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Synovial fibroblasts as potential drug targets in rheumatoid arthritis, where do we stand and where shall we go?
Tamás Németh, György Nagy, Thomas Pap
doi : 10.1136/annrheumdis-2021-222021
August 2022 - Volume 81 - 8
2022 EULAR points to consider for remote care in rheumatic and musculoskeletal diseases
Annette de Thurah, Philipp Bosch, Andrea Marques, Yvette Meissner, Chetan B Mukhtyar, Johannes Knitza, Aurélie Najm, Nina Østerås, Tim Pelle, Line Raunsbæk Knudsen, Hana Šmucrová, Francis Berenbaum, Meghna Jani, Rinie Geenen, Martin Krusche, Polina Pchelnikova, Savia de Souza, Sara Badreh, Dieter Wiek, Silvia Piantoni, James M Gwinnutt, Christina Duftner, Helena M Canhão, Luca Quartuccio, Nikolay Stoilov, Yeliz Prior, Johannes WJ Bijlsma, Alen Zabotti, Tanja A Stamm, Christian Dejaco
Learning from chess engines: how reinforcement learning could redefine clinical decision-making in rheumatology
Thomas Hügle
Safety and efficacy of the miR-124 upregulator ABX464 (obefazimod, 50 and 100 mg per day) in patients with active rheumatoid arthritis and inadequate response to methotrexate and/or anti-TNFα therapy: a placebo-controlled phase II study
Claire Daien, Marek Krogulec, Paul Gineste, Jean-Marc Steens, Laurence Desroys du Roure, Sophie Biguenet, Didier Scherrer, Julien Santo, Hartmut Ehrlich, Patrick Durez
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset
Saedis Saevarsdottir, Lilja Stefansdottir, Patrick Sulem, Gudmar Thorleifsson, Egil Ferkingstad, Gudrun Rutsdottir, Bente Glintborg, Helga Westerlind, Gerdur Grondal, Isabella C Loft, Signe Bek Sorensen, Benedicte A Lie, Mikael Brink, Lisbeth Ärlestig, Asgeir Orn Arnthorsson, Eva Baecklund, Karina Banasik, Steffen Bank, Lena I Bjorkman, Torkell Ellingsen, Christian Erikstrup, Oleksandr Frei, Inger Gjertsson, Daniel F Gudbjartsson, Sigurjon A Gudjonsson, Gisli H Halldorsson, Oliver Hendricks, Jan Hillert, Estrid Hogdall, Søren Jacobsen, Dorte Vendelbo Jensen, Helgi Jonsson, Alf Kastbom, Ingrid Kockum, Salome Kristensen, Helga Kristjansdottir, Margit H Larsen, Asta Linauskas, Ellen-Margrethe Hauge, Anne G Loft, Bjorn R Ludviksson, Sigrun H Lund, Thorsteinn Markusson, Gisli Masson, Pall Melsted, Kristjan H S Moore, Heidi Munk, Kaspar R Nielsen, Gudmundur L Norddahl, Asmundur Oddsson, Thorunn A Olafsdottir, Pall I Olason, Tomas Olsson, Sisse Rye Ostrowski, Kim Hørslev-Petersen, Solvi Rognvaldsson, Helga Sanner, Gilad N Silberberg, Hreinn Stefansson, Erik Sørensen, Inge J Sørensen, Carl Turesson, Thomas Bergman, Lars Alfredsson, Tore K Kvien, Søren Brunak, Kristján Steinsson, Vibeke Andersen, Ole A Andreassen, Solbritt Rantapää-Dahlqvist, Merete Lund Hetland, Lars Klareskog, Johan Askling, Leonid Padyukov, Ole BV Pedersen, Unnur Thorsteinsdottir, Ingileif Jonsdottir, Kari Stefansson, Members of the DBDS Genomic Consortium, The Danish RA Genetics Working Group
Isolation of HLA-DR-naturally presented peptides identifies T-cell epitopes for rheumatoid arthritis
Jaxaira Maggi, Montserrat Carrascal, Lilian Soto, Oscar Neira, MarÃa C Cuéllar, Octavio Aravena, Eddie A James, Joaquin Abian, Dolores Jaraquemada, Diego Catalan, Juan C Aguillón
Deletion of activin A in mesenchymal but not myeloid cells ameliorates disease severity in experimental arthritis
Vanessa Waltereit-Kracke, Corinna Wehmeyer, Denise Beckmann, Eugenie Werbenko, Julia Reinhardt, Fabienne Geers, Mike Dienstbier, Michelle Fennen, Johanna Intemann, Peter Paruzel, Adelheid Korb-Pap, Thomas Pap, Berno Dankbar
