دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Survival after extracorporeal membrane oxygenation in severe COVID-19 ARDS: results from an international multicenter registry
Alexander Supady, Fabio Silvio Taccone, Philipp M. Lepper, Stephan Ziegeler and Dawid L. Staudacher
doi : 10.1186/s13054-021-03486-9
Critical Care 2021 25:90
Renin–angiotensin system dysregulation in critically ill patients with acute respiratory distress syndrome due to COVID-19: a preliminary report
Davide Eleuteri, Luca Montini, Salvatore Lucio Cutuli, Cristina Rossi, Francesca Alcaro and Massimo Antonelli
doi : 10.1186/s13054-021-03507-7
Critical Care 2021 25:91
Towards use of POCUS to evaluate hemodynamics in critically ill neonates: caution before adoption in this population
Patrick J. McNamara, Piers Barker, Amish Jain and Wyman W. Lai
doi : 10.1186/s13054-020-03394-4
Critical Care 2021 25:92
Complete percutaneous angio-guided approach using preclosing for venoarterial extracorporeal membrane oxygenation implantation and explantation in patients with refractory cardiogenic shock or cardiac arrest
Anne-Sophie Martin-Tuffreau, François Bagate, Madjid Boukantar, Gabriel Saiydoun, Andrea Mangiameli, Laura Rostain, Gauthier Mouillet, Antonio Fiore, Olivier Langeron, Armand Mekontso-Dessap, Nicolas Mongardon, Thierry Folliguet, Emmanuel Teiger and Romain Gallet
doi : 10.1186/s13054-021-03522-8
Critical Care 2021 25:93
The approach for veno-arterial extracorporeal membrane oxygenation implantation (VA-ECMO) in patients with cardiogenic shock can be either surgical or percutaneous. Complete angio-guided percutaneous implantation and explantation could decrease vascular complications. We sought to describe the initial results of complete percutaneous angio-guided ECMO implantation and explantation using preclosing.
Early rehabilitation in ICU for COVID-19: what about FES-cycling?
Gaëlle Deley, Davy Laroche and Jean-Pierre Quenot
doi : 10.1186/s13054-021-03526-4
Critical Care 2021 25:94
Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation
Takashi Ito, Midori Kakuuchi and Ikuro Maruyama
doi : 10.1186/s13054-021-03524-6
Critical Care 2021 25:95
Endothelial cells play a key role in maintaining intravascular patency through their anticoagulant properties. They provide a favorable environment for plasma anticoagulant proteins, including antithrombin, tissue factor pathway inhibitor, and protein C. Under septic conditions, however, the anticoagulant properties of endothelial cells are compromised. Rather, activated/injured endothelial cells can provide a scaffold for intravascular coagulation. For example, the expression of tissue factor, an important initiator of the coagulation pathway, is induced on the surface of activated endothelial cells. Phosphatidylserine, a high-affinity scaffold for gamma-carboxyglutamate domain containing coagulation factors, including FII, FVII, FIX, and FX, is externalized to the outer leaflet of the plasma membrane of injured endothelial cells. Hemodilution decreases not only coagulation factors but also plasma anticoagulant proteins, resulting in unleashed activation of coagulation on the surface of activated/injured endothelial cells. The aberrant activation of coagulation can be suppressed in part by the supplementation of recombinant antithrombin and recombinant thrombomodulin. This review aims to overview the physiological and pathological functions of endothelial cells along with proof-of-concept in vitro studies. The pathophysiology of COVID-19-associated thrombosis is also discussed.
