Functional connectivity between mesial temporal and default mode structures may help lateralize surgical temporal lobe epilepsy

Saramati Narasimhan , Hernán F. J. González , Graham W. Johnson , Kristin E. Wills , Danika L. Paulo , Victoria L. Morgan , and Dario J. Englot

doi : 10.3171/2022.1.JNS212031

The most common surgically treatable epilepsy syndrome is mesial temporal lobe epilepsy (mTLE). Preoperative noninvasive lateralization of mTLE is challenging in part due to rapid contralateral seizure spread. Abnormal connections in both the mesial temporal lobe and resting-state networks have been described in mTLE, but it is unclear if connectivity between these networks may aid in lateralization.

خرید پکیج و مشاهده آنلاین مقاله

Optimal targeting of the anterior nucleus of the thalamus for epilepsy: a meta-analysis

Adeel Ilyas, MD,1–3 Kathryn M. Snyder, BE, 2,3 Tessy M. Thomas, PhD, 2,3 and Nitin Tandon, MD

doi : 10.3171/2022.2.JNS212550

Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) has been shown to be an effective therapeutic option for select patients with limbic epilepsy. However, the optimal target and electrode position for this indication remains undefined. Therefore, the objective of this systematic review and meta-analysis is to quantify the association between active contact location and outcomes across all published series of ANT DBS.

خرید پکیج و مشاهده آنلاین مقاله

Centromedian thalamic deep brain stimulation for drug-resistant epilepsy: single-center experience

*Jimmy C. Yang, MD,Katie L. Bullinger, MD, PhD,Faical Isbaine, PhD,Abdulrahman Alwaki, MD,Enrico Opri, PhD,Jon T. Willie, MD, PhD,and Robert E. Gross, MD, PhD

doi : 10.3171/2022.2.JNS212237

Neuromodulation of the centromedian nucleus of the thalamus (CM) has unclear effectiveness in the treatment of drug-resistant epilepsy. Prior reports suggest that it may be more effective in the generalized epilepsies such as Lennox-Gastaut syndrome (LGS). The objective of this study was to determine the outcome of CM deep brain stimulation (DBS) at the authors’ institution.

خرید پکیج و مشاهده آنلاین مقاله

Apparent diffusion coefficient of piriform cortex and seizure outcome in mesial temporal lobe epilepsy after MR-guided laser interstitial thermal therapy: a single-institution experience

Min Jae Kim,Brian Y. Hwang, MD,David Mampre, MD,Serban Negoita, BS,Yohannes Tsehay, BA,Haris I. Sair, MD,Joon Y. Kang, MD,and William S. Anderson, PhD, MD

doi : 10.3171/2022.3.JNS212490

Piriform cortex (PC) is one of the critical structures in the epileptogenesis of mesial temporal lobe epilepsy (mTLE), but its role is poorly understood. The authors examined the utility of apparent diffusion coefficient (ADC; an MR-based marker of tissue pathology) of the PC as a predictor of seizure outcome in patients with mTLE undergoing MR-guided laser interstitial thermal therapy (MRgLITT).

خرید پکیج و مشاهده آنلاین مقاله

Intraoperative localization and preservation of reading in ventral occipitotemporal cortex

Oscar Woolnough, PhD,Kathryn M. Snyder, BE,Cale W. Morse, BS,Meredith J. McCarty, BSA,Samden D. Lhatoo, MD,and Nitin Tandon, MD

doi : 10.3171/2022.2.JNS22170

Resective surgery in language-dominant ventral occipitotemporal cortex (vOTC) carries the risk of causing impairment to reading. Because it is not on the lateral surface, it is not easily accessible for intraoperative mapping, and extensive stimulation mapping can be time-consuming. Here the authors assess the feasibility of using task-based electrocorticography (ECoG) recordings intraoperatively to help guide stimulation mapping of reading in vOTC.

خرید پکیج و مشاهده آنلاین مقاله

Early repeat resection for residual glioblastoma: decision-making among an international cohort of neurosurgeons

*Anya A. Kim, BS,Antonio Dono, MD,Adham M. Khalafallah, MD,Barbara Nettel-Rueda, MD,George Samandouras, MD,Constantinos G. Hadjipanayis, MD, PhD,Debraj Mukherjee, MD, MPH,and Yoshua Esquenazi, MD

doi : 10.3171/2022.1.JNS211970

The importance of extent of resection (EOR) in glioblastoma (GBM) has been thoroughly demonstrated. However, few studies have explored the practices and benefits of early repeat resection (ERR) when residual tumor deemed resectable is unintentionally left after an initial resection, and the survival benefit of ERR is still unknown. Herein, the authors aimed to internationally survey current practices regarding ERR and to analyze differences based on geographic location and practice setting.

خرید پکیج و مشاهده آنلاین مقاله

Adult diffuse intrinsic pontine glioma: clinical, radiological, pathological, molecular features, and treatments of 96 patients

Yi Wang, MD,Changcun Pan, MD, PhD,Mingguo Xie, MD,Pengcheng Zuo, MD,Xiaoou Li, MD,Guocan Gu, MD,Tian Li, MM,Zhuang Jiang, MM,Zhen Wu, MD, PhD,Junting Zhang, MD,andLiwei Zhang, MD, PhD

doi : 10.3171/2022.2.JNS211920

Unlike its pediatric counterpart, adult diffuse intrinsic pontine glioma (DIPG) remains largely unelucidated. In this study, the authors examined the clinical, radiological, pathological, molecular, and clinical aspects of 96 adult DIPGs.

