دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Spatial Distribution of Tau and ?-Amyloid Pathologies and Their Role in Different Alzheimer Disease Phenotypes
Sebastian Palmqvist, Arman Eshaghi
doi : 10.1212/WNL.0000000000011272
February 02, 2021; 96 (5)
Gestational Hypertension The Pregnancy Stress Test for Cognitive Impairment
Lisa Leffert, View ORCID ProfileCalin I. Prodan, Nils Peters
doi : 10.1212/WNL.0000000000011364
February 02, 2021; 96 (5)
Network Analyses in Epilepsy Are Nodes and Edges Ready for Clinical Translation?
Kathryn A. Davis, Victoria L. Morgan
doi : 10.1212/WNL.0000000000011316
February 02, 2021; 96 (5)
Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET
Renaud La Joie, Adrienne V. Visani, Orit H. Lesman-Segev, Suzanne L. Baker, Lauren Edwards, Leonardo Iaccarino, David N. Soleimani-Meigooni, Taylor Mellinger, Mustafa Janabi, Zachary A. Miller, David C. Perry, Julie Pham, Amelia Strom, Maria Luisa Gorno-Tempini, Howard J. Rosen, Bruce L. Miller, William J. Jagust, Gil D. Rabinovici
doi : 10.1212/WNL.0000000000011270
February 02, 2021; 96 (5)
Objective To assess whether Alzheimer disease (AD) clinical presentation and APOE4 relate to the burden and topography of ?-amyloid (A?) and tau pathologies using in vivo PET imaging.
Association of ?-Amyloid Level, Clinical Progression, and Longitudinal Cognitive Change in Normal Older Individuals
Laura M. van der Kall, View ORCID ProfileThanh Truong, Samantha C. Burnham, Vincent Doré, Rachel S. Mulligan, Svetlana Bozinovski, Fiona Lamb, Pierrick Bourgeat, Jurgen Fripp, Stephanie Schultz, Yen Y. Lim, View ORCID ProfileSimon M. Laws, David Ames, Christopher Fowler, Stephanie R. Rainey-Smith, Ralph N. Martins, Olivier Salvado, Joanne Robertson, Paul Maruff, Colin L. Masters, Victor L. Villemagne, Christopher
doi : 10.1212/WNL.0000000000011222
February 02, 2021; 96 (5)
Objective To determine the effect of ?-amyloid (A?) level on progression risk to mild cognitive impairment (MCI) or dementia and longitudinal cognitive change in cognitively normal (CN) older individuals.
Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease
Ignacio Ill?n-Gala, Alberto Lleo, Anna Karydas, Adam M. Staffaroni, Henrik Zetterberg, Rajeev Sivasankaran, Lea T. Grinberg, Salvatore Spina, Joel H. Kramer, Eliana M. Ramos, View ORCID ProfileGiovanni Coppola, View ORCID ProfileRenaud La Joie, Gil D. Rabinovici, David C. Perry, Maria Luisa Gorno-Tempini, William W. Seeley, Bruce L. Miller, Howard J. Rosen, Kaj Blennow, Adam L. Boxer, Julio C. Rojas
doi : 10.1212/WNL.0000000000011226
February 02, 2021; 96 (5)
Objective To test the hypothesis that plasma total tau (t-tau) and neurofilament light chain (NfL) concentrations may have a differential role in the study of frontotemporal lobar degeneration syndromes (FTLD-S) and clinically diagnosed Alzheimer disease syndromes (AD-S), we determined their diagnostic and prognostic value in FTLD-S and AD-S and their sensitivity to pathologic diagnoses.
Nucleus Basalis of Meynert Stimulation for Lewy Body Dementia
View ORCID ProfileDavid Maltête, View ORCID ProfileDavid Wallon, Julie Bourilhon, Romain Lefaucheur, Teodor Danaila, Stéphane Thobois, Luc Defebvre, View ORCID ProfileKathy Dujardin, Jean-Luc Houeto, Olivier Godefroy, Pierre Krystkowiak, Olivier Martinaud, André Gillibert, Mathieu Chastan, Pierre Vera, Didier Hannequin, View ORCID ProfileMarie-Laure Welter, Stéphane Derrey
doi : 10.1212/WNL.0000000000011227
February 02, 2021; 96 (5)
Objectives Nucleus basalis of Meynert deep brain stimulation (NBM-DBS) has been proposed for patients with dementia. Here, we aim to assess the safety and effects of NBM-DBS in patients with Lewy body dementia (LBD), in a randomized, double-blind, crossover clinical trial.
