Neurology




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Spotlight on the May 11 Issue

José G. Merino

doi : 10.1212/WNL.0000000000011889

May 11, 2021; 96 (19)

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Pain Control in Aneurysmal Subarachnoid Hemorrhage Patients in the ICU

Gary L. Bernardini, John C.M. Brust

doi : 10.1212/WNL.0000000000011907

May 11, 2021; 96 (19)

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Prevalent Nonmotor Symptoms Associated With Huntington Disease Challenging to Interpret and With Early Impact on Function

Elizabeth Anne McCusker, Clement T. Loy

doi : 10.1212/WNL.0000000000011888

May 11, 2021; 96 (19)

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Physical Activity May Reduce Apolipoprotein E4-Associated Cognitive Decline in Parkinson Disease

Jacob Raber, Sirwan K.L. Darweesh,Rodolfo Savica

doi : 10.1212/WNL.0000000000011851

May 11, 2021; 96 (19)

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Neighborhood Socioeconomic Differences in Stroke Risk?

Anita Lindmark

doi : 10.1212/WNL.0000000000011887

May 11, 2021; 96 (19)

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Association of Refractory Pain in the Acute Phase After Subarachnoid Hemorrhage With Continued Outpatient Opioid Use

Matthew N. Jaffa, Jamie E. Podell, Madeleine C. Smith, Arshom Foroutan, Adam Kardon,Wan-Tsu W. Chang, Melissa Motta,Gunjan Y. Parikh, Kevin N. Sheth,Neeraj Badjatia, Michael J. Armahizer, J. Marc Simard,Nicholas A. Morris

doi : 10.1212/WNL.0000000000011906

May 11, 2021; 96 (19)

Objective Little is known about the prevalence of continued opioid use following aneurysmal subarachnoid hemorrhage (aSAH) despite guidelines recommending their use during the acute phase of disease. We sought to determine prevalence of opioid use following aSAH and test the hypothesis that acute pain and higher inpatient opioid dose increased outpatient opioid use.

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Hematoma Expansion in Intracerebral Hemorrhage With Unclear Onset

Andrea Morotti,Gregoire Boulouis,Andreas Charidimou,Qi Li, Loris Poli, Paolo Costa, Valeria De Giuli, Eleonora Leuci, Federico Mazzacane, Giorgio Busto,Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Michele Laudisi, Giuseppe Micieli, Anna Cavallini, Elisa Candeloro, Massimo Gamba, Mauro Magoni, Andrew D. Warren, Christopher D. Anderson, M. Edip Gurol, Alessandro Biffi, Anand Viswanathan, Ilaria Casetta, Enrico Fainardi, Andrea Zini, Alessandro Pezzini, Alessandro Padovani, Steven M. Greenberg, Jonathan Rosand, Joshua N. Goldstein

doi : 10.1212/WNL.0000000000011895

May 11, 2021; 96 (19)

Objective To investigate the prevalence, predictors, and prognostic effect of hematoma expansion (HE) in patients with intracerebral hemorrhage (ICH) with unclear symptom onset (USO).

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Early Neurologic Recovery, Practice Pattern Variation, and the Risk of Endotracheal Intubation Following Established Status Epilepticus

Eric S. Rosenthal, Jordan J. Elm, James Ingles,Alexander J. Rogers, Thomas E. Terndrup, Maija HolstiDanny G. Thomas,Lynn Babcock, Pamela J. Okada, Robert H. Lipsky, Joseph B. Miller, Robert W. Hickey, Megan E. Barra,Thomas P. Bleck, James C. Cloyd,Robert Silbergleit, Daniel H. Lowenstein, Lisa D. Coles,Jaideep Kapur, Shlomo Shinnar, James M. Chamberlain, ; on behalf of the Established Status Epilepticus Treatment Trial Study Group

doi : 10.1212/WNL.0000000000011879

May 11, 2021; 96 (19)

Objective To quantify the association between early neurologic recovery, practice pattern variation, and endotracheal intubation during established status epilepticus, we performed a secondary analysis within the cohort of patients enrolled in the Established Status Epilepticus Treatment Trial (ESETT).

