Huang, Jeannie S.?,†
doi : 10.1097/MPG.0000000000002985
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 181
Mehta, Nilesh M.
doi : 10.1097/MPG.0000000000002959
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 181-183
Vanderpool, Charles P.B.
doi : 10.1097/MPG.0000000000002986
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 183
Jain, Vandana†; Alexander, Emma C.†; Burford, Charlotte†; Verma, Anita?; Dhawan, Anil†
doi : 10.1097/MPG.0000000000002973
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 184-193
Biliary atresia (BA) is a fibro-obliterative condition of the biliary tree, presenting in infancy. The bilioenteric conduit formed at Kasai portoenterostomy (KPE), achieves restoration of bile flow in approximately 60% of infants. Even if the operation is successful, cirrhosis and its associated complications are, however, common. BA remains the leading cause for liver transplantation (LT) in children. Antibiotic, choleretic, and steroid therapy post-KPE have not convincingly reduced LT rates. Advances in molecular technology have enabled characterisation of the encoded genes of the gut microbiota (gut microbiome). The gut microbiome plays an important role in host metabolism, nutrition, and immune function, with alterations in its diversity and/or composition, known as dysbiosis, being described in disease states, including liver disease. Liver-gut microbiome exploration in adulthood largely focuses on nonalcoholic liver disease, cirrhosis (mainly alcohol- or viral-based aetiology) and cholestatic liver diseases (eg, primary sclerosing cholangitis), with microbial signatures correlating to disease severity. Investigation of the gut microbiota in BA had been limited to culture-based methodology, but molecular studies are emerging, and although in their infancy, highlight a potential pathogenic role for Enterobacteriaceae and Streptococcus, and a potential beneficial role for Bifidobacteria. Bacterial translocation, and the production of gut microbiome-derived metabolites, are key host-microbiome-mechanistic pathways in liver disease pathogenesis. Microbiome-targeted therapeutics for liver disease are in development, with faecal microbiota transplantation showing promise in cirrhosis. Could the gut microbiome be a novel modifiable risk factor in BA, reducing the need for LT?
Kemme, Sarah?; Stahl, Marisa?; Brigham, Dania?; Lovell, Mark A.†; Nakano, Taizo‡; Feldman, Amy G.?; Mack, Cara?
doi : 10.1097/MPG.0000000000002940
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 194-201
Hepatitis-associated aplastic anemia (HAAA) is a potentially life-threatening diagnosis without clear treatment guidelines. The goal of the study was to characterize the presentation, evaluation, histopathology, and outcomes of therapy in children with HAAA to guide future research and to develop standardized care guidelines for this rare disease.
Nomden, Mark?; van Wessel, Daan B.E.?; Ioannou, Solomon†; Verkade, Henkjan J.‡; de Kleine, Ruben H.§; Alizadeh, Behrooz Z.†; Bruggink, Janneke L.M.?; Hulscher, Jan B.F.?
doi : 10.1097/MPG.0000000000002916
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 202-209
Environmental factors may be involved in the pathogenesis of biliary atresia (BA). This epidemiological study aimed to analyze the relationships between the incidence of BA, the incidence of confirmed viral or bacterial infections and population density, and geographical and temporal clustering of BA in the Netherlands.
Chanpong, Atchariya?,†; Dhawan, Anil?
doi : 10.1097/MPG.0000000000002982
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 210-215
In Wilson disease (WD), 24-hour urinary copper excretion (UCE) is recommended to be used for diagnosis. It may be a useful tool to assess the efficacy of treatment during follow-up; however, there are limited data regarding the cutoff value of 24-hour UCE during follow-up in children. Therefore, we aim to evaluate the clinical use of 24-hour UCE during follow-up in children with WD.