Letter to the editor regarding “Accelerated versus standard initiation of renal replacement therapy for critically ill patients with acute kidney injury: a systematic review and meta-analysis of RCT studies”
Kate Magner, Edward Clark and Swapnil Hiremath
doi : 10.1186/s13054-021-03528-2
Critical Care 2021 25:96
Extracorporeal myoglobin removal in severe rhabdomyolysis with high cut-off membranes—intermittent dialysis achieves much greater clearances than continuous methods
Jakob Gubensek, Vanja Persic, Alexander Jerman and Vladimir Premru
doi : 10.1186/s13054-021-03531-7
Critical Care 2021 25:97
Diuretics decrease fluid balance in patients on invasive mechanical ventilation: the randomized-controlled single blind, IRIHS study
Raphaël Cinotti, Jean-Baptiste Lascarrou, Marie-Ange Azais, Gwenhaël Colin, Jean-Pierre Quenot, Pierre-Joachim Mahé, Antoine Roquilly, Aurélie Gaultier, Karim Asehnoune and Jean Reignier
doi : 10.1186/s13054-021-03509-5
Critical Care 2021 25:98
Fluid overload has been associated with increased morbidity and mortality in critically ill patients. The goal of this study was to assess the efficacy and safety of a diuretic strategy to overcome positive fluid balance in patients on invasive mechanical ventilation.
Prone mechanical ventilation in acute brain injury
Varun Suresh and Saurabh Sharma
doi : 10.1186/s13054-021-03530-8
Critical Care 2021 25:100
D-dimer specificity and clinical context: an old unlearned story
Matteo Marin, Daniele Orso, Nicola Federici, Luigi Vetrugno and Tiziana Bove
doi : 10.1186/s13054-021-03532-6
Critical Care 2021 25:101
Systematic review of cognitive impairment and brain insult after mechanical ventilation
Thiago G. Bassi, Elizabeth C. Rohrs and Steven C. Reynolds
doi : 10.1186/s13054-021-03521-9
Critical Care 2021 25:99
We conducted a systematic review following the PRISMA protocol primarily to identify publications that assessed any links between mechanical ventilation (MV) and either cognitive impairment or brain insult, independent of underlying medical conditions. Secondary objectives were to identify possible gaps in the literature that can be used to inform future studies and move toward a better understanding of this complex problem. The preclinical literature suggests that MV is associated with neuroinflammation, cognitive impairment, and brain insult, reporting higher neuroinflammatory markers, greater evidence of brain injury markers, and lower cognitive scores in subjects that were ventilated longer, compared to those ventilated less, and to never-ventilated subjects. The clinical literature suggests an association between MV and delirium, and that delirium in mechanically ventilated patients may be associated with greater likelihood of long-term cognitive impairment; our systematic review found no clinical study that demonstrated a causal link between MV, cognitive dysfunction, and brain insult. More studies should be designed to investigate ventilation-induced brain injury pathways as well as any causative linkage between MV, cognitive impairment, and brain insult.
Impact of withholding early parenteral nutrition in adult critically ill patients on ketogenesis in relation to outcome
Astrid De Bruyn, Lies Langouche, Sarah Vander Perre, Jan Gunst and Greet Van den Berghe
doi : 10.1186/s13054-021-03519-3
Critical Care 2021 25:102
Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood–brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study
Caroline Lindblad, Elisa Pin, David Just, Faiez Al Nimer, Peter Nilsson, Bo-Michael Bellander, Mikael Svensson, Fredrik Piehl and Eric Peter Thelin
doi : 10.1186/s13054-021-03503-x
Critical Care 2021 25:103
Severe traumatic brain injury (TBI) is associated with blood–brain barrier (BBB) disruption and a subsequent neuroinflammatory process. We aimed to perform a multiplex screening of brain enriched and inflammatory proteins in blood and cerebrospinal fluid (CSF) in order to study their role in BBB disruption, neuroinflammation and long-term functional outcome in TBI patients and healthy controls.
Letter to the Editor: Stroke volume is the key measure of fluid responsiveness
Jon-Emile S. Kenny and Igor Barjaktarevic
doi : 10.1186/s13054-021-03498-5
Critical Care 2021 25:104
Goal-directed therapy in the perioperative management: is a complete hemodynamics bundle of care better?
Nicolas Herzog, Jean-Baptiste Dablin, Christophe Giacardi and Marc Danguy des Déserts
doi : 10.1186/s13054-021-03527-3
Critical Care 2021 25:105
Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method
Prashant Nasa, Elie Azoulay, Ashish K. Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M. Arabi, Jan Bakker, Laurent J. Brochard, Adam M. Deane, Bin Du
doi : 10.1186/s13054-021-03491-y
Critical Care 2021 25:106
Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice.
