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November 2022 Stroke Highlights.
Romero, Jose Rafael MD
doi : 10.1161/STROKEAHA.122.041383
Volume 53(11) pgs. 3249-3523,e463-e495 November 2022
Nelonemdaz for Patients With Acute Ischemic Stroke Undergoing Endovascular Reperfusion Therapy: A Randomized Phase II Trial.
Hong, Ji Man MD, PhD ,*; Lee, Jin Soo MD, PhD; Lee, Yeong-Bae MD, PhD; Shin, Dong Hoon MD, PhD; Shin, Dong-Ick MD, PhD; Hwang, Yang-Ha MD, PhD; Ahn, Seong Hwan MD, PhD; Kim, Jae Guk MD, PhD; Sohn, Sung-Il MD, PhD; Kwon, Sun U. MD, PhD; Lee, Ji Sung PhD; Gwag, Byoung Joo PhD; Chamorro, Angel MD, PhD; Choi, Dennis W. MD, PhD; on behalf of the SONIC Investigators; Chammorro, Angel; Kim, Eung Yeop; Choi, Jin Wook; Yeo, Min-Ju; Kwak, Jaehyuk; Lee, Sung Eun; Hong, Jeong-Ho; Lee, Sangkil; Lee, Yoon-Joo; Lee, Min-Joo
doi : 10.1161/STROKEAHA.122.039649
Nelonemdaz is a multitarget neuroprotectant that selectively blocks N-methyl-D-aspartate receptors and scavenges free radicals, as proven in preclinical ischemia-reperfusion studies. We aimed to evaluate the safety and efficacy of nelonemdaz in patients with acute ischemic stroke receiving endovascular reperfusion therapy.
Yield of Dual Therapy With Statin and Ezetimibe in the Treat Stroke to Target Trial.
Amarenco, Pierre MD; Kim, Jong S. MD; Labreuche, Julien BST; Charles, Hugo BST; Giroud, Maurice MD; Lee, Byung-Chul MD; Lavallee, Philippa C. MD; Mahagne, Marie-Helene MD; Meseguer, Elena MD; Nighoghossian, Norbert MD; Steg, Philippe Gabriel MD; Vicaut, Eric MD; Bruckert, Eric MD; on behalf of the Treat Stroke to Target Investigators
doi : 10.1161/STROKEAHA.122.039728
In atherosclerotic stroke, lipid-lowering treatment with a target LDL (low-density lipoprotein) cholesterol of <70 compared with 100+/-10 mg/dL reduced the risk of subsequent cardiovascular events. This post hoc analysis explored the relative effects of the combination of statin and ezetimibe (dual therapy) and statin monotherapy in achieving the lower LDL cholesterol target and in reducing the risk of major vascular events, as compared with the higher target group.
Is It About the Destination or About the Journey?.
Blacquiere, Dylan MD, MSc; Sim, Holly MD; Dowlatshahi, Dar MD, PhD
Five-Year Results of Coronary Artery Bypass Grafting With or Without Carotid Endarterectomy in Patients With Asymptomatic Carotid Artery Stenosis: CABACS RCT.
Knipp, Stephan C. MD ,*; Holst, Torulv MD ,*; Bilbilis, Konstantinos Msc; von Velsen, Otgonzul Bsc; Ose, Claudia PhD; Diener, Hans-Christoph MD; Jakob, Heinz MD; Ruhparwar, Arjang MD; Jockel, Karl-Heinz PhD; Weimar, Christian MD; for the CABACS Study Group; Beyersdorf, Friedhelm; Breuer, Martin; Dahm, Manfred; Diegeler, Anno; Kowalski, Arne; Martens, Sven; Mohr, Friedrich-Wilhelm; Moritz, Anton; Ondrasek, Jiri; Reiter, Beate; Roth, Peter; Seipelt, Ralf; Siggelkow, Markus; Steinhoff, Gustav; Stock, Ulrich; Wilhelmi, Mathias; Wimmer-Greinecker, Gerhard
doi : 10.1161/STROKEAHA.121.037493
In patients with coronary artery disease and concomitant asymptomatic severe carotid stenosis, combined simultaneous coronary artery bypass grafting (CABG) and carotid endarterectomy (CEA) has been widely performed despite lack of evidence from randomized trials.
Effect of Intravenous Alteplase Treatment on First-Line Stent Retriever Versus Aspiration Alone During Endovascular Treatment.
