دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Thermoresponsive and Injectable Hydrogel for Tissue Agnostic Regeneration (Adv. Healthcare Mater. 23/2022)
Dax Calder, Ali Fathi, Farshad Oveissi, Simin Maleknia, Terence Abrams, Yiwei Wang, Joanneke Maitz, Kevin Hung-Yueh Tsai, Peter Maitz, Wojtek Chrzanowski, Ivan Canoy, Vivek Ashoka Menon, Kenneth Lee, Benjamin J. Ahern, Natasha E. Lean, Dina M. Silva, Paul M. Young, Daniela Traini, Hui Xin Ong, Rasoul Seyed Mahmoud, Hossein Montazerian, Ali Khademhosseini, Fariba Dehghani
doi : 10.1002/adhm.202270137
The coil structure represents the synthetic chemical composition of the featured biomaterial. The fluid network is temperature responsive and transitions into an adhesive hydrogel matrix upon administration.
3D-Printed Radiopaque Bioresorbable Stents to Improve Device Visualization (Adv. Healthcare Mater. 23/2022)
Yonghui Ding, Rao Fu, Caralyn Paige Collins, Sarah-Fatime Yoda, Cheng Sun, Guillermo A. Ameer
doi : 10.1002/adhm.202270138
In article 2201955, Cheng Sun, Guillermo A. Ameer, and co-workers report a method to confer X-ray contrast to 3D printed polymeric bioresorbable stents (BRS) through the incorporation of the clinically used contrast agent iodixanol into a citrate-based polymer ink. The 3D-printed BRS has strong X-ray visibility, mechanical competence, and excellent in vitro biocompatibility, characteristics that are important for successful clinical use.
High Throughput Omnidirectional Printing of Tubular Microstructures from Elastomeric Polymers (Adv. Healthcare Mater. 23/2022)
Chuan Liu, Scott B. Campbell, Jianzhao Li, Dawn Bannerman, Simon Pascual-Gil, Jennifer Kieda, Qinghua Wu, Peter R. Herman, Milica Radisic
doi : 10.1002/adhm.202270143
In article 2201346 by Milica Radisic and co-workers, scaffolds fabricated by coaxial printing of bioelastomers can mimic both the structures and mechanical properties of native tissues, which are ideal for organ-on-a-chip and tissue engineering applications. This image shows an artistic tubular structure made of a biodegradable elastomer called PICO.
NIR-Assisted MgO-Based Polydopamine Nanoparticles for Targeted Treatment of Parkinson's Disease through the Blood–Brain Barrier (Adv. Healthcare Mater. 23/2022)
Yifei Gao, Yuxue Cheng, Jiapeng Chen, Danmin Lin, Chao Liu, Ling-Kun Zhang, Liang Yin, Runcai Yang, Yan-Qing Guan
doi : 10.1002/adhm.202270144
In article 2201655, Yan-Qing Guan and co-workers successfully develop a novel photo-controlled drug delivery system for the treatment of Parkinson's disease. This nanoparticle uses MgO nanoparticles as a substrate, polydopamine as a shell and carries anti-SNCA plasmid and puerarin. Under the irradiation of 808 nm near-infrared light, the composite nanoparticles in deep tissues are activated, then absorbed by nerve cells after penetrating the blood–brain barrier, playing the role of antioxidation, anti-inflammation and inhibiting the accumulation of α-synuclein. Therefore, this strategy for intracerebral drug delivery can be an ideal approach to combat neurodegenerative diseases.
Cell-Derived Vesicles for Nanoparticles' Coating: Biomimetic Approaches for Enhanced Blood Circulation and Cancer Therapy
Carolina F. Rodrigues, Natanael Fernandes, Duarte de Melo-Diogo, IlÃÂdio J. Correia, André F. Moreira
doi : 10.1002/adhm.202201214
Cancer nanomedicines are designed to encapsulate different therapeutic agents, prevent their premature release, and deliver them specifically to cancer cells, due to their ability to preferentially accumulate in tumor tissue.
Thermoresponsive and Injectable Hydrogel for Tissue Agnostic Regeneration
Dax Calder, Ali Fathi, Farshad Oveissi, Simin Maleknia, Terence Abrams, Yiwei Wang, Joanneke Maitz, Kevin Hung-Yueh Tsai, Peter Maitz, Wojtek Chrzanowski, Ivan Canoy, Vivek Ashoka Menon, Kenneth Lee, Benjamin J. Ahern, Natasha E. Lean, Dina M. Silva, Paul M. Young, Daniela Traini, Hui Xin Ong, Rasoul Seyed Mahmoud, Hossein Montazerian, Ali Khademhosseini, Fariba Dehghani
doi : 10.1002/adhm.202201714
Injectable hydrogels can support the body's innate healing capability by providing a temporary matrix for host cell ingrowth and neovascularization. The clinical adoption of current injectable systems remains low due to their cumbersome preparation requirements, device malfunction, product dislodgment during administration, and uncontrolled biological responses at the treatment site.
