Journal of the European Academy of Dermatology and Venereology




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سفارش


Troubled times�but a year of success for JEADV

Johannes Ring

doi : 10.1111/jdv.18667

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Reactive granulomatous dermatitis: Lumping terms to split confusion

Misha Rosenbach

doi : 10.1111/jdv.18511

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Pioneers in Dermatology and Venereology: An interview with Professor Jean L. Bolognia

Jean L. Bolognia

doi : 10.1111/jdv.18643

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The global prevalence of primary psychodermatologic disorders: a systematic review

T. Turk, C. Liu, S. Straube, M. Dytoc, R. Hagtvedt, L. Dennett, A. Abba-Aji, E. Fujiwara

doi : 10.1111/jdv.18478

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Tropical parasitic itch in returned travellers and immigrants from endemic areas

T. Ju, A. Vander Does, G. Ingrasci, S.A. Norton, G. Yosipovitch

doi : 10.1111/jdv.18408

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Definitions of remission in psoriasis: a systematic literature review from the National Psoriasis Foundation

D.M.W. Balak, L.M. Perez-Chada, L.N. Guo, C Mita, A.W. Armstrong, S.J. Bell, G.C. Gondo, W. Liao, J.F. Merola

doi : 10.1111/jdv.18477

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Infection risk in psoriatic patients receiving tumour necrosis factor inhibitors: a 20-year systematic review and meta-analysis of randomized controlled trials

Y.-C. Wang, Y.-H. Lin, S.-H. Ma, Y.-T. Chang, C.-C. Chen

doi : 10.1111/jdv.18407

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Systematic literature review assessing the overall costs and societal impacts of moderate-to-severe atopic dermatitis in Europe

M. Augustin, L. Misery, L. von Kobyletzski, S. Mealing, M. Redding, C.C. Chuang, R. Massey, M. Cawkwell, G. Bego Le-Bagousse, L. Haddy, R. Rout

doi : 10.1111/jdv.18481

Atopic dermatitis (AD) is a chronic inflammatory disease, driven by type 2 inflammation. The condition manifests as moderate-to-severe disease in approximately 20% of adults with AD across Europe and is associated with a substantial burden on patients, society and healthcare systems. However, systematic assessments capturing the totality of disease burden associated with moderate-to-severe AD are limited; therefore, the overall impacts of the disease may be underestimated.

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Clinical findings are not helpful in detecting lentigo maligna melanoma in patients with biopsy-proven lentigo maligna

J. Zoutendijk, S. Koljenovic, M. Wakkee, A.L. Mooyaart, T. Nijsten, R.R. van den Bos

doi : 10.1111/jdv.18346

Lentigo maligna (LM) based on biopsy material might be lentigo maligna melanoma (LMM) after excision.

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Novel MSH6 mutation predicted metastasis in eyelid and periocular squamous cell carcinoma

Y. Luo, Y. Rao, X. Gu, P. Chai, Y. Yang, J. Lin, X. Xu, R. Jia, S. Xu

doi : 10.1111/jdv.18454

Our previous research revealed the relative local aggressiveness of eyelid and periocular squamous cell carcinoma (EPSCC), but its distinct genetic characteristics involved remain unknown.

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Genetic landscape of indolent and aggressive Kaposi sarcomas

G.G. Malouf, X. Lu, R. Mouawad, J.-P. Spano, P. Grange, F. Yan, S. Aractingi, X. Su, N. Dupin

doi : 10.1111/jdv.18463

Kaposi sarcoma (KS) is a rare skin tumour caused by herpesvirus 8 infection and characterized by either indolence or an aggressive course necessitating systemic therapies. The genetic basis of this difference remains unknown.

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Health-related quality of life trajectories in melanoma patients after electrochemotherapy: real-world insights from the InspECT register

L.G. Campana, P. Quaglino, F. de Terlizzi, M. Mascherini, M. Brizio, R. Spina, G. Bertino, C. Kunte, J. Odili, P. Matteucci, A. MacKenzie Ross, H. Schepler, J.A.P. Clover, E. Kis, InspECT Melanoma and QoL Working Groups

doi : 10.1111/jdv.18456

Electrochemotherapy (ECT) effectively controls skin metastases from cutaneous melanoma.

