دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Ovarian Signet-ring Stromal Tumor: A Morphologic, Immunohistochemical, and Molecular Study of 7 Cases With Discussion of the Differential Diagnosis.
Tchrakian, Nairi FRCPath *; Oliva, Esther MD +,++; Chong, Anne-Sophie MSc [S]; Rivera-Polo, Barbara PhD [S],[//],[P]; Bennett, Jennifer A. MD #; Nucci, Marisa R. MD **; Sah, Shatrughan FRCPath ++; Schoolmeester, J. Kenneth MD ++++; van der Griend, Rachael A. FRCPA [S][S]; Foulkes, William D. MBBS, PhD [S]; Clarke, Blaise A. MBBCh, FRCPC *; Young, Robert H. MD, FRCPath +,++; McCluggage, W. Glenn FRCPath [//][//]
doi : 10.1097/PAS.0000000000001954
Volume 46(12) pgs. 1599-1739 December 2022
AB Signet-ring stromal tumor (SRST) is a rare ovarian stromal neoplasm characterized by a population of bland signet-ring cells, devoid of mucin or lipid, in a generally cellular fibromatous stroma. Previous reports have described heterogenous immunohistochemical and molecular genetic findings, including occasional nuclear [beta]-catenin expression and/or CTNNB1 mutations. We report 10 ovarian stromal neoplasms originally diagnosed as SRST.
Molecular Analysis of HPV-independent Primary Endometrial Squamous Cell Carcinoma Reveals TP53 and CDKN2A Comutations: A Clinicopathologic Analysis With Re-evaluation of Diagnostic Criteria.
Hopkins, Mark R. MD *; Palsgrove, Doreen N. MD +; Ronnett, Brigitte M. MD *; Vang, Russell MD *; Lin, Jeffrey MD ++; Murdock, Tricia A. MD *
doi : 10.1097/PAS.0000000000001970
AB Human papillomavirus (HPV)-independent primary endometrial squamous cell carcinoma (PESCC) is a rare but aggressive subtype of endometrial carcinoma for which little is known about the genomic characteristics.
Plasmacytoid Dendritic Cell Dermatosis Associated to Myeloproliferative/Myelodysplastic Neoplasms.
Machan, Salma MD, PhD *; Alonso-Dominguez, Juan M. MD, PhD +; Sanchez Garcia, F. Javier MD ++; Nieves Salgado, Rocio MD, PhD +; Soto, Carlos MD +; Castro, Yolanda MD [S]; Pajares, Raquel Tech [S]; Manso, Rebeca PhD [S]; Santonja, Carlos MD, PhD [S]; Serrano del Castillo, Cristina MD, PhD +; Piris, Miguel A. MD, PhD ++; Requena, Luis MD, PhD *; Rodriguez Pinilla, Socorro M. MD, PhD ++
doi : 10.1097/PAS.0000000000001960
AB Cutaneous lesions in the setting of myeloproliferative neoplasms and myelodysplastic syndromes are poorly understood. We report 6 patients with pruritic papular eruptions composed of mature T-lymphocytes with large clusters of CD123-positive cells.
The IASLC Proposed Grading System Accurately Predicts Prognosis and Mediastinal Nodal Metastasis in Patients With Clinical Stage I Lung Adenocarcinoma.
Xu, Long MD *; Su, Hang MD *; Hou, Likun MD +; Wang, Fang MD *; Xie, Huikang MD +; She, Yunlang MD *; Gao, Jiani MD *; Zhao, Shengnan MD +; Dai, Chenyang MD, PhD *; Xie, Dong MD, PhD *; Zhu, Yuming MD *; Wu, Chunyan MD +; Zhao, Deping MD *; Chen, Chang MD, PhD *,++,[S]; and on behalf of the Surgical Thoracic Alliance of Rising Star Group
doi : 10.1097/PAS.0000000000001876
AB The International Association for the Study of Lung Cancer (IASLC) recently proposed a new grading system for lung adenocarcinoma (LUAD). We aimed to validate the prognostic performance of the grading system and explore its role in guiding the strategy of lymph node (LN) dissection.
Clonal-pattern Seborrheic Keratosis: Risk of Recurrence and Progression to Carcinoma.