Multi-shell Diffusion MRI Models for White Matter Characterization in Cerebral Small Vessel Disease
Marek J. Konieczny, Anna Dewenter, Annemieke ter Telgte, Benno Gesierich, Kim Wiegertjes, Sofia Finsterwalder, Anna Kopczak, Mathias Hübner, Rainer Malik, View ORCID ProfileAnil M. Tuladhar, José P. Marques, View ORCID ProfileDavid G. Norris, Alexandra Koch, View ORCID ProfileOlaf Dietrich, Michael Ewers, Reinhold Schmidt, Frank-Erik de Leeuw, View ORCID ProfileMarco Duering
doi : 10.1212/WNL.0000000000011213
February 02, 2021; 96 (5)
Objective To test the hypothesis that multi-shell diffusion models improve the characterization of microstructural alterations in cerebral small vessel disease (SVD), we assessed associations with processing speed performance, longitudinal change, and reproducibility of diffusion metrics.
Hypertensive Disorders of Pregnancy and Cognitive Impairment
Maria C. Adank, Rowina F. Hussainali, Lise C. Oosterveer, M.Arfan Ikram, View ORCID ProfileEric A.P. Steegers, Eliza C. Miller, View ORCID ProfileSarah Schalekamp-Timmermans
doi : 10.1212/WNL.0000000000011363
February 02, 2021; 96 (5)
Objective To determine the association between hypertensive disorders of pregnancy (HDP) and cognitive impairment 15 years after pregnancy, we measured cognitive performance in 115 women with a history of HDP and in 481 women with a previous normotensive pregnancy.
Association of MRI Brain Injury With Outcome After Pediatric Out-of-Hospital Cardiac Arrest
Matthew P. Kirschen, Daniel J. Licht, Jennifer Faerber, Antara Mondal, Kathryn Graham, Madeline Winters, Ramani Balu, Ramon Diaz-Arrastia, Robert A. Berg, Alexis Topjian, Arastoo Vossough
doi : 10.1212/WNL.0000000000011217
February 02, 2021; 96 (5)
Objective To determine the association between the extent of diffusion restriction and T2/fluid-attenuated inversion recovery (FLAIR) injury on brain MRI and outcomes after pediatric out-of-hospital cardiac arrest (OHCA).
Sex Differences in Diagnosis and Diagnostic Revision of Suspected Minor Cerebral Ischemic Events
Amy Y. X. Yu, View ORCID ProfileMichael D. Hill, Negar Asdaghi, Jean-Martin Boulanger, Marie-Christine Camden, View ORCID ProfileBruce C.V. Campbell, Andrew M. Demchuk, View ORCID ProfileThalia S. Field, Mayank Goyal, Martin Krause, Jennifer Mandzia, Bijoy K. Menon, Robert Mikulik, Francois Moreau, Andrew M. Penn, Richard H. Swartz, View ORCID ProfileShelagh B. Coutts, for the Diagnosis of Uncertain-Origin Benign Transient Neurological Symptoms (DOUBT) Study Group
doi : 10.1212/WNL.0000000000011212
February 02, 2021; 96 (5)
Objective To describe sex differences in the presentation, diagnosis, and revision of diagnosis after early brain MRI in patients who present with acute transient or minor neurologic events.
Regional Differences in the Response to Acute Blood Pressure Lowering After Cerebral Hemorrhage
Kazunori Toyoda, Yuko Y. Palesch, Masatoshi Koga, Lydia Foster, Haruko Yamamoto, Sohei Yoshimura, View ORCID ProfileMasafumi Ihara, Mayumi Fukuda-Doi, Shuhei Okazaki, View ORCID ProfileKanta Tanaka, View ORCID ProfileKaori Miwa, Yasuhiro Hasegawa, Yoshiaki Shiokawa, Toru Iwama, Kenji Kamiyama, Haruhiko Hoshino, View ORCID ProfileThorsten Steiner, Byung-Woo Yoon, Yongjun Wang, Chung Y. Hsu, Adnan I. Qureshi, for the ATACH-2 Trial Investigators
doi : 10.1212/WNL.0000000000011229
February 02, 2021; 96 (5)
Objective To compare the impact of intensive blood pressure (BP) lowering right after intracerebral hemorrhage (ICH) on clinical and hematoma outcomes among patients from different geographic locations, we performed a prespecified subanalysis of a randomized, multinational, 2-group, open-label trial to determine the efficacy of rapidly lowering BP in hyperacute ICH (Antihypertensive Treatment of Acute Cerebral Hemorrhage [ATACH]-2), involving 537 patients from East Asia and 463 recruited outside of Asia.