Rinkel, Leon A. MD ,*; Treurniet, Kilian M. MD, PhD ,,*; Nieboer, Daan PhD; Kappelhof, Manon MD, PhD; LeCouffe, Natalie E. MD; Bruggeman, Agnetha A.E. MD; van Zwam, Wim H. MD, PhD; Lycklama a Nijeholt, Geert J. MD, PhD; Ghariq, Elyas MD; Uyttenboogaart, Maarten MD, PhD; Dippel, Diederik W.J. MD, PhD; Roos, Yvo B.W.E.M. MD, PhD; Coutinho, Jonathan M. MD, PhD; Majoie, Charles B.L.M. MD, PhD ,+; Emmer, Bart J. MD, PhD ,+; for the MR CLEAN-NO IV Investigators; Roozenbeek, Bob MD, PhD; van Es, Adriaan MD, PhD; de Ridder, Inger MD, PhD; van der Worp, Bart MD, PhD; Lo, Rob MD, PhD; Keizer, Koos MD, PhD; Gons, Rob MD; Yo, Lonneke MD, PhD; Boiten, Jelis MD, PhD; van den Wijngaard, Ido MD, PhD; Hofmeijer, Jeanette MD, PhD; Martens, Jasper MD; Schonewille, Wouter MD, PhD; Albert Vos, Jan MD, PhD; Tuladhar, Anil MD, PhD; Schreuder, Floris MD, PhD; Boogaarts, Jeroen MD, PhD; Jenniskens, Sjoerd MD; de Laat, Karlijn MD, PhD; van Dijk, Lukas MD, PhD; den Hertog, Heleen MD, PhD; van Hasselt, Boudewijn MD; Brouwers, Paul MD, PhD; Sturm, Emiel MD; Bulut, Tomas MD; Remmers, Michel MD; van Norden, Anouk MD; de Jong, Thijs MD; Rozeman, Anouk MD; Elgersma, Otto MD, PhD; Bokkers, Reinoud MD, PhD; van Tuijl, Julia MD; Boukrab, Issam MD; Kortman, Hans MD; Costalat, Vincent MD, PhD; Arquizan, Caroline MD, PhD; Lemmens, Robin MD, PhD; Demeestere, Jelle MD, PhD; Desfontaines, Philippe MD, PhD; Brisbois, Denis MD, PhD; Clarencon, Frederic MD, PhD; Samson, Yves MD, PhD; van Es, Adriaan MD, PhD; Boiten, Jelis MD, PhD; Yo, Lonneke MD, PhD; Keizer, Koos MD, PhD; Brown, Martin MD-Chair; White, Phil MD, PhD; Gregson, John MD, PhD; van Nuland, Rick PhD; van der Lugt, Aad MD, PhD-Chair; Jacobi, Linda MD, PhD; van den Berg, Rene[Combining Acute Accent] MD, PhD; Beenen, Ludo MD; van Es, Adriaan MD, PhD; van Doormaal, Pieter-Jan MD; van den Wijngaard, Ido MD, PhD; Yoo, Albert MD, PhD; Yo, Lonneke MD, PhD; Martens, Jasper MD, PhD; Hammer, Bas MD, PhD; Roosendaal, Stefan MD, PhD; Meijer, Anton MD, PhD; Krietemeijer, Menno MD; Bokkers, Reinoud MD, PhD; van der Hoorn, Anouk MD, PhD; Gerrits, Dick MD; van Oostenbrugge, Robert MD, PhD-Chair; Jansen, Ben MD, PhD; Manschot, Sanne MD, PhD; Kerkhof, Henk MD, PhD; van den Wijngaard, Ido MD, PhD; Koudstaal, Peter MD, PhD; Keizer, Koos MD, PhD; Lingsma, Hester PhD; Chalos, Vicky MD; Berkhemer, Olvert MD, PhD; van der Lugt, Aad MD, PhD; Versteeg, Adriaan; Wolff, Lennard MD; Su, Jiahang MSc; Tolhuisen, Manon MSc; van Voorst, Henk MD; ten Cate, Hugo MD, PhD; de Maat, Moniek PhD; Donse-Donkel, Samantha MD; van Beusekom, Heleen PhD; Taha, Aladdin MD; Chalos, Vicky MD; van den Berg, Sophie MD; van de Graaf, Rob MD; Goldhoorn, Robert-Jan MD; Taha, Aladdin MD; Donse-Donkel, Samantha MD; Hinsenveld, Wouter MD; Pirson, Anne MD; Sondag, Lotte MD; Reinink, Rik MD; Tolhuisen, Manon MD; Brouwer, Josje MD; Wolff, Lennard MD; Collette, Sabine; van der Steen, Wouter MD; Sprengers, Rita; Sterrenberg, Martin; El Ghannouti, Naziha; Verheesen, Sabrina; Pellikaan, Wilma; Blauwendraat, Kitty; Drabbe, Yvonne; de Meris, Joke; Simons, Michelle; Bongenaar, Hester; van Loon, Anja; Ponjee, Eva; Eilander, Rieke; Kooij, Suze; de Jong, Marieke; Santegoets, Esther; Roodenburg, Suze; van Ahee, Ayla; Moynier, Marinette; Devroye, Annemie; Marcis, Evelyn; Iezzi, Ingrid; David, Annie; Talbi, Atika; Heiligers, Leontien; Martens, Yvonne
doi : 10.1161/STROKEAHA.121.038390
We aimed to assess whether the effect of intravenous alteplase treatment (IVT) before endovascular treatment (EVT) on outcome is modified by first-line technique during EVT in IVT eligible patients.
Determinants and Trends of the Use of Intravenous Thrombolysis for Minor Stroke: A Population-Based Study, 2016 to 2020.