Goldsmith, Joshua F. DO; Montaser Kouhsari, Laleh MD; Tahan, Steven R. MD
doi : 10.1097/PAS.0000000000001973
AB Seborrheic keratosis is a benign epidermal tumor. Seborrheic keratosis with clonal pattern (CPSK) displays histologic features distinct from other subtypes of SK (non-CPSK). We sought to quantitatively assess the risk of recurrence and progression to squamous cell carcinoma (SCC), either in situ or invasive, of incompletely excised CPSKs.
Prostate Cancer in Male-to-Female Transgender Individuals: Histopathologic Findings and Association With Gender-affirming Hormonal Therapy.
Baraban, Ezra MD *; Ding, Chien-Kuang C. MD, PhD +; White, Marissa MD *; Vohra, Poonam MD +; Simko, Jeffry MD, PhD +; Boyle, Karen MD ++; Guo, Charles MD [S]; Zhang, Miao MD, PhD [S]; Dobs, Adrian MD [//]; Ketheeswaran, Suvethavarshini MD [P]; Liang, Fan MD [P]; Epstein, Jonathan I. MD *,#,**
doi : 10.1097/PAS.0000000000001964
AB Male-to-female (MtF) transgender individuals are at risk for prostate cancer, although guidelines for screening and management in this population are not well established. We describe a series of 9 MtF transgender patients who underwent prostate tissue sampling and highlight histopathologic features and challenges related to pathologic interpretation of prostate tissue in this patient population.
Clinicopathologic and Prognostic Features of Pediatric Follicular Cell-derived Thyroid Carcinomas: A Retrospective Study of 222 Patients.
Saliba, Maelle MD *; Alzumaili, Bayan A. MD +; Katabi, Nora MD *; Dogan, Snjezana MD *; Tuttle, Robert M. MD ++; Zoltan, Antal MD ++; Pandit-Taskar, Neeta MD [S]; Xu, Bin MD, PhD *; Ghossein, Ronald A. MD *
doi : 10.1097/PAS.0000000000001958
AB Pediatric thyroid carcinomas (TCs) are rare and mainly approached based on data extrapolated from adults. We retrospectively reviewed 222 pediatric TCs (patient age less than or equal to 21 y).
Morphologic and Molecular Heterogeneity of Cervical Neuroendocrine Neoplasia: A Report of 14 Cases.
Ordulu, Zehra MD *; Mino-Kenudson, Mari MD *; Young, Robert H. MD, FRCPath *; Van de Vijver, Koen MD, PhD +,++; Zannoni, Gian Franco MD [S]; Felix, Ana MD, PhD [//]; Burandt, Eike MD [P]; Wong, Adele MB, BCh, BAO #; Nardi, Valentina MD *; Oliva, Esther MD *
doi : 10.1097/PAS.0000000000001943
AB Neuroendocrine neoplasms (NENs) of the cervix are rare aggressive tumors associated with poor prognosis and only limited treatment options.
The Clinical Significance of Either Extraprostatic Extension or Microscopic Bladder Neck Invasion Alone Versus Both in Men With pT3a Prostate Cancer Undergoing Radical Prostatectomy: A Proposal for a New pT3a Subclassification.
Teramoto, Yuki MD *,+; Numbere, Numbereye MD *; Wang, Ying MD, PhD *; Miyamoto, Hiroshi MD, PhD *,+,++
doi : 10.1097/PAS.0000000000001939
AB The prognosis of prostate cancers exhibiting extraprostatic extension [other than bladder or seminal vesicle invasion (EPE)] and/or microscopic bladder neck invasion (mBNI) is variable, and further risk stratification is required.
PSMA Immunohistochemistry in Hepatic Neoplasms: A Promising Diagnostic Marker With Potential Theranostic Applications.
Kmeid, Michel MD *; Park, Young Nyun MD, PhD +; Chung, Taek MD ++; Lukose, Georgi MD [S]; Sullivan, Luz MD *; Brar, Rupinder MD *; Lee, Hwajeong MD *
doi : 10.1097/PAS.0000000000001971
AB Accurate classification of well-differentiated hepatocellular neoplasms can be challenging especially in core biopsies. Prostate-specific membrane antigen (PSMA) has been shown to highlight tumor-associated neovasculature in many nonprostatic solid tumors including hepatocellular carcinoma (HCC).