Epithelial HIF2α expression induces intestinal barrier dysfunction and exacerbation of arthritis
Jinming Wen, Pang Lyu, Iris Stolzer, Jin Xu, Andreas Gießl, Zhen Lin, Darja Andreev, Katerina Kachler, Rui Song, Xianyi Meng, Shan Cao, Giuliana Guggino, Francesco Ciccia, Claudia Günther, Georg Schett, Aline Bozec
Concise report: a minimal-invasive method to retrieve and identify entheseal tissue from psoriatic arthritis patients
Milena L Pachowsky, Maria Gabriella Raimondo, Cong Xu, Simon Rauber, Koray Tascilar, Hannah Labinsky, Mario Vogg, Mina Saad Aziz Saad, David Simon, Juergen Rech, Alina Soare, Lars Braeuer, Arnd Kleyer, Georg Schett, Andreas Ramming
Biological impact of iberdomide in patients with active systemic lupus erythematosus
Peter E Lipsky, Ronald van Vollenhoven, Thomas Dörner, Victoria P Werth, Joan T Merrill, Richard Furie, Milan Petronijevic, Benito Velasco Zamora, Maria Majdan, Fedra Irazoque-Palazuelos, Robert Terbrueggen, Nikolay Delev, Michael Weiswasser, Shimon Korish, Mark Stern, Sarah Hersey, Ying Ye, Allison Gaudy, Zhaohui Liu, Robert Gagnon, Shaojun Tang, Peter H Schafer
Longitudinal analysis of ANA in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort
May Yee Choi, Ann Elaine Clarke, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J Wallace, David Isenberg, Anisur Rahman, Joan T Merrill, Paul R Fortin, Dafna D Gladman, Ian N Bruce, Michelle Petri, Ellen M Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jönsen, Graciela S Alarcón, Ronald F van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Ken Kalunian, Søren Jacobsen, Christine Peschken, Diane L Kamen, Anca Askanase, Jill P Buyon, Karen H Costenbader, Marvin J Fritzler
Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function
Sabrina Meisgen, Malin Hedlund, Aurelie Ambrosi, Lasse Folkersen, Vijole Ottosson, David Forsberg, Gudny Ella Thorlacius, Luca Biavati, Linn Strandberg, Johannes Mofors, Daniel Ramskold, Sabrina Ruhrmann, Lauro Meneghel, William Nyberg, Alexander Espinosa, Robert Murray Hamilton, Anders Franco-Cereceda, Anders Hamsten, Tomas Olsson, Lois Greene, Per Eriksson, Kristina Gemzell-Danielsson, Stina Salomonsson, Vijay K Kuchroo, Eric Herlenius, Ingrid Kockum, Sven-Erik Sonesson, Marie Wahren-Herlenius
CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis
Anthony Rousselle, Janis Sonnemann, Kerstin Amann, Alexander Mildner, Dörte Lodka, Lovis Kling, Markus Bieringer, Udo Schneider, Achim Leutz, Philipp Enghard, Ralph Kettritz, Adrian Schreiber
Low-ratio somatic NLRC4 mutation causes late-onset autoinflammatory disease
Jun Wang, Qiao Ye, Wenjie Zheng, Xiaomin Yu, Fang Luo, Ran Fang, Yaoyao Shangguan, Zhijun Du, Pui Y Lee, Taijie Jin, Qing Zhou
Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis
Manabu Kawata, Takeshi Teramura, Philip Ordoukhanian, Steven R Head, Padmaja Natarajan, Aishwarya Sundaresan, Merissa Olmer, Hiroshi Asahara, Martin K Lotz
Colchicine prophylaxis is associated with fewer gout flares after COVID-19 vaccination
Jie Lu, Yuwei He, Robert Terkeltaub, Mingshu Sun, Zijing Ran, Xinmiao Xu, Can Wang, Xinde Li, Shuhui Hu, Xiaomei Xue, Fei Yan, Hui Zhang, Huiyong Yin, Yongyong Shi, Nicola Dalbeth, Changgui Li
Severely impaired humoral response against SARS-CoV-2 variants of concern following two doses of BNT162b2 vaccine in patients with systemic lupus erythematosus (SLE)
Arthur Mageau, Valentine Marie Ferré, Tiphaine Goulenok, Charlotte Charpentier, Nicole Delory, Chrystel Francois, Nadhira Houhou-Fidouh, Thomas Papo, Diane Descamps, Karim Sacre