3D-Printed Radiopaque Bioresorbable Stents to Improve Device Visualization
Yonghui Ding, Rao Fu, Caralyn Paige Collins, Sarah-Fatime Yoda, Cheng Sun, Guillermo A. Ameer
doi : 10.1002/adhm.202201955
Bioresorbable stents (BRS) hold great promise for the treatment of many life-threatening luminal diseases. Tracking and monitoring of stents in vivo is critical for avoiding their malposition and inadequate expansion, which often leads to complications and stent failure. However, obtaining high X-ray visibility of polymeric BRS has been challenging because of their intrinsic radiolucency.
High Throughput Omnidirectional Printing of Tubular Microstructures from Elastomeric Polymers
Chuan Liu, Scott B. Campbell, Jianzhao Li, Dawn Bannerman, Simon Pascual-Gil, Jennifer Kieda, Qinghua Wu, Peter R. Herman, Milica Radisic
doi : 10.1002/adhm.202201346
Bioelastomers are extensively used in biomedical applications due to their desirable mechanical strength, tunable properties, and chemical versatility; however, three-dimensional (3D) printing bioelastomers into microscale structures has proven elusive.
NIR-Assisted MgO-Based Polydopamine Nanoparticles for Targeted Treatment of Parkinson's Disease through the Blood–Brain Barrier
Yifei Gao, Yuxue Cheng, Jiapeng Chen, Danmin Lin, Chao Liu, Ling-Kun Zhang, Liang Yin, Runcai Yang, Yan-Qing Guan
doi : 10.1002/adhm.202201655
The blood–brain barrier (BBB) is a major limiting factor that prevents the treatment of Parkinson's disease (PD). In the present study, MgOp@PPLP nanoparticles are explored by using MgO nanoparticles as a substrate, polydopamine as a shell, wrapping anti-SNCA plasmid inside, and modifying polyethylene glycol, lactoferrin, and puerarin on the surface to improve the hydrophilicity, brain targeting and antioxidant properties of the particles, respectively.
Viscoelastic Notch Signaling Hydrogel Induces Liver Bile Duct Organoid Growth and Morphogenesis (Adv. Healthcare Mater. 23/2022)
Muhammad Rizwan, Christopher Ling, Chengyu Guo, Tracy Liu, Jia-Xin Jiang, Christine E. Bear, Shinichiro Ogawa, Molly S. Shoichet
doi : 10.1002/adhm.202270140
In article 2200880 by Molly S. Shoichet and co-workers, an engineered hyaluronan hydrogel elucidates cell–matrix interactions and bile duct morphogenesis. The hydrogel viscoelasticity is systematically varied to promote primary cholangiocyte organoid growth from encapsulated single cells, which is mediated by Yes-associated protein signaling. The immobilized Jagged1 in the hydrogel activates Notch signaling in 3D cultured cholangiocytes, which leads to unprecedented bile duct-like morphogenesis.
Viscoelastic Notch Signaling Hydrogel Induces Liver Bile Duct Organoid Growth and Morphogenesis
Muhammad Rizwan, Christopher Ling, Chengyu Guo, Tracy Liu, Jia-Xin Jiang, Christine E. Bear, Shinichiro Ogawa, Molly S. Shoichet
doi : 10.1002/adhm.202200880
Cholangiocyte organoids can be used to model liver biliary disease; however, both a defined matrix to emulate cholangiocyte self-assembly and the mechano-transduction pathways involved therein remain elusive.
Targeted Delivery of PD-L1-Derived Phosphorylation-Mimicking Peptides by Engineered Biomimetic Nanovesicles to Enhance Osteosarcoma Treatment
Wei Wu, Haoyu Guo, Doudou Jing, Zhenhao Zhang, Zhicai Zhang, Feifei Pu, Wenbo Yang, Xin Jin, Xin Huang, Zengwu Shao
doi : 10.1002/adhm.202200955
Osteosarcoma is a rare malignant bone-originating tumor that usually occurs in young people. Programmed cell death 1 ligand 1 (PD-L1), an immune checkpoint protein, is highly expressed in osteosarcoma tissues.