خرید پکیج و مشاهده آنلاین مقاله

Natural history of meningiomas: a serial volumetric analysis of 240 tumors

*Pascal Thomann, MD,Levin Häni, MD,Sonja Vulcu, MD,Alessa Schütz, MD,Maximilian Frosch, MD,Christopher Marvin Jesse, MD,Marwan El-Koussy, MD,Nicole Söll,Arsany Hakim, MD,Andreas Raabe, MD,and Philippe Schucht, MD

doi : 10.3171/2022.3.JNS212626

The management of asymptomatic intracranial meningiomas is controversial. Through the assessment of growth predictors, the authors aimed to create the basis for practicable clinical pathways for the management of these tumors.

خرید پکیج و مشاهده آنلاین مقاله

Endoscope-assisted visualization of 5-aminolevulinic acid fluorescence in surgery for brain metastases

*Christoph Bettag, MD,Abdelhalim Hussein, MD,Bawarjan Schatlo, MD,Alonso Barrantes-Freer, MD, PhD,Tammam Abboud, MD,Veit Rohde, MD,andDorothee Mielke, MD

doi : 10.3171/2022.3.JNS212301

Fluorescence-guided resection of cerebral metastases has been proposed as an approach to visualize residual tumor tissue and maximize the extent of resection. Critics have argued that tumor cells at the resection margins might be overlooked under microscopic visualization because of technical limitations. Therefore, an endoscope, which is capable of inducing fluorescence, has been applied with the aim of improving exposure of fluorescent tumor tissue. In this retrospective analysis, authors assessed the utility of endoscope assistance in 5-aminolevulinic acid (5-ALA) fluorescence–guided resection of brain metastases.

خرید پکیج و مشاهده آنلاین مقاله

Regrowth factors of WHO grade I skull base meningiomas following incomplete resection

Hun Ho Park, MD, PhD,Jihwan Yoo, MD,Hyeong-Cheol Oh, MD,Yoon Jin Cha, MD, PhD,Se Hoon Kim, MD, PhD,Chang-Ki Hong, MD, PhD,and Kyu-Sung Lee, MD, PhD

doi : 10.3171/2022.3.JNS2299

The role of adjuvant radiation therapy following incomplete resection of WHO grade I skull base meningiomas (SBMs) is controversial, and little is known regarding the behavior of residual tumors. The authors investigated the factors that influence regrowth of residual WHO grade I SBMs following incomplete resection.

خرید پکیج و مشاهده آنلاین مقاله

How to dose-stage large or high-risk brain metastases: an alternative two-fraction radiosurgical treatment approach

Anna Cho, MD,1 Kira Medvedeva, MD, 2 Beate Kranawetter, MD,1 Helena Untersteiner, MD,1 Dorian Hirschmann, MD,1 Olga Lepilina, 2 Anatoly Baulin, 2 Martin Buschmann, PhD,1,3 Adolf Ertl, PhD,1 Wolfgang Marik, MD, 4 Christian Dorfer, MD,1 Karl Rössler, MD,1 Brigitte Gatterbauer, MD,1 Sergey Ilyalov, MD, PhD, 2 and Josa M. Frischer, MD, PhD1

doi : 10.3171/2022.2.JNS212440

The authors sought to evaluate clinical outcome in patients with large, high-risk brain metastases (BMs) treated with different dose strategies by use of two-fraction dose-staged Gamma Knife radiosurgery (GKRS).

خرید پکیج و مشاهده آنلاین مقاله

Single low-dose targeted bevacizumab infusion in adult patients with steroid-refractory radiation necrosis of the brain: a phase II open-label prospective clinical trial

Shervin R. Dashti, MD, PhD,Robert J. Kadner, MD,Bradley S. Folley, PhD,Jason P. Sheehan, MD, PhD,Dong Y. Han, PsyD,Richard J. Kryscio, PhD,Mary B. Carter, MD, PhD,Lisa B. E. Shields, MD,Brian M. Plato, DO,Renato V. La Rocca, MD,Aaron C. Spalding, MD, PhD,14Tom L. Yao, MD,Justin F. Fraser, MD

doi : 10.3171/2022.2.JNS212006

There is an unmet need for safe and rapidly effective therapies for refractory brain radiation necrosis (RN). The aim of this prospective single-arm phase II trial was to evaluate the safety and efficacy of a single low-dose targeted bevacizumab infusion after blood-brain barrier disruption (BBBD) in adult patients with steroid-refractory brain RN.