Neurological complications during veno-venous extracorporeal membrane oxygenation: Does the configuration matter? A retrospective analysis of the ELSO database
Roberto Lorusso, Mirko Belliato, Michael Mazzeffi, Michele Di Mauro, Fabio Silvio Taccone, Orlando Parise, Ayat Albanawi, Veena Nandwani, Paul McCarthy, Zachary Kon, Jay Menaker, Daniel M. Johnson, Sandro Gelsomino and Daniel Herr
doi : 10.1186/s13054-021-03533-5
Critical Care 2021 25:107
Single- (SL) and double-lumen (DL) catheters are used in clinical practice for veno-venous extracorporeal membrane oxygenation (V-V ECMO) therapy. However, information is lacking regarding the effects of the cannulation on neurological complications.
Long-term outcomes after critical illness: recent insights
Anne-Françoise Rousseau, Hallie C. Prescott, Stephen J. Brett, Bj?rn Weiss, Elie Azoulay, Jacques Creteur, Nicola Latronico, Catherine L. Hough, Steffen Weber-Carstens, Jean-Louis Vincent and Jean-Charles Preiser
doi : 10.1186/s13054-021-03535-3
Critical Care 2021 25:108
Intensive care survivors often experience post-intensive care sequelae, which are frequently gathered together under the term “post-intensive care syndrome” (PICS). The consequences of PICS on quality of life, health-related costs and hospital readmissions are real public health problems. In the present Viewpoint, we summarize current knowledge and gaps in our understanding of PICS and approaches to management.
Galectin-3 in septic acute kidney injury: a translational study
Haibing Sun, Huiping Jiang, Amity Eliaz, John A. Kellum, Zhiyong Peng and Isaac Eliaz
doi : 10.1186/s13054-021-03538-0
Critical Care 2021 25:109
Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). We aimed to explore Gal-3’s role and its potential utility as a therapeutic target in S-AKI.
Do changes in pulse pressure variation and inferior vena cava distensibility during passive leg raising and tidal volume challenge detect preload responsiveness in case of low tidal volume ventilation?
Temistocle Taccheri, Francesco Gavelli, Jean-Louis Teboul, Rui Shi and Xavier Monnet
doi : 10.1186/s13054-021-03515-7
Critical Care 2021 25:110
In patients ventilated with tidal volume (Vt)?<?8 mL/kg, pulse pressure variation (PPV) and, likely, the variation of distensibility of the inferior vena cava diameter (IVCDV) are unable to detect preload responsiveness. In this condition, passive leg raising (PLR) could be used, but it requires a measurement of cardiac output. The tidal volume (Vt) challenge (PPV changes induced by a 1-min increase in Vt from 6 to 8 mL/kg) is another alternative, but it requires an arterial line. We tested whether, in case of Vt?=?6 mL/kg, the effects of PLR could be assessed through changes in PPV (?PPVPLR) or in IVCDV (?IVCDVPLR) rather than changes in cardiac output, and whether the effects of the Vt challenge could be assessed by changes in IVCDV (?IVCDVVt) rather than changes in PPV (?PPVVt).
Early effects of ventilatory rescue therapies on systemic and cerebral oxygenation in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: a prospective observational study
Chiara Robba, Lorenzo Ball, Denise Battaglini, Danilo Cardim, Emanuela Moncalvo, Iole Brunetti, Matteo Bassetti, Daniele R. Giacobbe, Antonio Vena, Nicol? Patroniti, Patricia R. M. Rocco, Basil F. Matta and Paolo Pelosi
doi : 10.1186/s13054-021-03537-1
Critical Care 2021 25:111
In COVID-19 patients with acute respiratory distress syndrome (ARDS), the effectiveness of ventilatory rescue strategies remains uncertain, with controversial efficacy on systemic oxygenation and no data available regarding cerebral oxygenation and hemodynamics.
Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study
Alexandros Rovas, Jan Sackarnd, Jan Rossaint, Stefanie Kampmeier, Hermann Pavenst?dt, Hans Vink and Philipp Kümpers
doi : 10.1186/s13054-021-03520-w
Critical Care 2021 25:112
The availability of handheld, noninvasive sublingual video-microscopes allows for visualization of the microcirculation in critically ill patients. Recent studies demonstrate that reduced numbers of blood-perfused microvessels and increased penetration of erythrocytes into the endothelial glycocalyx are essential components of microvascular dysfunction. The aim of this study was to identify novel microvascular variables to determine the level of microvascular dysfunction in sepsis and its relationship with clinical variables.
Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS
Arianna Piotti, Deborah Novelli, Jennifer Marie Theresia Anna Meessen, Daniela Ferlicca, Sara Coppolecchia, Antonella Marino, Giovanni Salati, Monica Savioli, Giacomo Grasselli, Giacomo Bellani, Antonio Pesenti, Serge Masson, Pietro Caironi, Luciano Gattinoni, Marco Gobbi, Claudia Fracasso
doi : 10.1186/s13054-021-03545-1
Critical Care 2021 25:113
Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin has shown benefit in septic shock patients. Our aims were: (1) to identify the relations between circulating levels of syndecan-1 (SYN-1), sphingosine-1-phosphate (S1P) (endothelial glycocalyx), and VE-cadherin (endothelial cell junctions), severity of the disease, and survival; (2) to evaluate the effects of albumin supplementation on endothelial dysfunction in patients with septic shock.
Coagulation phenotypes in sepsis and effects of recombinant human thrombomodulin: an analysis of three multicentre observational studies
Daisuke Kudo, Tadahiro Goto, Ryo Uchimido, Mineji Hayakawa, Kazuma Yamakawa, Toshikazu Abe, Atsushi Shiraishi and Shigeki Kushimoto
doi : 10.1186/s13054-021-03541-5
Critical Care 2021 25:114
A recent randomised trial showed that recombinant thrombomodulin did not benefit patients who had sepsis with coagulopathy and organ dysfunction. Several recent studies suggested presence of clinical phenotypes in patients with sepsis and heterogenous treatment effects across different sepsis phenotypes. We examined the latent phenotypes of sepsis with coagulopathy and the associations between thrombomodulin treatment and the 28-day and in-hospital mortality for each phenotype.
Mechanical ventilation parameters in critically ill COVID-19 patients: a scoping review
Giacomo Grasselli, Emanuele Cattaneo, Gaetano Florio, Mariachiara Ippolito, Alberto Zanella, Andrea Cortegiani, Jianbo Huang, Antonio Pesenti and Sharon Einav
doi : 10.1186/s13054-021-03536-2
Critical Care 2021 25:115
The mortality of critically ill patients with COVID-19 is high, particularly among those receiving mechanical ventilation (MV). Despite the high number of patients treated worldwide, data on respiratory mechanics are currently scarce and the optimal setting of MV remains to be defined. This scoping review aims to provide an overview of available data about respiratory mechanics, gas exchange and MV settings in patients admitted to intensive care units (ICUs) for COVID-19-associated acute respiratory failure, and to identify knowledge gaps.
“I AM THOR/DUST DAHO”: mnemonic devices used by the Paris Fire Brigade to teach initial measures in undertaking a CBRN event
Louise Giaume, Yann Daniel, Franck Calamai, Clément Derkenne, Romain Kedzierewicz, Aude Demeny, Kilian Bertho, Stéphane Travers, Bertrand Prunet and Fréderic Dorandeu
doi : 10.1186/s13054-021-03539-z
Critical Care 2021 25:116
Comparison of clinical outcomes between nurse practitioner and registrar-led medical emergency teams: a propensity-matched analysis
Sachin Gupta, Mayurathan Balachandran, Gaby Bolton, Naomi Pratt, Jo Molloy, Eldho Paul and Ravindranath Tiruvoipati
doi : 10.1186/s13054-021-03534-4
Critical Care 2021 25:117
Medical emergency teams (MET) are mostly led by physicians. Some hospitals are currently using nurse practitioners (NP) to lead MET calls. These are no studies comparing clinical outcomes between these two care models. To determine whether NP-led MET calls are associated with lower risk of acute patient deterioration, when compared to intensive care (ICU) registrar (ICUR)-led MET calls.