Association of Interleukin-6 Levels and Futile Reperfusion After Mechanical Thrombectomy
Laura Mechtouff, Thomas Bochaton, Alexandre Paccalet, Claire Crola Da Silva, Marielle Buisson, Camille Amaz, Laurent Derex, Elodie Ong, Yves Berthezene, Omer Faruk Eker, Nathalie Dufay, Nathan Mewton, Michel Ovize, Tae-Hee Cho, Norbert Nighoghossian
doi : 10.1212/WNL.0000000000011268
February 02, 2021; 96 (5)
Objective To assess whether interleukin-6 (IL-6) level is a marker of futile reperfusion in patients with acute ischemic stroke (AIS) with large vessel occlusion treated with mechanical thrombectomy (MT).
Structural Brain Network Abnormalities and the Probability of Seizure Recurrence After Epilepsy Surgery
ProfileNishant Sinha, Yujiang Wang, N?dia Moreira da Silva, Anna Miserocchi, Andrew W. McEvoy, Jane de Tisi, View ORCID ProfileSjoerd B. Vos, Gavin P. Winston, John S. Duncan, View ORCID ProfilePeter N. Taylor
doi : 10.1212/WNL.0000000000011315
February 02, 2021; 96 (5)
Objective We assessed preoperative structural brain networks and clinical characteristics of patients with drug-resistant temporal lobe epilepsy (TLE) to identify correlates of postsurgical seizure recurrences.
Probiotics for Constipation in Parkinson Disease
Ai Huey Tan, Shen-Yang Lim, Kah Kian Chong, Mohammad Addin Azhan A Manap, Jia Wei Hor, Jia Lun Lim, Soon Chai Low, Chun Wie Chong, Sanjiv Mahadeva, Anthony E. Lang
doi : 10.1212/WNL.0000000000010998
February 02, 2021; 96 (5)
Objective To determine whether probiotics are effective for constipation, a common and often difficult-to-treat problem, in Parkinson disease (PD).
Effect of Disease-Modifying Therapy on Disability in Relapsing-Remitting Multiple Sclerosis Over 15 Years
Tomas Kalincik, Ibrahima Diouf, Sifat Sharmin, Charles Malpas, Tim Spelman, Dana Horakova, Eva Kubala Havrdova, Maria Trojano, Guillermo Izquierdo, Alessandra Lugaresi, Alexandre Prat, Marc Girard, Pierre Duquette, Pierre Grammond, Vilija Jokubaitis, Anneke van der Walt, Francois Grand'Maison, Patrizia Sola, Diana Ferraro, Vahid Shaygannejad, Raed Alroughani, Raymond Hupperts, Murat Terzi, Cavit Boz, Jeannette Lechner-Scott, Eugenio Pucci, Vincent Van Pesch, Franco Granella, Roberto Bergamaschi, Daniele Spitaleri, Mark Slee, Steve Vucic, Radek Ampapa, Pamela McCombe, Cristina Ramo-Tello, Julie Prevost, Javier Olascoaga, Edgardo Cristiano, Michael Barnett, Maria Laura Saladino, Jose Luis Sanchez-Menoyo, Suzanne Hodgkinson, Csilla Rozsa, Stella Hughes, Fraser Moore, Cameron Shaw, Ernest Butler, Olga Skibina, Orla Gray, Allan Kermode, Tunde Csepany, Bhim Singhal, Neil Shuey, Imre Piroska, Bruce Taylor, Magdolna Simo, Carmen-Adella Sirbu, Attila Sas, Helmut Butzkueven, on behalf of the MSBase Study Group
doi : 10.1212/WNL.0000000000011242
February 02, 2021; 96 (5)
Objective To test the hypothesis that immunotherapy prevents long-term disability in relapsing-remitting multiple sclerosis (MS), we modeled disability outcomes in 14,717 patients.
Skeletal Muscle Magnetic Resonance Biomarkers in GNE Myopathy
Chia-Ying Liu, Jianhua Yao, William C. Kovacs, Joseph A. Shrader, Galen Joe, View ORCID ProfileRonald Ouwerkerk, Ami K. Mankodi, View ORCID ProfileWilliam A. Gahl, View ORCID ProfileRonald M. Summers, View ORCID ProfileNuria Carrillo
doi : 10.1212/WNL.0000000000011231
February 02, 2021; 96 (5)
Objective To characterize muscle involvement and evaluate disease severity in patients with GNE myopathy using skeletal muscle MRI and proton magnetic resonance spectroscopy (1H-MRS).