Rahhal, Riad?; Goad, Lindsay†; Bishop, Warren?
doi : 10.1097/MPG.0000000000002954
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 220-225
Medical scribes may offer a route to improve physician productivity and workflow efficiency with reduced physician time for documentation. To our knowledge, there is no prior literature on medical scribe impact on outpatient pediatric gastroenterology clinic operations. The primary aim of our study was to address this knowledge gap.
van Lennep, Marinde?; Leijdekkers, Marin L.?; Oors, Jac M.†; Benninga, Marc A.?; van Wijk, Michiel P.?,‡; Singendonk, Maartje M.J.?
doi : 10.1097/MPG.0000000000003000
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 226-231
Pediatric high-resolution manometry (HRM) and 24-hour pH-impedance with/without ambulatory manometry (pH-MII+/-mano) tests are generally performed using adult-derived protocols. We aimed to assess the feasibility of these protocols in children, the occurrence of patient-related imperfections and their influence on test interpretability.
O’Donnell, Jonathan E.M.?,†; Purcell, Michael?; Mousa, Hayat‡,§; Dall’Oglio, Luigi||; Rosen, Rachel¶,#; Faure, Christophe??,††; Gottrand, Frédéric‡‡; Krishnan, Usha?,†
doi : 10.1097/MPG.0000000000002945
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 232-238
The aim of this study was to assess whether clinicians approached the management of children with esophageal atresia (EA) in accordance with the 2016 European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)/North American Society of Paediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) guidelines on the management of gastrointestinal and nutritional complications in this cohort.
Shah, Monisha?; Wan, David Q.†; Liu, Yuying?; Rhoads, Jon Marc?
doi : 10.1097/MPG.0000000000002923
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p e31-e36
To determine the demographics, potential risk factors, endoscopic interventions and outcomes relating to gastric bezoars in pediatric patients; and comparing results with previously published literature.
Bethell, George S.?; Long, Anna-May†,‡; Knight, Marian†; Hall, Nigel J.?; On behalf of BAPS-CASS†
doi : 10.1097/MPG.0000000000002921
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 239-243
Congenital duodenal obstruction (CDO) occurs in 1.2 per 10,000 live births and is frequently associated with other anomalies, most commonly cardiac. The aim of this study was to report important outcomes to 1 year following surgical repair.
Barakat, Monique T.?,†; Gugig, Roberto†; Imperial, Joanne†; Berquist, William E.†
doi : 10.1097/MPG.0000000000002914
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 244-249
Endoscopic retrograde cholangiopancreatography (ERCP) is a fluoroscopy and endoscopy-based procedure important for diagnosis and management of pediatric pancreaticobiliary disorders. Patient, procedure, endoscopist, and facility characteristics have been shown to influence ERCP complexity and procedure outcomes as well as fluoroscopy utilization in adults; however, the extent to which this is true in pediatric patients remains under-studied and there are minimal data regarding fluoroscopy utilization in pediatric ERCP.
Boster, Julia M.?,†; Iwanowski, Melissa‡; Kramer, Robert E.?,†
doi : 10.1097/MPG.0000000000002936
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 250-254
The aim of the study was to validate rates of fever after pediatric gastrointestinal endoscopy, to describe clinical outcomes of postendoscopy fever (PEF) cases, and to assess the effect of a PEF clinical care guideline (CCG) on hospital use.
Dhaliwal, Jasbir?,§; Erdman, Lauren†; Drysdale, Erik†; Rinawi, Firas?,§; Muir, Jennifer‡; Walters, Thomas D.?,§; Siddiqui, Iram‡; Griffiths, Anne M.?,§; Church, Peter C.?,§
doi : 10.1097/MPG.0000000000002956
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 262-269
The pediatric inflammatory bowel disease (PIBD) classes algorithm was developed to bring consistency to labelling of colonic IBD, but labels are exclusively based on features atypical for ulcerative colitis (UC).
