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Biologic sex and the estimation of GFR in pediatric and young adult patients with acute kidney injury
Guido Filler & Ajay P. Sharma
doi : 10.1007/s00467-022-05654-7
Pediatric Nephrology volume 37, pages 2971–2974 (2022)
Clinical practice guidelines for nephrotic syndrome: consensus is emerging
Aditi Sinha & Arvind Bagga
doi : 10.1007/s00467-022-05639-6
Pediatric Nephrology volume 37, pages 2975–2984 (2022)
Organs-on-chip technology: a tool to tackle genetic kidney diseases
Marta G. Valverde, Jo?o Faria, Elena Sendino Garv?, Manoe J. Janssen, Rosalinde Masereeuw & Silvia M. Mih?il?
doi : 10.1007/s00467-022-05508-2
Pediatric Nephrology volume 37, pages 2985–2996 (2022)
Chronic kidney disease (CKD) is a major healthcare burden that takes a toll on the quality of life of many patients. Emerging evidence indicates that a substantial proportion of these patients carry a genetic defect that contributes to their disease. Any effort to reduce the percentage of patients with a diagnosis of nephropathy heading towards kidney replacement therapies should therefore be encouraged.
Expectations in children with glomerular diseases from SGLT2 inhibitors
Luigi Cirillo, Fiammetta Ravaglia, Carmela Errichiello, Hans-Joachim Anders, Paola Romagnani & Francesca Becherucci
doi : 10.1007/s00467-022-05504-6
Pediatric Nephrology volume 37, pages 2997–3008 (2022)
Chronic kidney disease (CKD) is a global public healthcare concern in the pediatric population, where glomerulopathies represent the second most common cause. Although classification and diagnosis of glomerulopathies still rely mostly on histopathological patterns, patient stratification should complement information supplied by kidney biopsy with clinical data and etiological criteria. Genetic determinants of glomerular injury are particularly relevant in children, with important implications for prognosis and treatment.
Cellular senescence and acute kidney injury
Xiaoxi Lin, Heng Jin, Yanfen Chai & Songtao Shou
doi : 10.1007/s00467-022-05532-2
Pediatric Nephrology volume 37, pages 3009–3018 (2022)
Acute kidney injury (AKI) is a common clinical complication characterized by a sudden deterioration of the kidney’s excretory function, which normally occurs secondary to another serious illness. AKI is an important risk factor for chronic kidney disease (CKD) occurrence and progression to kidney failure.
A scoping review of the experiences and well-being of siblings of children with chronic kidney disease: implications for practice and research
Caroline Piotrowski, Ashley Giesbrecht, Aviva Goldberg, Danielle Judd, Regina Rempel, Julie Strong & Melissa Weavers
doi : 10.1007/s00467-022-05559-5
Pediatric Nephrology volume 37, pages 3019–3029 (2022)
Children with chronic kidney disease (CKD) and their families deal with challenging circumstances. While numerous studies have shown that both patients and parents in these families can experience a variety of challenges and concerns, the experience of siblings is less well understood. The focus of this scoping review was on research addressing the experiences and well-being of siblings of children with CKD.
Kidney disease and thyroid dysfunction: the chicken or egg problem
Fabian Echterdiek, Michael B. Ranke, Vedat Schwenger, Uwe Heemann & Joerg Latus
doi : 10.1007/s00467-022-05640-z
Pediatric Nephrology volume 37, pages 3031–3042 (2022)
Patients with non-dialysis-dependant chronic kidney disease (NDD-CKD) and dialysis-dependant chronic kidney disease (DD-CKD) frequently also suffer from thyroid disorders, especially hypothyroidism which is found two to five times more often among them compared to the general population. Emerging research has illustrated the potential prognostic implications of this association as NDD-CKD and DD-CKD patients with hypothyroidism have been shown to have higher mortality rates, and treatment of subclinical hypothyroidism in NDD-CKD patients has been reported to attenuate the decline of glomerular filtration rate over time.
Care of the pediatric patient on chronic peritoneal dialysis
Annabelle N. Chua, Reeti Kumar & Bradley A. Warady
doi : 10.1007/s00467-022-05605-2
Pediatric Nephrology volume 37, pages 3043–3055 (2022)
Peritoneal dialysis is the most commonly prescribed dialysis modality for infants and young children with kidney failure worldwide. Provision of high-quality care for the pediatric patient on chronic peritoneal dialysis requires a multidisciplinary approach and a strong collaboration with the patient and their caregiver.