Font, Maria Angels MD; Garcia-Sanchez, Sonia Maria MD; Mengual, Juan Jose MD; Mena, Luis MD; Avellaneda, Carla MD; Serena, Joaquin MD, PhD; Valls-Carbo, Adrian MD; Chamorro, Angel MD, PhD; Ustrell, Xavier MD; Molina, Carlos MD, PhD; Cardona, Pere MD; Guasch-Jimenez, Marina MD; Purroy, Francisco MD, PhD; Rodriguez-Campello, Ana MD; Palomeras, Ernest MD; Cocho, Dolores MD; Krupinski, Jerzy MD, PhD; Canovas, David MD; Garcia-Alhama, Jessica MD; Zaragoza, Jose MD; Puiggros, Elsa MD; Matos, Nuria MD; Aragones, Josep Maria MD; Costa, Xavier MD; Sanjurjo, Eduard MD; Pedroza, Claudia MD; Monedero, Jordi MD; Almendros, M. Cruz MD; Rybyeva, Maria MD; Carrion, Dolors MD; Diaz, Gloria MD; Barcelo, Miquel MD; Jimenez-Fabrega, Xavier MD; Salvat-Plana, Merce RN; Elosua, Roberto MD, PhD; Perez de la Ossa, Natalia MD, PhD; Gomez-Choco, Manuel MD, PhD; on behalf of the Catalan Stroke Code and Reperfusion Consortium (Cat-SCR Consortium)
doi : 10.1161/STROKEAHA.122.038996
We analyzed the main factors associated with intravenous thrombolysis (IVT) in patients with minor ischemic stroke. Methods: Data were obtained from a prospective, government-mandated, population-based registry of stroke code patients in Catalonia (6 Comprehensive Stroke Centers, 8 Primary Stroke Centers, and 14 TeleStroke Centers).
Alteplase for Stroke With Unknown Onset Time in Chronic Kidney Disease: A Pooled Analysis of Individual Participant Data.
Miwa, Kaori MD, PhD; Koga, Masatoshi MD, PhD; Jensen, Marit MD, PhD; Inoue, Manabu MD, PhD; Yoshimura, Sohei MD, PhD; Fukuda-Doi, Mayumi MD, PhD; Boutitie, Florent PhD; Ma, Henry MD, PhD; Ringleb, Peter A. MD, PhD; Wu, Ona MD, PhD; Schwamm, Lee H. MD, PhD; Warach, Steven MD, PhD; Hacke, Werner MD, PhD; Davis, Stephen M. MD, PhD; Donnan, Geoffrey A. MD, PhD; Gerloff, Christian MD, PhD; Thomalla, Gotz MD, PhD; Toyoda, Kazunori MD, PhD; on behalf of Evaluation of Unknown Onset Stroke Thrombolysis Trials (EOS) Investigators; Cheng, Bastian MD; Bendszus, Martin MD; Bladin, Christopher MD, PhD; Churilov, Leonid PhD; Campbell, Brunce PhD; Parsons, Mark PhD; Yassi, Nawaf PhD; Ebinger, Martin MD; Endres, Matthias MD; Fiebach, Jochen B. MD; Kleinig, Timothy PhD; Latour, Lawrence PhD; Lemmens, Robin MD; Levi, Christopher MD; Leys, Didier MD; Molina, Carlos MD; Muir, Keith MD; Nighoghossian, Norbert MD; Pedraza, Salvador PhD; Schellinger, Peter D.; Schwab, Stefan MD; Simonsen, Claus Z. MD; Song, Shlee S. MD; Thijs, Vincent PhD; Toni, Danilo MD; Hsu, Chung Y. PhD; Wahlgren, Nils MD
doi : 10.1161/STROKEAHA.122.039086
Although chronic kidney disease (CKD) is associated with worse stroke outcomes, data regarding the influence of CKD on intravenous thrombolysis outcomes are scarce
Should Patients With Acute Minor Ischemic Stroke With Isolated Internal Carotid Artery Occlusion Be Thrombolysed?.
Boulenoir, Naouel MD; Turc, Guillaume MD, PhD; Ter Schiphorst, Adrien MD, MSc; Heldner, Mirjam R. MD; Strambo, Davide MD; Laksiri, Nadia MD; Girard Buttaz, Isabelle MD; Papassin, Jeremie MD; Sibon, Igor MD, PhD; Chausson, Nicolas MD, PhD; Michel, Patrik MD, PhD; Rosso, Charlotte MD, PhD; Bourdain, Frederic MD; Lamy, Chantal MD; Weisenburger-Lile, David MD; Agius, Pierre MD; Yger, Marion MD; Obadia, Michael MD; Sablot, Denis MD; Legris, Nicolas MD; Jung, Simon MD; Pilgram-Pastor, Sara MD; Henon, Hilde MD; Bernardaud, Lucy MD; Arquizan, Caroline MD; Baron, Jean-Claude MD, ScD; Seners, Pierre MD, PhD; on behalf of the ISOCAR and MINOR-STROKE Collaborators; Ben Hassen, Wagih; Lapergue, Bertrand; Lucas, Ludovic; Leys, Didier; Philippeau, Frederic; Bennani, Omar; Mechtouff, Laura; Klapczynski, Frederic; Detante, Olivier; Costalat, Vincent; Mione, Gioia; Gazzola, Sebastien; Debiais, Severine; Cakmak, Serkan; Grigoras, Valer; Denier, Christian; Smadja, Didier; Mounier-Vehier, Francois; Peres, Roxane; Spelle, Laurent; Bricout, Nicolas; Bracard, Serge; Triquenot, Aude; Lyoubi, Aicha; Cottier, Jean-Philippe; Duong, Duc-Long; Ollivier, Camille
doi : 10.1161/STROKEAHA.122.039228
We recently reported a worrying 30% rate of early neurological deterioration (END) occurring within 24 hours following intravenous thrombolysis (IVT) in minor stroke with isolated internal carotid artery occlusion (ie, without additional intracranial occlusion), mainly due to artery-to-artery embolism. Here, we hypothesize that in this setting IVT-as compared to no-IVT-may foster END, in particular by favoring artery-to-artery embolism from thrombus fragmentation.
