Juanjuan Zhang, Xiaoli Qian, Ming Duan, Yi Li & Zhiming Wang
doi : 10.1007/s10620-022-07694-3
Digestive Diseases and Sciences volume 67, pages 5355–5358 (2022)
Ethan O. BrysonÂ
doi : 10.1007/s10620-022-07622-5
Digestive Diseases and Sciences volume 67, pages 5359–5360 (2022)
Sian Xie, Shengtao Zhu & Li Min
doi : 10.1007/s10620-022-07595-5
Digestive Diseases and Sciences volume 67, pages 5361–5363 (2022)
Alice A. Lee & Julia McNabb-Baltar
doi : 10.1007/s10620-022-07574-w
Digestive Diseases and Sciences volume 67, pages 5364–5365 (2022)
Vinay Dhir & Abhijith Bale
doi : 10.1007/s10620-022-07560-2
Digestive Diseases and Sciences volume 67, pages 5366–5367 (2022)
Ryan Flanagan, Conrad Worrell & Navin Kumar
doi : 10.1007/s10620-022-07710-6
Digestive Diseases and Sciences volume 67, pages 5368–5370 (2022)
John P. Gallagher, Patrick A. Twohig, Agnes Crnic & Fedja A. Rochling
doi : 10.1007/s10620-022-07619-0
Digestive Diseases and Sciences volume 67, pages 5371–5381 (2022)
Illicit drug use (IDU) is often encountered in patients undergoing elective ambulatory surgical procedures such as endoscopy. Given the variety of systemic effects of these drugs, sedation and anesthetics are believed to increase the risk of cardiopulmonary complications during procedures. Procedural cancelations are common, regardless of the drug type, recency of use, and total dosage consumed. There is a lack of institutional and society recommendations regarding the optimal approach to performing outpatient endoscopy on patients with IDU.
Alexander Keith Turbayne & Miles Patrick Sparrow
doi : 10.1007/s10620-022-07719-x
Digestive Diseases and Sciences volume 67, pages 5382–5391 (2022)
The inflammatory bowel diseases (IBD) are complex immune-mediated inflammatory diseases that are associated with significant morbidity around the world. As our understanding of IBD, and other immune-mediated inflammatory diseases, advances the number of therapeutic targets has increased which has rapidly driven the development and introduction of new therapies. While these new therapies have shown promise they come with the significant drawback of high costs.
Dikshita Deka, Renata D’Incà , Giacomo Carlo Sturniolo, Alakesh Das, Surajit Pathak & Antara Banerjee
doi : 10.1007/s10620-022-07467-y
Digestive Diseases and Sciences volume 67, pages 5392–5406 (2022)
Previous investigations have increased the knowledge about the pathological processes of inflammatory bowel diseases. Besides the complex organization of immune reactions, the mucosal epithelial lining has been recognized as a crucial regulator in the commencement and persistence of intestinal inflammation.
Michael J. Coles, Muaaz Masood, Madeline M. Crowley, Amit Hudgi, Chijioke Okereke & Jeremy Klein
doi : 10.1007/s10620-022-07480-1
Digestive Diseases and Sciences volume 67, pages 5407–5415 (2022)
The ongoing pandemic resulting from severe acute respiratory syndrome—caused by coronavirus 2 (SARS-CoV-2)—has posed a multitude of healthcare challenges of unprecedented proportions. Intestinal enterocytes have the highest expression of angiotensin-converting enzyme-2 (ACE2), which functions as the key receptor for SARS-CoV-2 entry into cells.
Hassan Ali Al Saleh, Thomas Malikowski, Dhyanesh Arvind Patel, Ijlal Akbar Ali & Sultan Mahmood
doi : 10.1007/s10620-022-07451-6
Digestive Diseases and Sciences volume 67, pages 5416–5424 (2022)
Non-obstructive dysphagia (NOD) is defined as symptomatic dysphagia in patients with negative endoscopic and radiographic workup. The management of NOD remains controversial as there is a discrepancy between different guidelines and clinical practice. Despite the lack of high-quality studies, empiric dilation for NOD is a common clinical practice among endoscopists and the approach varies between different clinical centers.
F. M. Mongardini, C. Cacciatore, A. Catauro, F. Maglione, F. Picardi, A. Lauro, C. Gambardella, A. Allaria & L. Docimo
doi : 10.1007/s10620-022-07711-5
Digestive Diseases and Sciences volume 67, pages 5425–5432 (2022)
Laparoscopic sleeve gastrectomy (LSG) is a commonly used procedure in bariatric patients that often has excellent results. Despite its advantages, LSG is burdened by specific intraoperative and postoperative early and late complications. One of the life-threatening complications is gastric fistula, usually treated with a multidisciplinary surgical–endoscopic approach.
