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Spotlight on the March 9 Issue
José G. Merino
doi : 10.1212/WNL.0000000000011550
March 09, 2021; 96 (10)
Cholesterol Trafficking in the BrainAre We Overlooking an Important Risk Factor for Parkinson Disease?
Giovanni Mario Pes, Yong-Moon Park, Gian Pietro Sechi
doi : 10.1212/WNL.0000000000011595
March 09, 2021; 96 (10)
A Better Blood Test to Differentiate Epileptic From Psychogenic Nonepileptic Seizures?
G. Bryan Young, View ORCID ProfileLiu Lin Thio
doi : 10.1212/WNL.0000000000011593
March 09, 2021; 96 (10)
When Determining Brain Death in Adults, Time Is of the Essence!The Last Nail in the Coffin of Dual Examination in Brain Death
Gregory Kapinos, Thomas A. Ala
doi : 10.1212/WNL.0000000000011594
March 09, 2021; 96 (10)
Association of High-Density Lipoprotein Cholesterol Variability and the Risk of Developing Parkinson Disease
Joo-Hyun Park, Chung-woo Lee, Myung Ji Nam, Hyunjin Kim, Do-Young Kwon, Ji Won Yoo, Kyu Na Lee, Kyungdo Han, Jin-Hyung Jung, Yong-Gyu Park, Do-Hoon Kim
doi : 10.1212/WNL.0000000000011553
March 09, 2021; 96 (10)
Objective To investigate the longitudinal association among high-density lipoprotein cholesterol (HDL-C) level, HDL-C variability, and the risk of developing Parkinson disease (PD).
Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder
Kheireddin Mufti, View ORCID ProfileEric Yu, View ORCID ProfileUladzislau Rudakou, Lynne Krohn, Jennifer A. Ruskey, Farnaz Asayesh, Sandra B. Laurent, Dan Spiegelman, Isabelle Arnulf, Michele T.M. Hu, Jacques Y. Montplaisir, Jean-François Gagnon, Alex Desautels, Yves Dauvilliers, Gian Luigi Gigli, Mariarosaria Valente, Francesco Janes, Andrea Bernardini, Birgit H?gl, View ORCID ProfileAmbra Stefani, Evi Holzknecht, Karel Sonka, View ORCID ProfileDavid Kemlink, View ORCID ProfileWolfgang Oertel, Annette Janzen, Giuseppe Plazzi, Elena Antelmi, Michela Figorilli, Monica Puligheddu, Brit Mollenhauer, Claudia Trenkwalder, Friederike Sixel-D?ring, Valérie Cochen De Cock, Christelle Charley Monaca, Anna Heidbreder, Luigi Ferini-Strambi, Femke Dijkstra, Mineke Viaene, Beatriz Abril, Bradley F. Boeve, Jean-François Trempe, Guy A. Rouleau, Ronald B. Postuma, Ziv Gan-Or
doi : 10.1212/WNL.0000000000011464
March 09, 2021; 96 (10)
Objective To examine the role of genes identified through genome-wide association studies (GWASs) of Parkinson disease (PD) in the risk of isolated REM sleep behavior disorder (iRBD).
Association of Initial Maximal Motor Ability With Long-term Functional Outcome in Patients With COL6-Related Dystrophies
Daniel Natera-de Benito, View ORCID ProfileA. Reghan Foley, Cristina Dom?nguez-Gonz?lez, View ORCID ProfileCarlos Ortez, Minal Jain, Aron Mebrahtu, Sandra Donkervoort, Ying Hu, Margaret Fink, Pomi Yun, Tracy Ogata, Julita Medina, Meritxell Vigo, Katherine G. Meilleur, Meganne E. Leach, Jahannaz Dastgir, Jordi D?az-Manera, View ORCID ProfileLaura Carrera-Garc?a, View ORCID ProfileJessica Exp?sito-Escudero, Macarena Alarcon, View ORCID ProfileDaniel Cuadras, Elena Montiel-Morillo, José C. Milisenda, Raul Dominguez-Rubio, View ORCID ProfileMontse Olivé, View ORCID ProfileJaume Colomer, View ORCID ProfileCristina Jou, View ORCID ProfileCecilia Jimenez-Mallebrera, View ORCID ProfileCarsten G. B?nnemann, View ORCID ProfileAndres Nascimento
doi : 10.1212/WNL.0000000000011499
March 09, 2021; 96 (10)
Objective To accurately categorize the phenotypes of individuals with collagen VI–related dystrophies (COL6-RDs) during the first years of life to predict long-term motor function and pulmonary function, to provide phenotype-specific anticipatory care, and to improve clinical trial readiness.
