Volume 77, Issue 8, 2 March 2021, Pages 1145-1146
GeorgiosBenetosMDMariaDrakopoulouMDGeorgiosOikonomouMDKonstantinosTsioufisMDKonstantinosToutouzasMD
doi : 10.1016/j.jacc.2020.11.076
Volume 77, Issue 8, 2 March 2021, Pages 1146-1147
AnnaKopczakMDAndreasSchindlerMDMartinDichgansMDTobiasSaamMD
doi : 10.1016/j.jacc.2020.12.038
Volume 77, Issue 8, 2 March 2021, Pages 1147-1148
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