Federico Maria MongardiniÂ
doi : 10.1007/s10620-022-07712-4
Digestive Diseases and Sciences volume 67, page 5433 (2022)
Wendy Zhou, George Triadafilopoulos & Nielsen Fernandez-Becker
doi : 0.1007/s10620-022-07693-4
Digestive Diseases and Sciences volume 67, pages 5434–5438 (2022)
Divya Ashat, Animesh Jain, Kimberly N. Weaver, Millie D. Long, Hans H. Herfarth & Edward L. Barnes
doi : 10.1007/s10620-022-07682-7
Digestive Diseases and Sciences volume 67, pages 5439–5443 (2022)
Aymane Ajbar, Eleanor Cross, Simbarashe Matoi, Charles A. Hay, Libby M. Baines, Benjamin Saunders, Adam D. Farmer & James A. Prior
doi : 10.1007/s10620-022-07452-5
Digestive Diseases and Sciences volume 67, pages 5444–5454 (2022)
Delays in diagnosing pediatric inflammatory bowel disease (IBD) are common, but the extent of this delay remains unclear due to variations in reported time-periods between studies. The objectives of this systematic review were to examine the extent of diagnostic delay in pediatric IBD and examine any association between specific characteristics and length of diagnostic delay.
Alyssa Caplan, Ryan McConnell, Fernando Velayos, Uma Mahadevan & Sara Lewin
doi : 10.1007/s10620-022-07490-z
Digestive Diseases and Sciences volume 67, pages 5455–5461 (2022)
Reducing hospitalization length of stay (LOS) for acute severe ulcerative colitis (ASUC) will reduce healthcare costs, mitigate hospitalization-associated risks (e.g., venous thromboembolism), and improve quality of life.
Kate E. Lee, Francesca Lim, Adam S. Faye, Bo Shen & Chin Hur
doi : 10.1007/s10620-022-07420-z
Digestive Diseases and Sciences volume 67, pages 5462–5471 (2022)
Endoscopic balloon dilation (EBD) has emerged as an alternative intervention to manage Crohn’s disease (CD) strictures. We determined the cost-effectiveness of EBD versus resection surgery for patients with short (< 4–5 cm) primary or secondary/anastomotic small or large bowel strictures.
Catherine Emerson, David Skvarc, Matthew Fuller-Tyszkiewicz, Lisa Olive, Peter R. Gibson & Antonina Mikocka-Walus
doi : 10.1007/s10620-022-07476-x
Digestive Diseases and Sciences volume 67, pages 5472–5482 (2022)
Fatigue in inflammatory bowel disease (IBD) is poorly controlled, with few existing interventions. Psychotherapy interventions for IBD fatigue show promise; however, due to mixed findings in efficacy and attrition, current interventions need improvement. Some research shows beliefs about psychotherapy and stigma toward psychotherapy may impact engagement in psychotherapy interventions.
Jacqueline B. Henson, James H. Helzberg & Andrew J. Muir
doi : 10.1007/s10620-022-07482-z
Digestive Diseases and Sciences volume 67, pages 5483–5492 (2022)
Primary sclerosing cholangitis (PSC) is a chronic, progressive liver disease, and many patients ultimately require liver transplantation (LT). PSC also confers an increased risk of malignancies, including cholangiocarcinoma (CCA) and colorectal cancer.
Ishani Shah, Rachel Bocchino, William Yakah, Awais Ahmed, Steven D. Freedman, Darshan J. Kothari & Sunil G. Sheth
doi : 10.1007/s10620-022-07459-y
Digestive Diseases and Sciences volume 67, pages 5493–5499 (2022)
Patients with chronic pancreatitis (CP) often require opioids for pain control. The goal of our study was to characterize opioid use in patients with CP in a real-life practice using a state-mandated online monitoring program and to assess outcomes compared to CP patients without opioid dependency.
Vivek Kumar, Russell D. Dolan, Allison L. Yang, David X. Jin, Peter A. Banks & Julia McNabb-Baltar
doi : 10.1007/s10620-022-07463-2
Digestive Diseases and Sciences volume 67, pages 5500–5510 (2022)
Previous studies on healthcare resource utilization and 30-day readmission risks among patients with acute pancreatitis (AP) have focused upon opioid and alcohol use. The data on other substance types are lacking. In this study we aim to estimate the 30-day readmission rates, predictors of readmission, impact of readmission on patient outcomes and resulting economic burden among patients with AP and substance use in the USA.
