Jay H. Hoofnagle, M.D., and Stephen M. Feinstone, M.D.
doi : 10.1056/NEJMp2031110
N Engl J Med 2020; 383:2297-2299
Stacie B. Dusetzina, Ph.D., Benyam Muluneh, Pharm.D., Nancy L. Keating, M.D., M.P.H., and Haiden A. Huskamp, Ph.D.
doi : 10.1056/NEJMp2027580
N Engl J Med 2020; 383:2299-2301
Megan L. Evans, M.D., M.P.H., Margo Lindauer, J.D., and Maureen E. Farrell, M.D.
doi : 10.1056/NEJMp2024046
N Engl J Med 2020; 383:2302-2304
Michael F. Greene, M.D., Mark A. Klebanoff, M.D., M.P.H., and David Harrington, Ph.D.
doi : 10.1056/NEJMp2031727
N Engl J Med 2020; 383:e130
Christina Y. Chang, M.D., M.P.H., Christine P. Nguyen, M.D., Barbara Wesley, M.D., M.P.H., Jia Guo, Ph.D., Laura Lee Johnson, Ph.D., and Hylton V. Joffe, M.D., M.M.Sc.
doi : 10.1056/NEJMp2031055
N Engl J Med 2020; 383:e131
Robert S. Rosenson, M.D., Lesley J. Burgess, M.D., Ph.D., Christoph F. Ebenbichler, M.D., Seth J. Baum, M.D., Erik S.G. Stroes, M.D., Ph.D., Shazia Ali, Pharm.D., Nagwa Khilla, M.S., Robert Hamlin, B.S., Robert Pordy, M.D., Yuping Dong, Ph.D., Vladimir Son, Ph.D., and Daniel Gaudet, M.D., Ph.D.
doi : 10.1056/NEJMoa2031049
N Engl J Med 2020; 383:2307-2319
Patients with refractory hypercholesterolemia, who have high low-density lipoprotein (LDL) cholesterol levels despite treatment with lipid-lowering therapies at maximum tolerated doses, have an increased risk of atherosclerosis. In such patients, the efficacy and safety of subcutaneous and intravenous evinacumab, a fully human monoclonal antibody against angiopoietin-like 3, are not known.
Cheryl Keech, M.D., Ph.D., Gary Albert, M.S., Iksung Cho, M.S., Andreana Robertson, M.S., Patricia Reed, B.S., Susan Neal, Joyce S. Plested, Ph.D., Mingzhu Zhu, Ph.D., Shane Cloney-Clark, B.S., Haixia Zhou, Ph.D., Gale Smith, Ph.D., Nita Patel, M.S.,
doi : 10.1056/NEJMoa2026920
N Engl J Med 2020; 383:2320-2332
NVX-CoV2373 is a recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike glycoproteins and Matrix-M1 adjuvant.
John H. Stone, M.D., M.P.H., Matthew J. Frigault, M.D., Naomi J. Serling-Boyd, M.D., Ana D. Fernandes, M.A., Liam Harvey, B.S., Andrea S. Foulkes, Ph.D., Nora K. Horick, M.S., Brian C. Healy, Ph.D., Ruta Shah, M.D., Ana Maria Bensaci, M.D., Ann E. Woolley, M.D., Sarah Nikiforow, M.D., Ph.D.,
doi : 10.1056/NEJMoa2028836
N Engl J Med 2020; 383:2333-2344
The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear.
Maha Hussain, M.D., Joaquin Mateo, M.D., Karim Fizazi, M.D., Fred Saad, M.D., Neal Shore, M.D., Shahneen Sandhu, M.D., Kim N. Chi, M.D., Oliver Sartor, M.D., Neeraj Agarwal, M.D., David Olmos, M.D., Antoine Thiery-Vuillemin, M.D., Przemyslaw Twardowski, M.D.,
doi : 10.1056/NEJMoa2022485
N Engl J Med 2020; 383:2345-2357
We previously reported that olaparib led to significantly longer imaging-based progression-free survival than the physician’s choice of enzalutamide or abiraterone among men with metastatic castration-resistant prostate cancer who had qualifying alterations in homologous recombination repair genes and whose disease had progressed during previous treatment with a next-generation hormonal agent. The results of the final analysis of overall survival have not yet been reported.
Esther S.H. Kim, M.D., M.P.H.
doi : 10.1056/NEJMra2001524
N Engl J Med 2020; 383:2358-2370
Taweevat Assavapokee, M.D., and Kunlawat Thadanipon, M.D.
doi : 10.1056/NEJMvcm1806474
N Engl J Med 2020; 383:e132
Lina Espinosa Saltarén, M.D., and Rafael Andrade Pérez, M.D.
doi : 10.1056/NEJMicm2007464
N Engl J Med 2020; 383:2371
Stephanie Lemaitre, M.D., Ph.D., and Amit Arora, M.B., B.S.
doi : 10.1056/NEJMicm2012968
N Engl J Med 2020; 383:e133
Lucas X. Marinacci, M.D., F. Joseph Simeone, M.D., Andrew L. Lundquist, M.D., Ph.D., David J. Kuter, M.D., D.Phil., and Grace K. Mahowald, M.D., Ph.D.
doi : 10.1056/NEJMcpc2004991
N Engl J Med 2020; 383:2372-2383
Seth S. Martin, M.D., M.H.S.
doi : 10.1056/NEJMe2032798
N Engl J Med 2020; 383:2385-2386
Edmund Huang, M.D., and Stanley C. Jordan, M.D.
doi : 10.1056/NEJMe2032071
N Engl J Med 2020; 383:2387-2388
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Joshua A. Barocas, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2034906
N Engl J Med 2020; 383:e143
doi : 10.1056/NEJMc2031085
N Engl J Med 2020; 383:2389-2390
doi : 10.1056/NEJMc2030030
N Engl J Med 2020; 383:2390-2394
David A. Paul, M.D.
doi : 10.1056/NEJMpv2030234
N Engl J Med 2020; 383:e135
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