خرید پکیج و مشاهده آنلاین مقاله

Pituitary adenoma in the elderly: surgical outcomes and treatment trends in the United States

Eric J. Chalif, BA, Ramin A. Morshed, MD, Jacob S. Young, MD, Alexander F. Haddad, MD,Saket Jain, PhD, and Manish K. Aghi, MD, PhD

doi : 10.3171/2022.3.JNS212940

Decision-making in how to manage pituitary adenomas (PAs) in the elderly (age ≥ 65 years) can be challenging given the benign nature of these tumors and concerns about surgical morbidity in these patients. In this study involving a large multicenter national registry, the authors examined treatment trends and surgical outcomes in elderly compared to nonelderly patients.

خرید پکیج و مشاهده آنلاین مقاله

Association between socioeconomic status and presenting characteristics and extent of disease in patients with surgically resected nonfunctioning pituitary adenoma

David J. Cote, MD, PhD,Jacob J. Ruzevick, MD,Keiko M. Kang, MD,Dhiraj J. Pangal, BS,Ilaria Bove, MD,John D. Carmichael, MD,Mark S. Shiroishi, MD, MS,Ben A. Strickland, MD,and Gabriel Zada, MD, MS

doi : 10.3171/2022.2.JNS212673

The aim of this study was to evaluate the association between zip code–level socioeconomic status (SES) and presenting characteristics and short-term clinical outcomes in patients with nonfunctioning pituitary adenoma (NFPA).

خرید پکیج و مشاهده آنلاین مقاله

Functional connectivity between mesial temporal and default mode structures may help lateralize surgical temporal lobe epilepsy

Saramati Narasimhan , Hern?n F. J. Gonz?lez , Graham W. Johnson , Kristin E. Wills , Danika L. Paulo , Victoria L. Morgan , and Dario J. Englot

doi : 10.3171/2022.1.JNS212031

The most common surgically treatable epilepsy syndrome is mesial temporal lobe epilepsy (mTLE). Preoperative noninvasive lateralization of mTLE is challenging in part due to rapid contralateral seizure spread. Abnormal connections in both the mesial temporal lobe and resting-state networks have been described in mTLE, but it is unclear if connectivity between these networks may aid in lateralization.

خرید پکیج و مشاهده آنلاین مقاله

Optimal targeting of the anterior nucleus of the thalamus for epilepsy: a meta-analysis

Adeel Ilyas, MD,1–3 Kathryn M. Snyder, BE, 2,3 Tessy M. Thomas, PhD, 2,3 and Nitin Tandon, MD

doi : 10.3171/2022.2.JNS212550

Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) has been shown to be an effective therapeutic option for select patients with limbic epilepsy. However, the optimal target and electrode position for this indication remains undefined. Therefore, the objective of this systematic review and meta-analysis is to quantify the association between active contact location and outcomes across all published series of ANT DBS.

خرید پکیج و مشاهده آنلاین مقاله

Centromedian thalamic deep brain stimulation for drug-resistant epilepsy: single-center experience

*Jimmy C. Yang, MD,Katie L. Bullinger, MD, PhD,Faical Isbaine, PhD,Abdulrahman Alwaki, MD,Enrico Opri, PhD,Jon T. Willie, MD, PhD,and Robert E. Gross, MD, PhD

doi : 10.3171/2022.2.JNS212237

Neuromodulation of the centromedian nucleus of the thalamus (CM) has unclear effectiveness in the treatment of drug-resistant epilepsy. Prior reports suggest that it may be more effective in the generalized epilepsies such as Lennox-Gastaut syndrome (LGS). The objective of this study was to determine the outcome of CM deep brain stimulation (DBS) at the authors’ institution.

خرید پکیج و مشاهده آنلاین مقاله

Apparent diffusion coefficient of piriform cortex and seizure outcome in mesial temporal lobe epilepsy after MR-guided laser interstitial thermal therapy: a single-institution experience

Min Jae Kim,Brian Y. Hwang, MD,David Mampre, MD,Serban Negoita, BS,Yohannes Tsehay, BA,Haris I. Sair, MD,Joon Y. Kang, MD,and William S. Anderson, PhD, MD

doi : 10.3171/2022.3.JNS212490

Piriform cortex (PC) is one of the critical structures in the epileptogenesis of mesial temporal lobe epilepsy (mTLE), but its role is poorly understood. The authors examined the utility of apparent diffusion coefficient (ADC; an MR-based marker of tissue pathology) of the PC as a predictor of seizure outcome in patients with mTLE undergoing MR-guided laser interstitial thermal therapy (MRgLITT).

خرید پکیج و مشاهده آنلاین مقاله

Intraoperative localization and preservation of reading in ventral occipitotemporal cortex

Oscar Woolnough, PhD,Kathryn M. Snyder, BE,Cale W. Morse, BS,Meredith J. McCarty, BSA,Samden D. Lhatoo, MD,and Nitin Tandon, MD

doi : 10.3171/2022.2.JNS22170

Resective surgery in language-dominant ventral occipitotemporal cortex (vOTC) carries the risk of causing impairment to reading. Because it is not on the lateral surface, it is not easily accessible for intraoperative mapping, and extensive stimulation mapping can be time-consuming. Here the authors assess the feasibility of using task-based electrocorticography (ECoG) recordings intraoperatively to help guide stimulation mapping of reading in vOTC.