What's Happening in Neurology® Genetics
doi : 10.1212/WNL.0000000000011367
February 02, 2021; 96 (5)
What's Happening in Equity, Diversity, & Inclusion
doi : 10.1212/WNL.0000000000011365
February 02, 2021; 96 (5)
The Wide Spectrum of Pathophysiologic Mechanisms of Paraproteinemic Neuropathy
Jean-Michel Vallat, Mathilde Duchesne, Philippe Corcia, Laurence Richard, Karima Ghorab, Laurent Magy, Stéphane Mathis
doi : 10.1212/WNL.0000000000011324
February 02, 2021; 96 (5)
Monoclonal gammopathy is encountered quite frequently in the general population. This type of hematologic abnormality may be mild, referred to as monoclonal gammopathy of undetermined significance or related to different types of hematologic malignancies. The association of a peripheral neuropathy with monoclonal gammopathy is also fairly common, and hemopathy may be discovered in an investigation of peripheral neuropathy. In such a situation, it is essential to determine the exact nature of the hematologic process in order not to miss a malignant disease and thus initiate the appropriate treatment (in conjunction with hematologists and oncologists). In this respect, nerve biopsy (discussed on a case-by-case basis) is of great value in the management of such patients. We therefore propose to present the objectives and main interests of nerve biopsy in this situation.
Association Between IL-5 Levels and the Clinicopathologic Features of Eosinophilic Granulomatosis With Polyangiitis
Ryoji Nishi, View ORCID ProfileHaruki Koike, Ken Ohyama, Yuki Fukami, Masahiro Iijima, Gen Sobue, View ORCID ProfileMasahisa Katsuno
doi : 10.1212/WNL.0000000000011142
February 02, 2021; 96 (5)
Postoperative Objective Tinnitus
Marie-Louise Kulas S?borg, Nina Imb?k, Mette Lindelof, William Kristian Karlsson
doi : 10.1212/WNL.0000000000011126
February 02, 2021; 96 (5)
Holmes Tremor With Perirolandic Demyelinating Lesions
Adrian Budhram, Hugh D. Simpson, James H. Bower, Anhar Hassan, Brittani L. Conway, Eoin P. Flanagan
doi : 10.1212/WNL.0000000000011235
February 02, 2021; 96 (5)
Training in Neurology: Feedback from Graduates About the Psychiatry Component of Residency Training
Dorthea Juul, Laurie Gutmann, Harold P. Adams, Sarah A. O'Shea, Larry R. Faulkner
doi : 10.1212/WNL.0000000000010857
February 02, 2021; 96 (5)
Objective To obtain feedback from early career adult and pediatric neurologists about the psychiatry component of residency training.
Clinical Reasoning: Rapidly Progressive Thalamic Dementia
Angelo Cascio Rizzo, Novella Bonaffini, Raffaele Bove, Mara Gentile, Letizia Maria Cupini, Enrico Cotroneo, Cesare Iani
doi : 10.1212/WNL.0000000000011161
February 02, 2021; 96 (5)
Teaching NeuroImages: Neuroimaging in Adult-Onset Alexander Disease
Neethu Gopal, View ORCID ProfileVivek Gupta, Lindsy N. Williams, View ORCID ProfileSukhwinder J.S. Sandhu
doi : 10.1212/WNL.0000000000010803
February 02, 2021; 96 (5)
Teaching Video NeuroImages: A Case of Lance Adams Syndrome With Seesaw Nystagmus
Gabriela Keeton, Tarek Ali, Padmaja Sudhakar, Zain Guduru
doi : 10.1212/WNL.0000000000010741
February 02, 2021; 96 (5)
Editors' Note: Biological Subtypes of Alzheimer Disease: A Systematic Review and Meta-analysis
View ORCID ProfileAravind Ganesh, Steven Galetta
doi : 10.1212/WNL.0000000000011405
February 02, 2021; 96 (5)
Reader Response: Biological Subtypes of Alzheimer Disease: A Systematic Review and Meta-analysis
Jeroen F. Uleman, René J.F. Melis, Marcel G.M. Olde Rikkert
doi : 10.1212/WNL.0000000000011407
February 02, 2021; 96 (5)
Author Response: Biological Subtypes of Alzheimer Disease: A Systematic Review and Meta-analysis
Daniel Ferreira, View ORCID ProfileAgneta Nordberg, View ORCID ProfileEric Westman
doi : 10.1212/WNL.0000000000011406
February 02, 2021; 96 (5)
