دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Macrophage polarization in placenta accreta and macrophage-trophoblast interactions
Jia-hui Che, Zi-meng Zheng, Ming-qing Li, Xiaoying Yao
doi : 10.1111/aji.13611
Placenta accreta (PA) is defined by an abnormal invasion of placental trophoblasts into the myometrium, which can lead to serious postpartum complications. Macrophages play an important role in the regulation of trophoblast function. Both granulocyte colony-stimulating factor (G-CSF) and its receptor (granulocyte colony-stimulating factor receptor, G-CSFR) have effects on trophoblast invasion. However, the current understanding of G-CSF secretion, G-CSFR expression, abnormal polarization of decidual macrophages (dM�•) in PA and the abnormal invasion of placental trophoblasts into the myometrium are limited.
Dysfunctional regulation of pivotal and key inflammatory pathways in infertile Indian women with genital tuberculosis
Firuza R. Parikh, Madhavi Panpalia, Trupti Mehta, Sapna Agarwal, Meenal Khandeparker, Shiva Shankaran Chettiar, Alpesh Patel, Devendrasinh D. Jhala, Venkatlaxmi Chettiar, Swapneil Parikh
doi : 10.1111/aji.13624
Diagnosis of female genital tuberculosis (FGTB) remains elusive due to the paucibacillary nature of the disease. We evaluated if analysis of inflammatory pathways of endometrial tissue could establish a better diagnosis of FGTB.
The immunological role of B7-H4 in pregnant women with Sars-Cov2 infection
Liyan Duan, Beatrix Reisch, Pawel Mach, Rainer Kimmig, Alexandra Gellhaus, Antonella Iannaccone
doi : 10.1111/aji.13626
T-cells are key players in fighting the coronavirus disease 2019 (COVID-19). The checkpoint molecule B7-H4, a member of the B7 family, can inhibit T-cell activation and proliferation by inhibiting NF-kb expression. We aimed to elucidate the immunological role of soluble B7-H4 (sB7-H4) and B7-H4 in pregnant women suffered from an acute Sars-Cov2 infection.
Salivary progesterone as a biomarker for predicting preterm birth: A systematic review and meta-analysis
Leslie Faye T. Cando, Micah D. Dispo, Ourlad Alzeus G. Tantengco
doi : 10.1111/aji.13628
Several biomarkers have been studied to predict spontaneous preterm birth, including salivary progesterone. However, due to limited studies, the utility of this biomarker remains controversial. This study synthesized the available literature and determined the role of salivary progesterone as a potential biomarker for preterm birth.
Changes in the proportion of regulatory T cell subpopulations during menstrual cycle and early pregnancy
Hiroyuki Okimura, Yukiko Tanaka, Maya Fujii, Koki Shimura, Eiko Maeda, Fumitake Ito, Khaleque N. Khan, Yoshitaka Nakamura, Taisuke Mori, Jo Kitawaki
doi : 10.1111/aji.13636
Regulatory T cells (Tregs) play important roles in diseases occurring in women of reproductive age and pregnancy. Tregs are functionally heterogeneous and can be divided into activated Tregs (aTregs), resting Tregs (rTregs), and non-suppressive Tregs (non-Tregs). The purpose of this study is to investigate the change of Treg subpopulations during the menstrual cycle and early pregnancy.
Adapting an organ-on-chip device to study the effect of fetal sex and maternal race/ethnicity on preterm birth related intraamniotic inflammation leading to fetal neuroinflammation
Lauren S. Richardson, Nkechinyere Emezienna, Irina Burd, Brandie D. Taylor, Morgan R. Peltier, Arum Han, Ramkumar Menon
doi : 10.1111/aji.13638
Fetal neuroinflammation has been linked to preterm birth-related intraamniotic infection and inflammation; However, the contribution of fetal sex and maternal race/ethnicity is unknown. To determine if fetal sex and maternal race/ethnicity influence neuroinflammation, an organ-on-chip (OOC) model were established under normal or pathologic conditions utilizing amniotic fluid.
Circ_0031027 adjusts the advancement of cervical cancer by miR-587/SOCS5 axis
Yajun Chen, Yuanju Yang, Shuang Wang, Fujuan Guan, Shenghua Zhen
doi : 10.1111/aji.13640
Circular RNAs (circRNAs) might participate in the growth of cervical cancer (CC). In this research, we reconnoitered the characters of circ_0031027 in CC.
Risk factors associated with adverse pregnancy outcomes and postpartum exacerbation in women with myasthenia gravis
Qian Zhou, Weifan Yin, Jiahao Zhu, Weiwei Duan, Yi Li, Wanlin Jin, Huan Yang
doi : 10.1111/aji.13641
Myasthenia gravis (MG), an autoimmune neuromuscular disease affecting women of childbearing age, exerts an impact on pregnancy, and vice versa. The purposes of the study were to evaluate adverse pregnancy outcomes and postpartum exacerbation in a cohort of Asian MG women, and to explore the predictors for these outcomes.
Increased HIV-1 infection in PBMCs treated in vitro with menstrual cycle phase hormones or medroxyprogesterone acetate likely occurs via different mechanisms
Alexis J. Bick, Chanel Avenant, Michele Tomasicchio, Zephne van der Spuy, Janet P. Hapgood
doi : 10.1111/aji.13643
Both luteal phase progesterone (P4) levels and use of the intramuscular (IM) injectable progestin-only contraceptive depo-medroxyprogesterone acetate (DMPA-IM) have been linked to increased S/HIV acquisition in animal, clinical and in vitro models. Several plausible mechanisms could explain MPA-induced HIV-1 acquisition while those for the luteal phase are underexplored.
Immunologic deviations in recurrent spontaneous abortion mouse model
Hossein Ansariniya, Fateme Zare, Nariman Mosaffa, Farah Idali, Mahdi Shabani, Hossein Hadinedoushan
doi : 10.1111/aji.13631
Recurrent spontaneous abortion (RSA) or recurrent pregnancy loss (RPL) is an abnormality that has a great impact on women's quality of life. RSA is defined as at least three unexplained abortions (without prior live birth) occurring before the 20th week of pregnancy.
The impact of maternal SARS-CoV-2 vaccination and first trimester infection on feto-maternal immune responses
Lillian J. Juttukonda, Elisha M. Wachman, Jeffery Boateng, Katherine Clarke, Jennifer Snyder-Cappione, Elizabeth S. Taglauer
doi : 10.1111/aji.13625
COVID-19 infection during pregnancy increases maternal and fetal morbidity and mortality. Infection in the second or third trimester leads to changes in the decidual leukocyte populations. However, it is not known whether COVID-19 infection in the first trimester or COVID-19 vaccination during pregnancy alters the decidual immune environment.