خرید پکیج و مشاهده آنلاین مقاله

Early repeat resection for residual glioblastoma: decision-making among an international cohort of neurosurgeons

*Anya A. Kim, BS,Antonio Dono, MD,Adham M. Khalafallah, MD,Barbara Nettel-Rueda, MD,George Samandouras, MD,Constantinos G. Hadjipanayis, MD, PhD,Debraj Mukherjee, MD, MPH,and Yoshua Esquenazi, MD

doi : 10.3171/2022.1.JNS211970

The importance of extent of resection (EOR) in glioblastoma (GBM) has been thoroughly demonstrated. However, few studies have explored the practices and benefits of early repeat resection (ERR) when residual tumor deemed resectable is unintentionally left after an initial resection, and the survival benefit of ERR is still unknown. Herein, the authors aimed to internationally survey current practices regarding ERR and to analyze differences based on geographic location and practice setting.

خرید پکیج و مشاهده آنلاین مقاله

Adult diffuse intrinsic pontine glioma: clinical, radiological, pathological, molecular features, and treatments of 96 patients

Yi Wang, MD,Changcun Pan, MD, PhD,Mingguo Xie, MD,Pengcheng Zuo, MD,Xiaoou Li, MD,Guocan Gu, MD,Tian Li, MM,Zhuang Jiang, MM,Zhen Wu, MD, PhD,Junting Zhang, MD,andLiwei Zhang, MD, PhD

doi : 10.3171/2022.2.JNS211920

Unlike its pediatric counterpart, adult diffuse intrinsic pontine glioma (DIPG) remains largely unelucidated. In this study, the authors examined the clinical, radiological, pathological, molecular, and clinical aspects of 96 adult DIPGs.

خرید پکیج و مشاهده آنلاین مقاله

Natural history of meningiomas: a serial volumetric analysis of 240 tumors

*Pascal Thomann, MD,Levin Häni, MD,Sonja Vulcu, MD,Alessa Schütz, MD,Maximilian Frosch, MD,Christopher Marvin Jesse, MD,Marwan El-Koussy, MD,Nicole Söll,Arsany Hakim, MD,Andreas Raabe, MD,and Philippe Schucht, MD

doi : 10.3171/2022.3.JNS212626

The management of asymptomatic intracranial meningiomas is controversial. Through the assessment of growth predictors, the authors aimed to create the basis for practicable clinical pathways for the management of these tumors.

خرید پکیج و مشاهده آنلاین مقاله

Endoscope-assisted visualization of 5-aminolevulinic acid fluorescence in surgery for brain metastases

*Christoph Bettag, MD,Abdelhalim Hussein, MD,Bawarjan Schatlo, MD,Alonso Barrantes-Freer, MD, PhD,Tammam Abboud, MD,Veit Rohde, MD,andDorothee Mielke, MD

doi : 10.3171/2022.3.JNS212301

Fluorescence-guided resection of cerebral metastases has been proposed as an approach to visualize residual tumor tissue and maximize the extent of resection. Critics have argued that tumor cells at the resection margins might be overlooked under microscopic visualization because of technical limitations. Therefore, an endoscope, which is capable of inducing fluorescence, has been applied with the aim of improving exposure of fluorescent tumor tissue. In this retrospective analysis, authors assessed the utility of endoscope assistance in 5-aminolevulinic acid (5-ALA) fluorescence–guided resection of brain metastases.

خرید پکیج و مشاهده آنلاین مقاله

Regrowth factors of WHO grade I skull base meningiomas following incomplete resection

Hun Ho Park, MD, PhD,Jihwan Yoo, MD,Hyeong-Cheol Oh, MD,Yoon Jin Cha, MD, PhD,Se Hoon Kim, MD, PhD,Chang-Ki Hong, MD, PhD,and Kyu-Sung Lee, MD, PhD

doi : 10.3171/2022.3.JNS2299

The role of adjuvant radiation therapy following incomplete resection of WHO grade I skull base meningiomas (SBMs) is controversial, and little is known regarding the behavior of residual tumors. The authors investigated the factors that influence regrowth of residual WHO grade I SBMs following incomplete resection.

خرید پکیج و مشاهده آنلاین مقاله

How to dose-stage large or high-risk brain metastases: an alternative two-fraction radiosurgical treatment approach

Anna Cho, MD,1 Kira Medvedeva, MD, 2 Beate Kranawetter, MD,1 Helena Untersteiner, MD,1 Dorian Hirschmann, MD,1 Olga Lepilina, 2 Anatoly Baulin, 2 Martin Buschmann, PhD,1,3 Adolf Ertl, PhD,1 Wolfgang Marik, MD, 4 Christian Dorfer, MD,1 Karl Rössler, MD,1 Brigitte Gatterbauer, MD,1 Sergey Ilyalov, MD, PhD, 2 and Josa M. Frischer, MD, PhD1

doi : 10.3171/2022.2.JNS212440

The authors sought to evaluate clinical outcome in patients with large, high-risk brain metastases (BMs) treated with different dose strategies by use of two-fraction dose-staged Gamma Knife radiosurgery (GKRS).