Eoin P. McNeill, Vikas S. Gupta, David J. Sequeira, Noah F. Shroyer & Allison L. Speer
doi : 10.1007/s10620-022-07442-7
Digestive Diseases and Sciences volume 67, pages 5511–5521 (2022)
Human intestinal organoids (HIOs), when transplanted into immunocompromised mice (tHIOs), demonstrate significant growth and maturation. While both male and female mice are reported to be viable hosts for these experiments, a direct comparison of sex-related differences in tHIO structure and development has not been performed.
Leila Ganji, Mohammad Hassan Shirazi, Nasser Ebrahimi-Daryani, Parisa Eslami, Mohammad Rahbar, Mohammad Reza Zali & Masoud Alebouyeh
doi : 10.1007/s10620-022-07468-x
Digestive Diseases and Sciences volume 67, pages 5522–5528 (2022)
Cytolethal distending toxin (Cdt) is one of the bacterial toxins that present in a variety of gram-negative human pathogens, such as E. coli, Salmonella spp., and Campylobacter spp. CDT is composed of three subunits encoded by three adjacent genes, including cdtA, cdtB, and cdtC. cdtB has been shown to have toxic activity and cause DNA damage in host cells.
Shaoxin Wang, Jiang Pu, Xiaowei Li, Zhihui Yan, Chao Li, Yan Zheng, Zhe Luo & Lihong Cui
doi : 10.1007/s10620-022-07453-4
Digestive Diseases and Sciences volume 67, pages 5529–5539 (2022)
The NF-κB signaling cascade regulates immune response and is often dysregulated in tumor development. UBE2W is a novel type I ubiquitin-conjugating enzyme (E2) whose biological function is still unclear.
R. M. Corcoran, P. MacDonagh, F. O’Connell, M. E. Morrissey, M. R. Dunne, R. Argue, J. O’Sullivan & D. Kevans
doi : 10.1007/s10620-022-07411-0
Digestive Diseases and Sciences volume 67, pages 5540–5550 (2022)
The clinical course of ulcerative colitis (UC) is variable. There is an unmet clinical need for biomarkers of UC disease behaviour. We aimed to evaluate the association between ex vivo human UC explant conditioned media (explant-CM) secreted protein profiles and UC disease behaviour.
Amil Sinha, Meha Bhuva, Claire Grant, Alexander E. Gimson, Edward Thompson, Adam Duckworth, Susan E. Davies, Guruprasad Aithal & William J. Griffiths
doi : 10.1007/s10620-022-07416-9
Digestive Diseases and Sciences volume 67, pages 5551–5561 (2022)
Mutations in the ABCB4 gene are associated with failure of bile acid emulsification leading to cholestatic liver disease. Presentations range from progressive familial intrahepatic cholestasis type 3 (PFIC3) in childhood, to milder forms seen in adulthood.
Yichen Wang, Wei Zhang, Bing Chen, Xiaoquan Huang, Si Li, Yuting Huang & Pardeep Bansal
doi : 10.1007/s10620-022-07475-y
Digestive Diseases and Sciences volume 67, pages 5562–5570 (2022)
Current guidelines suggest antibiotics prophylaxis is not necessary for patients with orthopedic prosthetics undergoing gastrointestinal endoscopy. Clinical evidence to support this recommendation is lacking.
Charlotte K. Pitcher, Adam D. Farmer, Jordan J. Haworth, Sam Treadway & Anthony R. Hobson
doi : 10.1007/s10620-022-07487-8
Digestive Diseases and Sciences volume 67, pages 5571–5579 (2022)
Hydrogen and methane breath tests (HMBT) are widely used clinical investigations but lack standardization. To address this, the North American Consensus (NAC) group published evidence-based recommendations for HMBT.
Yangfan Hou, Lei Dong, Xiaolan Lu, Haitao Shi, Bing Xu, Wenting Zhong, Lin Ma, Shuhui Wang, Caifeng Yang, Xinyi He, Yidi Zhao & Shenhao Wang
doi : 10.1007/s10620-022-07588-4
Digestive Diseases and Sciences volume 67, pages 5580–5592 (2022)
Recent studies have shown that changes in the intestinal microbiota contribute to the pathogenesis of irritable bowel syndrome (IBS). This study aimed to investigate the characteristics of the fecal and intestinal mucosal microbiota in IBS patients, and the correlation between microbiota and clinical manifestations.