Ronel, Naama?,†; Tzion, Raffi Lev?; Orlanski-Meyer, Esther?; Shteyer, Eyal?,†; Guz-Mark, Anat‡,§; Assa, Amit‡,§; Strich, David||; Turner, Dan?,†; Ledder, Oren?,†
doi : 10.1097/MPG.0000000000002911
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 270-275
Chronic inflammation of Crohn disease (CD) is associated with reduced bone mineral density (BMD). As bone mass is almost exclusively accrued during childhood, early recognition of osteopenia is especially important in pediatric CD. We aimed to identify variables associated with osteopenia to guide dual-energy X-ray absorptiometry (DXA) scan screening to those who most need it.
Ye, Ziqing?,†; Hu, Wenhui?; Wu, Bingbing‡; Zhang, Yueping§; Lei, Caixia§; Williams, Isabelle†; Shouval, Dror S.||; Kanegane, Hirokazu¶; Kim, Kyung Mo#; de Ridder, Lissy??; Shah, Neil††; Ling, Galina‡‡; Yerushalmi, Baruch‡‡; Kotlarz, Daniel§§; Snapper, Scott||||; Horn, Ruth¶¶; Klein, Christoph§§; Muise, Aleixo M.##,???; Huang, Ying?; Uhlig, Holm H.†,†††,‡‡‡,§§§
doi : 10.1097/MPG.0000000000002937
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 276-281
Advances in genetic technologies provide opportunities for patient care and ethical challenges. Clinical care of patients with rare Mendelian disorders is often at the forefront of those developments. Whereas in classical polygenic inflammatory bowel disease (IBD), the predictive value of genetic variants is very low, predictive prenatal genetic diagnosis can inform families at high risk of severe genetic disorders. Patients with IL-10 signalling defects because of pathogenic variants in IL10RA, Il10RB, and IL10 develop severe infantile onset inflammatory bowel disease that is completely penetrant and has a high morbidity and substantial mortality despite treatment.
Di Dato, Fabiola?; Ranucci, Giulia?; de Ville de Goyet, Jean†; Alberti, Daniele‡; Iorio, Raffaele?
doi : 10.1097/MPG.0000000000002932
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 216-219
In biliary atresia, infants left untreated, and in those with unsuccessful porto-enterostomy, hepatic condition and function worsen rapidly towards cirrhosis, malnutrition, portal hypertension with ascites, and variceal haemorrhage; many die within the first 3 years of life unless they benefit from liver replacement. We describe a girl with biliary atresia splenic malformation syndrome, who had portal vein cavernoma and microsplenia; she did not undergo porto-enterostomy. She survived with her native liver over the age of 3 years. Remarkably, she remained in satisfactory condition in absence of ascites or severe hepatic dysfunction, when 4 other similar patients—managed during the same period of time—all had the usual clinical deterioration and ascites, with the need for liver replacement. To our knowledge, there is no similar report in literature. Possible pathogenetic mechanisms and the role of portal hypertension as important factors are discussed.
George, Lovya?,†; Menden, Heather?; Xia, Sheng?; Yu, Wei?; Holmes, Anne?; Johnston, Jeffrey‡; Reid, Kimberly J.§; Josephson, Cassandra D.||,#; Patel, Ravi M.||; Ahmed, Atif†,¶; Mulrooney, Neil??; Miller, Neil A.‡; Farrow, Emily‡; Sampath, Venkatesh?,†
doi : 10.1097/MPG.0000000000002941
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p e37-e41
Aberrant toll-like receptor (TLR) activation is central to necrotizing enterocolitis (NEC) pathogenesis. ?2 integrins regulate TLR signaling, and integrin ?2 (ITGB2) deficiency causes TLR hyperresponsiveness. To test the hypothesis that ITGB2 genetic variants modulate NEC susceptibility, we sequenced the exonic ITGB2 locus to compare the prevalence of deleterious variants among 221 preterm infants with and without NEC. ITGB2 variants were not associated with NEC in our entire cohort (NEC [9/56] versus controls [16/165], P = 0.19) or in extremely low birthweight infants (ELBW, controls [7.9%] versus NEC [18.2%]; P = 0.11) but were increased compared to the populace (4.5%, gnomad.broadinstitute.org). Combined annotation-dependent depletion -predicted deleterious ITGB2 variants increased proportionately with increasing NEC severity in ELBW infants (controls [6.7%] versus medical NEC [16.7%] versus surgical NEC [19%] (P = 0.03). Although ITGB2 variants were not associated with NEC in our preterm cohort, subgroup analysis showed a trend towards enrichment with NEC severity in ELBW infants.