A Cross-Sectional Study of Nemaline Myopathy
Kimberly Amburgey, Meryl Acker, Samia Saeed, Reshma Amin, View ORCID ProfileAlan H. Beggs, View ORCID ProfileCarsten G. B?nnemann, View ORCID ProfileMichael Brudno, Andrei Constantinescu, Jahannaz Dastgir, Mamadou Diallo, Casie A. Genetti, View ORCID ProfileMichael Glueck, Stacy Hewson, View ORCID ProfileCourtney Hum, Minal S. Jain, Michael W. Lawlor, Oscar H. Meyer, View ORCID ProfileLeslie Nelson, Nicole Sultanum, Faiza Syed, Tuyen Tran, Ching H. Wang, James J. Dowling
doi : 10.1212/WNL.0000000000011458
March 09, 2021; 96 (10)
Objective Nemaline myopathy (NM) is a rare neuromuscular condition with clinical and genetic heterogeneity. To establish disease natural history, we performed a cross-sectional study of NM, complemented by longitudinal assessment and exploration of pilot outcome measures.
Prolonged Unconsciousness Following Severe COVID-19
Wilson F. Abdo, Catharina I. Broerse, Bart P. Grady, Agnes A.A.C.M. Wertenbroek, Onno Vijlbrief, Marc P. Buise, Menno Beukema, Mark van der Kuil, Anil M. Tuladhar, Frederick J.A. Meijer, Johannes G. van der Hoeven
doi : 10.1212/WNL.0000000000011355
March 09, 2021; 96 (10)
Objective We report a case series of patients with prolonged but reversible unconsciousness after coronavirus disease 2019 (COVID-19)–related severe respiratory failure.
Association of Epileptic and Nonepileptic Seizures and Changes in Circulating Plasma Proteins Linked to Neuroinflammation
John M. Gledhill, Elizabeth J. Brand, John R. Pollard, Richard D. St. Clair, Todd M. Wallach, Peter B. Crino
doi : 10.1212/WNL.0000000000011552
March 09, 2021; 96 (10)
Objective To develop a diagnostic test that stratifies epileptic seizures (ES) from psychogenic nonepileptic seizures (PNES) by developing a multimodal algorithm that integrates plasma concentrations of selected immune response–associated proteins and patient clinical risk factors for seizure.
Comparison of 1 vs 2 Brain Death Examinations on Time to Death Pronouncement and Organ Donation
Panayiotis N. Varelas, Mohammed Rehman, Chandan Mehta, Lisa Louchart, Lonni Schultz, Paul Brady, Mohammed F. Kananeh, View ORCID ProfileEelco F.M. Wijdicks
doi : 10.1212/WNL.0000000000011554
March 09, 2021; 96 (10)
Objective To fill the evidence gap on the value of a single brain death (SBD) or dual brain death (DBD) examination by providing data on irreversibility of brain function, organ donation consent, and transplantation.
Slow-Wave Sleep and MRI Markers of Brain Aging in a Community-Based Sample
Andrée-Ann Baril, Alexa S. Beiser, View ORCID ProfileVincent Mysliwiec, Erlan Sanchez, Charles S. DeCarli, Susan Redline, Daniel J. Gottlieb, Pauline Maillard, Jose Rafael Romero, View ORCID ProfileClaudia L. Satizabal, Jared M. Zucker, Sudha Seshadri, Matthew P. Pase, Jayandra J. Himali
doi : 10.1212/WNL.0000000000011377
March 09, 2021; 96 (10)
Objective To test the hypothesis that reduced slow-wave sleep, or N3 sleep, which is thought to underlie the restorative functions of sleep, is associated with MRI markers of brain aging, we evaluated this relationship in the community-based Framingham Heart Study Offspring cohort using polysomnography and brain MRI.
Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease
Alexandra N. Trelle, Valerie A. Carr, View ORCID ProfileEdward N. Wilson, Michelle S. Swarovski, Madison P. Hunt, Tyler N. Toueg, Tammy T. Tran, Divya Channappa, Nicole K. Corso, View ORCID ProfileMonica K. Thieu, Manasi Jayakumar, Ayesha Nadiadwala, Wanjia Guo, View ORCID ProfileNatalie J. Tanner, Jeffrey D. Bernstein, Celia P. Litovsky, Scott A. Guerin, Anna M. Khazenzon, Marc B. Harrison, Brian K. Rutt, Gayle K. Deutsch, Frederick T. Chin, Guido A. Davidzon, Jacob N. Hall, Sharon J. Sha, Carolyn A. Fredericks, Katrin I. Andreasson, Geoffrey A. Kerchner, View ORCID ProfileAnthony D. Wagner, Elizabeth C. Mormino
doi : 10.1212/WNL.0000000000011477
March 09, 2021; 96 (10)
Objective To determine whether memory tasks with demonstrated sensitivity to hippocampal function can detect variance related to preclinical Alzheimer disease (AD) biomarkers, we examined associations between performance in 3 memory tasks and CSF ?-amyloid (A?)42/A?40 and phosopho-tau181 (p-tau181) in cognitively unimpaired older adults (CU).