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Synchronous primary cutaneous melanomas: a descriptive study of their clinical features, histology, genetic background of the patients and clinical outcomes

A. Antúnez-Lay, S. Podlipnik, C. Carrera, M. Potrony, G. Tell-Martí, C. Badenas, J.A. Puig-Butille, N. Espinosa, S. Puig, J. Malvehy

doi : 10.1111/jdv.18467

Around 0.5% of cutaneous melanoma (CM) patients will present with synchronous melanomas when first seen. Moreover, 26–40% of patients with multiple primary melanomas present with synchronous lesions.

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Dermoscopy as response evaluation tool for cutaneous malignant melanoma metastases treated with Talimogene Laherparepvec: a prospective feasibility study

E.H.A. Stahlie, A.C.J. van Akkooi, E. Plasmeijer

doi : 10.1111/jdv.18479

Currently, the response of cutaneous melanoma metastases (CMM) to treatment with Talimogene Laherparepvec (T-VEC) is evaluated by clinical examination, macroscopic lesion photography and 3-monthly PET-CT scans. When a complete response (CR) is suspected, biopsies are taken for histopathological confirmation.

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The long-term evolution of melanocytic nevi among high-risk adults

O. Reiter, N.R. Kurtansky, S.T. Musthaq, S. Dusza, A.C. Halpern, M.A. Marchetti, A.A. Marghoob, A. Scope, V. Rotemberg

doi : 10.1111/jdv.18470

There is little understanding regarding the long-term natural history of melanocytic nevi among adults.

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Primary cutaneous lymphoma patients seen at a referral dermatological centre in 1 year: A single-centre observational retrospective cohort study of the diagnoses and staging, comorbidities and associated symptoms, treatment performed and clinical course

N. Macagno, L. Mastorino, M. Rubatto, G. Avallone, M. Merli, A. Agostini, P. Fava, S. Ribero, P. Quaglino

doi : 10.1111/jdv.18469

Primary cutaneous lymphomas (PCL) are rare diseases, but the indolent course makes their prevalence high. Although there are many treatment options, no hierarchy is recommended.

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Super-response to guselkumab treatment in patients with moderate-to-severe psoriasis: age, body weight, baseline Psoriasis Area and Severity Index, and baseline Investigator's Global Assessment scores predict complete skin clearance

K. Reich, K.B. Gordon, B. Strober, R.G. Langley, M. Miller, Y.-W. Yang, Y.-K. Shen, Y. You, Y. Zhu, P. Foley, A. Blauvelt

doi : 10.1111/jdv.18474

Psoriasis is a chronic immune-mediated inflammatory skin disease that often leads to a diminished quality of life. Goals of treating patients with psoriasis have shifted with more focus on achieving near or complete clearance of the skin. Guselkumab, a fully human monoclonal antibody targeting interleukin-23, is effective in treating moderate-to-severe psoriasis.

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Psoriasis and progression of Parkinson's disease: a Mendelian randomization study

C. Li, X. Li, J. Lin, Y. Cui, H. Shang

doi : 10.1111/jdv.18459

Epidemiological studies have suggested psoriasis was associated with an increased risk of Parkinson's disease (PD). However, whether psoriasis has an effect on PD progression is not explored yet.

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Adults with concomitant atopic dermatitis and asthma have more frequent urgent healthcare utilization and less frequent scheduled follow-up visits than adults with atopic dermatitis or asthma only: a nationwide cohort study

Z. Ali, A. Egeberg, J.P. Thyssen, C.S. Ulrik, S.F. Thomsen

doi : 10.1111/jdv.18415

Atopic dermatitis (AD) and asthma often co-occur in the same patient, and healthcare utilization is related to disease severity of these diseases.