Fast Construction of Biomimetic Organic–Inorganic Interface by Crosslinking of Calcium Phosphate Oligomers: A Strategy for Instant Regeneration of Hard Tissue
Lumiao Yan, Chen Zheng, Ding Yuan, Zhengxi Guo, Yihao Cui, Zhijian Xie, Zhi Chen, Ruikang Tang, Zhaoming Liu
doi : 10.1002/adhm.202201161
The organic–inorganic structure in biological hard tissues ensures their marvelous characteristics but these hybrids are easily destroyed by the demineralization of inorganic components, e.g., the damage of dentin.
Facile Fabrication of Injectable Alginate and Poly(3,4-ethylenedioxythiophene)-Based Soft Electrodes toward the Goal of Neuro-Regenerative Applications
Ivana Perkucin, Kylie S. K. Lau, Tianhao Chen, Stephanie N. Iwasa, Hani E. Naguib, Cindi M. Morshead
doi : 10.1002/adhm.202201164
Resident brain neural precursor cells (NPCs) are electrosensitive cells that respond to electric field application by proliferating, differentiating, and undergoing rapid and directed cathodal migration. Harnessing NPC potential is a promising strategy to facilitate neural repair following injury or disease.
Inflammatory Microenvironment-Responsive Nanomaterials Promote Spinal Cord Injury Repair by Targeting IRF5
Dezun Ma, He Shen, Fangman Chen, Weiyuan Liu, Yannan Zhao, Zhifeng Xiao, Xianming Wu, Bing Chen, Junna Lu, Dan Shao, Jianwu Dai
doi : 10.1002/adhm.202201319
Spinal cord injury (SCI) involves excessive inflammatory responses, which are characterized by the existence of high levels of proinflammatory M1 macrophages rather than prohealing M2 macrophages, and oxidative stress. Interferon regulatory factor 5 (IRF5) is a promising therapeutic target in regulation of macrophage reprogramming from the M1 to M2 phenotype.
Magnetic Nanodroplets for Enhanced Deep Penetration of Solid Tumors and Simultaneous Magnetothermal-Sensitized Immunotherapy against Tumor Proliferation and Metastasis
Junrui Wang, Wenli Zhang, Zhuoyan Xie, Xingyue Wang, Ying Luo, Weixi Jiang, Yun Liu, Zhigang Wang, Haitao Ran, Weixiang Song, Dajing Guo
doi : 10.1002/adhm.202201399
The central cells of solid tumors are more proliferative and metastatic than the marginal cells. Therefore, more intelligent strategies for targeting cells with deep spatial distributions in solid tumors remain to be explored.
Mapping of Spatiotemporal Auricular Electrophysiological Signals Reveals Human Biometric Clusters
Qingyun Huang, Cong Wu, Senlin Hou, Kuanming Yao, Hui Sun, Yufan Wang, Yikai Chen, Junhui Law, Mingxiao Yang, Ho-yin Chan, Vellaisamy A. L. Roy, Yuliang Zhao, Dong Wang, Enming Song, Xinge Yu, Lixing Lao, Yu Sun, Wen Jung Li
doi : 10.1002/adhm.202201404
Underneath the ear skin there are rich vascular network and sensory nerve branches. Hence, the 3D mapping of auricular electrophysiological signals can provide new biomedical perspectives. However, it is still extremely challenging for current sensing techniques to cover the entire ultra-curved auricle.
Injectable Prevascularized Mature Adipose Tissues (iPAT) to Achieve Long-Term Survival in Soft Tissue Regeneration
Fiona Louis, Yoshihiro Sowa, Shinji Irie, Yuriko Higuchi, Shiro Kitano, Osam Mazda, Michiya Matsusaki
doi : 10.1002/adhm.202201440
Soft tissue regeneration remains a challenge in reconstructive surgery. So far, both autologous fat implantations and artificial implants methods used in clinical applications lead to various disadvantages and limited lifespan. To overcome these limitations and improve the graft volume maintenance, reproducing a mature adipose tissue already including vasculature structure before implantation can be the solution.
Programmed Upregulation of HSP70 by Metal-Organic Frameworks Nanoamplifier for Enhanced Microwave Thermal-Immunotherapy
Wenna Guo, Meng Niu, Zengzhen Chen, Qiong Wu, Longfei Tan, Xiangling Ren, Changhui Fu, Jun Ren, Deen Gu, Xianwei Meng
doi : 10.1002/adhm.202201441
Thermotherapy can directly kill tumor cells whilst being accompanied by immune-enhancing effects. However, this immune-enhancing effect suffers from insufficient expression of immune response factors (e.g., heat shock protein 70, HSP70), resulting in no patient benefiting due to the recurrence of tumor cells after thermotherapy.