Nicola A. Bray, Natasha A. Koloski, Michael P. Jones, Anh Do, Siong Pang, Jeff S. Coombes, Sarah McAllister, Jane Campos, Leela Arthur, Paul Stanley,, Katherine DeMaria, Che-yung Chao, Rachel Catague, Amanda Whaley, Nicholas J. Talley & Gerald J. Holtmann
doi : 10.1007/s10620-022-07464-1
Digestive Diseases and Sciences volume 67, pages 5593–5601 (2022)
Functional gastrointestinal disorders (FGID) are linked to a variety of potential causes, and treatments include reassurance, life-style (including diet), psychological, or pharmacologic interventions.
Jong Hyeon Jeong, Sun-Young Lee, Jeong Hwan Kim, In-Kyung Sung & Hyung Seok Park
doi : 10.1007/s10620-022-07471-2
Digestive Diseases and Sciences volume 67, pages 5602–5609 (2022)
The serum pepsinogen (PG) assay is used to screen subjects at high risk for gastric cancer. Currently, there are few studies on the PG levels for the detection of Helicobacter pylori infection. This study aimed to determine the PG assay findings for detecting ongoing infection.
Haruhiko Takahashi, Kenshi Yao, Takashi Nagahama, Masaki Miyaoka, Kensei Ohtsu, Takao Kanemitsu, Kazuhisa Matsunaga, Tetsuya Ueo & Toshiharu Ueki
doi : 10.1007/s10620-022-07470-3
Digestive Diseases and Sciences volume 67, pages 5610–5616 (2022)
Subepithelial microvascular pattern cannot be visualized on the surface of adenoma and carcinoma by magnifying endoscopy due to a white opaque substance (WOS), which consists of minute lipid droplets accumulated in the neoplastic epithelium.
Claire L. Jansson-Knodell, Edward J. Krajicek, Monica Ramakrishnan, Nicholas A. Rogers, Robert Siwiec, Matt Bohm, Thomas Nowak, John Wo, Carolyn Lockett, Huiping Xu, Dennis A. Savaiano & Andrea Shin
doi : 10.1007/s10620-022-07469-w
Digestive Diseases and Sciences volume 67, pages 5617–5627 (2022)
Approximately two-thirds of adults are genetically predisposed to decreased lactase activity after weaning, putting them at risk of lactose intolerance. However, symptoms are a poor marker of lactose maldigestion.
P. Kaazan, Z. Tan, P. Maiyani, M. Mickenbecker, S. Edwards, C. McIvor & J. M. Andrews
doi : 10.1007/s10620-022-07488-7
Digestive Diseases and Sciences volume 67, pages 5628–5636 (2022)
Biologic therapies are effective at inducing and maintaining remission in people with inflammatory bowel disease (IBD). Previous studies have associated TNF-a inhibitors with weight gain, however, it is unclear if this is a class-specific effect or a manifestation of good disease control. To clarify this issue, a retrospective study was undertaken to examine weight changes over time during therapy with different biologic agents.
Laurent Peyrin-Biroulet, Guillaume Bouguen, David Laharie, Gauthier Pellet, Guillaume Savoye, Cyrielle Gilletta, Christophe Michiels, Anthony Buisson,, Mathurin Fumery, Jean-Noël Trochu, Patrice Cacoub & The CARENFER study group
doi : 10.1007/s10620-022-07474-z
Digestive Diseases and Sciences volume 67, pages 5637–5646 (2022)
Iron deficiency (ID) is a frequent condition in patients with inflammatory bowel disease (IBD).
Michiel E. de Jong, Iris D. Nagtegaal, Shoko Vos, Rachel S. van der Post, Yasmijn van Herwaarden, Lauranne A. A. P. Derikx & Frank Hoentjen
doi : 10.1007/s10620-022-07485-w
Digestive Diseases and Sciences volume 67, pages 5647–5656 (2022)
The impact of serrated polyps on the advanced colorectal neoplasia (CRN) risk in inflammatory bowel disease (IBD) patients is unknown. Serrated polyps are histologically categorized as hyperplastic polyps (HPs), sessile serrated lesions (SSLs), and traditional serrated adenomas (TSAs).