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Association of Gyrification Pattern, White Matter Changes, and Phenotypic Profile in Patients With Parkinson Disease

Xie Tang, Yuanchao Zhang, Daihong Liu, Yixin Hu, Liling Jiang,Jiuquan Zhang

doi : 10.1212/WNL.0000000000011894

May 11, 2021; 96 (19)

Objective To investigate the cortical gyrification changes as well as their relationships with white matter (WM) microstructural abnormalities in the akinetic-rigid (AR) and tremor-dominant (TD) subtypes of Parkinson disease (PD).

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Timing and Impact of Psychiatric, Cognitive, and Motor Abnormalities in Huntington Disease

Branduff McAllister, James F. Gusella, G. Bernhard Landwehrmeyer, Jong-Min Lee, Marcy E. MacDonald, Michael Orth, Anne E. Rosser, Nigel M. Williams,Peter Holmans, Lesley Jones,Thomas H. Massey, on behalf of the REGISTRY Investigators of the European Huntington's Disease Network

doi : 10.1212/WNL.0000000000011893

May 11, 2021; 96 (19)

Objective To assess the prevalence, timing, and functional impact of psychiatric, cognitive, and motor abnormalities in Huntington disease (HD) gene carriers, we analyzed retrospective clinical data from individuals with manifest HD.

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Association of CAG Repeat Length in the Huntington Gene With Cognitive Performance in Young Adults

Jordan L. Schultz, Carsten Saft, Peggy C. Nopoulos

doi : 10.1212/WNL.0000000000011823

May 11, 2021; 96 (19)

Objective To investigate the relationships between CAG repeat length in the huntingtin gene and cognitive performance in participants above and below the disease threshold for Huntington disease (HD), we performed a cross-sectional analysis of the Enroll-HD database.

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Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease

Jing Qian, Rebecca A. Betensky, Bradley T. Hyman, Alberto Serrano-Pozo

doi : 10.1212/WNL.0000000000011883

May 11, 2021; 96 (19)

Objective To test the hypothesis that the APOE genotype is a significant driver of heterogeneity in Alzheimer disease (AD) clinical progression, which could have important implications for clinical trial design and interpretation.

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Association of Physical Activity and APOE Genotype With Longitudinal Cognitive Change in Early Parkinson Disease

Ryul Kim, Sangmin Park, Dallah Yoo, Jin-Sun Jun, Beomseok Jeon

doi : 10.1212/WNL.0000000000011852

May 11, 2021; 96 (19)

Objective To determine whether greater physical activity could modify the negative association of APOE ?4 with longitudinal cognitive changes in early Parkinson disease (PD) and to uncover the disease-specific mechanism for explaining such benefits of physical activity.

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Development of a New Quality of Life Measure for Duchenne Muscular Dystrophy Using Mixed Methods

Philip A. Powell,Jill Carlton, Donna Rowen, Fleur Chandler,Michela Guglieri,  View ORCID ProfileJohn E. Brazier

doi : 10.1212/WNL.0000000000011896

May 11, 2021; 96 (19)

Objective Based on concerns about existing patient-reported outcome measures (PROMs) for assessing quality of life (QoL) in Duchenne muscular dystrophy (DMD), we describe the mixed methods development of a new QoL PROM for use in boys and men with DMD: the DMD-QoL.

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What's Happening in Neurology® Clinical Practice

doi : 10.1212/WNL.0000000000011899

May 11, 2021; 96 (19)

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What's Happening in Neurology® Genetics

doi : 10.1212/WNL.0000000000011897

May 11, 2021; 96 (19)

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What's Happening in Neurology® Neuroimmunology & Neuroinflammation

doi : 10.1212/WNL.0000000000011903

May 11, 2021; 96 (19)

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The Quest for Covert Consciousness Bringing Neuroethics to the Bedside

Michael J. Young,Brian L. Edlow

doi : 10.1212/WNL.0000000000011734

May 11, 2021; 96 (19)

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Neighborhood Socioeconomic Status and Stroke Incidence

Yeonwoo Kim,Erica Twardzik,Suzanne E. Judd, Natalie Colabianchi

doi : 10.1212/WNL.0000000000011892

May 11, 2021; 96 (19)

Objective To summarize overall patterns of the impact of neighborhood socioeconomic status (nSES) on stroke incidence and uncover potential gaps in the literature, we conducted a systematic review of studies examining the association between nSES and stroke incidence, independent of individual SES.