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Prenatal exposure to nickel and atopic dermatitis at age 3 years: a birth cohort study with cytokine profiles

J.C. Ho, H.J. Wen, C.W. Sun, S.F. Tsai, P.H. Su, C.L. Chang, H.L. Sun, S.L. Wang, C.H. Lee

doi : 10.1111/jdv.18425

Nickel, the fifth most common element on Earth, is the leading inducer of contact allergies in humans, with potent immunological effects. Nickel-induced contact allergies predominantly affect females. Maternal exposure to nickel has been associated with several developmental abnormalities. However, how a maternal nickel exposure affects the development of atopic diathesis and immune abnormalities in children has never been addressed.

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Effectiveness and safety of dupilumab in the treatment of atopic dermatitis in children (6–11 years): data from a French multicentre retrospective cohort in daily practice

A. Lasek, N. Bellon, S. Mallet, E. Puzenat, A.C. Bursztejn, C. Abasq, J. Mazereeuw-Hautier, C. Chiaverini, T. Hubiche, N. Raison Peyron, A. Du Thanh, S. Barbarot, H. Aubert, Z. Reguiai, C. Droitcourt, C. Fievet, A. Bellissen, M. Bachelerie, A. Nosbaum, A. Leymarie, P. Armingaud, M. Masson Regnault, E. Mahé, Research Group of the Société Française de Dermatologie Pédiatrique (GR SFDP), Research Group of eczéma atopique (GREAT)

doi : 10.1111/jdv.18450

Dupilumab is the first biotherapy available for the treatment of moderate-to-severe childhood atopic dermatitis (AD).

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Childhood maltreatment is not associated with atopic dermatitis in adults: results from a cross-sectional population-based cohort study

K. Piontek, T. Ittermann, U. Wiesmann, A. Arnold, H.J. Grabe, H. Völzke, C. Apfelbacher

doi : 10.1111/jdv.18480

Childhood maltreatment (CM) is related to poor physical and mental health outcomes in adults. Knowledge on the impact of CM on skin diseases is limited, and no study has previously addressed the association of CM with atopic dermatitis (AD) in adult age.

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Erythema multiforme associated with anti-plakin antibodies: a multicentric retrospective case series

A. Weill, V. Descamps, F. Chasset, T. Mahévas, I. Bourgault-Villada, P. Wolkenstein, S. Chollet-Martin, S. Ingen-Housz-Oro, S. Grootenboer-Mignot

doi : 10.1111/jdv.18259

Erythema multiforme (EM) is a muco-cutaneous inflammatory disease mainly triggered by herpes simplex virus (HSV) recurrences. Association of EM and circulating auto-antibodies against plakins (anti-PLK-Abs [EM-PLK+]) has been reported. However, little is known about this subset of EM.

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Reactive granulomatous dermatitis as a clinically relevant and unifying term: a retrospective review of clinical features, associated systemic diseases, histopathology and treatment for a series of 65 patients at Mayo Clinic

A. Bangalore Kumar, J.S. Lehman, E.F. Johnson, H.M. Cantwell, J.C. Sartori Valinotti, O. Sokumbi, M.D.P. Davis, D.A. Wetter

doi : 10.1111/jdv.18203

Reactive granulomatous dermatitis (RGD) is an umbrella term used to describe interstitial granulomatous dermatitis (IGD), palisaded neutrophilic and granulomatous dermatitis (PNGD), and interstitial granulomatous drug eruption (IGDR).

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Narrow-band reflectance spectrophotometry and infrared thermography for assessment of skin lesions in localized scleroderma

M. Szczepanek, A. Frątczak, K. Polak, A. Lis-Święty

doi : 10.1111/jdv.18483

Infrared thermography (IRT) is a useful method to detect activity/inflammation in localized scleroderma (LoS); however, inactive skin lesions with a severe degree of dermal and subcutaneous atrophy may show false-positive results. Narrow-band reflectance spectrophotometry (NBRS) is an objective, non-invasive technique of measuring erythema and hyperpigmentation severity, yet has not been extensively studied in LoS.