Routine treatment of rheumatoid arthritis with biologics and targeted agents: changes in patients and their response over 15 years
Ingrid M Visman, Maarten Boers, Daisy Vedder, Jos WR Twisk, Michael T Nurmohamed
No excess mortality in contemporary undifferentiated arthritis, in contrast to rheumatoid arthritis: a study with a follow-up of at least 10 years
Marloes Verstappen, Tom WJ Huizinga, Annette HM van der Helm-van Mil
Comparison of ultrasound attenuation by calcium pyrophosphate, hydroxyapatite and monosodium urate crystals: a proof-of-concept study
Georgios Filippou, Giovanni Pacini, Silvia Sirotti, Matthias Zadory, Davide Carboni, Arianna Damiani, Elisa Fiorentini, Edoardo Cipolletta, Emilio Filippucci, Johannes M Froehlich, Piercarlo Sarzi Puttini, Fabio Becce
Eosinopenia to differentiate crystal-induced and septic arthritis
Agathe Vigouroux, Agnes Ostertag, Anne-Claude Crémieux, Thomas Bardin, Augustin Latourte, Hang-Korng Ea, Pascal Richette
COVID-19 in patients with rheumatic diseases: what is the real mortality risk?
Claudia Marques, Marcelo M Pinheiro, Edgard Torres Reis Neto, Andrea Tavares Dantas, Francinne Machado Ribeiro, Ana Karla G Melo
Response to: ‘COVID-19 in patients with rheumatic diseases: what is the real mortality risk?’ by Marques et al
Kristin M D’Silva, Naomi Serling-Boyd, Rachel Wallwork, Tiffany Y-T Hsu, Jeffrey A Sparks, Zachary Scott Wallace
Comment on ‘Implication of baseline levels and early changes of C-reactive protein for subsequent clinical outcomes of patients with rheumatoid arthritis treated with tocilizumab’
Attila Pethoe-Schramm, Jenny Devenport, William Reiss
Response to: ‘Comment on ‘Implication of baseline levels and early changes of C-reactive protein for subsequent clinical outcomes of patients with rheumatoid arthritis treated with tocilizumab’’ by Pethoe-Schramm et al
Inbal Haya Shafran, Farideh Alasti, Josef S Smolen, Daniel Aletaha
Comment on: ‘EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update’ by Gossec et al
Chen-Yu Wei, Yung-Heng Lee, James Cheng Chung Wei
Response to: ‘Comment on: ‘EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update’ by Gossec et al’ by Wei et al
Laure Gossec, Xenofon Baraliakos, Iain McInnes, Andreas Kerschbaumer, Maarten de Wit, Maxime Dougados, Jette Primdahl, Désirée van der Heijde, Josef S Smolen
Association of subcutaneous belimumab and long-term antimalarial treatment reduces antiphospholipid antibodies levels in systemic lupus erythematosus: post-hoc analysis of a randomised placebo-controlled trial—comment on: ‘Effect of belimumab treatment on antiphospholipid antibody levels: post-hoc analysis based on two randomised placebo-controlled trials in systemic lupus erythematosus’ by Chatzidionysiou et al
Alessandra Bettiol, Francesca Pregnolato, Savino Sciascia, Giacomo Emmi, Domenico Prisco, Pier Luigi Meroni
Response to: ‘Association of subcutaneous belimumab and long-term antimalarial treatment reduces antiphospholipid antibodies levels in systemic lupus erythematosus: post-hoc analysis of a randomised placebo-controlled trial–comment on: ‘Effect of belimumab treatment on antiphospholipid antibody levels: post-hoc analysis based on two randomised placebo-controlled trials in systemic lupus erythematosus’ by Chatzidionysiou et al’ by Bettiol et al
Katerina Chatzidionysiou, Evangelia Samoli, Petros P Sfikakis, Maria G Tektonidou
Can telerheumatology improve rheumatic and musculoskeletal disease service delivery in sub-Saharan Africa?
