دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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What good can neutrophils do in UC?
Azucena Salas
doi : 10.1136/gutjnl-2021-326484
December 2022 - Volume 71 - 12
Tiny contributors to severe obesity inside the gut
Yolanda Sanz, Marta Olivares
Understanding pain in chronic pancreatitis: not yet the end of the story?
Jonas Rosendahl
The future of drug development for inflammatory bowel disease: the need to ACT (advanced combination treatment)
Silvio Danese, Virginia Solitano, Vipul Jairath, Laurent Peyrin-Biroulet
Vessel and tissue recognition during third-space endoscopy using a deep learning algorithm
Alanna Ebigbo, Robert Mendel, Markus W Scheppach, Andreas Probst, Neal Shahidi, Friederike Prinz, Carola Fleischmann, Christoph Römmele, Stefan Karl Goelder, Georg Braun, David Rauber, Tobias Rueckert, Luis A de Souza, Joao Papa, Michael Byrne, Christoph Palm, Helmut Messmann
doi : 10.1136/gutjnl-2021-326470
In this study, we aimed to develop an artificial intelligence clinical decision support solution to mitigate operator-dependent limitations during complex endoscopic procedures such as endoscopic submucosal dissection and peroral endoscopic myotomy, for example, bleeding and perforation. A DeepLabv3-based model was trained to delineate vessels, tissue structures and instruments on endoscopic still images from such procedures.
Nationwide gastric cancer prevention in China, 2021–2035: a decision analysis on effect, affordability and cost-effectiveness optimisation
Zixing Wang, Wei Han, Fang Xue, Yujie Zhao, Peng Wu, Yali Chen, Cuihong Yang, Wentao Gu, Jingmei Jiang
doi : 10.1136/gutjnl-2021-325948
Objective To project future trajectories of the gastric cancer (GC) burden in China under different scenarios of GC prevention and identify strategies to improve affordability and cost-effectiveness.
Faecal microbiota transplantation with anti-inflammatory diet (FMT-AID) followed by anti-inflammatory diet alone is effective in inducing and maintaining remission over 1 year in mild to moderate ulcerative colitis: a randomised controlled trial
Saurabh Kedia, Shubi Virmani, Sudheer K Vuyyuru, Peeyush Kumar, Bhaskar Kante, Pabitra Sahu, Kanav Kaushal, Mariyam Farooqui, Mukesh Singh, Mahak Verma, Aditya Bajaj, Manasvini Markandey, Karan Sachdeva, Prasenjit Das, Govind K Makharia, Vineet Ahuja
doi : 10.1136/gutjnl-2022-327811
Objective Microbiome and dietary manipulation therapies are being explored for treating ulcerative colitis (UC). We aimed to examine the efficacy of multidonor faecal microbiota transplantation (FMT) and anti-inflammatory diet in inducing remission followed by long-term maintenance with anti-inflammatory diet in patients with mild-moderate UC.
Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis
Moritz Leppkes, Aylin Lindemann, Stefanie Gößwein, Susanne Paulus, Dominik Roth, Anne Hartung, Eva Liebing, Sebastian Zundler, Miguel Gonzalez-Acera, Jay V Patankar, Fabrizio Mascia, Kristina Scheibe, Markus Hoffmann, Stefan Uderhardt, Christine Schauer, Sebastian Foersch, Clemens Neufert, Michael Vieth, Georg Schett, Raja Atreya, Anja A Kühl, Andre Bleich, Christoph Becker, Martin Herrmann, Markus F Neurath
doi : 10.1136/gutjnl-2021-324725
Objective Bleeding ulcers and erosions are hallmarks of active ulcerative colitis (UC). However, the mechanisms controlling bleeding and mucosal haemostasis remain elusive.
Double-blinded randomised placebo controlled trial of enterosgel (polymethylsiloxane polyhydrate) for the treatment of IBS with diarrhoea (IBS-D)
Carol Angela Howell, Anu Kemppinen, Victoria Allgar, Matthew Dodd, Charles H Knowles, John McLaughlin, Preeti Pandya, Peter Whorwell, Elena Markaryan, Yan Yiannakou
doi : 10.1136/gutjnl-2022-327293
Objective Irritable bowel syndrome with diarrhoea (IBS-D) is a common and challenging condition that significantly reduces quality of life. Enterosgel (polymethylsiloxane polyhydrate) is an intestinal adsorbent which sequesters harmful molecules and is safe and effective in acute infective diarrhoea. This randomised controlled multicentre trial aimed to investigate its safety and efficacy in patients with IBS-D.
Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites
Xiaowu Bai, Hong Wei, Weixin Liu, Olabisi Oluwabukola Coker, Hongyan Gou, Changan Liu, Liuyang Zhao, Chuangen Li, Yunfei Zhou, Guoping Wang, Wei Kang, Enders Kwok-wai Ng, Jun Yu
doi : 10.1136/gutjnl-2021-325021
Objective Cigarette smoking is a major risk factor for colorectal cancer (CRC). We aimed to investigate whether cigarette smoke promotes CRC by altering the gut microbiota and related metabolites.
Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins
Jing Yang, Lingling Hou, Jinfeng Wang, Liwen Xiao, Jinyang Zhang, Nanlin Yin, Su Yao, Kun Cheng, Wen Zhang, Zhonghua Shi, Jing Wang, Hai Jiang, Nana Huang, Yanxia You, Mingmei Lin, Ruiyan Shang, Yuan Wei, Yangyu Zhao, Fangqing Zhao
doi : 10.1136/gutjnl-2021-326482
Objective Fetal growth restriction (FGR) is a devastating pregnancy complication that increases the risk of perinatal mortality and morbidity. This study aims to determine the combined and relative effects of genetic and intrauterine environments on neonatal microbial communities and to explore selective FGR-induced gut microbiota disruption, metabolic profile disturbances and possible outcomes.
Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism
Eugeni Belda, Lise Voland, Valentina Tremaroli, Gwen Falony, Solia Adriouch, Karen E Assmann, Edi Prifti, Judith Aron-Wisnewsky, Jean Debédat, Tiphaine Le Roy, Trine Nielsen, Chloé Amouyal, Sébastien André, Fabrizio Andreelli, Matthias Blüher, Rima Chakaroun, Julien Chilloux, Luis Pedro Coelho, Maria Carlota Dao, Promi Das, Soraya Fellahi, Sofia Forslund, Nathalie Galleron, Tue H Hansen, Bridget Holmes, Boyang Ji, Helle Krogh Pedersen, Phuong Le, Emmanuelle Le Chatelier, Christian Lewinter, Louise Mannerås-Holm, Florian Marquet, Antonis Myridakis, Veronique Pelloux, Nicolas Pons, Benoit Quinquis, Christine Rouault, Hugo Roume, Joe-Elie Salem, Nataliya Sokolovska, Nadja B Søndertoft, Sothea Touch, Sara Vieira-Silva, The MetaCardis Consortium, Pilar Galan, Jens Holst, Jens Peter Gøtze, Lars Køber, Henrik Vestergaard, Torben Hansen, Serge Hercberg, Jean-Michel Oppert, Jens Nielsen, Ivica Letunic, Marc-Emmanuel Dumas, Michael Stumvoll, Oluf Borbye Pedersen, Peer Bork, Stanislav Dusko Ehrlich, Jean-Daniel Zucker, Fredrik Bäckhed, Jeroen Raes, Karine Clément
doi : 10.1136/gutjnl-2021-325753
Objectives Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome’s functional composition in healthy metabolic state and the most severe states of obesity and type 2 diabetes within the MetaCardis cohort. We focused on the role of B vitamins and B7/B8 biotin for regulation of host metabolic state, as these vitamins influence both microbial function and host metabolism and inflammation.
Oncological outcomes after piecemeal endoscopic mucosal resection of large non-pedunculated colorectal polyps with covert submucosal invasive cancer
Dave J Gibson, Mayenaaz Sidhu, Simon Zanati, David J Tate, Dileep Mangira, Alan Moss, Rajvinder Singh, Luke F Hourigan, Spiro Raftopoulos, Alan Pham, Phil Kostos, M Priyanthi Kumarasinghe, Andrew Ruszkiewicz, Duncan McLeod, Gregor J E Brown, Michael J Bourke
doi : 10.1136/gutjnl-2020-323666
Objective Management of covert submucosal invasive cancer (SMIC) discovered after piecemeal endoscopic mucosal resection (pEMR) of large (>20 mm) non-pedunculated colorectal polyps is challenging. The residual cancer risk is largely unknown. We sought to evaluate this in a large tertiary referral cohort.