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Outcome and long-term treatment protocol for topical tacrolimus in oral lichen planus

S. Utz, V.G.A. Suter, S. Cazzaniga, L. Borradori, L. Feldmeyer

doi : 10.1111/jdv.18457

Topical tacrolimus has been shown to be beneficial in the treatment of oral lichen planus (OLP). However, long-term effects and its optimal application protocol with gradual reduction have not been studied. Accordingly, we analysed the clinical response of OLP to tacrolimus in our daily clinical practice with a focus on the optimal long-term therapeutic scheme.

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Lymphocyte subsets and Langerhans cells in the skin of kidney transplant recipients under three different immunosuppressive regimens

M.V. Quaresma, L.S. Azevedo, N.V. Pereira, M.G. Saldanha, E. David-Neto, M.N. Sotto

doi : 10.1111/jdv.18430

Renal transplant recipients (RTRs) are at increased risk of developing skin cancer; however, the role of immunosuppression is not yet fully understood. In this study, we evaluated the immunohistochemical changes in the skin of RTRs under three different immunosuppression regimens: mTOR inhibitors (mTORi), sirolimus or everolimus, mycophenolic acid (MPA) precursors such as mycophenolate sodium or mofetil, or azathioprine (AZA).

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Mortality and prognostic factors in patients with bullous pemphigoid: a retrospective multicenter Italian study

F. Bardazzi, F. Filippi, M.A. Chessa, M. Iommi, C. Loi, A. Campanati, G. Rizzetto, C. Tagliati, L. Atzori, S. Muratori, G. Genovese, P. Gisondi, D. Schena, R. Balestri, G. Rech, C. Feliciani, C. Lasagni, L. Bigi, C. De Simone, G. Di Zenzo, F. Moro, A. Borghi, V. Di Lernia, G. D'Arrigo, G. Tripepi, M. Gori, A. Pitino

doi : 10.1111/jdv.18441

Bullous pemphigoid is the most common autoimmune bullous dermatosis. In recent years several studies have tried to identify the main factors of the disease related with an increased risk of death. The aim of this multicenter Italian study was to assess the risk score of death considering epidemiologic, clinical, immunological, and therapeutic factors in a cohort of patients affected by bullous pemphigoid and try to identify the cumulative survival up to 120 months.

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Genome-wide association study of dermatophytosis in the UK Biobank cohort

S. Lehrer, P.H. Rheinstein

doi : 10.1111/jdv.18413

Analyses of the hereditary propensity to dermatophytosis have revealed several proven genetic relationships. They include CARD9 deficiency, HLA-DR4 and HLA-DR8 type and genes encoding interleukin-22, defensin 2 and 4, and genetic defects in dectin-1, which increased the prevalence of dermatophytosis in families and were involved in the inheritance of susceptibility in their members.

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Stress signalling and STAT1 activation characterize the keratinocytic gene expression pattern in Hidradenitis suppurativa

V.G. Frings, L. Jopp, M. Srivastava, D. Presser, M. Goebeler, M. Schmidt

doi : 10.1111/jdv.18465

The pathogenetic factors generating the innate immune signal necessary for T-cell activation, initiation and chronification of Hidradenitis suppurativa (HS, also known as Acne inversa) are still poorly understood. Emerging evidence suggests that a defective keratinocyte function critically contributes to HS disease development and progression.

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First ex vivo cultivation of human Demodex mites and evaluation of different drugs on mite proliferation

B.M. Clanner-Engelshofen, L.M. Ständer, T. Steegmüller, T. Kämmerer, L.H. Frommherz, P.-C. Stadler, A. Gürtler, M. Reinholz

doi : 10.1111/jdv.18468

Demodex spp. mites are the most complex resident of the human skin microbiome. Although they are considered commensals, they can be pathophysiologically relevant in inflammatory skin diseases like rosacea. Until now, there is no culture system available for these mites except for using live vertebrate hosts.