Correction to: Risks of ventilator-associated pneumonia and invasive pulmonary aspergillosis in patients with viral acute respiratory distress syndrome related or not to Coronavirus 19 disease
Keyvan Razazi, Romain Arrestier, Anne Fleur Haudebourg, Brice Benelli, Guillaume Carteaux, Jean?Winoc Decousser, Slim Fourati, Paul Louis Woerther, Frederic Schlemmer, Anais Charles-Nelson, Francoise Botterel, Nicolas de Prost and Armand Mekontso Dessap
doi : 10.1186/s13054-021-03517-5
Critical Care 2021 25:118
Urinary metabolites predict mortality or need for renal replacement therapy after combat injury
Sarah Gisewhite, Ian J. Stewart, Greg Beilman & Elizabeth Lusczek
doi : 10.1186/s13054-021-03544-2
Critical Care 2021 25:119
Traditionally, patient risk scoring is done by evaluating vital signs and clinical severity scores with clinical intuition. Urinary biomarkers can add objectivity to these models to make risk prediction more accurate. We used metabolomics to identify prognostic urinary biomarkers of mortality or need for renal replacement therapy (RRT). Additionally, we assessed acute kidney injury (AKI) diagnosis, injury severity score (ISS), and AKI stage.
Lung compartmentalization of inflammatory biomarkers in COVID-19-related ARDS
Youenn Jouan, Thomas Baranek, Mustapha Si-Tahar, Christophe Paget and Antoine Guillon
doi : 10.1186/s13054-021-03513-9
Critical Care 2021 25:120
Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: a systematic review and meta-analysis of non-randomized cohort studies
Eleni Papoutsi, Vassilis G. Giannakoulis, Eleni Xourgia, Christina Routsi, Anastasia Kotanidou and Ilias I. Siempos
doi : 10.1186/s13054-021-03540-6
Critical Care 2021 25:121
Although several international guidelines recommend early over late intubation of patients with severe coronavirus disease 2019 (COVID-19), this issue is still controversial. We aimed to investigate the effect (if any) of timing of intubation on clinical outcomes of critically ill patients with COVID-19 by carrying out a systematic review and meta-analysis.
Decreased mortality in acute respiratory distress syndrome patients treated with corticosteroids: an updated meta-analysis of randomized clinical trials with trial sequential analysis
Ping Lin, Yuean Zhao, Xiaoqian Li, Faming Jiang and Zongan Liang
doi : 10.1186/s13054-021-03546-0
Critical Care 2021 25:122
The possible benefits associated with corticosteroid treatment in acute respiratory distress syndrome (ARDS) patients are not fully known. We conducted an updated meta-analysis to assess the effect of corticosteroids in the treatment of patients with ARDS.
Re: Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs (Friedrichson et al., Critical Care, January 2021)
Alex Warren, Luigi Camporota, Stephane Ledot, Ian Scott and Alain Vuylsteke
doi : 10.1186/s13054-021-03529-1
Critical Care 2021 25:123
Comments on ‘Comparison of anticoagulation strategies for veno-venous ECMO support in acute respiratory failure’: the bitter truth about unfractionated heparin monitoring assays
Mouhamed Djahoum Moussa, Osama Abou-Arab, Emmanuel Robin and André Vincentelli
doi : 10.1186/s13054-021-03525-5
Critical Care 2021 25:124
Agreement between continuous and intermittent pulmonary artery thermodilution for cardiac output measurement in perioperative and intensive care medicine: a systematic review and meta-analysis
Karim Kouz, Frederic Michard, Alina Bergholz, Christina Vokuhl, Luisa Briesenick, Phillip Hoppe, Moritz Flick, Gerhard Sch?n and Bernd Saugel
doi : 10.1186/s13054-021-03523-7
Critical Care 2021 25:125
Pulmonary artery thermodilution is the clinical reference method for cardiac output monitoring. Because both continuous and intermittent pulmonary artery thermodilution are used in clinical practice it is important to know whether cardiac output measurements by the two methods are clinically interchangeable.
Noninvasive sampling of the distal airspace via HME-filter fluid is not useful to detect SARS-CoV-2 in intubated patients
Joerg Reifart, Christoph Liebetrau, Christian Troidl, Katharina Madlener and Andreas Rolf
doi : 10.1186/s13054-021-03549-x
Critical Care 2021 25:126