Effective Sonosensitizer Delivery by Redox Sensitive Nanoparticles for Prostate Cancer Sonodynamic Therapy via Amplifying Oxidative Stress and Peroxidation
Tongyu Tong, Hanqi Lei, Shiqiang Zhang, Donggen Jiang, Yupeng Guan, Chengyuan Xing, Huikun Chen, Xiangwei Yang, Yang Kang, Jun Pang
doi : 10.1002/adhm.202201472
Sonodynamic therapy (SDT), a novel noninvasive therapeutic modality, provides many noteworthy benefits by generating reactive oxygen species (ROS). However, water-insoluble sonosensitizer delivery strategies have continuously underperformed because of unavoidable toxicity and a short circulation time.
Polydopamine-Engineered Theranostic Nanoscouts Enabling Intracellular HSP90 mRNAs Fluorescence Detection for Imaging-Guided Chemo–Photothermal Therapy
Geng Yang, Mengyue Li, Ting Song, Xiangyan Chen, Hanxi Zhang, Xiaodan Wei, Ningxi Li, Tingting Li, Xiang Qin, Shun Li, Fengming You, Chunhui Wu, Wei Zhang, Yiyao Liu, Hong Yang
doi : 10.1002/adhm.202201615
The combination of photothermal therapy (PTT) and chemotherapy is considered a promising tumor treatment modality, nevertheless, cellular resistance induced by heat shock proteins (HSPs) overexpressed in tumor cells will restrict the therapeutic effect.
Totally Organic Hydrogel-Based Self-Closing Cuff Electrode for Vagus Nerve Stimulation (Adv. Healthcare Mater. 23/2022)
Daigo Terutsuki, Hayato Yoroizuka, Shin-ichiro Osawa, Yuka Ogihara, Hiroya Abe, Atsuhiro Nakagawa, Masaki Iwasaki, Matsuhiko Nishizawa
doi : 10.1002/adhm.202270142
In article 2201627 by Matsuhiko Nishizawa and co-workers, a totally organic hydrogel-based cuff-type stimulation electrode with self-closing properties is developed. The cuff electrode is spontaneously immobilized to the vagus nerve by wrapped around the nerve bundle with harmless pressure. The organic nature of the electrode is compatible with MRI imaging.
Totally Organic Hydrogel-Based Self-Closing Cuff Electrode for Vagus Nerve Stimulation
Daigo Terutsuki, Hayato Yoroizuka, Shin-ichiro Osawa, Yuka Ogihara, Hiroya Abe, Atsuhiro Nakagawa, Masaki Iwasaki, Matsuhiko Nishizawa
doi : 10.1002/adhm.202201627
An intrinsically soft organic electrode consisting of poly(3,4-ethylenedioxythiophene)-modified polyurethane (PEDOT-PU) is embedded into a bilayer film of polyvinyl alcohol (PVA) hydrogels for developing a self-closing cuff electrode for neuromodulation. The curled form of the PVA hydrogel is prepared by releasing internal stress in the bilayer structure.
Upregulating HIF-1α to Boost the Survival of Neural Stem Cells via Functional Peptides-Complexed MRI-Visible Nanomedicine for Stroke Therapy
Zhe Wang, Yujun Cai, Qinyuan Zhang, Jianing Li, Bingling Lin, Junya Zhao, Fang Zhang, Yunhua Li, Xieqing Yang, Liejing Lu, Xintao Shuai, Jun Shen
doi : 10.1002/adhm.202201630
Neural stem cells (NSCs) transplantation has been considered as a promising strategy for the treatment of ischemic stroke. However, the therapeutic prospect is limited by the poor control over the survival, migration, and maturation of transplanted NSCs. Upregulating hypoxia inducible factor (HIF)-1α expression in stem cells can improve the survival and migration of NSCs grafted for stroke therapy.
Instant and Tough Adhesives for Rapid Gastric Perforation and Traumatic Pneumothorax Sealing
Xiaowei Liu, Ying Yang, Haojie Yu, Li Wang, Yan Sheng, Zhikun Huang, Jian Yang, Zhipeng Ni, Di Shen
doi : 10.1002/adhm.202201798
Hydrogel adhesives are hot spots due to their ubiquity and practical relevance. However, achieving a robust wet adhesion is still a challenge due to the preferential formation of hydrogen bonds between interfacial fluids and bulk hydrogel, as well as targeted substrates.