Ludwig, Thomas?; Oukid, Ines†; Wong, Jill?; Ting, Steven?; Huysentruyt, Koen‡; Roy, Puspita?; Foussat, Agathe C.?; Vandenplas, Yvan‡
doi : 10.1097/MPG.0000000000003007
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 255-261
Accurate stool consistency classification of non–toilet-trained children remains challenging. This study evaluated the feasibility of automated classification of stool consistencies from diaper photos using machine learning (ML).
Mandile, Roberta?; Maglio, Mariantonia†; Pellino, Nicoletta?; Russo, Marina?; Miele, Erasmo?; Spagnuolo, Maria Immacolata?; Troncone, Riccardo?,†; Auricchio, Renata?,†
doi : 10.1097/MPG.0000000000002917
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 282-287
Villous atrophy (VA) is not pathognomonic of celiac disease (CD). We aimed at reporting distribution, clinical, and immunohistochemical features of seronegative VA (SNVA) in a pediatric population.
Devara, Janaki?; Alsawas, Mouaz§; Larson, Joseph J.‡; Mounajjed, Taofic||; Murray, Joseph A.†; Absah, Imad?,†
doi : 10.1097/MPG.0000000000002942
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 288-293
Lymphocytic duodenosis (LD) defined as increased intraepithelial lymphocytes >25 intraepithelial lymphocytes (IELs) per 100 epithelial cells with normal villous architecture is associated with many gastrointestinal (GI) disorders. We aim to assess the rate and outcome of LD in children and perform a systematic review.
Meyer, Sonya?,†; Lamash, Liron†
doi : 10.1097/MPG.0000000000002946
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p e42-e47
The aim was to examine the reliability and validity of the Illness Identity Questionnaire (IIQ) among adolescents with celiac disease (CD), to describe their illness identity characteristics, and to examine relationships between illness identity and self-reported participation in food-related activities and quality of life.
Friend, Linda L.; Gutierrez dos Santos, Bruna; El-Khouri, Kristina G.; Perrin, Maryanne T.
doi : 10.1097/MPG.0000000000002918
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 306-310
Determine how thaw stage and bag manipulation (folding and squeezing) influence the retention of fat and number of aerobic bacteria colony-forming units when decanting human milk (HM) from plastic storage bags.
Shah, Mubashir Hassan?; Roshan, Reashma†; Parikh, Tushar?; Sathe, Sayali?; Vaidya, Umesh?; Pandit, Anand?
doi : 10.1097/MPG.0000000000002927
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p e48-e52
World Health Organization recommends exclusive breastfeeding (EBF) for 6 months after birth. However, problems with the baby failing to latch properly are common in the postpartum period contributing to breastfeeding cessation. The aim of the study was to evaluate the utility of LATCH score to predict EBF and weight gain at 6 weeks postpartum along with an optimum LATCH score cutoff.
Duran, Sedef?; Duran, R?dvan†; Acuna?, Betül†; Cesur, Gülay†; ?iftdemir, Nükhet Alada?†
doi : 10.1097/MPG.0000000000002947
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 311-315
Preterm infants are at high risk for nutritional difficulties during the neonatal period and early childhood. Long-term nutritional difficulties contribute to unbalanced food intake and growth disorders and are the source of major emotional stress for the family. The aim of this study is to investigate the eating problems of late and moderately preterm (LMPT) infants at the age of 2 years, and to examine the association of these problems with the mental status of their mothers.