Risk of Stroke After Posterior Reversible Encephalopathy Syndrome.
Parauda, Sarah C. MD; Zhang, Cenai MS; Salehi Omran, Setareh MD; Schweitzer, Andrew D. MD; Murthy, Santosh B. MD, MPH; Merkler, Alexander E. MD, MS; Navi, Babak B. MD, MS; Iadecola, Costantino MD; Kamel, Hooman MD, MS; Parikh, Neal S. MD, MS
doi : 10.1161/STROKEAHA.122.038673
Posterior reversible encephalopathy syndrome (PRES) can cause short-term cerebrovascular complications, such as brain infarction and hemorrhage. We hypothesized that PRES is also associated with an increased long-term risk of stroke. Methods: We performed a retrospective cohort study in the United States using statewide all-payer claims data from 2016 to 2018 on all admissions to nonfederal hospitals in 11 states.
Association of Retinal Age Gap With Arterial Stiffness and Incident Cardiovascular Disease.
Zhu, Zhuoting MD, PhD ,,,*; Chen, Yifan MBBS ,*; Wang, Wei MD, PhD ,,*; Wang, Yueye MD; Hu, Wenyi MBBS; Shang, Xianwen PhD; Liao, Huan MD, PhD; Shi, Danli MD; Huang, Yu MD, PhD; Ha, Jason MBBS; Tan, Zachary MBBS; Kiburg, Katerina V. MPH, PhD; Zhang, Xueli PhD; Tang, Shulin PhD; Yu, Honghua MD, PhD; Yang, Xiaohong MD, PhD; He, Mingguang MD, PhD
doi : 10.1161/STROKEAHA.122.038809
Retinal parameters could reflect systemic vascular changes. With the advances of deep learning technology, we have recently developed an algorithm to predict retinal age based on fundus images, which could be a novel biomarker for aging and mortality.
Temporal Trends of Functional Outcome in Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis.
Marko, Martha MD; Miksova, Dominika PhD; Ebner, Johanna MD; Lang, Marie MD, PhD; Serles, Wolfgang MD; Sommer, Peter MD; Sykora, Marek MD; Lang, Wilfried MD; Knoflach, Michael MD; Kiechl, Stefan MD; Greisenegger, Stefan MD; on behalf of the Austrian Stroke Unit Registry Collaborators; Mutzenbach, Johannes Sebastian MD; Bubel, Nele MD; Zellner, Thomas MD; Krstic, Miroslav MD; Grandits, Waltraud MD; Katzenschlager, Regina MD; Vosko, Milan R. MD; von Orzten, Tim MD; Struhal, Walter MD; Brunner, Cornelia MD; Yilmaz-Kaymaz, Nilguen MD; Hosseiny, Omid MD; Krisper, Eva MD; Sackl, Felix MD; Baumgartner, Christoph MD; Rumpl, Elke MD; Pirker-Kees, Agnes MD; Berger, Otto MD; Beirer, Sebastian MD; Komenda-Lett, Martin MD; Weber, Jorg R. MD; Hofner, Elmar MD; Seiler, Stephan MD; Berek, Klaus MD; Mayr, Markus MD; Haaser, Stefan MD; Asenbaum-Nan, Susanne MD; Heumesser, Rebecca MD; Rumpl, Barbara Almut MD; Rus, Marc MD; Muellauer, Barbara MD; Hoger, Franz MD; Lampl, Christian MD; Bocksrucker, Christof MD; Lackner, Peter MD; Schlager, Markus MD; Mayer, Florian MD; Fertl, Elisabeth MD; Steiner, Sandrina MD; Koller, Herbert MD; Doppler, Wolfgang MD; Ferrari, Julia MD; Krebs, Stefan MD; Mitrovic, Nenad MD; Salletmayr, Thomas MD; Grunenberg, Monika MD; Bancher, Christian MD; Pinter, Hajnalka MD; Karpat, Frantisek MD; Sellner, Johann MD; Wolf, Thomas MD; Schnider, Peter MD; Wallner-Blazek, Mirja MD; Enzinger, Christian MD; Gattringer, Thomas MD; Poltrum, Birgit MD; Bohme, Christian MD; Mayer, Lukas MD; Hofeneder, Dominik MD; Daniel, Gerhard MD; Kaniak, Kitty MD; Grossmann, Josef MD; Morgenstern, Gabi MD; Wendlinger, Nadja MD; Staykov, Dimitre MD; Halilovic, Almin MD; Frattner, Michael MD; Wai[latin sharp s], Christoph MD; Tinchon, Alexander MD; Fischer, Anna MD; Kapeller, Peter MD; Luschin, Gerda MD; Gasser, Sibylle MD; Heine, Martin MD; Wurzinger, Harald MD; Wuhrer, Susanne MD; Werner, Philipp MD; Mayr, Andrea MD; Matosevic, Benjamin MD; Gollmer, A.; Kern, R.
doi : 10.1161/STROKEAHA.121.038400
Intravenous thrombolysis improves functional outcome in patients with acute stroke and frequencies of r-tPA (recombinant tissue-type plasminogen activator) treatment have been increasing over time. We aimed to assess whether functional outcome in r-tPA-treated patients improved over time and to investigate the influence of clinical variables on functional outcome.