A girl with hearing loss, dizziness, hypertension, and pyelonephritis with ureteral edema: Questions
Shuya Kaneko, Masaki Shimizu, Asami Shimbo, Hitoshi Irabu, Susumu Yamazaki, Toru Kanamori, Tomohiro Udagawa, Tomohiro Morio & Masaaki Mori
doi : 10.1007/s00467-022-05545-x
Pediatric Nephrology volume 37, pages 3057–3058 (2022)
A girl with hearing loss, dizziness, hypertension, and pyelonephritis with ureteral edema: Answers
Shuya Kaneko, Masaki Shimizu, Asami Shimbo, Hitoshi Irabu, Susumu Yamazaki, Toru Kanamori, Tomohiro Udagawa, Tomohiro Morio & Masaaki Mori
doi : 10.1007/s00467-022-05555-9
Pediatric Nephrology volume 37, pages 3059–3061 (2022)
A difficult case of hyponatremic and hypokalemic metabolic alkalosis: Questions
Saverio La Bella, Riccardo Fiorentino, Maura Carabotta, Mauro Lizzi, Teresa Rosato, Daniela Trotta & Maurizio Aric?
doi : 10.1007/s00467-022-05596-0
Pediatric Nephrology volume 37, pages 3063–3064 (2022)
A difficult case of hyponatremic and hypokalemic metabolic alkalosis: Answers
Saverio La Bella, Riccardo Fiorentino, Maura Carabotta, Mauro Lizzi, Teresa Rosato, Daniela Trotta & Maurizio Aric?
doi : 10.1007/s00467-022-05610-5
Pediatric Nephrology volume 37, pages 3065–3067 (2022)
A 15-year-old girl with a parotid mass and hypertension: Questions
Philip K. Angelides, Clement D. Lee & Stephanie Clark
doi : 10.1007/s00467-022-05565-7
Pediatric Nephrology volume 37, pages 3069–3070 (2022)
A 15-year-old girl with a parotid mass and hypertension: Answers
Philip K. Angelides, Clement D. Lee & Stephanie Clark
doi : 10.1007/s00467-022-05603-4
Pediatric Nephrology volume 37, pages 3071–3073 (2022)
Zinner syndrome in children: clinical presentation, imaging findings, diagnosis, and outcome
Chun-Chen Lin, Jin-Cherng Sheu, Pei-Shan Tsai, Ming-Dar Lee, Tsu-Hua Lin & Jeng-Daw Tsai
doi : 10.1007/s00467-022-05516-2
Pediatric Nephrology volume 37, pages 3075–3084 (2022)
Zinner syndrome (ZS), the association of congenital seminal vesicle cyst (SVC) and ipsilateral kidney anomalies, is rarely diagnosed in childhood. This study aimed to assess presentation, imaging findings, management, and outcome of pediatric ZS.
Relationship between biomarkers of tubular injury and intrarenal hemodynamic dysfunction in youth with type 1 diabetes
Melissa J. Johnson, Kalie L. Tommerdahl, Carissa Vinovskis, Sushrut Waikar, Trenton Reinicke, Chirag R. Parikh, Wassim Obeid, Robert G. Nelson, Daniel H. van Raalte, Laura Pyle, Kristen J. Nadeau & Petter Bjornstad
doi : 10.1007/s00467-022-05487-4
Pediatric Nephrology volume 37, pages 3085–3092 (2022)
Early identification of youth with type 1 diabetes (T1D) at risk for diabetic kidney disease may improve clinical outcomes. We examined the cross-sectional relationship between kidney biomarkers neutrophil gelatinase–associated lipocalin (NGAL), copeptin, interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), chitinase-3-like protein-1 (YKL-40), and monocyte chemoattractant protein-1 (MCP-1) and intrarenal hemodynamic function in adolescents with T1D.