خرید پکیج و مشاهده آنلاین مقاله

Single low-dose targeted bevacizumab infusion in adult patients with steroid-refractory radiation necrosis of the brain: a phase II open-label prospective clinical trial

Shervin R. Dashti, MD, PhD,Robert J. Kadner, MD,Bradley S. Folley, PhD,Jason P. Sheehan, MD, PhD,Dong Y. Han, PsyD,Richard J. Kryscio, PhD,Mary B. Carter, MD, PhD,Lisa B. E. Shields, MD,Brian M. Plato, DO,Renato V. La Rocca, MD,Aaron C. Spalding, MD, PhD,14Tom L. Yao, MD,Justin F. Fraser, MD

doi : 10.3171/2022.2.JNS212006

There is an unmet need for safe and rapidly effective therapies for refractory brain radiation necrosis (RN). The aim of this prospective single-arm phase II trial was to evaluate the safety and efficacy of a single low-dose targeted bevacizumab infusion after blood-brain barrier disruption (BBBD) in adult patients with steroid-refractory brain RN.

خرید پکیج و مشاهده آنلاین مقاله

Pituitary adenoma in the elderly: surgical outcomes and treatment trends in the United States

Eric J. Chalif, BA, Ramin A. Morshed, MD, Jacob S. Young, MD, Alexander F. Haddad, MD,Saket Jain, PhD, and Manish K. Aghi, MD, PhD

doi : 10.3171/2022.3.JNS212940

Decision-making in how to manage pituitary adenomas (PAs) in the elderly (age ≥ 65 years) can be challenging given the benign nature of these tumors and concerns about surgical morbidity in these patients. In this study involving a large multicenter national registry, the authors examined treatment trends and surgical outcomes in elderly compared to nonelderly patients.

خرید پکیج و مشاهده آنلاین مقاله

Association between socioeconomic status and presenting characteristics and extent of disease in patients with surgically resected nonfunctioning pituitary adenoma

David J. Cote, MD, PhD,Jacob J. Ruzevick, MD,Keiko M. Kang, MD,Dhiraj J. Pangal, BS,Ilaria Bove, MD,John D. Carmichael, MD,Mark S. Shiroishi, MD, MS,Ben A. Strickland, MD,and Gabriel Zada, MD, MS

doi : 10.3171/2022.2.JNS212673

The aim of this study was to evaluate the association between zip code–level socioeconomic status (SES) and presenting characteristics and short-term clinical outcomes in patients with nonfunctioning pituitary adenoma (NFPA).

خرید پکیج و مشاهده آنلاین مقاله

Effects of clazosentan on cerebral vasospasm–related morbidity and all-cause mortality after aneurysmal subarachnoid hemorrhage: two randomized phase 3 trials in Japanese patients

Hidenori Endo, MD,Yasushi Hagihara, MD,Naoto Kimura, MD,Katsumi Takizawa, MD,Kuniyasu Niizuma, MD,Osamu Togo, MSc,and Teiji Tominaga, MD

doi : 10.3171/2022.2.JNS212914

Clazosentan has been investigated globally for the prevention of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). The authors evaluated its effects on vasospasm-related morbidity and all-cause mortality following aSAH in Japanese patients.

خرید پکیج و مشاهده آنلاین مقاله

Radiological and clinical features of twig-like middle cerebral artery in comparison with moyamoya angiopathy: a multicenter retrospective study

Yudai Goto, MD,Masataka Nanto, MD,Hideki Oka, MD,Nobukuni Murakami, MD, PhD,Toru Nakagawa, MD, PhD,Satoshi Kimura, MD, PhD,Yoshihiro Iwamoto, MD, PhD,Yasuo Inoue, MD, PhD,Keigo Matsumoto, MD, PhD,Junichi Miyamoto, MD, PhD,andNaoya Hashimoto, MD, PhD

doi : 10.3171/2022.2.JNS212338

Twig-like middle cerebral artery (T-MCA) is a rare congenital anomaly that is difficult to distinguish from moyamoya angiopathy (MMA), given the similarity of the angioarchitectures. The aim of this study was to gain insights into the radiological and clinical features of T-MCA and to distinguish this condition from MMA.

خرید پکیج و مشاهده آنلاین مقاله

Morphological characteristics of symptomatic and asymptomatic carotid webs

Borna Ethan Tabibian, MD, Matthew Parr, MD, Arsalaan Salehani, MD, Anil Mahavadi, MD,Sage Rahm, MD, Manmeet Kaur, MD, Sasha Howell, MD, Jesse G. Jones, MD,Elizabeth Liptrap, MD, and Mark R. Harrigan, MD

doi : 10.3171/2022.2.JNS212310

Carotid webs (CWs) are an increasingly recognized source of recurrent stroke among young patients without conventional vascular risk factors. There have been no previous studies demonstrating that specific web morphological characteristics correlate with a higher stroke risk. The authors aim to report distinct morphological features of symptomatic and asymptomatic CWs.