Trends in 1-Year Recurrent Ischemic Stroke in the US Medicare Fee-for-Service Population.
Leifheit, Erica C. PhD; Wang, Yun PhD; Goldstein, Larry B. MD; Lichtman, Judith H. PhD
doi : 10.1161/STROKEAHA.122.039438
There have been important advances in secondary stroke prevention and a focus on healthcare delivery over the past decades. Yet, data on US trends in recurrent stroke are limited. We examined national and regional patterns in 1-year recurrence among Medicare beneficiaries hospitalized for ischemic stroke from 2001 to 2017.
Persistent Disparities in Recurrent Ischemic Stroke by Race and Geography in the US Medicare Fee-for-Service Population.
Madsen, Tracy E. MD, PhD
Importance of Delayed Reperfusions in Patients With Incomplete Thrombectomy.
Mujanovic, Adnan MD; Jungi, Noel MD; Kurmann, Christoph C. MD; Dobrocky, Tomas MD; Meinel, Thomas R. MD; Almiri, William MD; Grunder, Lorenz MD; Beyeler, Morin MD; Lang, Matthias F. MD; Jung, Simon MD; Klail, Tomas MD; Hoffmann, Angelika MD; Seiffge, David J. MD; Heldner, Mirjam R. MD; Pilgram-Pastor, Sara MD; Mordasini, Pasquale MD; Arnold, Marcel MD; Piechowiak, Eike I. MD; Gralla, Jan MD; Fischer, Urs MD; Kaesmacher, Johannes MD
doi : 10.1161/STROKEAHA.122.040063
There is paucity of data regarding the effects of delayed reperfusion (DR) on clinical outcomes in patients with incomplete reperfusion following mechanical thrombectomy. We hypothesized that DR has a strong association with clinical outcome in patients with incomplete reperfusion after mechanical thrombectomy (expanded Thrombolysis in Cerebral Infarction, 2a-2c).
Associations Between Adherence to Evidence-Based, Stroke Quality Indicators and Outcomes of Acute Reperfusion Therapy.
Ren, Nice MD, PhD; Ogata, Soshiro PhD, MHS, RN, PHN; Kiyoshige, Eri PhD, MHS, RN, PHN; Nishimura, Kunihiro MD, PhD; Nishimura, Ataru MD, PhD; Matsuo, Ryu MD, PhD; Kitazono, Takanari MD, PhD; Higashi, Takahiro MD, PhD; Ogasawara, Kuniaki MD, PhD; Iihara, Koji MD, PhD; on behalf of Close The Gap-Stroke, J-ASPECT Study Collaborators
doi : 10.1161/STROKEAHA.121.038483
Quality indicators (QIs) are an accepted tool for measuring a hospital's performance in routine care. We examined national trends in adherence to the QIs developed by the Close The Gap-Stroke program by combining data from the health insurance claims database and electronic medical records, and the association between adherence to these QIs and early outcomes in patients with acute ischemic stroke in Japan.
Prevalence and Predictors of Food Insecurity Among Stroke Survivors in the United States.
Kim-Tenser, May A. MD, MHA; Ovbiagele, Bruce MD, MLS, MBA, MAS, MSc; Markovic, Daniela MS; Towfighi, Amytis MD
doi : 10.1161/STROKEAHA.122.038574
Food insecurity (FI)-lack of consistent access to food due to poor financial resources-limits the ability to eat a healthy diet, which is essential for secondary stroke prevention.
Disparities in Reperfusion Therapy and Time Delays Among Patients With Ischemic Stroke and a History of Mental Illness.
Mackenhauer, Julie MD; Frischknecht Christensen, Erika MD; Andersen, Grethe MD; DMSc; Mainz, Jan MD, PhD; Johnsen, Soren Paaske MD, PhD
doi : 10.1161/STROKEAHA.122.038591
Comorbid mental illness may delay recognition of stroke symptoms and reduce the chance of reperfusion therapy. The aim of this study was to compare the use of reperfusion therapy and treatment delays in patients with or without a history of mental illness. Methods: A nationwide registry-based cohort study of patients with ischemic stroke.
US Surveillance of Acute Ischemic Stroke Patient Characteristics, Care Quality, and Outcomes for 2019.
Ziaeian, Boback MD, PhD; Xu, Haolin MS; Matsouaka, Roland A. PhD; Xian, Ying PhD; Khan, Yosef MD PhD; Schwamm, Lee S. MD; Smith, Eric E. MD, MPH; Fonarow, Gregg C. MD
doi : 10.1161/STROKEAHA.122.039098
The United States lacks a timely and accurate nationwide surveillance system for acute ischemic stroke (AIS). We use the Get With The Guidelines-Stroke registry to apply poststratification survey weights to generate national assessment of AIS epidemiology, hospital care quality, and in-hospital outcomes.
Differential Impact of Stroke on Cognitive Impairment in Mexican Americans and Non-Hispanic White Americans.