Nephrocalcinosis in very low birth weight infants: incidence, associated factors, and natural course
Jeanne Fayard, Pierre Pradat, Sylvie Lorthois, Justine Bacchetta & Jean-Charles Picaud
doi : 10.1007/s00467-021-05417-w
Pediatric Nephrology volume 37, pages 3093–3104 (2022)
Preterm kidney is exposed to various exogenous factors that may impact its function such as nephrotoxic drugs or nephrocalcinosis. We investigated prevalence and risk factors of nephrocalcinosis (NC) in recently born very low birth weight (VLBW) infants submitted to improved biological monitoring.
Basement membrane defects in CD151-associated glomerular disease
Richard W. Naylor, Elizabeth Watson, Samantha Williamson, Rebecca Preston, J Bernard Davenport, Nicole Thornton, Martin Lowe, Maggie Williams & Rachel LennonÂ
doi : 10.1007/s00467-022-05447-y
Pediatric Nephrology volume 37, pages 3105–3115 (2022)
CD151 is a cell-surface molecule of the tetraspanin family. Its lateral interaction with laminin-binding integrin ɑ3β1 is important for podocyte adhesion to the glomerular basement membrane (GBM). Deletion of Cd151 in mice induces glomerular dysfunction, with proteinuria and associated focal glomerulosclerosis, disorganisation of GBM and tubular cystic dilation. Despite this, CD151 is not routinely screened for in patients with nephrotic-range proteinuria. We aimed to better understand the relevance of CD151 in human kidney disease.
Efficacy of rituximab versus tacrolimus in difficult-to-treat steroid-sensitive nephrotic syndrome: an open-label pilot randomized controlled trial
Georgie Mathew, Aditi Sinha, Aijaz Ahmed, Neetu Grewal, Priyanka Khandelwal, Pankaj Hari & Arvind Bagga
doi : 10.1007/s00467-022-05475-8
Pediatric Nephrology volume 37, pages 3117–3126 (2022)
Rituximab and tacrolimus are therapies reserved for patients with frequently relapsing or steroid-dependent nephrotic syndrome who have failed conventional steroid-sparing agents. Given their toxicities, demonstrating non-inferiority of rituximab to tacrolimus may enable choice between these medications.
Clinicopathologic features of non-lupus membranous nephropathy in a pediatric population
Paul Miller, Li Lei, Vivek Charu, John Higgins, Megan Troxell & Neeraja Kambham
doi : 10.1007/s00467-022-05503-7
Pediatric Nephrology volume 37, pages 3127–3137 (2022)
Membranous nephropathy is an uncommon cause of nephrotic syndrome in pediatrics.
Utility of the 2018 revised ISN/RPS thresholds for glomerular crescents in childhood-onset lupus nephritis: a Pediatric Nephrology Research Consortium study
Pooja Patel, Marietta de Guzman, M. John Hicks, Joseph G. Maliakkal, Michelle N. Rheault, David T. Selewski, Katherine Twombley, Jason M. Misurac, Cheryl L. Tran, Alexandru R. Constantinescu, Ali M. Onder, Meredith Seamon, Wacharee Seeherunvong, Vaishali Singh, Cynthia Pan, Daryl M. Okamura, Abiodun Omoloja, Mahmoud Kallash, William E. Smoyer, Guillermo Hidalgo & Scott E. Wenderfer
doi : 10.1007/s00467-022-05524-2
Pediatric Nephrology volume 37, pages 3139–3145 (2022)
The revised 2018 ISN/RPS Classification System for lupus nephritis (LN) includes calculations for both activity index (A.I.) and chronicity index (C.I.). Unchanged were the thresholds of < 25%, 25–50%, and > 50% crescents to distinguish between mild, moderate, and severe activity/chronicity. We aimed to evaluate these thresholds for percent crescents in childhood-onset LN.
Dyslipidemia may be a risk factor for progression in children with IgA nephropathy
Hongjie Zhuang· Zhilang Lin· Shuhan Zeng· Mengjie Jiang· Lizhi Chen· Xiaoyun Jiang· Yuanyuan Xu
doi : 10.1007/s00467-022-05480-x
Pediatric Nephrology volume 37, pages 3147–3156 (2022)
IgA nephropathy (IgAN) is often chronically progressive and commonly accompanied by dyslipidemia. However, the intrinsic relationship between dyslipidemia and IgAN remains to be elucidated. This study aimed to investigate the impact of different types of dyslipidemia on clinical and pathological characteristics in children with IgAN.
Do dietary factors play a role in infantile urolithiasis?