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The temporal association of hyperhidrosis and its comorbidities – a nationwide hospital-based cohort study

M.A.S. Henning, R. Reguant, I.F. Jørgensen, R.K. Andersen, K.S. Ibler, O.B. Pedersen, G.B.E. Jemec, S. Brunak

doi : 10.1111/jdv.18351

Research on hyperhidrosis comorbidities has documented the co-occurrence of diseases but has not provided information about temporal disease associations.

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Artificial intelligence for the automated single-shot assessment of psoriasis severity

T. Okamoto, M. Kawai, Y. Ogawa, S. Shimada, T. Kawamura

doi : 10.1111/jdv.18354

PASI score is globally used to assess disease activity of psoriasis. However, it is relatively complicated and time-consuming, and the score will vary due to the inconsistent subjectivity between dermatologists. Therefore, an AI system capable of assessing psoriasis severity will be useful.

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Deep learning-based classification of dermatological lesions given a limited amount of labelled data

S. Krammer, Y. Li, N. Jakob, A.S. Boehm, H. Wolff, P. Tang, T. Lasser, L.E. French, D. Hartmann

doi : 10.1111/jdv.18460

Artificial intelligence (AI) techniques are promising in early diagnosis of skin diseases. However, a precondition for their success is the access to large-scaled annotated data. Until now, obtaining this data has only been feasible with very high personnel and financial resources.

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Improved diagnosis by automated macro- and micro-anatomical region mapping of skin photographs

L. Amruthalingam, P. Gottfrois, A. Gonzalez Jimenez, B. Gökduman, M. Kunz, T. Koller, DERMANATOMY Consortium, M. Pouly, A.A. Navarini

doi : 10.1111/jdv.18476

The exact location of skin lesions is key in clinical dermatology. On one hand, it supports differential diagnosis (DD) since most skin conditions have specific predilection sites. On the other hand, location matters for dermatosurgical interventions. In practice, lesion evaluation is not well standardized and anatomical descriptions vary or lack altogether. Automated determination of anatomical location could benefit both situations.

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Generalized and persistent skin pigmentation after COVID-19 vaccination

J. Lu, Y. Liu, Y. Sun

doi : 10.1111/jdv.18379

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Influence of Covid-19 vaccination on immune-mediated skin diseases

N. A. Alelq, M. E. Kubieniec, L. E French, J. C. Prinz

doi : 10.1111/jdv.18388

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Pyoderma gangrenosum after mRNA-based SARS-CoV-2 vaccine

J. Franceschi, A.S. Darrigade, P. Sanchez-Pena, V. Legrain-Lifermann, B. Milpied

doi : 10.1111/jdv.18389

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Reactions in leprosy patients triggered by COVID-19 vaccination – a cross-sectional study from a tertiary care centre in India

A. Bhandari, Shilpa, S. Gupta, S. Dogra, T. Narang

doi : 10.1111/jdv.18390

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Face mask-induced purpura: another unexpected effect of COVID era

V. Piccolo, A. Bassi, C. Mazzatenta, T. Russo, G. Argenziano, M. Cutrone, Markus ES Danielsson Darlington, R. Grimalt

doi : 10.1111/jdv.18392

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Reply to ‘development of severe pemphigus vulgaris following SARS-CoV-2 vaccination with BNT162b2’ by Solimani F et al.

F. Falcinelli, A. Lamberti, C. Cota, P. Rubegni, E. Cinotti

doi : 10.1111/jdv.18398

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Pityriasis lichenoides chronica after BNT162b2 Pfizer-BioNTech vaccine: A novel cutaneous reaction after SARS-CoV-2 vaccine

F. Drago, G. Ciccarese, A. Guadagno, A. Parodi

doi : 10.1111/jdv.18418

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A severe case of papulovesicular exthanthema with rhabdomyolysis after corona virus disease 2019 heterologous booster vaccination

A. Baba, Y. Maki, T. Kanekura, H. Tsubouchi

doi : 10.1111/jdv.18420

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Transient aquagenic syringeal acrokeratoderma during COVID-19 outbreak: a retrospective case series of eight patients