Metzger, Gregory A.†; Sebasti?o, Yuri V.†; Carsel, Alex C.†; Nishimura, Leah†; Fisher, Jeremy G.†; Deans, Katherine J.?,†; Minneci, Peter C.?,†
doi : 10.1097/MPG.0000000000002958
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 316-323
Adults with decreased muscle mass experience worse outcomes and more frequent complications. The effects of sarcopenia on pediatric outcomes are unknown. Our objective was to define reference values for lean muscle mass in a healthy pediatric population to facilitate future studies on the impact of lean muscle mass on pediatric outcomes.
Egritas Gurkan, Odul?; Ozturk, Hakan?; Karagol, Hacer Ilbilge Ertoy†; Ceylan, Kamercan?; Duztas, Demet Teker?; Ekinci, Ozgur‡; Sari, Sinan?; Dalgic, Buket?; Bakirtas, Arzu†
doi : 10.1097/MPG.0000000000002925
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 294-299
There are many unknowns about primary eosinophilic gastrointestinal disease (EGID) in childhood. The aim of this study is to provide data about the frequency, management, control level, and prognosis of well documented primary EGID in childhood.
Lin, Tom K.?,†; Pathak, Sagar J.†; Hornung, Lindsey N.‡; Vitale, David S.?,†; Nathan, Jaimie D.§; Abu-El-Haija, Maisam?,†
doi : 10.1097/MPG.0000000000002996
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 300-305
Pancreas divisum (PD) is a risk factor in children for the development of acute pancreatitis. Endoscopic retrograde cholangiopancreatography (ERCP) with minor papilla endoscopic sphincterotomy (mPES) may be of clinical benefit, however, the clinical outcomes from endotherapy remain unclear. We sought to review the outcomes and safety of therapeutic ERCP in children with PD.
Freeman, A. Jay?; Maqbool, Asim†; Bellin, Melena D.‡; Goldschneider, Kenneth R.§; Grover, Amit S.||; Hartzell, Cheryl¶; Piester, Travis L.#; Szabo, Flora??; Kiernan, Bridget Dowd†; Khalaf, Racha††; Kumar, Rakesh‡‡; Rios, Mirta§§; Husain, Sohail Z.||||; Morinville, Veronique D.¶¶; Abu-El-Haija, Maisam##
doi : 10.1097/MPG.0000000000003001
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p 324-340
This position paper summarizes the current understanding of the medical management of chronic pancreatitis (CP) in children in light of the existing medical literature, incorporating recent advances in understanding of nutrition, pain, lifestyle considerations, and sequelae of CP. This article complements and is intended to integrate with parallel position papers on endoscopic and surgical aspects of CP in children. Concepts and controversies related to pancreatic enzyme replacement therapy (PERT), the use of antioxidants and other CP medical therapies are also reviewed. Highlights include inclusion of tools for medical decision-making for PERT, CP-related diabetes, and multimodal pain management (including an analgesia ladder). Gaps in our understanding of CP in children and avenues for further investigations are also reviewed.
Dong, Tao?,†; Zhao, Lili?,†; Lu, Tao‡; Fan, Zhining?,†
doi : 10.1097/MPG.0000000000002890
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p e53
Lepus, Chelsea A.?; Karasik, Michael S.†; Moote, Douglas J.‡; Hyams, Jeffrey S.?
doi : 10.1097/MPG.0000000000002971
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p e53
Rizvi, Syed Ahsan†; Ge, Li?; Li, Shuan?; Pandey, Akash†
doi : 10.1097/MPG.0000000000002827
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p e54-e55
Bossacoma Busquets, Ferran?; Pujol Muncunill, Gemma†; Arrojo Su?rez, Joëlle‡; Mart?nez Osorio, Johanna Marcela†; ?lvarez Carnero, Laura†; Martin de Carpi, Javier†
doi : 10.1097/MPG.0000000000002999
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p e56
van Wassenaer, Elsa A.; Benninga, Marc A.; Koot, Bart G.P.
doi : 10.1097/MPG.0000000000002998
Journal of Pediatric Gastroenterology and Nutrition: February 2021 - Volume 72 - Issue 2 - p e56
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