Naohisa Yoshida, Ken Inoue, Osamu Dohi, Reo Kobayashi, Yuri Tomita, Hikaru Hashimoto, Satoshi Sugino, Ryohei Hirose, Takaaki Murakami, Yutaka Inada, Yukiko Morinaga & Yoshito Itoh
doi : 10.1007/s10620-022-07460-5
Digestive Diseases and Sciences volume 67, pages 5657–5665 (2022)
An endoscopic system using 5-color light-emitting diodes (LEDs) (EVIS X1; Olympus Co., Tokyo, Japan), which includes texture and color enhancement imaging (TXI), has been released. In this study, we analyzed the effects of TXI on the visibility of non-polypoid colorectal lesions and its diagnostic accuracy.
Juan I. Olmos, Mar?a M. Piskorz, Nestor Litwin, Sara Schaab, Adriana Tevez, Gladys Bravo-Velez, Tatiana Uehara, Harumi Hashimoto, Enzo Rey,Juan A. Sorda & Jorge A. Olmos
doi : 10.1007/s10620-022-07568-8
Digestive Diseases and Sciences volume 67, pages 5666–5675 (2022)
Irritable bowel syndrome (IBS) is one of the most frequent disorders in clinical practice, with a mean 7.6–10.8% worldwide prevalence. A study showed that 6.1% of patients with diarrhea-predominant IBS (IBS-D) had severe exocrine pancreatic insufficiency (EPI). We aimed to identify the prevalence of EPI based on fecal elastase stool testing (Fel-1) in IBS-D and the clinical characteristics that may predict the diagnosis of EPI.
Akihisa Ohno, Nao Fujimori, Toyoma Kaku, Yu Takamatsu, Kazuhide Matsumoto, Masatoshi Murakami, Katsuhito Teramatsu, Ayumu Takeno, Masayuki Hijioka, Ken Kawabe, Naohiko Harada, Makoto Nakamuta, Akira Aso, Takamasa Oono & Yoshihiro Ogawa
doi : 10.1007/s10620-022-07555-z
Digestive Diseases and Sciences volume 67, pages 5676–5684 (2022)
Recently, endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) procedures have been gradually established; nonetheless, some adverse events (AEs) have been reported. Dilation procedures using a non-cautery or cautery device increase the incidence of AEs in EUS-HGS.
Alyssa Y. Choi, Kenneth J. Chang, Jason B. Samarasena, John G. Lee, Xiaodong Li, Wenchang Guo, Vishal S. Chandan & Ke-Qin Hu
doi : 10.1007/s10620-022-07418-7
Digestive Diseases and Sciences volume 67, pages 5685–5692 (2022)
Endoscopic ultrasound is a novel diagnostic approach to chronic liver diseases (CLDs), and EUS-guided porto-systemic pressure gradient measurement (EUS-PPG) is an important expansion with a well-developed technique. However, the clinical value and applicability of EUS-PPG measurement in predicting histologically advanced hepatic fibrosis remain unknown.
Theresa Bucsics, Katharina Lampichler, Constantin Vierziger, Maria Schoder, Florian Wolf, David Bauer, Benedikt Simbrunner, Lukas Hartl, Mathias Jachs, Bernhard Scheiner, Michael Trauner, Thomas Gruenberger, Franz Karnel, Mattias Mandorfer & Thomas Reiberger
doi : 10.1007/s10620-022-07443-6
Digestive Diseases and Sciences volume 67, pages 5693–5703 (2022)
Patients with cirrhosis often develop portal hypertension-associated splenomegaly and hypersplenism, potentially causing severe cytopenia.
Atsuo Takigawa, Ryotaro Sakamori, Yuki Tahata, Teppei Yoshioka, Ryoko Yamada, Takahiro Kodama, Hayato Hikita, Takayuki Yakushijin, Kazuyoshi Ohkawa, Naoki Hiramatsu, Eiji Mita, Hideki Hagiwara, Toshifmi Ito, Yasuharu Imai, Tomohide Tatsumi & Tetsuo Takehara
doi : 10.1007/s10620-022-07455-2
Digestive Diseases and Sciences volume 67, pages 5704–5711 (2022)
Intrahepatic hepatocellular carcinoma (HCC) has a high recurrence rate after radiofrequency ablation (RFA). However, to date, no standalone predictive factors for intrahepatic distant recurrence after curative ablation have been reported.
Gabriel G?rate, Marta Pascual, José Manuel Olmos, Carmen Fari?as, Monserrat Rivero, Javier Crespo & Julio Pascual
doi : 10.1007/s10620-022-07473-0
Digestive Diseases and Sciences volume 67, pages 5712–5713 (2022)
Manhal Izzy & Lisa B. VanWagner
doi : 10.1007/s10620-022-07580-y
Digestive Diseases and Sciences volume 67, pages 5714–5715 (2022)
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