Tumour-associated neutrophils secrete AGR2 to promote colorectal cancer metastasis via its receptor CD98hc–xCT
Shaobo Tian, Yanan Chu, Jia Hu, Xueliang Ding, Zhibo Liu, Daan Fu, Ye Yuan, Yan Deng, Guobin Wang, Lin Wang, Zheng Wang
doi : 10.1136/gutjnl-2021-325137
Objective Reciprocal cellular crosstalk within the tumour microenvironment (TME) actively participates in tumour progression. The anterior gradient-2 (AGR2) can be secreted to extracellular compartments and contribute to colorectal cancer (CRC) metastasis. We investigated the cellular source for secreted AGR2 in the TME and underlying mechanisms mediating secreted AGR2’s effects.
Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer
Shania M Corry, Amy MB McCorry, Tamsin RM Lannagan, Niamh A Leonard, Natalie C Fisher, Ryan M Byrne, Petros Tsantoulis, Xabier Cortes-Lavaud, Raheleh Amirkhah, Keara L Redmond, Aoife J McCooey, Sudhir B Malla, Emily Rogan, Svetlana Sakhnevych, Michael A Gillespie, Mark White, Susan D Richman, Rene-Filip Jackstadt, Andrew D Campbell, Sarah Maguire, S:CORT and ACRCelerate consortia, Simon S McDade, Daniel B Longley, Maurice B Loughrey, Helen G Coleman, Emma M Kerr, Sabine Tejpar, Timothy Maughan, Simon J Leedham, Donna M Small, Aideen E Ryan, Owen J Sansom, Mark Lawler, Philip D Dunne
doi : 10.1136/gutjnl-2021-326183
Objective Stroma-rich tumours represent a poor prognostic subtype in stage II/III colon cancer (CC), with high relapse rates and limited response to standard adjuvant chemotherapy.
Overlap and cumulative effects of pancreatic duct obstruction, abnormal pain processing and psychological distress on patient-reported outcomes in chronic pancreatitis
Søren S Olesen, Anna E Phillips, Mahya Faghih, Louise Kuhlmann, Emily Steinkohl, Jens B Frøkjær, Benjamin L Bick, Mitchell L Ramsey, Phil A Hart, Pramod K Garg, Vikesh K Singh, Dhiraj Yadav, Asbjørn M Drewes
doi : 10.1136/gutjnl-2021-325855
Objective Several factors have been suggested to mediate pain in patients with chronic pancreatitis. However, it is unknown whether these factors are overlapping and if they have cumulative effects on patient-reported outcomes (PROs).
Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells
Martin J Lett, Hema Mehta, Adrian Keogh, Tina Jaeger, Maxime Jacquet, Kate Powell, Marie-Anne Meier, Isabel Fofana, Hassan Melhem, Jürg Vosbeck, Gieri Cathomas, Andres Heigl, Markus H Heim, Emanuel Burri, Kirsten D Mertz, Jan Hendrik Niess, Otto Kollmar, Christoph J Zech, Robert Ivanek, Urs Duthaler, Paul Klenerman, Deborah Stroka, Magdalena Filipowicz Sinnreich
doi : 10.1136/gutjnl-2021-324478
Objective Mucosal-associated invariant T (MAIT) cells are the most abundant T cells in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1. MAIT cells exert regulatory and antimicrobial functions and are implicated in liver fibrogenesis. It is not well understood which liver cells function as antigen (Ag)-presenting cells for MAIT cells, and under which conditions stimulatory Ags reach the circulation.
FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2
Jianhua Rao, Hao Wang, Ming Ni, Zeng Wang, Ziyi Wang, Song Wei, Mu Liu, Peng Wang, Jiannan Qiu, Lei Zhang, Chen Wu, Hongbing Shen, Xuehao Wang, Feng Cheng, Ling Lu
doi : 10.1136/gutjnl-2021-325150
Objective Follistatin-like protein 1 (FSTL1) is widely recognised as a secreted glycoprotein, but its role in modulating macrophage-related inflammation during liver fibrosis has not been documented. Herein, we aimed to characterise the roles of macrophage FSTL1 in the development of liver fibrosis.
PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma
Li-Gong Lu, Zhi-Ling Zhou, Xu-Yan Wang, Bo-Yuan Liu, Jin-Ying Lu, Shuai Liu, Guang-Bo Zhang, Mei-Xiao Zhan, Yun Chen
doi : 10.1136/gutjnl-2021-326350
Objective Patients with increased PD-L1+ host cells in tumours are more potent to benefit from antiprogrammed death-1/programmed death ligand-1 (PD-L1) treatment, but the underlying mechanism is still unclear. We aim to elucidate the nature, regulation and functional relevance of PD-L1+ host cells in hepatocellular carcinoma (HCC).
NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression
Muhammad Umair Latif, Geske Elisabeth Schmidt, Sercan Mercan, Raza Rahman, Christine Silvia Gibhardt, Ioana Stejerean-Todoran, Kristina Reutlinger, Elisabeth Hessmann, Shiv K Singh, Abdul Moeed, Abdul Rehman, Umer Javed Butt, Hanibal Bohnenberger, Philipp Stroebel, Sebastian Christopher Bremer, Albrecht Neesse, Ivan Bogeski, Volker Ellenrieder
doi : 10.1136/gutjnl-2021-325013
Objectives Non-alcoholic fatty liver disease (NAFLD) can persist in the stage of simple hepatic steatosis or progress to steatohepatitis (NASH) with an increased risk for cirrhosis and cancer. We examined the mechanisms controlling the progression to severe NASH in order to develop future treatment strategies for this disease.
Diet fuelling inflammatory bowel diseases: preclinical and clinical concepts
Timon E Adolph, Jingwan Zhang
doi : 10.1136/gutjnl-2021-326575
The diet and gut microbiota have been extensively interrogated as a fuel for gut inflammation in inflammatory bowel diseases (IBDs) in the last few years. Here, we review how specific nutrients, typically enriched in a Western diet, instigate or deteriorate experimental gut inflammation in a genetically susceptible host and we discuss microbiota-dependent and independent mechanisms.
Recent advances in clinical practice: advances in cross-sectional imaging in inflammatory bowel disease
Jordi Rimola, Joana Torres, Shankar Kumar, Stuart A Taylor, Torsten Kucharzik
doi : 10.1136/gutjnl-2021-326562
Endoscopy remains the reference standard for the diagnosis and assessment of patients with inflammatory bowel disease (IBD), but it has several important limitations. Cross-sectional imaging techniques such as magnetic resonance enterography (MRE) and intestinal ultrasound (IUS) are better tolerated and safer. Moreover, they can examine the entire bowel, even in patients with stenoses and/or severe inflammation.
Alcohol consumption and smoking dose-dependently and synergistically worsen local pancreas damage
Andrea Szentesi, Nelli Farkas, Zoltán Sipos, Péter Mátrai, �ron Vincze, Ferenc Izbéki, Andrea Párniczky, Péter Hegyi
SARS-CoV-2 pandemic has impacted on patterns of aetiology for acute pancreatitis and management of gallstone pancreatitis in the UK
Chris Varghese, Manu Nayar, Sanjay Pandanaboyana
High antibody response in relation to immunosuppressive blood levels in liver transplant recipients after SARS-CoV-2 vaccination: an observational, cohort study
Midas B Mulder, Annemiek A van der Eijk, Corine H GeurtsvanKessel, Nicole S Erler, Brenda C M de Winter, Wojciech G Polak, Herold J Metselaar, Caroline M den Hoed
Lack of inflammatory bowel disease flare-up following two-dose BNT162b2 vaccine: a population-based cohort study
Xue Li, Xinning Tong, Ian Chi Kei Wong, Kuan Peng, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Eric Yuk Fai Wan, Carlos King Ho Wong, Wai Keung Leung, Esther Wai Yin Chan
Comment on Murphy et al: maternal obesity, pregnancy weight gain, and birth weight and risk of colorectal cancer
Ravi Dhawan, Denys Shay, Yu Chen Zhao, Yujia Lu, Edward Giovannucci
‘Fish-eye’ polypectomy defect: a new sign during endoscopic mucosal resection?
Sergei Vosko, Neal Shahidi, Sunil Gupta, W Arnout van Hattem, Michael J Bourke