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Absent Words, Present Person

Joan Yujae Lee

doi : 10.1212/WNL.0000000000011758

May 11, 2021; 96 (19)

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Child Neurology: Late-Onset Vitamin B6–Dependent Epilepsy Identified by Rapid Genome Sequencing

A. Chris Espinoza, Melissa A. Wright, Meghan S. Candee, Cristina Trandafir, Gary R. Nelson

doi : 10.1212/WNL.0000000000011891

May 11, 2021; 96 (19)

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Pearls & Oy-sters: “Quiet Nerve Paralysis” due to Symmetrical Neuropathy in Pure Neuritic Leprosy

Pratishtha Sengar, Ritu Verma,Varun Kumar Singh,Vimal Kumar Paliwal

doi : 10.1212/WNL.0000000000011880

May 11, 2021; 96 (19)

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Teaching NeuroImages: Linear Radial Periventricular Enhancement in Glial Fibrillary Acidic Protein Astrocytopathy

Yongyao Kong, Andrew McKeon, Odelia S.Q. Koh, Yi Rong Chiew, Bela Purohit, Chee Fang Chin, Anastasia Zekeridou, Adeline S.L. Ng

doi : 10.1212/WNL.0000000000011496

May 11, 2021; 96 (19)

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Teaching NeuroImages: Ohtahara Syndrome due to Unilateral Perisylvian Polymicrogyria

Sabarish Sekar, Pavankumar Rudrabhatla, Vinayagamani Selvadasan, Bejoy Thomas, Chandrasekharan Kesavadas

doi : 10.1212/WNL.0000000000011497

May 11, 2021; 96 (19)

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Editors' Note: Association of Initial Imaging Modality and Futile Recanalization After Thrombectomy

Ariane Lewis, Steven Galetta

doi : 10.1212/WNL.0000000000011904

May 11, 2021; 96 (19)

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Reader Response: Association of Initial Imaging Modality and Futile Recanalization After Thrombectomy

James E. Siegler, Jesse M. Thon

doi : 10.1212/WNL.0000000000011898

May 11, 2021; 96 (19)

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Author Response: Association of Initial Imaging Modality and Futile Recanalization After Thrombectomy

Thomas Raphael Meinel, Johannes Kaesmacher, Urs Fischer

doi : 10.1212/WNL.0000000000011900

May 11, 2021; 96 (19)

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Editors' Note: Comparison of Ice Pack Test and Single-Fiber EMG Diagnostic Accuracy in Patients Referred for Myasthenic Ptosis

Ariane Lewis, Steven Galetta

doi : 10.1212/WNL.0000000000011905

May 11, 2021; 96 (19)

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Reader Response: Comparison of Ice Pack Test and Single-Fiber EMG Diagnostic Accuracy in Patients Referred for Myasthenic Ptosis

Nicholas Silvestri

doi : 10.1212/WNL.0000000000011901

May 11, 2021; 96 (19)

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Author Response: Comparison of Ice Pack Test and Single-Fiber EMG Diagnostic Accuracy in Patients Referred for Myasthenic Ptosis

Maria Pia Giannoccaro, Rocco Liguori

doi : 10.1212/WNL.0000000000011902

May 11, 2021; 96 (19)

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Lesion Evolution and Neurodegeneration in RVCL-S

doi : 10.1212/WNL.0000000000011323

May 11, 2021; 96 (19)

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Apathy and Risk of Probable Incident Dementia Among Community-Dwelling Older Adults

doi : 10.1212/WNL.0000000000011756

May 11, 2021; 96 (19)

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