خرید پکیج و مشاهده آنلاین مقاله

Giant cerebral cavernous malformations: redefinition based on surgical outcomes and systematic review of the literature

*Visish M. Srinivasan, MD, Katherine Karahalios, MS, Kavelin Rumalla, MD,Nathan A. Shlobin, BA, Redi Rahmani, MD, Lea Scherschinski, MD, Dimitri Benner, BS,Joshua S. Catapano, MD, Mohamed A. Labib, MD, CM, Christopher S. Graffeo, MD, MS, andMichael T. Lawton, MD

doi : 10.3171/2022.2.JNS22166

Giant cerebral cavernous malformations (GCCMs) are rare vascular malformations. Unlike for tumors and aneurysms, there is no clear definition of a "giant" cavernous malformation (CM). As a result of variable definitions, working descriptions and outcome data of patients with GCCM are unclear. A new definition of GCCM related to surgical outcomes is needed.

خرید پکیج و مشاهده آنلاین مقاله

Longitudinal neuropsychological assessment after aneurysmal subarachnoid hemorrhage and its relationship with delayed cerebral ischemia: a prospective Swiss multicenter study

Martin N. Stienen, MD, FEBNS,1,2,13 Menno R. Germans, MD, PhD,1,2 Olivia Zindel-Geisseler, PhD, 3 Noemi Dannecker, MSc, 3 Yannick Rothacher, PhD, 3 Ladina Schlosser, MSc, 3 Julia Velz, MD,1,2 Martina Sebök, MD,1,2 Noemi Eggenberger, MSc, 3 Adrien May, MD, 4 Julien Haemmerli, MD, 4 Philippe Bijlenga, MD, PhD, 4 Karl Schaller, MD, 4 Ursula Guerra-Lopez, PsyD, 5 Rodolfo Maduri, MD,6 Valérie Beaud, MSc,7 Khalid Al-Taha, MD, 8 Roy Thomas Daniel, MD, 8 Alessio Chiappini, MD, 9 Stefania Rossi, PsyD,10 Thomas Robert, MD, 9 Sara Bonasia, MD, 9 Johannes Goldberg, MD,11 Christian Fung, MD,11,12 David Bervini, MD,11 Marie Elise Maradan-Gachet, MSc,13 Klemens Gutbrod, PhD,13 Nicolai Maldaner, MD,14 Marian C. Neidert, MD,14 Severin Früh, MSc,15 Marc Schwind, PhD,15 Oliver Bozinov, MD,1,2,14 Peter Brugger, PhD, 3,16 Emanuela Keller, MD,1,2 Angelina Marr, BSc,17 Sébastien Roux, MD,17 and Luca Regli, MD,1,2 on behalf of the MoCA-DCI Study Group

doi : 10.3171/2022.2.JNS212595

While prior retrospective studies have suggested that delayed cerebral ischemia (DCI) is a predictor of neuropsychological deficits after aneurysmal subarachnoid hemorrhage (aSAH), all studies to date have shown a high risk of bias. This study was designed to determine the impact of DCI on the longitudinal neuropsychological outcome after aSAH, and importantly, it includes a baseline examination after aSAH but before DCI onset to reduce the risk of bias.

خرید پکیج و مشاهده آنلاین مقاله

Evolution of the patient-first approach: a dual-trained, single-neurosurgeon experience with 2002 consecutive intracranial aneurysm treatments

Muhammad Waqas, MBBS,Andre Monteiro, MD,Justin M. Cappuzzo, MD,Vincent M. Tutino, PhD,and Elad I. Levy, MD, MBA

doi : 10.3171/2022.2.JNS22105

The paradigm for intracranial aneurysm (IA) treatment is shifting toward a hybrid approach involving open and endovascular techniques. The authors chronicled the evolution of IA treatment by retrospectively examining a large series of IA cases treated by a single dual-trained neurosurgeon, focusing on evolving technology relative to the choice of treatment options, perioperative morbidity, and mortality.

خرید پکیج و مشاهده آنلاین مقاله

Endovascular treatment of anterior cranial base dural arteriovenous fistulas as a first-line approach: a multicenter study

Felipe P. Trivelato, MD, PhD,Stanislas Smajda, MD,Suzana Saleme, MD,Luís Henrique de Castro-Afonso, MD, PhD,Thiago G. Abud, MD, PhD,Alexandre C. Ulhôa, MD,Raphael Blanc, MD, MSc,Daniel G. Abud, MD, PhD,Charbel Mounayer, MD, PhD,Michel Piotin, MD, PhD,and Marco Túlio S. Rezende, MD, PhD

doi : 10.3171/2022.2.JNS212588

Anterior cranial fossa dural arteriovenous fistulas (DAVFs) have been almost exclusively considered as surgical lesions. However, new advances in endovascular technology have made the endovascular treatment (EVT) of ethmoidal DAVFs feasible. The aim of this study was to report the clinical and angiographic outcomes of patients harboring DAVFs of the anterior cranial fossa who had undergone EVT as a first-line approach.

خرید پکیج و مشاهده آنلاین مقاله

Early surgical versus endovascular repair of ruptured blood-blister aneurysm of the internal carotid artery: a single-center 20-year experience

Per K. Eide, MD, PhD,Angelika Sorteberg, MD, PhD,Terje Nome, MD,Pål A. Rønning, MD, PhD,and Wilhelm Sorteberg, MD, PhD

doi : 10.3171/2022.3.JNS2216

Early repair of ruptured blood-blister aneurysms (BBAs) of the internal carotid artery (ICA) remains challenging. Although both surgical and endovascular therapies have been established, their relative superiority remains debated. The authors assessed their single-center experience and compared early deconstructive versus reconstructive repair and early reconstructive surgical versus endovascular repair of ruptured BBAs of the ICA.