Aysun Calt?k Y?lmaz & Necla Unal
doi : 10.1007/s00467-022-05501-9
Pediatric Nephrology volume 37, pages 3157–3163 (2022)
Urolithiasis is a significant cause of morbidity that may be diagnosed at a young age. However, there is little research on the role of nutrition in pediatric urolithiasis, and research on the infantile period is extremely rare. The aim of this study is to investigate the effect of dietary factors on those diagnosed with “idiopathic� infantile urolithiasis.
Cardiac biomarkers in pediatric CKD—a prospective follow-up study
Ylva Tran?us Lindblad, Georgios Vavilis, Milan Chromek, Abdul Rashid Quershi, Christian L?wbeer & Peter B?r?ny
doi : 10.1007/s00467-022-05481-w
Pediatric Nephrology volume 37, pages 3165–3175 (2022)
The N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitive cardiac-specific troponin T (hs-cTnT) are associated with abnormal cardiac structure and function and an increased risk of cardiovascular death in chronic kidney disease (CKD) patients. There is limited knowledge about these cardiac markers in pediatric CKD patients.
Baseline characteristics of participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD)
Peong Gang Park, Hee Gyung Kang, Eujin Park, Yo Han Ahn, Hyun Jin Choi, Kyoung Hee Han, Seong Heon Kim, Heeyeon Cho, Keum Hwa Lee, Jae Il Shin, Min Hyun Cho, Joo Hoon Lee, Young Seo Park, Jayoun Kim & Il-Soo Ha
doi : 10.1007/s00467-021-05278-3
Pediatric Nephrology volume 37, pages 3177–3187 (2022)
We developed the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD) as a subcohort of KNOW-CKD to investigate the different characteristics of pediatric CKD between countries and races.
In vitro measurements of ultrafiltration precision in hemofiltration and hemodialysis devices used in infants
Jean Crosier, Mike Whitaker, Heather J. Lambert, Paul Wellman, Andrew Nyman & Malcolm G. Coulthard
doi : 10.1007/s00467-022-05439-y
Pediatric Nephrology volume 37, pages 3189–3194 (2022)
To determine in vitro whether infant hemofiltration and hemodialysis devices can reliably deliver precise ultrafiltration (UF) control.
Association between socioeconomic status and academic performance in children and adolescents with chronic kidney disease
Rabia Khalid, Anita Van Zwieten, Siah Kim, Madeleine Didsbury, Anna Francis, Steven Mctaggart, Amanda Walker, Fiona E. Mackie, Chanel Prestidge, Armando Teixeira-Pinto, Belinda Barton, Jennifer Lorenzo, Suncica Lah, Kirsten Howard, Natasha Nassar, Eric Au, Allison Tong, Katrina Blazek, Jonathan C. Craig & Germaine Wong
doi : 10.1007/s00467-022-05515-3
Pediatric Nephrology volume 37, pages 3195–3204 (2022)
Lower socioeconomic status (SES) is associated with lower academic achievement; however, this relationship is understudied in children with chronic kidney disease (CKD). This study examined the relationship between SES and academic performance in children and adolescents with CKD.
Doppler ultrasound in the assessment of renal perfusion before and during continuous kidney replacement therapy in the pediatric intensive care unit
Sarah N. Fern?ndez, Jorge L?pez, Rafael Gonz?lez, Mar?a J. Solana, Javier Urbano, Alejandra Aguado, ?ngel Lancharro, Jes?s L?pez-Herce & Mar?a J. SantiagoÂ
doi : 10.1007/s00467-022-05428-1
Pediatric Nephrology volume 37, pages 3205–3213 (2022)
This study aimed to assess observer variability and describe renal resistive index (RRI) and pulsatility index (PI) before and after onset of continuous kidney replacement therapy (CKRT). A secondary objective was to correlate Doppler ultrasound findings with those from direct measurement of renal blood flow (RBF).