What's Happening in Neurology® Clinical Practice
doi : 10.1212/WNL.0000000000011556
March 09, 2021; 96 (10)
What's Happening in Neurology® Neuroimmunology & Neuroinflammation
doi : 10.1212/WNL.0000000000011558
March 09, 2021; 96 (10)
What's Happening in Innovations in Care Delivery
doi : 10.1212/WNL.0000000000011559
March 09, 2021; 96 (10)
Academic Neurology DepartmentsStructure, Diversity, and Financial Pressures in 2019 vs 2002
Robin L. Brey, Tasha Ostendorf, Matthew Rizzo, Ralph L. Sacco
doi : 10.1212/WNL.0000000000011538
March 09, 2021; 96 (10)
Deep Medullary Vein Thrombosis in a Neonate
View ORCID ProfileAna Paula Alves Fonseca, View ORCID ProfileRuann Melo de Carvalho, View ORCID ProfileM?rio Padula, View ORCID ProfileRita de Cassia Maciel Pincerato
doi : 10.1212/WNL.0000000000011502
March 09, 2021; 96 (10)
Frontal Parafalcine Meningioma Presenting as Anterior Cerebral Artery Stroke
Luciano Silveira Basso, Diego Zambonin, Luiz Roberto Tomasi Ribeiro, Armando Schmidt Cardoso, View ORCID ProfilePaulo Valdeci Worm
doi : 10.1212/WNL.0000000000011541
March 09, 2021; 96 (10)
Pearls & Oy-sters: SARS-CoV-2 Infection of the CNS in a Patient With Meningeosis Carcinomatosa
Philipp A. Steininger, Frank Seifert, Stefanie Balk, Joji Kuramatsu, Andreas E. Kremer, Roland Coras, Tobias Engelhorn, Clara Maier, Matthias Tenbusch, Klaus Korn, Armin Ensser
doi : 10.1212/WNL.0000000000011357
March 09, 2021; 96 (10)
Training in Neurology: Neuro Day
Jessica Frey, Brandon Neeley, Amna Umer, View ORCID ProfileJames W. Lewis, Anna Lama, Gauri Pawar, Ann Murray
doi : 10.1212/WNL.0000000000010859
March 09, 2021; 96 (10)
Objective To determine whether increased patient interaction, exposure to the neurologic examination, and access to positive neurology mentors increase interest in neurology for first-year medical students.
Teaching NeuroImages: CLOVES Syndrome
Meagan Collins, Eric Krochmalnek, Sarah Alsubhi, Myriam Srour
doi : 10.1212/WNL.0000000000010856
March 09, 2021; 96 (10)
Teaching Video NeuroImages: Choreoathetosis Due to Radiation-Induced Brachial Plexopathy
Teruhiko Sekiguchi, Toshiro Kanazawa, Takuya Ohkubo
doi : 10.1212/WNL.0000000000010855
March 09, 2021; 96 (10)
Editors' Note: Association of Prestroke Metformin Use, Stroke Severity, and Thrombolysis Outcome
Ariane Lewis, Steven Galetta
doi : 10.1212/WNL.0000000000011565
March 09, 2021; 96 (10)
Reader Response: Association of Prestroke Metformin Use, Stroke Severity, and Thrombolysis Outcome
Richard Dasheiff
doi : 10.1212/WNL.0000000000011564
March 09, 2021; 96 (10)
Author Response: Association of Prestroke Metformin Use, Stroke Severity, and Thrombolysis Outcome
Laura P. Westphal, Ulrike Held, Stefan Engelter, Susanne Wegener
doi : 10.1212/WNL.0000000000011563
March 09, 2021; 96 (10)
Editors' Note: Association of Guideline Publication and Delays to Treatment in Pediatric Status Epilepticus
Ariane Lewis, Steven Galetta
doi : 10.1212/WNL.0000000000011562
March 09, 2021; 96 (10)
Reader Response: Association of Guideline Publication and Delays to Treatment in Pediatric Status Epilepticus
Ana C. Albuja, Meriem K. Bensalem-Owen, View ORCID ProfileMauricio F. Villamar
doi : 10.1212/WNL.0000000000011561
March 09, 2021; 96 (10)
Author Response: Association of Guideline Publication and Delays to Treatment in Pediatric Status Epilepticus
Marta Amengual-Gual, Cristina Barcia Aguilar, Tobias Loddenkemper
doi : 10.1212/WNL.0000000000011560
March 09, 2021; 96 (10)
Evaluation of Multiple Sclerosis Disability Outcome Measures Using Pooled Clinical Trial Data
doi : 10.1212/WNL.0000000000011677
March 09, 2021; 96 (10)