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Ischemic complications in the neurosurgical and endovascular treatments of craniocervical junction arteriovenous fistulas: a multicenter study

Keisuke Takai, MD, PhD,Toshiki Endo, MD, PhD,Toshitaka Seki, MD, PhD,Tomoo Inoue, MD, PhD,Izumi Koyanagi, MD, PhD,Takafumi Mitsuhara, MD, PhD,and the Neurospinal Society of Japan CCJ AVF Study Investigators

doi : 10.3171/2022.3.JNS22341

A recent comparative analysis between neurosurgical and endovascular treatments for craniocervical junction (CCJ) arteriovenous fistulas (AVFs) revealed better treatment outcomes in the neurosurgery group than in the endovascular group. This finding was attributed to the higher than expected rate of ischemic complications in the endovascular group than in the neurosurgery group (26% vs 7.7%, p = 0.037). The aim of the present study was to describe ischemic complications associated with treatments for CCJ AVFs.

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Woven EndoBridge versus stent-assisted coil embolization of cerebral bifurcation aneurysms

Kareem El Naamani, MD,Ching-Jen Chen, MD,Rawad Abbas, MD,Ahmad Sweid, MD,Georgios S. Sioutas, MD,Khodr Badih, BSc,Sunidhi Ramesh, BS,Stavropoula I. Tjoumakaris, MD,M. Reid Gooch, MD,Nabeel A. Herial, MD, MPH,Hekmat Zarzour, MD,Richard F. Schmidt, MD,Robert H. Rosenwasser, MD, MBA,and Pascal M. Jabbour, MD

doi : 10.3171/2022.3.JNS2217

Stent-assisted coil (SAC) embolization has been the mainstay endovascular treatment for bifurcation aneurysms. The recent introduction of the Woven EndoBridge (WEB) device has presented an alternative endovascular treatment modality for these aneurysms. Direct comparisons of outcomes between these two modalities are limited in the literature. Here, the authors compared the outcomes of bifurcation aneurysms treated with SAC and WEB devices.

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Immediate flow-diversion characteristics of a novel primarily bioresorbable flow-diverting stent

Sandeep Muram, MD,Ronan Corcoran, BEng,Jillian Cooke, PEng,Kendall Forrester, BHSc, AAS,Elana Lapins, BS,Rosalie Morrish,Osama Zahoor Ahmad Cheema, BSc,Mayank Goyal, MD, PhD,Muneer Eesa, MD,David Fiorella, MD, PhD,John H. Wong, MD, MSc, MBA,Chander Sadasivan, PhD,andAlim P. Mitha, MD, SM

doi : 10.3171/2022.1.JNS212975

Flow-diverting stents with a resorbable component have significant theoretical benefits over full metal stents, although currently there are none in clinical use. In this study, the authors sought to determine the immediate flow-diversion characteristics of a novel primarily bioresorbable flow-diverting stent.

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Impact of collateral flow on cost-effectiveness of endovascular thrombectomy

Mihir Khunte, BS,Xiao Wu, MD,Emily W. Avery, BS,Dheeraj Gandhi, MD,Seyedmehdi Payabvash, MD,Charles Matouk, MD,Jeremy J. Heit, MD, PhD,Max Wintermark, MD,Gregory W. Albers, MD,Pina Sanelli, MD,and Ajay Malhotra, MD

doi : 10.3171/2022.2.JNS212887

Acute ischemic stroke patients with large-vessel occlusion and good collateral blood flow have significantly better outcomes than patients with poor collateral circulation. The purpose of this study was to evaluate the cost-effectiveness of endovascular thrombectomy (EVT) based on collateral status and, in particular, to analyze its effectiveness in ischemic stroke patients with poor collaterals.

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Sweet spots of standard and directional leads in patients with refractory essential tremor: white matter pathways associated with maximal tremor improvement

Josue M. Avecillas-Chasin, MD, PhD,Christopher R. Honey, MD, DPhil,Manraj K. S. Heran, MD,and Marie T. Krüger, MD

doi : 10.3171/2022.3.JNS212374

In patients with essential tremor (ET) treated with standard deep brain stimulation (sDBS) whose ET had progressed and who no longer received optimal benefit from sDBS, directional deep brain stimulation (dDBS) may provide better tremor control. Current steering may provide better coverage of subcortical structures related to tremor control in patients with ET and significant progression without optimal response to sDBS.