Pleomorphic Liposarcoma: A Series of 120 Cases With Emphasis on Morphologic Variants.
Gjorgova Gjeorgjievski, Sandra MD *; Thway, Khin MD +; Dermawan, Josephine K. MD, PhD *; John, Ivy MD ++; Fisher, Cyril MD [S]; Rubin, Brian P. MD, PhD *; Jenkins, Sarah MS [//]; Thangaiah, Judith J. MD [P]; Folpe, Andrew L. MD [P]; Fritchie, Karen J. MD *
doi : 10.1097/PAS.0000000000001962
AB Pleomorphic liposarcoma (PLPS) is a highly aggressive sarcoma comprising variable numbers of pleomorphic lipoblasts mixed with undifferentiated pleomorphic sarcoma (UPS)-like areas.
NUTM1-rearranged Carcinoma of the Thyroid: A Distinct Subset of NUT Carcinoma Characterized by Frequent NSD3-NUTM1 Fusions.
Barletta, Justine A. MD *; Gilday, Steven D. MD, PhD *; Afkhami, Michelle MD +; Bell, Diana MD +; Bocklage, Theresa MD ++; Boisselier, Pierre MD [S]; Chau, Nicole G. MD [//]; Cipriani, Nicole A. MD [P]; Costes-Martineau, Valerie MD #; Ghossein, Ronald A. MD **; Hertzler, Hans J. *; Kramer, Alan M. MD ++; Limaye, Sewanti MBBS, MD, MS ++++; Lopez, Carlos A. MD, MPH [S][S]; Ng, Tony L. MD, PhD [//][//]; Weissferdt, Annikka MD [P][P]; Xu, Bin MD, PhD **; Zhang, Songlin MD, PhD ##; French, Christopher A. MD *
doi : 10.1097/PAS.0000000000001967
AB NUT carcinoma (NC) is a rare subtype of squamous cell carcinoma defined by NUTM1 rearrangements encoding NUT fusion oncoproteins (the most frequent fusion partner being BRD4) that carries a very poor prognosis, with most patients dying in under 1 year.
Sinonasal Bacteroma/Bacteria-related Concretions: A Distinct Pathologic Entity of the Sinonasal Tract.
Holliday, Dean Jr MD *; Mehrad, Mitra MD *; Ely, Kim A. MD *; Lewis, James S. Jr MD *,+
doi : 10.1097/PAS.0000000000001969
AB Patients can be seen where "fungal debris," "mycetoma," or "mass-like obstruction" of the sinonasal tract is suspected clinically but lack fungus and instead have granular, eosinophilic debris and bacterial colonies.
Desmoplastic Adamantinoma-like Thymic Carcinoma: Clinicopathologic, Immunohistochemical, and Molecular Study of 5 Cases.
Suster, David I. MD *; Mejbel, Haider MD +; Mackinnon, Alexander C. MD, PhD +; Suster, Saul MD ++
doi : 10.1097/PAS.0000000000001947
AB Five cases of a heretofore unreported rare variant of thymic carcinoma characterized by a striking resemblance to adamantinoma of the mandible are described. The tumors occurred in 4 women and 1 man aged 58 to 76 years (mean: 67.8 y); they arose in the anterior mediastinum and measured from 5.3 to 12.0 cm in greatest diameter (mean: 8.9 cm).
Angiosarcoma-like Kaposi Sarcoma: A Distinctive Histomorphologic Variant Representing an Important Diagnostic Pitfall.
Plaza, Jose A. MD *; Sangueza, Omar P. MD +; Giubellino, Alessio MD ++; Gru, Alejandro A. MD [S]; Kaffenberger, Benjamin MD *; Wakely, Paul E. Jr MD *; Sangueza, Martin J. MD [//]
doi : 10.1097/PAS.0000000000001946
AB Kaposi sarcoma (KS) is a rare low-grade angioproliferative neoplasm associated with human herpesvirus 8 (HHV-8) infection with multiple clinical subtypes and varying histopathologic patterns.
Response to Letter to the Editor: IRF8 is a Reliable Monoblast Marker for Acute Monocytic Leukemias but does not Discriminate Between Monoblasts and Plasmacytoid Dendritic Cells.
Xu, Mina L. MD; Katz, Samuel G. MD, PhD