Becker, Christopher J. MD; Heeringa, Steven G. PhD; Chang, Wen MS; Briceno, Emily M. PhD; Mehdipanah, Roshanak PhD; Levine, Deborah A. MD, MPH; Langa, Kenneth M. MD, PhD; Gonzales, Xavier F. PhD; Garcia, Nelda BA; Longoria, Ruth BA; Springer, Mellanie V. MD, MS; Zahuranec, Darin B. MD, MS; Morgenstern, Lewis B. MD
doi : 10.1161/STROKEAHA.122.039533
The association between stroke and dementia is well established. Less is known about this association in underrepresented ethnic groups. In a large ethnically diverse cohort, we examined whether history of stroke was associated with cognitive impairment, and whether this relationship differed by ethnicity (Mexican American [MA] versus non-Hispanic White).
Tuberculosis and Risk of Ischemic Stroke: A Nationwide Cohort Study.
Lee, Han Rim MD; Yoo, Jung Eun MD, PhD; Choi, Hayoung MD; Han, Kyungdo PhD; Jung, Jin Hyung PhD; Park, Jongkyu MD; Lee, Hyun MD, PhD ,*; Shin, Dong Wook MD, PhD, MBA ,,,*
doi : 10.1161/STROKEAHA.122.039484
Conflicting results exist regarding the risk of ischemic stroke in tuberculosis survivors. We aimed to estimate the risk of ischemic stroke using a nationwide population-based retrospective cohort.
Incidence of Stroke in Randomized Trials of COVID-19 Therapeutics: A Systematic Review and Meta-Analysis.
Nagraj, Sanjana MBBS ,*; Varrias, Dimitrios MD ,*; Hernandez Romero, Gabriel MD; Santos, Heitor T. MD; Karamanis, Dimitrios PhD; Sagris, Dimitrios MD; Korompoki, Eleni MD, PhD; Milionis, Haralampos MD; PhD; Palaiodimos, Leonidas MD ,+; Ntaios, George MD, MSc, PhD ,+
doi : 10.1161/STROKEAHA.122.040233
COVID-19 has been frequently associated with an increased risk of thrombotic complications. There have also been reports of an increased likelihood of stroke, although its true incidence in patients with COVID-19 is currently unknown.
Clinical Diagnosis and Magnetic Resonance Imaging in Patients With Transient and Minor Neurological Symptoms: A Prospective Cohort Study.
Whiteley, William N. PhD; MacRaild, Allan BA, BSc; Wang, Ying MD; Dennis, Martin MD; Al-Shahi Salman, Rustam PhD; Gray, Alasdair MD; Reed, Matthew J. MD; Graham, Catriona MSc; Wardlaw, Joanna M. MD
doi : 10.1161/STROKEAHA.122.039082
The utility of magnetic resonance imaging (MRI) brain in patients with transient or minor neurological symptoms is uncertain. We sought to determine the proportion of participants with transient or minor neurological symptoms who had MRI evidence of acute ischemia at different clinical probabilities of transient ischemic attack (TIA) or minor stroke.
Perfusion Imaging and Clinical Outcome in Acute Minor Stroke With Large Vessel Occlusion.
Seners, Pierre MD, PhD; Arquizan, Caroline MD; Fontaine, Louis MD; Ben Hassen, Wagih MD, MSc; Heldner, Mirjam R. MD, MSc; Strambo, Davide MD; Nagel, Simon MD, PhD; Carrera, Emmanuel MD, PhD; Mechtouff, Laura MD, PhD; McCullough-Hicks, Margy MD; Mohammaden, Mahmoud H. MD; Cottier, Jean-Philippe MD, PhD; Henon, Hilde MD, PhD; Aignatoaie, Andreea MD; Laksiri, Nadia MD; Papassin, Jeremie MD; Lucas, Ludovic MD; Garnier, Pierre MD; Triquenot, Aude MD; Mione, Gioia MD; Hajdu, Steven MD; Costalat, Vincent MD, PhD; Potreck, Arne MD; Detante, Olivier MD, PhD; Bonneville, Fabrice MD, PhD; Berthezene, Yves MD, PhD; Bracard, Serge MD; Sibon, Igor MD; Bricout, Nicolas MD; Boutet, Claire MD, PhD; Mordasini, Pasquale MD, MSc; Michel, Patrik MD; Oppenheim, Catherine MD, PhD; Olivot, Jean-Marc MD, PhD; Nogueira, Raul G. MD; Albers, Gregory W. MD; Baron, Jean-Claude MD, ScD; Turc, Guillaume MD, PhD; on behalf of the MINOR-STROKE-Perfusion Collaborators; Cognard, Christophe; Marnat, Gaultier; Menegon, Patrice; Ledure, Sylvain; Dargazanli, Cyril; Cho, Tae-Hee; Nighoghossian, Norbert; Eker, Omer; Gouttard, Sylvain; Haussen, Diogo; Debiais, Severine; Charron, Vladimir; Charron, Nicolas; Leys, Didier; Ozsancak, Canan; Delpech, Mathilde; Brunel, Herve; Papagiannaki, Chrysanti; Girardin, Emmanuel; Richard, Sebastien; Gory, Benjamin; Zbinden, Martin; Dobrocky, Tomas; Ringelb, Peter; Mohlenbruch, Markus
doi : 10.1161/STROKEAHA.122.039182
Whether bridging therapy (intravenous thrombolysis [IVT] followed by mechanical thrombectomy) is superior to IVT alone in minor stroke with large vessel occlusion is unknown.