Akpabio Akpabio, Richard Oluyinka Akintayo, Utibe Effiong
Response to: ‘Can telerheumatology improve rheumatic and musculoskeletal disease service delivery in sub-Saharan Africa?’ by Akpabio et al
Francesco Caso, Antonio del Puente, Nicolò Girolimetto, Marco Tasso, Corrado Caso, Raffaele Scarpa, Luisa Costa
Impact of COVID-19 pandemic on hospitalisation of patients with systemic lupus erythematosus (SLE): report from a tertiary hospital during the peak of the pandemic
Seow Lin Chuah, Cheng Lay Teh, Sharifah Aishah Wan Mohd Akbar, Yaw Kiet Cheong, Benjamin Sachdev Manjit Singh
Response to ‘Impact of COVID-19 pandemic on hospitalisation of patients with systemic lupus erythematosus (SLE): report from a tertiary hospital during the peak of the pandemic’ by Chuah et al
Alexis Mathian, Zahir Amoura
Comment on Ye et al ‘Presence of respiratory failure of COVID-19 infection in rheumatism patients in Wuhan, China’
Xiao-Huan Chen, Chih-Jung Yeh, Han-You Mo, James Cheng Chung Wei
Response to: ‘Comment on Ye et al ‘Presence of respiratory failure of COVID-19 infection in patients with rheumatism in Wuhan, China’’ by Chen et al
Jixin Zhong, Cong Ye, Shaozhe Cai, Lingli Dong
Clinical features of patients with rheumatic diseases and COVID-19 infection in Sarawak, Malaysia
Sharifah Aishah Wan, Cheng Lay Teh, Benjamin Sachdev Manjit Singh, Yaw Kiet Cheong, Seow Lin Chuah, Ahmad Tirmizi Jobli
Response to: ‘Clinical features of patients with rheumatic diseases and COVID-19 infection in Sarawak, Malaysia’ by Wan et al
Jixin Zhong, Lingli Dong
Should patients starting biologics be screened for COVID-19?
Jesus Alberto Cardenas-de la Garza, Rosa I Arvizu-Rivera, Dionicio Angel Galarza-Delgado
Response to: ‘Should patients starting biologics be screened for COVID-19?’ by Cardenas-de la Garza et al
Robert B M Landewé, Hendrik Schulze-Koops
Implications of SARS-CoV-2 infection for patients with rheumatic disease
Changsong Lin, Ziyu Wang, Jie Li, Xinyi Xia, Yun Liu, Qianghu Wang
Response to: ‘Implications of SARS-CoV-2 infection for patients with rheumatic disease’ by Lin et al
Alexis Mathian, Zahir Amoura
Emergency arising from patients' fear of taking antimalarials during these COVID-19 times: are antimalarials as unsafe for cardiovascular health as recent reports suggest?
Pedro Santos-Moreno, Diana Buitrago-Garcia, Laura Villarreal, Anggie Aza, Michael Cabrera, Wilberto Rivero, Adriana Rojas-Villarraga
Response to: ‘Emergency arising from patients’ fear of taking antimalarials during these COVID-19 times: are antimalarials as unsafe for cardiovascular health as recent reports suggest?’ by Santos-Moreno et al
Jean W Liew, Elizabeth R Graef, Jeffrey A Sparks, Alfred Hyoungju Kim
Correction: B cell subset composition segments clinically and serologically distinct groups in chronic cutaneous lupus erythematosus