P. Burgos-Blasco, M. González-Cañete, A. Melian-Olivera, D. Vega-Diez, I. Aldanondo-Fernandez de la Mora, B. Perez-Garcia, D. De Perosanz-Lobo

doi : 10.1111/jdv.18434

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Measuring well-being in psoriasis: psychometric properties of the WHO-5 questionnaire

R. Sommer, L. Westphal, U. Mrowietz, S. Gerdes, M. Augustin

doi : 10.1111/jdv.18396

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Proposed management algorithm for dupilumab-associated ocular side effects: a collaborative effort between dermatologists and ophthalmologists

D. Wu, B.S. Daniel, A.J.X. Lai, N. Wong, D.K.A. Lim, D.F. Murrell, B.X.H. Lim, J.S. Mehta, C.H.L. Lim

doi : 10.1111/jdv.18397

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Management of atypical junctional melanocytic proliferations: a single-institution cross-sectional study

J.R. Terrell, L. Qi, H. Wu, J. Joo, M.A. Fung, A.R. Vaughn, M. Kiuru

doi : 10.1111/jdv.18399

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Patient–physician (dis)agreement on their reports of body surface area affected by psoriasis and its associations with disease burden

N. da Silva, M. Augustin, C. Hilbring, C.C. von Stülpnagel, R. Sommer

doi : 10.1111/jdv.18400

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Pemphigus vegetans with antibodies against desmoglein 1 and desmocollin 1–3: a case report and literature review

K. Kosaka, Y. Endo, S. Toki, A. Oka, A. Uehara, O. Ishikawa, H. Koga, N. Ishii, S.-i. Motegi

doi : 10.1111/jdv.18401

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Validation of case identification for hyperpigmentation in the setting of medication use using international classification of diseases coding

N. Theodosakis, J. Yoon, K. Young, E. Getachew, A. Mostaghimi, Y. Semenov

doi : 10.1111/jdv.18402

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Interpretation of comorbidity risk in hidradenitis suppurativa: comparing odds ratio and ‘number needed to be exposed’

J.P. Pham, K. Glasenhardt, A. Garg, J.W. Frew

doi : 10.1111/jdv.18403

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Knowledge and role of dermatologists in life-threatening infections: a national survey among hospital skin specialists

A. Pulido-Perez, M. Bergon-Sendin, L. Barchino-Ortiz, R. Suarez-Fernandez, P. Muñoz, E. Bouza, Skin&Sepsis Group

doi : 10.1111/jdv.18404

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Enfortumab vedotin-induced cutaneous adverse events manifesting as miliaria-like eruptions with the presence of keratinocyte apoptosis in clinically intact skin

K. Oya, Y. Nakamura, K. Iwamoto, T. Kimura, H. Negoro, H. Nishiyama, Y. Fujisawa

doi : 10.1111/jdv.18406

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Vintage descriptions of IgA pemphigus

D. Wallach

doi : 10.1111/jdv.18419

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Downregulation of pathogenic MICA-NKG2D interactions as a novel strategy in alopecia areata management: a new rationale for adjunct statin therapy?

J. Gherardini, K.E. Rivas, J. Chéret, N. Strbo, R. Paus

doi : 10.1111/jdv.18423

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Monkeypox: a new (sexually transmissible) epidemic?

M. Alpalhão, J.V. Frade, D. Sousa, J. Patrocínio, P.M. Garrido, C. Correia, C. Brazão, D. Mancha, M.J. Borrego, P. Filipe

doi : 10.1111/jdv.18424

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Telemedical care of men with androgenetic alopecia demonstrates improved access to care and patient benefit

F. Abeck, J. Kött, I. Wiesenhütter, T. Hiebenthal, I. Hansen, S.W. Schneider, J. von Büren

doi : 10.1111/jdv.18426

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Impact of comorbidities in the response of atopic patients treated with dupilumab: a real-life study up to 36 weeks

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