Novel Temperature-Sensitive Hydrogel Promotes Wound Healing Through YAP and MEK-Mediated Mechanosensitivity
Ze Li, Jinjian Huang, Yungang Jiang, Ye Liu, Guiwen Qu, Kang Chen, Yun Zhao, Peige Wang, Xiuwen Wu, Jianan Ren
doi : 10.1002/adhm.202201878
Wound healing is a significant problem in clinical management. Various functional dressings are studied to promote wound healing through biochemical factors. They are generally expensive, complex to fabricate, and may adversely affect the wound. Mechanical forces are the critical regulators of tissue repair.
Enzymatic Nanosphere-to-Nanofiber Transition and Autophagy Inducer Release Promote Tumor Chemotherapy
Xiaotong Cheng, Tiantian Xia, Wenjun Zhan, Hai-Dong Xu, Jiaoming Jiang, Xiaoyang Liu, Xianbao Sun, Fu-Gen Wu, Gaolin Liang
doi : 10.1002/adhm.202201916
Chemotherapy has remained an effective and predominant cancer treatment for the past decades, but is hampered by its low response rate and severe systemic toxicity. Combination chemotherapies are proposed to address these issues, yet their therapeutic outcomes are still far from satisfactory.
Cell-Derived Vesicles with Increased Stability and On-Demand Functionality by Equipping Their Membrane with a Cross-Linkable Copolymer
Xinan Huang, Dimitri Hürlimann, Hendrik T. Spanke, Dalin Wu, Michal Skowicki, Ionel Adrian Dinu, Eric R. Dufresne, Cornelia G. Palivan
doi : 10.1002/adhm.202202100
Cell-derived vesicles retain the cytoplasm and much of the native cell membrane composition. Therefore, they are attractive for investigations of membrane biophysics, drug delivery systems, and complex molecular factories.
Acellularized Uvea Hydrogel as Novel Injectable Platform for Cell-Based Delivering Treatment of Retinal Degeneration and Optimizing Retinal Organoids Inducible System
Guilan Li, Sheng Liu, Wenfei Chen, Zhijian Jiang, Yuanting Luo, Dongliang Wang, Yingfeng Zheng, Yizhi Liu
doi : 10.1002/adhm.202202114
Replenishing the retina with retinal pigment epithelial (RPE) cells derived from pluripotent stem cells (PSCs) has great promise for treating retinal degenerative diseases, but it is limited by poor cell survival and integration in vivo.
Niobium Diselenide Nanosheets: An Emerging Biodegradable Nanoplatform for Efficient Cancer Phototheranostics in the NIR-II Window
Hanhan Xie, Shengyong Geng, Jundong Shao, Guanghong Luo, Qian Liu, Jiahong Wang, Yue Chen, Paul K. Chu, Zhibin Li, Xue-Feng Yu
doi : 10.1002/adhm.202202126
As a prominent class of 2D transition metal dichalcogenides (TMDCs), niobium diselenide nanosheets (NbSe2 NSs) have garnered tremendous interest on account of promising applications pertaining to optoelectronics and energy storage.
Miniature NIR-II Nanoprobes for Active-Targeted Phototheranostics of Brain Tumors
Yayun Wu, Dehong Hu, Duyang Gao, Chunchen Liu, Hairong Zheng, Zonghai Sheng
doi : 10.1002/adhm.202202379
Nanoprobes (NPs) in the second near-infrared biowindow (NIR-II, 1000–1700 nm) are developed and widely used in cancer phototheranostics. However, most NIR-II NPs exhibit low phototheranostic efficiency due to their tedious synthetic routes, large particle sizes (>20 nm), and lack of active targeting properties.
Mechanical Stability of Nano-Coatings on Clinically Applicable Electrodes, Generated by Electrophoretic Deposition
Vaijayanthi Ramesh, Nadine Stratmann, Viktor Schaufler, Svilen D. Angelov, Ilona D. Nordhorn, Hans E. Heissler, Ricardo MartÃÂnez-Hincapié, Viktor ÄŒolić, Christoph Rehbock, Kerstin Schwabe, Uwe Karst, Joachim K. Krauss, Stephan Barcikowski
doi : 10.1002/adhm.202102637
The mechanical stability of implant coatings is crucial for medical approval and transfer to clinical applications. Here, electrophoretic deposition (EPD) is a versatile coating technique, previously shown to cause significant post-surgery impedance reduction of brain stimulation platinum electrodes.