Cardiac involvement in pediatric hemolytic uremic syndrome
Corentin Tanné, Etienne Javouhey, Olivia Boyer, Morgan Recher, Emma Allain-Launay, Catherine Monet-Didailler, Caroline Rouset-Rouvière, Amélie Ryckewaert, François Nobili, Francine Arfbez Gindre, Jérôme Rambaud, Anita Duncan, Julien Berthiller, Justine Bacchetta & Anne-Laure Sellier-LeclercÂ
doi : 10.1007/s00467-022-05427-2
Pediatric Nephrology volume 37, pages 3215–3221 (2022)
Cardiac involvement is a known but rare complication of pediatric hemolytic uremic syndrome (HUS). We conducted a nationwide observational, retrospective case–control study describing factors associated with the occurrence of myocarditis among HUS patients.
Derivation and evaluation of baseline creatinine equations for hospitalized children and adolescents: the AKI baseline creatinine equation
Chloe Braun, A. K. M. Fazlur Rahman, Eric Macomb, David Askenazi & Erica C. Bjornstad
doi : 10.1007/s00467-022-05571-9
Pediatric Nephrology volume 37, pages 3223–3233 (2022)
Acute kidney injury (AKI) definitions incorporate baseline creatinine (Crb) values, but Crb are frequently unknown in pediatrics. Our primary aim was to derive and validate a novel AKI Baseline Creatinine (ABC) estimation equation and compare it to existing methods of estimating Crb values.
Association between acute kidney injury and brain injury on term-equivalent age brain magnetic resonance imaging in very preterm infants
Mountasser M. Al-Mouqdad, Dima Z. Jamjoom, Ayman T. Abdalgader, Waleed S. Ameen, Thanaa M. Khalil, Yasmeen S. Asfour, Maha R. Al-Anazi & Suzan S. AsfourÂ
doi : 10.1007/s00467-022-05534-0
Pediatric Nephrology volume 37, pages 3235–3242 (2022)
This study aimed to investigate the relationship between acute kidney injury (AKI) in the first 2Â weeks of life and brain injury on term-equivalent age magnetic resonance imaging in very preterm infants.
SERPINB11 variant-related liver injury in STEC-HUS: case reports and literature review
Nazl? Umman, Mey Talip Petmezci, Ci?dem Arikan, Cansu Altunta?, Biray Ertürk & Hasan Dursun
doi : 10.1007/s00467-022-05602-5
Pediatric Nephrology volume 37, pages 3243–3247 (2022)
Liver damage is uncommon in Shiga toxin-producing Escherichia coli–associated hemolytic uremic syndrome (STEC-HUS). Herein, we present two cases with a diagnosis of STEC-HUS that progressed to liver damage, with findings presumably related to the SERPINB11 gene c.268G > T (p.Glu90Ter) variant.
Preventing heme-induced nephropathy in children with glucose 6 phosphate dehydrogenase deficiency: is there a role for acetazolamide?
Xiaojing Qian, Huifang Chen & Jiaying Chen
doi : 10.1007/s00467-022-05642-x
Pediatric Nephrology volume 37, page 3249 (2022)
Response to the Letter to the Editor “Preventing heme-induced nephropathy in children with glucose 6 phosphate dehydrogenase deficiency: is there a role for acetazolamide?�
Afshin Safaei-Asl & Hamidreza Badeli
doi : 10.1007/s00467-022-05686-z
Pediatric Nephrology volume 37, page 3251 (2022)
Correction to: In vitro measurements of ultrafiltration precision in hemofiltration and hemodialysis devices used in infants
Jean Crosier, Mike Whitaker, Heather J. Lambert, Paul Wellman, Andrew Nyman & Malcolm G. Coulthard
doi : 10.1007/s00467-022-05623-0
Pediatric Nephrology volume 37, page 3253 (2022)
Correction to: Utility of the 2018 revised ISN/RPS thresholds for glomerular crescents in childhood-onset lupus nephritis: a Pediatric Nephrology Research Consortium study
Pooja Patel, Marietta Guzman, M. John Hicks, Joseph G. Maliakkal, Michelle N. Rheault, David T. Selewski, Katherine Twombley, Jason M. Misurac, Cheryl L. Tran, Alexandru R. Constantinescu, Ali M. Onder, Meredith Seamon, Wacharee Seeherunvong, Vaishali Singh, Cynthia Pan, Daryl M. Okamura, Abiodun Omoloja, Mahmoud Kallash, William E. Smoyer, Guillermo Hidalgo & Scott E. Wenderfer
doi : 10.1007/s00467-022-05625-y
Pediatric Nephrology volume 37, page 3255 (2022)