Estimating Perfusion Deficits in Acute Stroke Patients Without Perfusion Imaging.
Reyes, Dennys MD; Simpkins, Alexis N. MD, PhD; Hitomi, Emi BS; Lynch, John K. DO, MPH; Hsia, Amie W. MD; Nadareishvili, Zurab MD, PhD; Luby, Marie PhD; Latour, Lawrence L. PhD; Leigh, Richard MD
doi : 10.1161/STROKEAHA.121.038101
Perfusion weighted imaging (PWI) is critical for determining whether stroke patients presenting in an extended time window are candidates for mechanical thrombectomy. However, PWI is not always available.
Texture Features of Magnetic Resonance Images Predict Poststroke Cognitive Impairment: Validation in a Multicenter Study.
Betrouni, Nacim PhD; Jiang, Jiyang PhD; Duering, Marco MD, PhD; Georgakis, Marios K. MD, PhD; Oestreich, Lena PhD; Sachdev, Perminder S. MD, PhD; O'Sullivan, Michael PhD; Wright, Paul PhD; Lo, Jessica W. PhD; Bordet, Regis MD, PhD; on behalf of the Stroke and Cognition (STROKOG) Collaboration
doi : 10.1161/STROKEAHA.122.039732
Imaging features derived from T1-weighted (T1w) images texture analysis were shown to be potential markers of poststroke cognitive impairment, with better sensitivity than atrophy measurement. However, in magnetic resonance images, the signal distribution is subject to variations and can limit transferability of the method between centers.
Pharmacological Characterization of a Novel Neuroactive Steroid Prodrug, NTS-104, and Its Neuroprotective Activity in Experimental Stroke Models.
Zhang, Li MD ,*; Schwartz-Byrne, Robin MS ,*; Gertz, Steven BA; McGuire, Matthew BA; Woodhouse, Colleen BA; Powell, Brianna BS; Wei, Min BS; Li, Chao PhD; Billing, Clare B. MS; Verdoorn, Todd A. PhD; Lam, Leslie MS; Parry, Tom J. PhD; Buller, Benjamin PhD; Zhang, Zheng Gang MD, PhD; Poulsen, David PhD; Chopp, Michael PhD
doi : 10.1161/STROKEAHA.122.038507
Ischemic stroke affects about 700 000 patients per year in the United States, and to date, there are no effective pharmacological agents that promote recovery. Here, we studied the pharmacokinetics, pharmacodynamics, and efficacy of NTS-105, a novel neuroactive steroid, and NTS-104, a prodrug of NTS-105, in 2 models of ischemic stroke.
Differentiation of Fibroblasts Into Myofibroblasts in the Arachnoid Membrane of Moyamoya Disease.
Yamamoto, Shusuke MD; Yamamoto, Seiji PhD; Akai, Takuya MD, PhD; Sasahara, Masakiyo MD, PhD; Kuroda, Satoshi MD, PhD
doi : 10.1161/STROKEAHA.122.039961
Moyamoya disease (MMD) is a very specific disorder in terms of spontaneous development of extracranial-to-intracranial collateral circulation through the dura mater, but the underlying mechanisms are unclear. This study aimed to investigate the role of the arachnoid membrane in this unique angiogenesis in MMD.
Mechanism of Spontaneous Intracerebral Hemorrhage Formation: An Anatomical Specimens-Based Study.
Rzeplinski, Radoslaw MD; Slugocki, Mikolaj MD; Tarka, Sylwia MD, PhD; Tomaszewski, Michal MEng, PhD; Kucewicz, Michal MEng; Karczewski, Krzysztof MEng, PhD; Krajewski, Pawel MD, PhD; Malachowski, Jerzy PhD, DSc; Ciszek, Bogdan MD, PhD
doi : 10.1161/STROKEAHA.122.040143
Despite advances in understanding various risk and prognostic factors, spontaneous intracerebral hemorrhage is connected to very high morbidity and mortality, while the therapy is mainly supportive.
Hemorrhagic Stroke in Children and Adults With Sickle Cell Anemia: The Post-STOP Cohort.
Fox, Christine K. MD, MAS; Leykina, Liza BA; Hills, Nancy K. PhD; Kwiatkowski, Janet L. MD, MSCE; Kanter, Julie MD; Strouse, John J. MD, PhD; Voeks, Jenifer H. PhD; Fullerton, Heather J. MD, MAS; Adams, Robert J. MS, MD; for the Post-STOP Study Group
doi : 10.1161/STROKEAHA.122.038651
Hemorrhagic stroke in young patients with sickle cell anemia remains poorly characterized. Methods: The Post-STOP (Stroke Prevention Trial in Sickle Cell Anemia) retrospective study collected follow-up data on STOP and STOP II clinical trial cohorts.
Association of Lesion Location and Depressive Symptoms Poststroke.
Klingbeil, Julian MD ,*; Brandt, Max-Lennart MD ,*; Wawrzyniak, Max MD; Stockert, Anika MD; Schneider, Hans R. MD; Baum, Petra MD; Hoffmann, Karl-Titus MD; Saur, Dorothee MD
doi : 10.1161/STROKEAHA.122.039068
Depressive symptoms are a common stroke sequela, yet their neurobiological substrates are still unclear. We sought to determine if they are associated with specific lesion locations. Methods: In a prospective observational study, 270 patients with stroke were tested twice with the Hospital Anxiety and Depression Scale around day 6 and again 6 months poststroke and voxel-based lesion behavior mapping was performed.