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Idiopathic Parkinson’s disease and chronic pain in the era of deep brain stimulation: a systematic review and meta-analysis

*Oliver Flouty, MD,Kazuaki Yamamoto, MD,Jurgen Germann, PhD,Irene E. Harmsen, PhD,Hyun Ho Jung, MD, PhD,Cletus Cheyuo, MD, PhD,Ajmal Zemmar, MD, PhD,Vanessa Milano, MD,Can Sarica, MD,and Andres M. Lozano, MD, PhD

doi : 10.3171/2022.2.JNS212561

Pain is the most common nonmotor symptom of Parkinson’s disease (PD) and is often undertreated. Deep brain stimulation (DBS) effectively mitigates the motor symptoms of this multisystem neurodegenerative disease; however, its therapeutic effect on nonmotor symptoms, especially pain, remains inconclusive. While there is a critical need to help this large PD patient population, guidelines for managing this significant disease burden are absent. Herein, the authors systematically reviewed the literature and conducted a meta-analysis to study the influence of traditional (subthalamic nucleus [STN] and globus pallidus internus [GPi]) DBS on chronic pain in patients with PD.

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Decompressive hemicraniectomy and cranioplasty using subcutaneously preserved autologous bone flaps versus synthetic implants: perioperative outcomes and cost analysis

*Ehsan Dowlati, MD,Kory B. Dylan Pasko, BS,Esteban A. Molina, MS,Daniel R. Felbaum, MD,R. Bryan Mason, MD,Jeffrey C. Mai, MD, PhD,M. Nathan Nair, MD, MBA, MPH,Edward F. Aulisi, MD,and Rocco A. Armonda, MD

doi : 10.3171/2022.3.JNS212637

It has not been well-elucidated whether there are advantages to preserving bone flaps in abdominal subcutaneous (SQ) tissue after decompressive hemicraniectomy (DHC), compared to discarding bone flaps. The authors aimed to compare perioperative outcomes and costs for patients undergoing autologous cranioplasty (AC) after DHC with the bone flap preserved in abdominal SQ tissue, and for patients undergoing synthetic cranioplasty (SC).

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An independent, external validation and component analysis of the Surviving Penetrating Injury to the Brain score for civilian cranial gunshot injuries

Mark D. Johnson, MD,Uwe Stolz, PhD, MPH,Christopher P. Carroll, MD,George L. Yang, MD,Norberto Andaluz, MD,Brandon Foreman, MD, MS,Natalie Kreitzer, MD,Michael D. Goodman, MD,and Laura B. Ngwenya, MD, PhD

doi : 10.3171/2022.2.JNS212256

The Surviving Penetrating Injury to the Brain (SPIN) score utilizes clinical variables to estimate in-hospital and 6-month mortality for patients with civilian cranial gunshot wounds (cGSWs) and demonstrated good discrimination (area under the receiver operating characteristic curve [AUC] 0.880) in an initial validation study. The goal of this study was to provide an external, independent validation of the SPIN score for in-hospital and 6-month mortality.

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Utility of intraoperative neuromonitoring for decompression of Chiari type I malformation in 93 adult patients

Joseph Schaefer, BS, Elias Atallah, MD, Eric Tecce, BS, Sara Thalheimer, BA,James Harrop, MD, and Joshua E. Heller, MD, MBA

doi : 10.3171/2022.3.JNS22127

There is currently a lack of consensus on the utility of intraoperative neuromonitoring (IONM) for decompression of Chiari type I malformation (CM-I). Commonly used monitoring modalities include somatosensory evoked potentials (SSEPs), motor evoked potentials (MEPs), and brainstem auditory evoked potentials (BAEPs). The purpose of this study was to evaluate the utility of IONM in preventing neurological injury for CM-I decompression.

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Impact of intraoperative direct cortical stimulation dynamics on perioperative seizures and afterdischarge frequency in patients undergoing awake craniotomy

Collin J. Larkin, MSc,Ketan Yerneni, BA,Constantine L. Karras, MD,Zachary A. Abecassis, MD,Guangyu Zhou, PhD,Christina Zelano, PhD,Ashley N. Selner, MD, PhD,Jessica W. Templer, MD,and Matthew C. Tate, MD, PhD

doi : 10.3171/2022.3.JNS226

Intraoperative stimulation is used as a crucial adjunct in neurosurgical oncology, allowing for greater extent of resection while minimizing morbidity. However, limited data exist regarding the impact of cortical stimulation on the frequency of perioperative seizures in these patients.

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Obituary. Robert G. Grossman, MD, 1933–2021

Gavin W. Britz  MD and David S. Baskin  MD

doi : 10.3171/2022.7.JNS22821

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The path to neurosurgery: identifying obstacles to pursuing a medical career unique to rural high school students when compared with urban and suburban students

Joshua C. Hunsaker  BS , Laura Herring  BS , Sarah Franklin  PhD , Kylie B. Christensen  MPH , Benjamin Chan  MD, MBA, MEd , and Randy L. Jensen  MD, PhD, MHPE

doi : 10.3171/2022.5.JNS22954

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Letter to the Editor. Global trends of female representation in neurosurgery

Bhavya Pahwa and Mohamed A. Zaazoue  MD, MSc

doi : 10.3171/2022.6.JNS221388

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Letter to the Editor. Global trends of female representation in neurosurgery

Andrew Nguyen  BS , Ryan S. Beyer  BS , and Nolan J. Brown  BS

doi : 10.3171/2022.6.JNS221388

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Letter to the Editor. Twig-like middle cerebral artery and moyamoya disease

Takahiro Ota  MD, PhD

doi : 10.3171/2022.5.JNS22983

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