Novel Approach to Visualize Microglia Death and Proliferation After Intracerebral Hemorrhage in Mice.
Ye, Fenghui MD; Yang, Jinting BS; Hua, Ya MD; Keep, Richard F. PhD; Xi, Guohua MD
doi : 10.1161/STROKEAHA.122.040302
Microglia are important brain immune cells. However, it is difficult to differentiate microglia from monocyte-derived macrophages. To visualize microglia changes following intracerebral hemorrhage (ICH), we utilized a genetic knock-in mouse line, Tmem119 (transmembrane protein 119)-EGFP (enhanced green fluorescent protein), which expresses EGFP specifically in microglia.
Advance Care Planning Engagement May Increase Among Stroke Survivors: Results From the PREPARE for Your Care Trial.
Skolarus, Lesli E. MD, MS; Brown, Devin L. MD, MS; Reynolds, Evan PhD; Shi, Ying PhD; Volow, Aiesha M. MPH; Burke, James F. MD, MS; Sudore, Rebecca L. MD
Bilateral Earlobe Crease (Frank's Sign) and Multifocal Vascular Disease.
Carreon-Camarena, Elizabeth MD; Ayala-Alvarez, Juan Carlos MD; Ruiz-Sandoval, Jose Luis MD; Jimenez-Ruiz, Amado MD
Whole-Brain Perfusion via Right Common Carotid Artery With Type 2 Proatlantal Intersegmental Artery.
Zuflacht, Jonah P. MD; Liang, Chuan MD; Burkhardt, Jan-Karl MD; Favilla, Christopher G. MD
Vessel Wall Magnetic Resonance Imaging of a Nonstenotic Craniocervical Vertebral Artery Dissection.
Dang, Quynh-Anh BS; Andres, Wells MD; Cucchiara, Brett L. MD; Song, Jae W. MD
Advances in Epidemiology, Outcomes, and Population Science.
Elkind, Mitchell S.V. MD, MS; Hankey, Graeme J. MBBS, MD
Nursing Implications of Mindfulness-Informed Interventions for Stroke Survivors and Their Families.
Saban, Karen L. PhD, RN, CNRN; Tell, Dina PhD; De La Pena, Paula MSN, RN
doi : 10.1161/STROKEAHA.122.038457
AB The consequences of stroke can be devastating and include psychological distress, such as anxiety and depression, functional deficits, pain, and cognitive impairment. Symptoms are complex and impact not only the stroke survivor but may also be challenging for family caregivers. Studies have consistently demonstrated that mindfulness-informed interventions (MBI), such as mindfulness-based stress reduction and acceptance and self-compassion therapies, improve symptoms in a wide variety of clinical populations. However, research examining MBIs within the stroke population is in its infancy.
Walk the Talk: Current Evidence for Walking Recovery After Stroke, Future Pathways and a Mission for Research and Clinical Practice.
Moore, Sarah A. PhD; Boyne, Pierce PhD; Fulk, George PhD; Verheyden, Geert PhD; Fini, Natalie A. PhD
doi : 10.1161/STROKEAHA.122.038956
AB Achieving safe, independent, and efficient walking is a top priority for stroke survivors to enable quality of life and future health. This narrative review explores the state of the science in walking recovery after stroke and potential for development.
Glenzocimab: A GPVI (Glycoprotein VI)-Targeted Potential Antiplatelet Agent for the Treatment of Acute Ischemic Stroke.
Wichaiyo, Surasak PhD; Parichatikanond, Warisara PhD; Rattanavipanon, Wipharak BPharm, BCP
doi : 10.1161/STROKEAHA.122.039790
AB It has previously been shown in several animal experiments that platelet GPVI (glycoprotein VI) contributes to thrombosis, particularly in ischemic stroke. Moreover, GPVI levels are upregulated in stroke patients.
Willis Lecture: Biomarkers for Inflammatory White Matter Injury in Binswanger Disease Provide Pathways to Precision Medicine.
Rosenberg, Gary A. MD
doi : 10.1161/STROKEAHA.122.039211
AB Binswanger disease is the small vessel form of vascular cognitive impairment and dementia. Deposition of Alzheimer disease proteins can begin in midlife and progress slowly, whereas aging of the vasculature also can begin in midlife, continuing to progress into old age, making mixed dementia the most common type of dementia.
Stroke Literature Synopsis (Clinical).
Welsh, Silje MBChB; Quinn, Terence J. MD
Introduction to Biomedical Engineering in Stroke Diagnosis and Treatment.
Xu, Tongtong PhD; Chen, Peiqian PhD; Wang, Jixian PhD; Tang, Yaohui PhD
Atypical Presentation of Primary Angiitis of Central Nervous System Responsive to Rituximab.
Kesav, Praveen DM; John, Seby MD; Al-Sharif, Khalid MD; Thomas, Moncy DM; Alduaij, Ahmad MD; Alkuwaiti, Mohammed MD; Hussain, Syed Irteza MD
Correction to: Fibrinogen Depletion Coagulopathy Predicts Major Bleeding After Thrombolysis for Ischemic Stroke: A Multicenter Study.
